ONO-2235; ONO 2235; ONO2235; Sorbistat (BioDeep_00000173132)
human metabolite blood metabolite
代谢物信息卡片
2-[5-(2-methyl-3-phenylprop-2-en-1-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
化学式: C15H13NO3S2 (319.0336828)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C=C1SC(=S)N(CC(O)=O)C1=O)=CC1=CC=CC=C1
InChI: InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)
数据库引用编号
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ling Li, Jin Yan, Kai Hu, Juan Gu, Jun-Jie Wang, Xiao-Lan Deng, Hui Li, Xian Jing, Zhen-Yu Li, Qi-Fa Ye, Dong-Sheng Ouyang. Protective effects of Eucommia lignans against hypertensive renal injury by inhibiting expression of aldose reductase.
Journal of ethnopharmacology.
2012 Jan; 139(2):454-61. doi:
10.1016/j.jep.2011.11.032. [PMID: 22138658] - H Liu, Y Luo, T Zhang, Y Zhang, Q Wu, L Yuan, S S M Chung, P J Oates, J Y Yang. Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice.
Diabetologia.
2011 May; 54(5):1242-51. doi:
10.1007/s00125-011-2045-4. [PMID: 21267539] - Juan Gu, Jun-Jie Wang, Jin Yan, Chang-Fu Cui, Wei-Hua Wu, Ling Li, Zhen-Shan Wang, Min Yu, Na Gao, Li Liu, Dong-Sheng Ouyang. Effects of lignans extracted from Eucommia ulmoides and aldose reductase inhibitor epalrestat on hypertensive vascular remodeling.
Journal of ethnopharmacology.
2011 Jan; 133(1):6-13. doi:
10.1016/j.jep.2010.08.055. [PMID: 20817083] - Wolfgang Neuhofer. Role of NFAT5 in inflammatory disorders associated with osmotic stress.
Current genomics.
2010 Dec; 11(8):584-90. doi:
10.2174/138920210793360961. [PMID: 21629436] - Ke-Xuan Liu, Cai Li, Yun-Sheng Li, Bao-Long Yuan, Miao Xu, Zhengyuan Xia, Wen-Qi Huang. Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase.
Proteomics.
2010 Dec; 10(24):4463-75. doi:
10.1002/pmic.201000078. [PMID: 21136599] - Toshihide Kawai, Izumi Takei, Mikiya Tokui, Osamu Funae, Kazunori Miyamoto, Mitsuhisa Tabata, Takumi Hirata, Takao Saruta, Akira Shimada, Hiroshi Itoh. Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine.
Journal of diabetes and its complications.
2010 Nov; 24(6):424-32. doi:
10.1016/j.jdiacomp.2008.10.005. [PMID: 19716319] - Gregory M Preston, Roberto A Calle. Elevated Serum Sorbitol and not Fructose in Type 2 Diabetic Patients.
Biomarker insights.
2010 May; 5(?):33-8. doi:
10.4137/bmi.s4530. [PMID: 20520742] - Joong Kyung Sung, Jang Hyun Koh, Mi Young Lee, Bo Hwan Kim, Soo Min Nam, Jae Hyun Kim, Jin Hee Yoo, So Hee Kim, Sun Won Hong, Eun Young Lee, Ran Choi, Choon Hee Chung. Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats.
Yonsei medical journal.
2010 May; 51(3):385-91. doi:
10.3349/ymj.2010.51.3.385. [PMID: 20376891] - Satoshi Endo, Toshiyuki Matsunaga, Anna Fujita, Kazuo Tajima, Ossama El-Kabbani, Akira Hara. Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal.
Biological & pharmaceutical bulletin.
2010; 33(11):1886-90. doi:
10.1248/bpb.33.1886. [PMID: 21048316] - Pierre Watcho, Roman Stavniichuk, David M Ribnicky, Ilya Raskin, Irina G Obrosova. High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L.
Mediators of inflammation.
2010; 2010(?):268547. doi:
10.1155/2010/268547. [PMID: 20396384] - Chun Wang, Ruilan Yan, Dixian Luo, Kounosuke Watabe, Duan-Fang Liao, Deliang Cao. Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.
The Journal of biological chemistry.
2009 Sep; 284(39):26742-8. doi:
10.1074/jbc.m109.022897. [PMID: 19643728] - Chie Ohmura, Hirotaka Watada, Kosuke Azuma, Tomoaki Shimizu, Akio Kanazawa, Fuki Ikeda, Tomoaki Yoshihara, Yoshio Fujitani, Takahisa Hirose, Yasushi Tanaka, Ryuzo Kawamori. Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes.
Endocrine journal.
2009; 56(1):149-56. doi:
10.1507/endocrj.k08e-237. [PMID: 18997444] - Wing-Yee So, Ying Wang, Maggie C Y Ng, Xilin Yang, Ronald C W Ma, Vincent Lam, Alice P S Kong, Peter C Y Tong, Juliana C N Chan. Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients.
