Glucaric acid (BioDeep_00000001735)

 

Secondary id: BioDeep_00000270998, BioDeep_00000405324

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds


代谢物信息卡片


(2S,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioic acid

化学式: C6H10O8 (210.03756600000003)
中文名称: 葡糖二酸, 葡萄糖二酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.27%

分子结构信息

SMILES: C(C(C(C(=O)O)O)O)(C(C(=O)O)O)O
InChI: InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)

描述信息

Glucaric acid, also known as glucarate or D-saccharic acid, belongs to the class of organic compounds known as glucuronic acid derivatives. Glucuronic acid derivatives are compounds containing a glucuronic acid moiety (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid. Glucaric acid is a sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups. D-glucaric acid is found in fruits, vegetables, and mammals. The highest concentrations of glucaric acid are found in grapefruits, apples, oranges, and cruciferous vegetables (PMID: 18772850). Glucaric acid is produced through the oxidation of glucose. Cytochrome P450 is thought to be responsible for the production of D-glucaric acid in vivo (PMID: 3779687). In mammals, D-glucaric acid and D-glucaro-l,4-lactone are also known end-products of the D-glucuronic acid pathway (PMID: 18772850). Glucaric is available as a dietary supplement in the form of calcium D-glucarate and has been studied for therapeutic purposes including cholesterol reduction and cancer chemotherapy (PMID: 9101079). D-Glucaric acid has a potential use as a building block for a number of polymers, including new nylons and hyperbranched polyesters. D-glucaric acid produced from D-glucose has been successfully utilized to produce a hydroxylated nylon.
A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups. [HMDB]
KEIO_ID S025

同义名列表

45 个代谢物同义名

(2S,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioic acid; (2R,3S,4S,5S)-2,3,4,5-Tetrahydroxyhexanedioic acid; (2R,3S,4S,5S)-2,3,4,5-Tetrahydroxyhexanedioate; Tetrahydrate, calcium saccharate; Saccharate tetrahydrate, calcium; Calcium saccharate tetrahydrate; Calcium saccharate, anhydrous; Saccharate, anhydrous calcium; Calcium glucarate, anhydrous; Glucarate, anhydrous calcium; Anhydrous calcium saccharate; Calcium saccharate anhydrous; Anhydrous calcium glucarate; D-Tetrahydroxyadipic acid; Tetrahydroxyadipic acid; D-Glucosaccharic acid; D-Tetrahydroxyadipate; D-(+)-Saccharic acid; Saccharate, calcium; Glucosaccharic acid; Glucarate, calcium; CalciuM Saccharate; Calcium glucarate; D-Glucosaccharate; Levo-gularic acid; Levo gularic acid; DL-Glucaric acid; D Saccharic acid; D-Saccharic acid; D-(+)-Saccharate; D Glucaric acid; Acid, saccharic; D-Glucaric acid; L Gularic acid; Saccharic acid; L-Gularic acid; Glucaric acid; D-Saccharate; D-Glucarate; L-Gularate; Saccharate; Glucarate; GKR; Glucaric acid; D-Glucarate



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yichao Ge, Yihan Ma, Meilu Zhao, Jihua Wei, Xiaodan Wu, Zunjing Zhang, Han Yang, Houxing Lei, Bin Wu. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European journal of medicinal chemistry. 2022 Nov; 242(?):114699. doi: 10.1016/j.ejmech.2022.114699. [PMID: 36001934]
  • Yujie Li, Qiangqiang Jia, Min Zhang, Lu Kang, Zihan Li, Yu Liu, Hongyang Zhang, Ping Hu. Isolation of three glucaric acids from Leonurus japonicus Houtt. by using high-speed countercurrent chromatography combined with semi-preparative high-performance liquid chromatography. Journal of separation science. 2022 Jul; 45(13):2140-2147. doi: 10.1002/jssc.202100876. [PMID: 35396803]
  • Vibhudutta Awasthi, Hariprasad Gali, Andria F Hedrick, Huining Da, Venkateswararao Eeda, Diwakar Jain. Positron Emission Tomography (PET) with 18F-FGA for Diagnosis of Myocardial Infarction in a Coronary Artery Ligation Model. Molecular imaging. 2022; 2022(?):9147379. doi: 10.1155/2022/9147379. [PMID: 35250392]
  • Cen Hong, Xiangbo Xu, Ruirui Feng, Fernando Gomes Romeiro, Dan Zhang, Zhaohui Bai, Xiaozhong Guo, Xingshun Qi. Use of iron sucrose injection in anemia patients with reduced serum iron concentration during hospitalizations of digestive and liver diseases. Annals of palliative medicine. 2021 Feb; 10(2):1145-1153. doi: 10.21037/apm-19-499. [PMID: 32954752]
