2-Cyanoethylene oxide (BioDeep_00000173244)
human metabolite blood metabolite
代谢物信息卡片
化学式: C3H3NO (69.0214628)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(O1)C#N
InChI: InChI=1S/C3H3NO/c4-1-3-2-5-3/h3H,2H2
描述信息
D009676 - Noxae > D002273 - Carcinogens
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- T Schettgen, J Bertram, T Kraus. Accurate quantification of the mercapturic acids of acrylonitrile and its genotoxic metabolite cyanoethylene-epoxide in human urine by isotope-dilution LC-ESI/MS/MS.
Talanta.
2012 Aug; 98(?):211-9. doi:
10.1016/j.talanta.2012.06.074. [PMID: 22939149] - Chia-Fang Wu, Shi-Nian Uang, Su-Yin Chiang, Wei-Chung Shih, Yu-Fang Huang, Kuen-Yuh Wu. Simultaneous quantitation of urinary cotinine and acrylonitrile-derived mercapturic acids with ultraperformance liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2012 Feb; 402(6):2113-20. doi:
10.1007/s00216-011-5661-4. [PMID: 22231508] - Emmanuel Minet, Francis Cheung, Graham Errington, Katharina Sterz, Gerhard Scherer. Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2011 Feb; 16(1):89-96. doi:
10.3109/1354750x.2010.533287. [PMID: 21108560] - Brian Chanas, Hongbing Wang, Burhan I Ghanayem. Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases.
Toxicology and applied pharmacology.
2003 Dec; 193(2):293-302. doi:
10.1016/j.taap.2003.08.006. [PMID: 14644629] - Hongbing Wang, Brian Chanas, Burhan I Ghanayem. Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Aug; 30(8):911-7. doi:
10.1124/dmd.30.8.911. [PMID: 12124309] - G L Kedderis, S C Sumner, S D Held, R Batra, M J Turner, A E Roberts, T R Fennell. Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice.
Toxicology and applied pharmacology.
1993 Jun; 120(2):288-97. doi:
10.1006/taap.1993.1114. [PMID: 8511799] - B Yuan, J L Wong. Inactivity of acrylonitrile epoxide to modify a Ha-ras DNA in a non-focus transfection-transformation assay.
Carcinogenesis.
1991 May; 12(5):787-91. doi:
10.1093/carcin/12.5.787. [PMID: 1903090] - I Linhart, J Smejkal, J Novák. N-acetyl-S-(1-cyano-2-hydroxyethyl)-L-cysteine, a new urinary metabolite of acrylonitrile and oxiranecarbonitrile.
Archives of toxicology.
1988; 61(6):484-8. doi:
10.1007/bf00293695. [PMID: 3190446] - V Holecek, J Kopecký. Conjugations of acrylonitrile and glycidonitrile with glutathione--a contribution to problems of metabolism of acrylonitrile.
Czechoslovak medicine.
1983; 6(2):116-21. doi:
NULL. [PMID: 6409562]