Diabetes care.
2008 Nov; 31(11):2148-53. doi:
10.2337/dc08-0712. [PMID: 18716049] - Hyun Ah Jung, Na Young Yoon, Sam Sik Kang, Yeong Sik Kim, Jae Sue Choi. Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts.
The Journal of pharmacy and pharmacology.
2008 Sep; 60(9):1227-36. doi:
10.1211/jpp.60.9.0016. [PMID: 18718128] - Eun Ha Lee, Dae-Geun Song, Joo Young Lee, Cheol-Ho Pan, Byung Hun Um, Sang Hoon Jung. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts.
Biological & pharmaceutical bulletin.
2008 Aug; 31(8):1626-30. doi:
10.1248/bpb.31.1626. [PMID: 18670102] - Eui-Young Choi, Hyuck Moon Kwon, Chul-Woo Ahn, Geun Taek Lee, Boyoung Joung, Bum Kee Hong, Young Won Yoon, Dongsoo Kim, Ki-Hyun Byun, Tae Soo Kang, Se-Jung Yoon, Sung Woo Kwon, Sung-Ju Lee, Jong-Kwan Park, Hyun-Seung Kim. Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients.
Yonsei medical journal.
2005 Feb; 46(1):78-85. doi:
10.3349/ymj.2005.46.1.78. [PMID: 15744809] - Toru Tsugawa, Rikio Shinohara, Akio Nagasaka, Itsuko Nakano, Fumiko Takeda, Minoru Nagata, Naohisa Oda, Yoshikuni Sawai, Nobuki Hayakawa, Atsushi Suzuki, Mitsuyasu Itoh. Alteration of urinary sorbitol excretion in WBN-kob diabetic rats - treatment with an aldose reductase inhibitor.
The Journal of endocrinology.
2004 Jun; 181(3):429-35. doi:
10.1677/joe.0.1810429. [PMID: 15171691] - Tomoaki Yamaguchi, Takashi Ida, Masazumi Hiraga, Kazuhiko Oishi, Masaatsu K Uchida, Hirotoshi Echizen. [Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2004 Mar; 124(3):159-63. doi:
10.1248/yakushi.124.159. [PMID: 15049134] - S Ii, M Ohta, E Kudo, T Yamaoka, T Tachikawa, M Moritani, M Itakura, K Yoshimoto. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency.
Diabetologia.
2004 Mar; 47(3):541-548. doi:
10.1007/s00125-004-1325-7. [PMID: 14968292] - M Oya, M Hosokawa, H Tsukada, K Fukuda, H Nakamura, K Tsukiyama, K Nagashima, S Fujimoto, Y Yamada, Y Seino. Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Diabetes research and clinical practice.
2003 Nov; 62(2):69-77. doi:
10.1016/s0168-8227(03)00165-7. [PMID: 14581143] - Ioannis Nicolaou, Vassilis J Demopoulos. Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Journal of medicinal chemistry.
2003 Jan; 46(3):417-26. doi:
10.1021/jm0209477. [PMID: 12540241] - Mankil Jung, Hyun Chul Lee, Chul Woo Ahn, Whuijung Park, Sunhee Choi, Hanjo Kim, Donghak Cho, Geun Taek Lee, Hai-Ri Li. Effective isolation of magnesium lithospermate B and its inhibition of aldose reductase and fibronectin on mesangial cell line.
Chemical & pharmaceutical bulletin.
2002 Aug; 50(8):1135-6. doi:
10.1248/cpb.50.1135. [PMID: 12192155] - Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Masayuki Yoshikawa. Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.
Chemical & pharmaceutical bulletin.
2002 Jun; 50(6):788-95. doi:
10.1248/cpb.50.788. [PMID: 12045333] - Tomoichiro Asano, Yasushi Saito, Masanobu Kawakami, Nobuhiro Yamada. Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients.
Journal of diabetes and its complications.
2002 Mar; 16(2):133-8. doi:
10.1016/s1056-8727(01)00175-1. [PMID: 12039395] - K Iso, H Tada, K Kuboki, T Inokuchi. Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients.
Journal of diabetes and its complications.
2001 Sep; 15(5):241-4. doi:
10.1016/s1056-8727(01)00160-x. [PMID: 11522497] - N Ishii, H Ikenaga, Z Ogawa, Y Aoki, T Saruta, T Suga. Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats.
Annals of clinical biochemistry.
2001 Jul; 38(Pt 4):391-8. doi:
10.1258/0004563011900713. [PMID: 11471882] - H Sobajima, T Aoki, H Sassa, T Suzuki, K Taniko, M Makino, K Mizuno, T Suzuki. Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Pharmacology.
2001 May; 62(4):193-9. doi:
10.1159/000056094. [PMID: 11359994]