2-Nonene-1,4-diol (BioDeep_00000173401)
human metabolite blood metabolite
代谢物信息卡片
1,4-Dihydroxy-2-nonene
化学式: C9H18O2 (158.1306728)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.77%
分子结构信息
SMILES: CCCCCC(O)C=CCO
InChI: InChI=1S/C9H18O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7,9-11H,2-4,6,8H2,1H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qingling Li, Kristyen Tomcik, Shenghui Zhang, Michelle A Puchowicz, Guo-Fang Zhang. Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.
Free radical biology & medicine.
2012 Mar; 52(6):1043-53. doi:
10.1016/j.freeradbiomed.2011.12.022. [PMID: 22245097] - Toshiyuki Matsunaga, Yuhki Shinoda, Yukari Inoue, Satoshi Endo, Ossama El-Kabbani, Akira Hara. Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal.
Chemico-biological interactions.
2011 May; 191(1-3):364-70. doi:
10.1016/j.cbi.2010.12.018. [PMID: 21187080] - Heather C Kuiper, Richard S Bruno, Maret G Traber, Jan F Stevens. Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans.
Free radical biology & medicine.
2011 Apr; 50(7):848-53. doi:
10.1016/j.freeradbiomed.2011.01.004. [PMID: 21236333] - E M McElnea, B Quill, N G Docherty, M Irnaten, W F Siah, A F Clark, C J O'Brien, D M Wallace. Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.
Molecular vision.
2011; 17(?):1182-91. doi:
NULL. [PMID: 21617752] - Kornelia Edes, Pamela Cassidy, Paul J Shami, Philip J Moos. JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1.
PloS one.
2010 Jan; 5(1):e8786. doi:
10.1371/journal.pone.0008786. [PMID: 20098717] - Heather C Kuiper, Brandi L Langsdorf, Cristobal L Miranda, Jacqueline Joss, Carole Jubert, John E Mata, Jan F Stevens. Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study.
Free radical biology & medicine.
2010 Jan; 48(1):65-72. doi:
10.1016/j.freeradbiomed.2009.10.025. [PMID: 19819328] - P Muthuraman, K Srikumar. A comparative study on the effect of homobrassinolide and gibberellic acid on lipid peroxidation and antioxidant status in normal and diabetic rats.
Journal of enzyme inhibition and medicinal chemistry.
2009 Oct; 24(5):1122-7. doi:
10.1080/14756360802667563. [PMID: 19619070] - Lijun Xu, Ludmila A Voloboueva, YiBing Ouyang, John F Emery, Rona G Giffard. Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2009 Feb; 29(2):365-74. doi:
10.1038/jcbfm.2008.125. [PMID: 18985056] - Seiji Sekine, Kazuhiro Kubo, Tadahiro Tadokoro, Morio Saito. Effect of Docosahexaenoic Acid Ingestion on Temporal Change in Urinary Excretion of Mercapturic Acid in ODS Rats.
Journal of clinical biochemistry and nutrition.
2007 Nov; 41(3):184-90. doi:
10.3164/jcbn.2007026. [PMID: 18299714] - Caroline Asselin, Bertrand Bouchard, Jean-Claude Tardif, Christine Des Rosiers. Circulating 4-hydroxynonenal-protein thioether adducts assessed by gas chromatography-mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats.
Free radical biology & medicine.
2006 Jul; 41(1):97-105. doi:
10.1016/j.freeradbiomed.2006.03.011. [PMID: 16781458] - Françoise Guéraud, Géraldine Peiro, Hervé Bernard, Jacques Alary, Christophe Créminon, Laurent Debrauwer, Estelle Rathahao, Marie-Françoise Drumare, Cécile Canlet, Jean-Michel Wal, Georges Bories. Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation.
Free radical biology & medicine.
2006 Jan; 40(1):54-62. doi:
10.1016/j.freeradbiomed.2005.08.011. [PMID: 16337879] - Giancarlo Aldini, Paola Granata, Marica Orioli, Enzo Santaniello, Marina Carini. Detoxification of 4-hydroxynonenal (HNE) in keratinocytes: characterization of conjugated metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS.
2003 Nov; 38(11):1160-8. doi:
10.1002/jms.533. [PMID: 14648823] - Sanjeev Choudhary, Sanjay Srivastava, Tianlin Xiao, Usha P Andley, Satish K Srivastava, Naseem H Ansari. Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens.
Investigative ophthalmology & visual science.
2003 Jun; 44(6):2675-82. doi:
10.1167/iovs.02-0965. [PMID: 12766072] - M E Burczynski, G R Sridhar, N T Palackal, T M Penning. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.
The Journal of biological chemistry.
2001 Jan; 276(4):2890-7. doi:
10.1074/jbc.m006655200. [PMID: 11060293] - T Grune, W G Siems, T Petras. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney.
Journal of lipid research.
1997 Aug; 38(8):1660-5. doi:
NULL. [PMID: 9300788] - W G Siems, H Zollner, T Grune, H Esterbauer. Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product.
Journal of lipid research.
1997 Mar; 38(3):612-22. doi:
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