  • Hailey Houson, Alexander Mdzinarishvili, Hariprasad Gali, Evgeny Sidorov, Vibhudutta Awasthi. PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2-[18F]Fluoro-D-Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke. Molecular imaging and biology. 2020 10; 22(5):1353-1361. doi: 10.1007/s11307-020-01513-9. [PMID: 32557188]
  • Minzi Ju, Yaqun Liu, Mingyue Li, Mengjing Cheng, Yuan Zhang, Guozhe Deng, Xuejun Kang, Hua Liu. Baicalin improves intestinal microecology and abnormal metabolism induced by high-fat diet. European journal of pharmacology. 2019 Aug; 857(?):172457. doi: 10.1016/j.ejphar.2019.172457. [PMID: 31202804]
  • Charose Marie Ting Perez, Kenshi Watanabe, Yoshiko Okamura, Yutaka Nakashimada, Tsunehiro Aki. Metabolite Profile Analysis of Aurantiochytrium limacinum SR21 Grown on Acetate-based Medium for Lipid Fermentation. Journal of oleo science. 2019 Jun; 68(6):541-549. doi: 10.5650/jos.ess19020. [PMID: 31092798]
  • Wenlong Yang, Guanlin Zhou, Shubing Zou, Wentao Yang, Aihong Liu, Shuilin Sun, Baogang Xie. Metabonomics of d-glucaro-1,4-lactone in preventing diethylnitrosamine-induced liver cancer in rats. Pharmaceutical biology. 2018 Dec; 56(1):643-648. doi: 10.1080/13880209.2018.1525414. [PMID: 31070541]
  • Gonçalo J L Cunha, Bruno M L Rocha, Luiz Menezes Falcão. Iron deficiency in chronic and acute heart failure: A contemporary review on intertwined conditions. European journal of internal medicine. 2018 06; 52(?):1-7. doi: 10.1016/j.ejim.2018.04.013. [PMID: 29680173]
  • Kimberley Span, Ebel H E Pieters, Vera Brinks, Wim E Hennink, Huub Schellekens. Evaluation of the suitability of a Sprague Dawley rat model to assess intravenous iron preparations. Journal of pharmacological and toxicological methods. 2018 May; 91(?):7-17. doi: 10.1016/j.vascn.2017.12.001. [PMID: 29278742]
  • Susana Pastor, Elisabeth Coll, Lara Rodríguez-Ribera, Elitsa Stoyanova, Zuray F Corredor, Ricard Marcos. Influence of Carnicor, Venofer, and Sevelamer on the levels of genotoxic damage in end-stage renal disease patients. Environmental and molecular mutagenesis. 2018 05; 59(4):302-311. doi: 10.1002/em.22170. [PMID: 29359355]
  • Hailey A Houson, Gregory N Nkepang, Andria F Hedrick, Vibhudutta Awasthi. Imaging of isoproterenol-induced myocardial injury with 18F labeled fluoroglucaric acid in a rat model. Nuclear medicine and biology. 2018 04; 59(?):9-15. doi: 10.1016/j.nucmedbio.2017.12.006. [PMID: 29413753]
  • Julia Schnorr, Sören Fütterer, Karsten Spicher, Maria Catarinolo, Christoph Schlösser, Harald Enzmann, Peter Langguth. Bioequivalence decision for nanoparticular iron complex drugs for parenteral administration based on their disposition. Regulatory toxicology and pharmacology : RTP. 2018 Apr; 94(?):293-298. doi: 10.1016/j.yrtph.2018.02.009. [PMID: 29454888]
  • Kazuya Takasawa, Chikako Takaeda, Takashi Wada, Norishi Ueda. Optimal Serum Ferritin Levels for Iron Deficiency Anemia during Oral Iron Therapy (OIT) in Japanese Hemodialysis Patients with Minor Inflammation and Benefit of Intravenous Iron Therapy for OIT-Nonresponders. Nutrients. 2018 Mar; 10(4):. doi: 10.3390/nu10040428. [PMID: 29596361]
  • Thi-Kieu-Oanh Nguyen, Arash Jamali, Eric Grand, Kris Morreel, Paulo Marcelo, Eric Gontier, Rebecca Dauwe. Phenylpropanoid profiling reveals a class of hydroxycinnamoyl glucaric acid conjugates in Isatis tinctoria leaves. Phytochemistry. 2017 Dec; 144(?):127-140. doi: 10.1016/j.phytochem.2017.09.007. [PMID: 28930667]
  • Yasuhiro Taki, Naohiko Imai, Yugo Shibagaki. Zinc deficiency anaemia in haemodialysis patients: Often overlooked but a treatable cause of anaemia. Nephrology (Carlton, Vic.). 2017 12; 22(12):1037-1038. doi: 10.1111/nep.12993. [PMID: 29145703]
  • Dante A Suffredini, Wanying Xu, Junfeng Sun, Jesús Barea-Mendoza, Steven B Solomon, Samuel L Brashears, Andreas Perlegas, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson, Irene Cortés-Puch. Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia. Transfusion. 2017 10; 57(10):2338-2347. doi: 10.1111/trf.14214. [PMID: 28656646]
