2-(3,7,11-Trimethyldodeca-2,6,10-trienylsulfanyl)benzoic acid (BioDeep_00000173100)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H30O2S (358.1966)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 86.25%
分子结构信息
SMILES: CC(C)=CCCC(C)=CCCC(C)=CCSC1=CC=CC=C1C(O)=O
InChI: InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)
描述信息
同义名列表
8 个代谢物同义名
2-[(3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)sulphanyl]benzoic acid; 2-[(3,7,11-trimethyldodeca-2,6,10-trien-1-yl)sulfanyl]benzoic acid; 2-[(3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)sulphanyl]benzoate; 2-[(3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)sulfanyl]benzoate; 2-(3,7,11-Trimethyldodeca-2,6,10-trienylsulphanyl)benzoic acid; 2-(3,7,11-Trimethyldodeca-2,6,10-trienylsulfanyl)benzoic acid; 2-(3,7,11-Trimethyldodeca-2,6,10-trienylsulphanyl)benzoate; 2-(3,7,11-Trimethyldodeca-2,6,10-trienylsulfanyl)benzoate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Daniel Laheru, Preeti Shah, N V Rajeshkumar, Florencia McAllister, Gretchen Taylor, Howard Goldsweig, Dung T Le, Ross Donehower, Antonio Jimeno, Sheila Linden, Ming Zhao, Dongweon Song, Michelle A Rudek, Manuel Hidalgo. Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer.
Investigational new drugs.
2012 Dec; 30(6):2391-9. doi:
10.1007/s10637-012-9818-6. [PMID: 22547163] - Ibolya E András, Sung Yong Eum, Michal Toborek. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells.
Biochemical and biophysical research communications.
2012 May; 421(2):177-83. doi:
10.1016/j.bbrc.2012.03.128. [PMID: 22490665] - Adi Mor, Elizabeta Aizman, Jacob George, Yoel Kloog. Ras inhibition induces insulin sensitivity and glucose uptake.
PloS one.
2011; 6(6):e21712. doi:
10.1371/journal.pone.0021712. [PMID: 21738773] - Pinkesh Bhagatji, Rania Leventis, Rebecca Rich, Chen-ju Lin, John R Silvius. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.
Biophysical journal.
2010 Nov; 99(10):3327-35. doi:
10.1016/j.bpj.2010.10.001. [PMID: 21081081] - Nicolas Charette, Christine De Saeger, Valérie Lannoy, Yves Horsmans, Isabelle Leclercq, Peter Stärkel. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition.
Molecular cancer.
2010 Sep; 9(?):256. doi:
10.1186/1476-4598-9-256. [PMID: 20860815] - Ernesto Bustinza-Linares, Razelle Kurzrock, Apostolia-Maria Tsimberidou. Salirasib in the treatment of pancreatic cancer.
Future oncology (London, England).
2010 Jun; 6(6):885-91. doi:
10.2217/fon.10.71. [PMID: 20528225] - Ming Zhao, Ping He, Linping Xu, Manuel Hidalgo, Dan Laheru, Michelle A Rudek. Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jun; 869(1-2):142-5. doi:
10.1016/j.jchromb.2008.05.028. [PMID: 18534927] - Michael Maher, Hong Ao, Tue Banke, Nadia Nasser, Nyan-Tsz Wu, J Guy Breitenbucher, Sandra R Chaplan, Alan D Wickenden. Activation of TRPA1 by farnesyl thiosalicylic acid.
Molecular pharmacology.
2008 Apr; 73(4):1225-34. doi:
10.1124/mol.107.042663. [PMID: 18171730] - Roni Haklai, Galit Elad-Sfadia, Yaakov Egozi, Yoel Kloog. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice.
Cancer chemotherapy and pharmacology.
2008 Jan; 61(1):89-96. doi:
10.1007/s00280-007-0451-6. [PMID: 17909812] - Richard J Santen, Robert X Song, Shigeru Masamura, Wei Yue, Ping Fan, Tetsuya Sogon, Shin-ichi Hayashi, Kei Nakachi, Hidtek Eguchi. Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells.
Advances in experimental medicine and biology.
2008; 630(?):19-34. doi:
10.1007/978-0-387-78818-0_2. [PMID: 18637482] - Barak Rotblat, Marcello Ehrlich, Roni Haklai, Yoel Kloog. The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
Methods in enzymology.
2008; 439(?):467-89. doi:
10.1016/s0076-6879(07)00432-6. [PMID: 18374183] - Anastacia C Berzat, Donita C Brady, James J Fiordalisi, Adrienne D Cox. Using inhibitors of prenylation to block localization and transforming activity.
Methods in enzymology.
2006; 407(?):575-97. doi:
10.1016/s0076-6879(05)07046-1. [PMID: 16757354] - Arif Khwaja, Claire C Sharpe, Mazhar Noor, Yoel Kloog, Bruce M Hendry. The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid.
Kidney international.
2005 Aug; 68(2):474-86. doi:
10.1111/j.1523-1755.2005.00425.x. [PMID: 16014024] - R J Santen, R X Song, Z Zhang, R Kumar, M-H Jeng, A Masamura, J Lawrence, L Berstein, W Yue. Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity.
Endocrine-related cancer.
2005 Jul; 12 Suppl 1(?):S61-73. doi:
10.1677/erc.1.01018. [PMID: 16113100] - Alexander Dietrich, Alexander Scheer, Daria Illenberger, Yoel Kloog, Yoav I Henis, Peter Gierschik. Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.
The Biochemical journal.
2003 Dec; 376(Pt 2):449-56. doi:
10.1042/bj20030578. [PMID: 12952523] - Helen C Clarke, Hemant M Kocher, Arif Khwaja, Yoel Kloog, H Terence Cook, Bruce M Hendry. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis.
Journal of the American Society of Nephrology : JASN.
2003 Apr; 14(4):848-54. doi:
10.1097/01.asn.0000057543.55318.8b. [PMID: 12660318] - Keiran S M Smalley, Tim G Eisen. Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects.
International journal of cancer.
2002 Apr; 98(4):514-22. doi:
10.1002/ijc.10213. [PMID: 11920610] - A Katzav, Y Kloog, A D Korczyn, H Niv, D M Karussis, N Wang, R Rabinowitz, M Blank, Y Shoenfeld, J Chapman. Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS).
Clinical and experimental immunology.
2001 Dec; 126(3):570-7. doi:
10.1046/j.1365-2249.2001.01674.x. [PMID: 11737078]
