1H-Indol-5-ol, 3-(2-amino-1-methylethyl)- (BioDeep_00000173064)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H14N2O (190.1106)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 60%
分子结构信息
SMILES: CC(CN)C1=CNC2=C1C=C(C=C2)O
InChI: InChI=1S/C11H14N2O/c1-7(5-12)10-6-13-11-3-2-8(14)4-9(10)11/h2-4,6-7,13-14H,5,12H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 115292
- HMDB: HMDB0244888
- ChEMBL: CHEMBL281497
- chemspider: 103152
- CAS: 22965-81-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yinghua Tian, Rolf Graf, Ashraf Mohammad El-Badry, Mickaël Lesurtel, Katarzyna Furrer, Wolfgang Moritz, Pierre-Alain Clavien. Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice.
Hepatology (Baltimore, Md.).
2011 Jan; 53(1):253-62. doi:
10.1002/hep.23960. [PMID: 21254175] - Giovanni Tulipano, PierFranco Spano, Daniela Cocchi. Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts.
Molecular and cellular endocrinology.
2008 Sep; 292(1-2):42-9. doi:
10.1016/j.mce.2008.04.010. [PMID: 18514390] - M Danielle McDonald, Patrick J Walsh. Dogmas and controversies in the handling of nitrogenous wastes: 5-HT2-like receptors are involved in triggering pulsatile urea excretion in the gulf toadfish, Opsanus beta.
The Journal of experimental biology.
2004 May; 207(Pt 12):2003-10. doi:
10.1242/jeb.00957. [PMID: 15143134] - Leonor Pinilla, Lucas C Gonzalez, Manuel Tena-Sempere, Enrique Aguilar. 5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats.
European journal of endocrinology.
2003 Jan; 148(1):121-7. doi:
10.1530/eje.0.1480121. [PMID: 12534365] - Yumiko Tozawa, Kouji Matsushima. Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
European journal of pharmacology.
2002 Apr; 440(1):37-44. doi:
10.1016/s0014-2999(02)01310-9. [PMID: 11959086] - L W Fu, J C Longhurst. Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats.
The Journal of physiology.
1998 Jun; 509 ( Pt 3)(?):729-40. doi:
10.1111/j.1469-7793.1998.729bm.x. [PMID: 9596795] - P Soares-da-Silva, P C Pinto-do-O, A M Bertorello. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors.
British journal of pharmacology.
1996 Mar; 117(6):1199-203. doi:
10.1111/j.1476-5381.1996.tb16716.x. [PMID: 8882616] - J K Gill, G Stansby, N Shukla, G Hamilton, M A Barradas, J Y Jeremy. 5-Hydroxytryptamine stimulates 45Ca2+ uptake by human umbilical vein endothelial cells in culture: mediation by 5-HT2 receptor subtypes.
European journal of pharmacology.
1992 Apr; 214(2-3):269-72. doi:
10.1016/0014-2999(92)90128-q. [PMID: 1516643] - A L Killam, M L Cohen. Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: ketanserin and SCH 23390.
Thrombosis research.
1991 Nov; 64(3):331-40. doi:
10.1016/0049-3848(91)90004-g. [PMID: 1805448] - F Chaouloff, D Laude, V Baudrie. Effects of the 5-HT1C/5-5-HT2 receptor agonists DOI and alpha-methyl-5-HT on plasma glucose and insulin levels in the rat.
European journal of pharmacology.
1990 Oct; 187(3):435-43. doi:
10.1016/0014-2999(90)90370-l. [PMID: 2127400]