  • Hiroshi Nomoto, Hideaki Miyoshi, Akinobu Nakamura, So Nagai, Naoyuki Kitao, Chikara Shimizu, Tatsuya Atsumi. A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report. Medicine. 2017 Sep; 96(39):e8147. doi: 10.1097/md.0000000000008147. [PMID: 28953654]
  • Peng Zou, Katherine Tyner, Andre Raw, Sau Lee. Physicochemical Characterization of Iron Carbohydrate Colloid Drug Products. The AAPS journal. 2017 09; 19(5):1359-1376. doi: 10.1208/s12248-017-0126-0. [PMID: 28762128]
  • Ali C M Johnson, Jeff J Delrow, Richard A Zager. Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury. Translational research : the journal of laboratory and clinical medicine. 2017 08; 186(?):1-18. doi: 10.1016/j.trsl.2017.05.005. [PMID: 28586635]
  • Kristiyana Kaneva, Erika Chow, Cathy G Rosenfield, Michael J Kelly. Intravenous Iron Sucrose for Children With Iron Deficiency Anemia. Journal of pediatric hematology/oncology. 2017 07; 39(5):e259-e262. doi: 10.1097/mph.0000000000000879. [PMID: 28562517]
  • Wolfgang C Winkelmayer, Benjamin A Goldstein, Aya A Mitani, Victoria Y Ding, Medha Airy, Sreedhar Mandayam, Tara I Chang, M Alan Brookhart, Steven Fishbane. Safety of Intravenous Iron in Hemodialysis: Longer-term Comparisons of Iron Sucrose Versus Sodium Ferric Gluconate Complex. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Jun; 69(6):771-779. doi: 10.1053/j.ajkd.2016.10.031. [PMID: 28063734]
  • Shruti B Bhavi, Purushottam B Jaju. Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial. BMC pregnancy and childbirth. 2017 May; 17(1):137. doi: 10.1186/s12884-017-1313-9. [PMID: 28482869]
  • Keisuke Oshima, Yasumasa Ikeda, Yuya Horinouchi, Hiroaki Watanabe, Hirofumi Hamano, Yoshitaka Kihira, Seiji Kishi, Yuki Izawa-Ishizawa, Licht Miyamoto, Tasuku Hirayama, Hideko Nagasawa, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki. Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation. Laboratory investigation; a journal of technical methods and pathology. 2017 05; 97(5):555-566. doi: 10.1038/labinvest.2017.11. [PMID: 28263291]
  • Thomas Lee, Thomas Clavel, Kirill Smirnov, Annemarie Schmidt, Ilias Lagkouvardos, Alesia Walker, Marianna Lucio, Bernhard Michalke, Philippe Schmitt-Kopplin, Richard Fedorak, Dirk Haller. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 05; 66(5):863-871. doi: 10.1136/gutjnl-2015-309940. [PMID: 26848182]
  • Iain C Macdougall, Naomi V Dahl, Kristine Bernard, Zhu Li, Alka Batycky, William E Strauss. The Ferumoxytol for Anemia of CKD Trial (FACT)-a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale. BMC nephrology. 2017 04; 18(1):117. doi: 10.1186/s12882-017-0523-8. [PMID: 28372549]
  • Yinghui Deng, Jinglin Wu, Qiang Jia. Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome (RLS): A Randomized, Placebo-Controlled Study. Medical science monitor : international medical journal of experimental and clinical research. 2017 Mar; 23(?):1254-1260. doi: 10.12659/msm.900520. [PMID: 28285317]
  • Julia Cordelia Hempel, Felix Poppelaars, Mariana Gaya da Costa, Casper F M Franssen, Thomas P G de Vlaam, Mohamed R Daha, Stefan P Berger, Marc A J Seelen, Carlo A J M Gaillard. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations. American journal of nephrology. 2017; 45(1):49-59. doi: 10.1159/000451060. [PMID: 27889746]
  • Sara Valério de Azevedo, Catarina Maltez, Ana Isabel Lopes. Pediatric Crohn's disease, iron deficiency anemia and intravenous iron treatment: a follow-up study. Scandinavian journal of gastroenterology. 2017 Jan; 52(1):29-33. doi: 10.1080/00365521.2016.1224381. [PMID: 27576956]
  • Weerapon Sangartit, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Wanida Donpunha, Shigeki Shibahara, Upa Kukongviriyapan. Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice. Vascular pharmacology. 2016 12; 87(?):199-208. doi: 10.1016/j.vph.2016.10.001. [PMID: 27713040]
  • Matthew A Roberts, Louis Huang, Darren Lee, Robert MacGinley, Stefanie M A Troster, Annette B Kent, Sukhvinder S Bansal, Iain C Macdougall, Lawrence P McMahon. Effects of intravenous iron on fibroblast growth factor 23 (FGF23) in haemodialysis patients: a randomized controlled trial. BMC nephrology. 2016 11; 17(1):177. doi: 10.1186/s12882-016-0391-7. [PMID: 27852236]
