2,3-Dimethylbut-2-enedioic acid (BioDeep_00000173512)
human metabolite blood metabolite
代谢物信息卡片
化学式: C6H8O4 (144.0422568)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 0.93%
分子结构信息
SMILES: CC(=C(C)C(O)=O)C(O)=O
InChI: InChI=1S/C6H8O4/c1-3(5(7)8)4(2)6(9)10/h1-2H3,(H,7,8)(H,9,10)
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chang Joo Oh, Joon-Young Kim, Young-Keun Choi, Han-Jong Kim, Ji-Yun Jeong, Kwi-Hyun Bae, Keun-Gyu Park, In-Kyu Lee. Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling.
PloS one.
2012; 7(10):e45870. doi:
10.1371/journal.pone.0045870. [PMID: 23056222] - Julie Adam, Emine Hatipoglu, Linda O'Flaherty, Nicola Ternette, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emma Nye, Gordon W Stamp, Kathryn Wolhuter, Marcus Stevens, Roman Fischer, Peter Carmeliet, Patrick H Maxwell, Chris W Pugh, Norma Frizzell, Tomoyoshi Soga, Benedikt M Kessler, Mona El-Bahrawy, Peter J Ratcliffe, Patrick J Pollard. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Cancer cell.
2011 Oct; 20(4):524-37. doi:
10.1016/j.ccr.2011.09.006. [PMID: 22014577] - Martin Rostami-Yazdi, Bernd Clement, Ulrich Mrowietz. Pharmacokinetics of anti-psoriatic fumaric acid esters in psoriasis patients.
Archives of dermatological research.
2010 Sep; 302(7):531-8. doi:
10.1007/s00403-010-1061-4. [PMID: 20574745] - Til Menge, Martin S Weber, Bernhard Hemmer, Bernd C Kieseier, Hans-Christian von Büdingen, Clemens Warnke, Scott S Zamvil, Aaron Boster, Omar Khan, Hans-Peter Hartung, Olaf Stüve. Disease-modifying agents for multiple sclerosis: recent advances and future prospects.
Drugs.
2008; 68(17):2445-68. doi:
10.2165/0003495-200868170-00004. [PMID: 19016573] - Nicole Schupp, Reinhard Schinzel, August Heidland, Helga Stopper. Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors.
Annals of the New York Academy of Sciences.
2005 Jun; 1043(?):685-95. doi:
10.1196/annals.1333.079. [PMID: 16037294] - Nicolle H R Litjens, Elisabeth van Strijen, Co van Gulpen, Herman Mattie, Jaap T van Dissel, H Bing Thio, Peter H Nibbering. In vitro pharmacokinetics of anti-psoriatic fumaric acid esters.
BMC pharmacology.
2004 Oct; 4(?):22. doi:
10.1186/1471-2210-4-22. [PMID: 15479475] - Nicolle H R Litjens, Jacobus Burggraaf, Elisabeth van Strijen, Co van Gulpen, Herman Mattie, Rik C Schoemaker, Jaap T van Dissel, H Bing Thio, Peter H Nibbering. Pharmacokinetics of oral fumarates in healthy subjects.
British journal of clinical pharmacology.
2004 Oct; 58(4):429-32. doi:
10.1111/j.1365-2125.2004.02145.x. [PMID: 15373936] - L L Fan, B S Masters, R A Prough. Microsomal lauric acid 11- and 12-hydroxylation: a new assay method utilizing high pressure liquid chromatography.
Analytical biochemistry.
1976 Mar; 71(1):265-72. doi:
10.1016/0003-2697(76)90035-x. [PMID: 5910]