2-Hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid (BioDeep_00000173293)
human metabolite blood metabolite
代谢物信息卡片
化学式: C26H34O5S (458.21268340000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CCCCCCCCC2=CC=CC=C2C(C(C(=O)O)O)SCCC(=O)O
InChI: InChI=1S/C26H34O5S/c27-23(28)18-19-32-25(24(29)26(30)31)22-17-11-10-16-21(22)15-9-4-2-1-3-6-12-20-13-7-5-8-14-20/h5,7-8,10-11,13-14,16-17,24-25,29H,1-4,6,9,12,15,18-19H2,(H,27,28)(H,30,31)
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
同义名列表
14 个代谢物同义名
3-[(2-Carboxyethyl)sulphanyl]-2-hydroxy-3-[2-(8-phenyloctyl)phenyl]propanoic acid; 3-[(2-carboxyethyl)sulfanyl]-2-hydroxy-3-[2-(8-phenyloctyl)phenyl]propanoic acid; 3-[(2-Carboxyethyl)sulphanyl]-2-hydroxy-3-[2-(8-phenyloctyl)phenyl]propanoate; 2-Hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid; 3-[(2-Carboxyethyl)sulfanyl]-2-hydroxy-3-[2-(8-phenyloctyl)phenyl]propanoate; 2-Hydroxy-3-((2-carboxyethyl)thio)-3-(2-(8-phenyloctyl)phenyl)propanoic acid; 2-Hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoate; Pobilukast edamine, (R-(r*,s*))-isomer; Pobilukast, sodium salt; Pobilukast edamine; SK And F 104353-Z2; SK And F-104353; SK And F 104353; Pobilukast
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Blaithin McMahon, Derick Mitchell, Richard Shattock, Finian Martin, Hugh R Brady, Catherine Godson. Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2002 Nov; 16(13):1817-9. doi:
10.1096/fj.02-0416fje. [PMID: 12223454] - T Katoh, E A Lianos, M Fukunaga, K Takahashi, K F Badr. Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis.
The Journal of clinical investigation.
1993 Apr; 91(4):1507-15. doi:
10.1172/jci116356. [PMID: 8386188] - A H Krauss, D F Woodward. An atypical vasopermeability response to leukotrienes in the iris-ciliary body.
Prostaglandins.
1991 Jun; 41(6):559-70. doi:
10.1016/0090-6980(91)90061-j. [PMID: 1647045] - J L Ellis, B J Undem. Role of peptidoleukotrienes in capsaicin-sensitive sensory fibre-mediated responses in guinea-pig airways.
The Journal of physiology.
1991 May; 436(?):469-84. doi:
10.1113/jphysiol.1991.sp018561. [PMID: 2061842] - D W Hay, R M Muccitelli, L M Vickery-Clark, L S Novak, R R Osborn, J G Gleason, L A Yodis, C M Saverino, R D Eckardt, H M Sarau. Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig.
Pulmonary pharmacology.
1991; 4(3):177-89. doi:
10.1016/0952-0600(91)90009-r. [PMID: 1668219] - J L Zellner, J A Cook, H D Reines, E F Smith, L D Kessler, P V Halushka. Effect of a LTD4 receptor antagonist in porcine septic shock.
Eicosanoids.
1991; 4(3):169-75. doi:
NULL. [PMID: 1663380] - R F Spurney, P Ruiz, D S Pisetsky, T M Coffman. Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.
Kidney international.
1991 Jan; 39(1):95-102. doi:
10.1038/ki.1991.12. [PMID: 1848329] - J W Watson, M Conklyn, H J Showell. IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
The American review of respiratory disease.
1990 Nov; 142(5):1093-8. doi:
10.1164/ajrccm/142.5.1093. [PMID: 2240832] - J A Cook, E J Li, K M Spicer, W C Wise, P V Halushka. Effect of leukotriene receptor antagonists on vascular permeability during endotoxic shock.
Circulatory shock.
1990 Nov; 32(3):209-18. doi:
NULL. [PMID: 2175680] - A Muller, F Meynier, C Bonne. PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Journal of ocular pharmacology.
1990; 6(3):227-32. doi:
10.1089/jop.1990.6.227. [PMID: 1963192] - M A Bayorh, L McGee, G Feuerstein. Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system.
Research communications in chemical pathology and pharmacology.
1989 Dec; 66(3):355-74. doi:
NULL. [PMID: 2558405] - P H Lento, K Saukkonen, N Aoki, A M Lefer, M J Slivjak, E F Smith. Beneficial effects of a specific leukotriene receptor antagonist in splanchnic artery occlusion shock.
European journal of pharmacology.
1989 Jun; 165(2-3):241-9. doi:
10.1016/0014-2999(89)90718-8. [PMID: 2550251] - E F Smith, M J Slivjak, R D Eckardt, J F Newton. Antagonism of leukotriene C4, leukotriene D4 and leukotriene E4 vasoconstrictor responses in the conscious rat with the peptidoleukotriene receptor antagonist SK&F 104353: evidence for leukotriene D4 receptor heterogeneity.
The Journal of pharmacology and experimental therapeutics.
1989 Jun; 249(3):805-11. doi:
. [PMID: 2543811] - T J Torphy, J F Newton, M A Wasserman, L Vickery-Clark, R R Osborn, L S Bailey, L A Yodis, D C Underwood, D W Hay. The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.
The Journal of pharmacology and experimental therapeutics.
1989 May; 249(2):430-7. doi:
. [PMID: 2542530] - K F Badr, D K DeBoer, M Schwartzberg, C N Serhan. Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.
Proceedings of the National Academy of Sciences of the United States of America.
1989 May; 86(9):3438-42. doi:
10.1073/pnas.86.9.3438. [PMID: 2541448] - E F Smith, L B Kinter, M Jugus, R D Eckardt, J F Newton. Concentration-dependent, stereoselective inhibition of the endotoxin-induced hemoconcentration in conscious rats with the peptidoleukotriene receptor antagonist SK & F 104353.
Eicosanoids.
1989; 2(2):101-7. doi:
. [PMID: 2560662] - K F Badr, G F Schreiner, M Wasserman, I Ichikawa. Preservation of the glomerular capillary ultrafiltration coefficient during rat nephrotoxic serum nephritis by a specific leukotriene D4 receptor antagonist.
The Journal of clinical investigation.
1988 Jun; 81(6):1702-9. doi:
10.1172/jci113509. [PMID: 3384947] - E F Smith, L B Kinter, M Jugus, M A Wasserman, R D Eckardt, J F Newton. Beneficial effects of the peptidoleukotriene receptor antagonist, SK&F 104353, on the responses to experimental endotoxemia in the conscious rat.
Circulatory shock.
1988 May; 25(1):21-31. doi:
NULL. [PMID: 3042186]