  • Lisa H Fell, Sarah Seiler-Mußler, Alexander B Sellier, Björn Rotter, Peter Winter, Martina Sester, Danilo Fliser, Gunnar H Heine, Adam M Zawada. Impact of individual intravenous iron preparations on the differentiation of monocytes towards macrophages and dendritic cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2016 11; 31(11):1835-1845. doi: 10.1093/ndt/gfw045. [PMID: 27190361]
  • Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt, Alpaslan Mayadagli. Is there any role of intravenous iron for the treatment of anemia in cancer?. BMC cancer. 2016 08; 16(1):661. doi: 10.1186/s12885-016-2686-2. [PMID: 27542823]
  • Javier Deira, Silvia González-Sanchidrián, Santiago Polanco, Clarencio Cebrián, María Jiménez, Jesús Marín, Juan-Ramón Gómez-Martino, Luis Fernández-Pereira, José Tabernero. Very low doses of direct intravenous iron in each session as maintenance therapy in hemodialysis patients. Renal failure. 2016 Aug; 38(7):1076-81. doi: 10.1080/0886022x.2016.1184937. [PMID: 27197731]
  • Baogang Xie, Yalan Liu, Huiqin Zou, Yong Son, Huiyun Wang, Haipeng Wang, Jianghua Shao. Determination of D-glucaric acid and/or D-glucaro-1,4-lacton in different apple varieties through hydrophilic interaction chromatography. Food chemistry. 2016 Jul; 203(?):1-7. doi: 10.1016/j.foodchem.2016.02.009. [PMID: 26948581]
  • Richard A Zager, Ali C M Johnson, Kirsten B Frostad. Combined iron sucrose and protoporphyrin treatment protects against ischemic and toxin-mediated acute renal failure. Kidney international. 2016 07; 90(1):67-76. doi: 10.1016/j.kint.2016.01.022. [PMID: 27165818]
  • Kimmi Mukhija, Kirti Singhal, Stanzin Angmo, Kamalendra Yadav, Hariom Yadav, Rajat Sandhir, Nitin Kumar Singhal. Potential of Alginate Encapsulated Ferric Saccharate Microemulsions to Ameliorate Iron Deficiency in Mice. Biological trace element research. 2016 Jul; 172(1):179-192. doi: 10.1007/s12011-015-0564-4. [PMID: 26637994]
  • Sigismond Lasocki, Pascale Piednoir, Camille Couffignal, Emmanuel Rineau, Guillaume Dufour, Thibaud Lefebvre, Herve Puy, Xavier Duval, Fathi Driss, Clementine Schilte. Does IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A Comparison With Healthy Volunteers. Critical care medicine. 2016 Mar; 44(3):521-30. doi: 10.1097/ccm.0000000000001420. [PMID: 26605680]
  • Iain C Macdougall. Iron Treatment Strategies in Nondialysis CKD. Seminars in nephrology. 2016 03; 36(2):99-104. doi: 10.1016/j.semnephrol.2016.02.003. [PMID: 27236130]
  • Richa Pandey, Reem Daloul, Daniel W Coyne. Iron Treatment Strategies in Dialysis-Dependent CKD. Seminars in nephrology. 2016 03; 36(2):105-11. doi: 10.1016/j.semnephrol.2016.02.004. [PMID: 27236131]
  • M Alan Brookhart, Janet K Freburger, Alan R Ellis, Wolfgang C Winkelmayer, Lily Wang, Abhijit V Kshirsagar. Comparative Short-term Safety of Sodium Ferric Gluconate Versus Iron Sucrose in Hemodialysis Patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2016 Jan; 67(1):119-27. doi: 10.1053/j.ajkd.2015.07.026. [PMID: 26385819]
  • Naomi Niari Dalimunthe, Abdurrahim Rasyid Lubis. Usefulness of Reticulocyte Hemoglobin Equivalent in Management of Regular Hemodialysis Patients with Iron Deficiency Anemia. Romanian journal of internal medicine = Revue roumaine de medecine interne. 2016 Jan; 54(1):31-6. doi: 10.1515/rjim-2016-0003. [PMID: 27141568]
  • Carlo Barbieri, Elena Bolzoni, Flavio Mari, Isabella Cattinelli, Francesco Bellocchio, José D Martin, Claudia Amato, Andrea Stopper, Emanuele Gatti, Iain C Macdougall, Stefano Stuard, Bernard Canaud. Performance of a Predictive Model for Long-Term Hemoglobin Response to Darbepoetin and Iron Administration in a Large Cohort of Hemodialysis Patients. PloS one. 2016; 11(3):e0148938. doi: 10.1371/journal.pone.0148938. [PMID: 26939055]
  • Yu S Milovanov, N A Mukhin, L V Kozlovskaya, S Yu Milovanova, M M Markina. [Impact of anemia correction on the production of the circulating morphogenetic protein α-Klotho in patients with Stages 3B-4 chronic kidney disease: A new direction of cardionephroprotection]. Terapevticheskii arkhiv. 2016; 88(6):21-25. doi: 10.17116/terarkh201688621-25. [PMID: 27296257]
  • Michael M Strauss, Anupkumar Shetty, Daniel Witheiler. Bullous Skin Lesions in a Patient with End-Stage Renal Disease and Hepatitis C. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 2016 ; 32(?):56-60. doi: NULL. [PMID: 28988591]
  • Jianshuang Jiang, Yixiu Li, Ziming Feng, Yanan Yang, Peicheng Zhang. Glucaric acids from Leonurus japonicus. Fitoterapia. 2015 Dec; 107(?):85-89. doi: 10.1016/j.fitote.2015.10.007. [PMID: 26526024]
  • Medha Airy, Sreedhar Mandayam, Aya A Mitani, Tara I Chang, Victoria Y Ding, M Alan Brookhart, Benjamin A Goldstein, Wolfgang C Winkelmayer. Comparative outcomes of predominant facility-level use of ferumoxytol versus other intravenous iron formulations in incident hemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2015 Dec; 30(12):2068-75. doi: 10.1093/ndt/gfv305. [PMID: 26311216]
  • Rajiv Agarwal, John W Kusek, Maria K Pappas. A randomized trial of intravenous and oral iron in chronic kidney disease. Kidney international. 2015 Oct; 88(4):905-14. doi: 10.1038/ki.2015.163. [PMID: 26083656]
  • Tilman B Drüeke, Ziad A Massy. Oral or intravenous iron for anemia correction in chronic kidney disease?. Kidney international. 2015 Oct; 88(4):673-5. doi: 10.1038/ki.2015.189. [PMID: 26422625]
  • Sunil Bhandari, Philip A Kalra, Jatin Kothari, Patrice M Ambühl, Jeppe H Christensen, Ashot M Essaian, Lars L Thomsen, Iain C Macdougall, Daniel W Coyne. A randomized, open-label trial of iron isomaltoside 1000 (Monofer®) compared with iron sucrose (Venofer®) as maintenance therapy in haemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2015 Sep; 30(9):1577-89. doi: 10.1093/ndt/gfv096. [PMID: 25925701]
  • Susan J Allison. Chronic kidney disease: Serious adverse effects associated with IV iron in CKD. Nature reviews. Nephrology. 2015 Sep; 11(9):506. doi: 10.1038/nrneph.2015.112. [PMID: 26149838]
  • Xuewen Ren, Qiuying Zhang, Hao Wang, Chunyan Man, Heng Hong, Li Chen, Tanshi Li, Ping Ye. Effect of Intravenous Iron Supplementation on Acute Mountain Sickness: A Preliminary Randomized Controlled Study. Medical science monitor : international medical journal of experimental and clinical research. 2015 Jul; 21(?):2050-7. doi: 10.12659/msm.891182. [PMID: 26175087]
  • Jorge E Toblli, Federico Di Gennaro, Carlos Rivas. Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron. Heart, lung & circulation. 2015 Jul; 24(7):686-95. doi: 10.1016/j.hlc.2014.12.161. [PMID: 25666998]
  • J E Toblli, G Cao, J F Giani, F P Dominici, M Angerosa. Nitrosative Stress and Apoptosis by Intravenous Ferumoxytol, Iron Isomaltoside 1000, Iron Dextran, Iron Sucrose, and Ferric Carboxymaltose in a Nonclinical Model. Drug research. 2015 Jul; 65(7):354-60. doi: 10.1055/s-0034-1384534. [PMID: 25050519]
  • Jorge E Toblli, Gabriel Cao, Margarita Angerosa. Nitrosative stress and apoptosis in non-anemic healthy rats induced by intravenous iron sucrose similars versus iron sucrose originator. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2015 Apr; 28(2):279-92. doi: 10.1007/s10534-015-9822-3. [PMID: 25609135]
  • Muhammad Owais Hanif, Rafia Afzal. Gastric Antral Vascular Ectasia (GAVE): an overlooked diagnosis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2015 Mar; 25(3):227-8. doi: 03.2015/jcpsp.227228. [PMID: 25772970]
  • Monika Praschberger, Kathrin Haider, Carolin Cornelius, Markus Schitegg, Brigitte Sturm, Hans Goldenberg, Barbara Scheiber-Mojdehkar. Iron sucrose and ferric carboxymaltose: no correlation between physicochemical stability and biological activity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2015 Feb; 28(1):35-50. doi: 10.1007/s10534-014-9801-0. [PMID: 25326244]
  • Reza Solgi, Amir Baghaei, Ali Golaghaei, Shokoufeh Hasani, Maryam Baeeri, Mona Navaei, Seyyed Nasser Ostad, Rohollah Hosseini, Mohammad Abdollahi. Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: a time course study. Toxicology mechanisms and methods. 2015; 25(4):249-57. doi: 10.3109/15376516.2015.1015086. [PMID: 25906050]
  • James R Connor, Xuesheng Zhang, Anne M Nixon, Becky Webb, Joseph R Perno. Comparative evaluation of nephrotoxicity and management by macrophages of intravenous pharmaceutical iron formulations. PloS one. 2015; 10(5):e0125272. doi: 10.1371/journal.pone.0125272. [PMID: 25973894]
  • Baogang Xie, Zhirong Zhang, Tao Gong, Ningning Zhang, Huiyun Wang, Huiqing Zou. Application of metabonomic strategy to discover an unreported active ingredient in LiuWeiDiHuang pills suppressing beta-glucuronidase. Analytical and bioanalytical chemistry. 2015 Jan; 407(2):609-14. doi: 10.1007/s00216-014-8253-2. [PMID: 25381611]
  • Elisabeth Brock, Peter Braunhofer, Josef Troxler, Heinz Schneider. Budget impact of parenteral iron treatment of iron deficiency: methodological issues raised by using real-life data. The European journal of health economics : HEPAC : health economics in prevention and care. 2014 Dec; 15(9):907-16. doi: 10.1007/s10198-013-0533-9. [PMID: 24081613]
  • Elizabeth Price, Andrew S Artz, Huiman Barnhart, Shelly Sapp, Gordon Chelune, William B Ershler, Jeremy D Walston, Victor R Gordeuk, Nathan A Berger, David Reuben, Josef Prchal, Sunil V Rao, Cindy N Roy, Mark A Supiano, Stanley L Schrier, Harvey Jay Cohen. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood cells, molecules & diseases. 2014 Dec; 53(4):221-30. doi: 10.1016/j.bcmd.2014.06.003. [PMID: 25065855]
  • Ko-Lin Kuo, Szu-Chun Hung, Tzong-Shyuan Lee, Der-Cherng Tarng. Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD. Journal of the American Society of Nephrology : JASN. 2014 Nov; 25(11):2596-606. doi: 10.1681/asn.2013080838. [PMID: 24722448]
  • Yves Beguin, Aurélie Jaspers. Iron sucrose - characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas. Expert opinion on pharmacotherapy. 2014 Oct; 15(14):2087-103. doi: 10.1517/14656566.2014.953928. [PMID: 25186219]
  • Fredric M Pieracci, Robert T Stovall, Brant Jaouen, Maria Rodil, Anthony Cappa, Clay Cothren Burlew, Daniel N Holena, Ronald Maier, Stepheny Berry, Jerry Jurkovich, Ernest E Moore. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*. Critical care medicine. 2014 Sep; 42(9):2048-57. doi: 10.1097/ccm.0000000000000408. [PMID: 24797376]
  • Bhavesh S Barot, Punit B Parejiya, Dharmik M Mehta, Pragna K Shelat, Gaurang B Shah. Physicochemical and structural characterization of iron-sucrose formulations: a comparative study. Pharmaceutical development and technology. 2014 Aug; 19(5):513-20. doi: 10.3109/10837450.2013.795171. [PMID: 23701359]
  • Baogang Xie, Aihong Liu, Xuejun Zhan, Xinming Ye, Jing Wei. Alteration of gut bacteria and metabolomes after glucaro-1,4-lactone treatment contributes to the prevention of hypercholesterolemia. Journal of agricultural and food chemistry. 2014 Jul; 62(30):7444-51. doi: 10.1021/jf501744d. [PMID: 24972288]
  • Jane E Onken, David B Bregman, Robert A Harrington, David Morris, John Buerkert, Douglas Hamerski, Hussain Iftikhar, Roberto Mangoo-Karim, Edouard R Martin, Carlos O Martinez, George Edward Newman, Wajeh Y Qunibi, Dennis L Ross, Bhupinder Singh, Mark T Smith, Angelia Butcher, Todd A Koch, Lawrence T Goodnough. Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Apr; 29(4):833-42. doi: 10.1093/ndt/gft251. [PMID: 23963731]
  • Iain C Macdougall, William E Strauss, Justin McLaughlin, Zhu Li, Frank Dellanna, Joachim Hertel. A randomized comparison of ferumoxytol and iron sucrose for treating iron deficiency anemia in patients with CKD. Clinical journal of the American Society of Nephrology : CJASN. 2014 Apr; 9(4):705-12. doi: 10.2215/cjn.05320513. [PMID: 24458078]
  • Yong Wang, Baoping Ji, Wei Wu, Ruojun Wang, Zhiwei Yang, Di Zhang, Wenli Tian. Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components. Journal of the science of food and agriculture. 2014 Jan; 94(2):265-72. doi: 10.1002/jsfa.6245. [PMID: 23716136]
  • Yusuke Sasaki, Yasushi Shimonaka, Katsuya Ikuta, Takaaki Hosoki, Katsunori Sasaki, Yoshihiro Torimoto, Hirotaka Kanada, Yoshiyuki Moriguchi, Yutaka Kohgo. Hepcidin production in response to iron is controlled by monocyte-derived humoral factors. International journal of hematology. 2014 Jan; 99(1):12-20. doi: 10.1007/s12185-013-1476-8. [PMID: 24293278]
  • Carlos Contreras, María Dolores Barnuevo, Isabel Guillén, Antonio Luque, Elisabet Lázaro, Jordi Espadaler, Javier López-Román, José A Villegas. Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans. European journal of nutrition. 2014; 53(2):567-74. doi: 10.1007/s00394-013-0565-z. [PMID: 23892521]
  • Ahmad Almilaji, Sabina Honisch, Guilai Liu, Bernat Elvira, Sumant Singh Ajay, Zohreh Hosseinzadeh, Musaab Ahmed, Carlos Munoz, Mentor Sopjani, Florian Lang. Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein. Kidney & blood pressure research. 2014; 39(6):609-22. doi: 10.1159/000368472. [PMID: 25571875]
  • Shinya Toyokuni. Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis. Redox report : communications in free radical research. 2014 Jan; 19(1):1-7. doi: 10.1179/1351000213y.0000000075. [PMID: 24257681]
  • Kendra Grim, Bernard Lee, Alan Y Sung, Suresh Kotagal. Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. Sleep medicine. 2013 Nov; 14(11):1100-4. doi: 10.1016/j.sleep.2013.06.006. [PMID: 23993871]
  • Peter Elford, Johanne Bouchard, Léonore Jaillet, Nick Pearson, Alexandra Rogue, Caroline Sabadie, Roy Forster. Biodistribution and predictive hepatic gene expression of intravenous iron sucrose. Journal of pharmacological and toxicological methods. 2013 Nov; 68(3):374-83. doi: 10.1016/j.vascn.2013.04.005. [PMID: 23624021]
  • Charles R Pedlar, Gregory P Whyte, Richard Burden, Brian Moore, Gill Horgan, Noel Pollock. A case study of an iron-deficient female Olympic 1500-m runner. International journal of sports physiology and performance. 2013 Nov; 8(6):695-8. doi: 10.1123/ijspp.8.6.695. [PMID: 23436684]
  • David Vadasz, Vincent Ries, Wolfgang H Oertel. Intravenous iron sucrose for restless legs syndrome in pregnant women with low serum ferritin. Sleep medicine. 2013 Nov; 14(11):1214-6. doi: 10.1016/j.sleep.2013.05.018. [PMID: 24012019]
  • Veronique Douard, Yves Sabbagh, Jacklyn Lee, Chirag Patel, Francis W Kemp, John D Bogden, Sheldon Lin, Ronaldo P Ferraris. Excessive fructose intake causes 1,25-(OH)(2)D(3)-dependent inhibition of intestinal and renal calcium transport in growing rats. American journal of physiology. Endocrinology and metabolism. 2013 Jun; 304(12):E1303-13. doi: 10.1152/ajpendo.00582.2012. [PMID: 23571713]
  • S A Potthoff, H G Münch. [Safety aspects of parenteral iron supplementation therapies in patients with chronic kidney disease]. Deutsche medizinische Wochenschrift (1946). 2013 Jun; 138(24):1312-7. doi: 10.1055/s-0033-1343219. [PMID: 23737117]
  • George R Bailie, Catherine Schuler, Robert E Leggett, Hsin Li, Hsin-Dat Li, Hiten Patadia, Robert Levin. Oxidative effect of several intravenous iron complexes in the rat. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2013 Jun; 26(3):473-8. doi: 10.1007/s10534-013-9632-4. [PMID: 23681275]
  • Saadet Akarsu, Hatice Demir, Sahabettin Selek, Ferdane Oguzoncul. Iron deficiency anemia and levels of oxidative stress induced by treatment modality. Pediatrics international : official journal of the Japan Pediatric Society. 2013 Jun; 55(3):289-95. doi: 10.1111/ped.12054. [PMID: 23316876]
  • Katie Palmer, Karen Cameron, Marisa Battistella. Review of available intravenous iron preparations in hemodialysis. CANNT journal = Journal ACITN. 2013 Apr; 23(2):51-4; quiz 55. doi: NULL. [PMID: 24069699]
  • Stuart L Goldstein, David Morris, Bradley A Warady. Comparison of the safety and efficacy of 3 iron sucrose iron maintenance regimens in children, adolescents, and young adults with CKD: a randomized controlled trial. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2013 Apr; 61(4):588-97. doi: 10.1053/j.ajkd.2012.10.019. [PMID: 23245582]
  • Semantee Bhattacharya, Prasenjit Manna, Ratan Gachhui, Parames C Sil. D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling. Toxicology and applied pharmacology. 2013 Feb; 267(1):16-29. doi: 10.1016/j.taap.2012.12.005. [PMID: 23261973]
  • Adnan Musanovic, Senaid Trnacevic, Mevludin Mekic, Affan Musanovic. The influence of inflammatory markers and CRP predictive value in relation to the target hemoglobin level in patients on chronic hemodialysis. Medical archives (Sarajevo, Bosnia and Herzegovina). 2013; 67(5):361-4. doi: 10.5455/medarh.2013.67.361-364. [PMID: 24601173]
  • Alka Kriplani, Reeta Mahey, Biswa Bhusan Dash, Vidushi Kulshreshta, Nutan Agarwal, Neerja Bhatla. Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy. The Indian journal of medical research. 2013; 138(?):78-82. doi: NULL. [PMID: 24056559]
  • Khushnooma Italia, Roshan Colah, Kanjaksha Ghosh. Hydroxyurea could be a good clinically relevant iron chelator. PloS one. 2013; 8(12):e82928. doi: 10.1371/journal.pone.0082928. [PMID: 24349400]
  • Paul D Wilson, Adam Hutchings, Aruna Jeans, Iain C Macdougall. An analysis of the health service efficiency and patient experience with two different intravenous iron preparations in a UK anaemia clinic. Journal of medical economics. 2013; 16(1):108-14. doi: 10.3111/13696998.2012.731458. [PMID: 22989163]
  • Motoko Takahashi, Satoshi Miyata, Junichi Fujii, Yoko Inai, Shigemitsu Ueyama, Motoko Araki, Tomoyoshi Soga, Reiko Fujinawa, Chiaki Nishitani, Shigeru Ariki, Takeyuki Shimizu, Tomomi Abe, Yoshito Ihara, Morimitsu Nishikimi, Yasunori Kozutsumi, Naoyuki Taniguchi, Yoshio Kuroki. In vivo role of aldehyde reductase. Biochimica et biophysica acta. 2012 Nov; 1820(11):1787-96. doi: 10.1016/j.bbagen.2012.07.003. [PMID: 22820017]
  • Todd A Conner, Charles McQuade, Jonathan Olp, Amy Barton Pai. Effect of intravenous vitamin C on cytokine activation and oxidative stress in end-stage renal disease patients receiving intravenous iron sucrose. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2012 Oct; 25(5):961-9. doi: 10.1007/s10534-012-9562-6. [PMID: 22706571]
  • Guy Rostoker, Mireille Griuncelli, Christelle Loridon, Renaud Couprie, Abbes Benmaadi, Catherine Bounhiol, Myriam Roy, Gabrielle Machado, Phillippe Janklewicz, Gilles Drahi, Hervé Dahan, Yves Cohen. Hemodialysis-associated hemosiderosis in the era of erythropoiesis-stimulating agents: a MRI study. The American journal of medicine. 2012 Oct; 125(10):991-999.e1. doi: 10.1016/j.amjmed.2012.01.015. [PMID: 22998881]
  • Baoru Yang, Maaria Kortesniemi, Pengzhan Liu, Maarit Karonen, Juha-Pekka Salminen. Analysis of hydrolyzable tannins and other phenolic compounds in emblic leafflower (Phyllanthus emblica L.) fruits by high performance liquid chromatography-electrospray ionization mass spectrometry. Journal of agricultural and food chemistry. 2012 Sep; 60(35):8672-83. doi: 10.1021/jf302925v. [PMID: 22889097]
  • Janet K Freburger, Leslie J Ng, Brian D Bradbury, Abhijit V Kshirsagar, M Alan Brookhart. Changing patterns of anemia management in US hemodialysis patients. The American journal of medicine. 2012 Sep; 125(9):906-14.e9. doi: 10.1016/j.amjmed.2012.03.011. [PMID: 22938926]
  • Mauricio da Silva Krause, Aline Bittencourt, Paulo Ivo Homem de Bittencourt, Neville H McClenaghan, Peter R Flatt, Colin Murphy, Philip Newsholme. Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets. The Journal of endocrinology. 2012 Sep; 214(3):301-11. doi: 10.1530/joe-12-0223. [PMID: 22761278]
  • Abdulbaki Kumbasar, Meltem Gursu, Cagdas Kaya, Savas Ozturk, Abdulkadir Ergen, Ahu Kemik, Zeki Aydin, Sami Uzun, Serhat Karadag, Rumeyza Kazancioglu. The effect of different doses and types of intravenous iron on oxidative stress and inflammation in hemodialysis patients. Journal of nephrology. 2012 Sep; 25(5):825-32. doi: 10.5301/jn.5000072. [PMID: 22307439]
  • Li Yin, Xing Chen, Junxiang Chen, Meichu Cheng, Youming Peng, Lijun Yang. [Multi-frequency low-dose intravenous iron on oxidative stress in maintenance hemodialysis patients]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2012 Aug; 37(8):844-8. doi: 10.3969/j.issn.1672-7347.2012.08.015. [PMID: 22954919]
  • Paul Joseph Galutira, Marcela Del Rio. Understanding renal posttransplantation anemia in the pediatric population. Pediatric nephrology (Berlin, Germany). 2012 Jul; 27(7):1079-85. doi: 10.1007/s00467-011-2036-1. [PMID: 22086345]
  • C C D Thai, H Bakir, W O S Doherty. Insights to the clarification of sugar cane juice expressed from sugar cane stalk and trash. Journal of agricultural and food chemistry. 2012 Mar; 60(11):2916-23. doi: 10.1021/jf204998b. [PMID: 22364593]