17-(2-Hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one (BioDeep_00000172956)
human metabolite blood metabolite
代谢物信息卡片
17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
化学式: C21H30O3 (330.21948299999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2C(=O)CO)CCC4=CC(=O)CCC34C
InChI: InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emily P McQuarrie, E Marie Freel, Patrick B Mark, Robert Fraser, Rajan K Patel, Henry G Dargie, John M C Connell, Alan G Jardine. Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease.
Clinical science (London, England : 1979).
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Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):69-74. doi:
10.1016/j.prostaglandins.2011.12.003. [PMID: 22210049] - Pichavaram Prahalathan, Subramanian Kumar, Boobalan Raja. Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation.
Metabolism: clinical and experimental.
2012 Aug; 61(8):1087-99. doi:
10.1016/j.metabol.2011.12.012. [PMID: 22386933] - Priscila S Guimaraes, Nivia M Santiago, Carlos H Xavier, Elizabeth P P Velloso, Marco A P Fontes, Robson A S Santos, Maria Jose Campagnole-Santos. Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats.
American journal of physiology. Heart and circulatory physiology.
2012 Aug; 303(3):H393-400. doi:
10.1152/ajpheart.00075.2012. [PMID: 22661512] - Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Kodukkur Viswanathan Pugalendi. Protective effect of Melothria maderaspatana leaf fraction on electrolytes, catecholamines, endothelial nitric oxide synthase and endothelin-1 peptide in uninephrectomized deoxycorticosterone acetate-salt hypertensive rats.
Journal of natural medicines.
2012 Jul; 66(3):535-43. doi:
10.1007/s11418-011-0621-z. [PMID: 22246664] - Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Kodukkur Viswanathan Pugalendi. Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats.
Asian Pacific journal of tropical medicine.
2012 Jun; 5(6):434-9. doi:
10.1016/s1995-7645(12)60074-1. [PMID: 22575974] - Yasuhiro Nakamura, Juilee Rege, Fumitoshi Satoh, Ryo Morimoto, Michael R Kennedy, Clarence N Ahlem, Seijiro Honma, Hironobu Sasano, William E Rainey. Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation.
Clinical endocrinology.
2012 Jun; 76(6):778-84. doi:
10.1111/j.1365-2265.2011.04316.x. [PMID: 22150161] - Masashi Asanoma, Nobuhiko Tachibana, Motohiko Hirotsuka, Mitsutaka Kohno, Yasuo Watanabe. Effects of soy protein isolate feeding on severe kidney damage in DOCA salt-treated obese Zucker rats.
Journal of agricultural and food chemistry.
2012 May; 60(21):5367-72. doi:
10.1021/jf300598a. [PMID: 22553937] - Likun Ma, Jinsheng Hua, Lifeng He, Qian Li, Junling Zhou, Jiangtao Yu. Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism.
Bosnian journal of basic medical sciences.
2012 May; 12(2):69-73. doi:
10.17305/bjbms.2012.2498. [PMID: 22642589] - Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Adel A Alhamdan, Kodukkur Viswanathan Pugalendi. Antihypertensive effect of Melothria maderaspatana leaf fractions on DOCA-salt-induced hypertensive rats and identification of compounds by GC-MS analysis.
Journal of natural medicines.
2012 Apr; 66(2):302-10. doi:
10.1007/s11418-011-0590-2. [PMID: 21964566] - John N Lorenz, Naomi Oshiro, Elizabeth L Loreaux, Jerry B Lingrel. DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.
American journal of hypertension.
2012 Apr; 25(4):421-9. doi:
10.1038/ajh.2011.255. [PMID: 22258333] - Christian Krebs, Christoph Fraune, Robin Schmidt-Haupt, Jan-Eric Turner, Ulf Panzer, Michael N Quang, Andrea Tannapfel, Joachim Velden, Rolf A Stahl, Ulrich O Wenzel. CCR5 deficiency does not reduce hypertensive end-organ damage in mice.
American journal of hypertension.
2012 Apr; 25(4):479-86. doi:
10.1038/ajh.2011.243. [PMID: 22258337] - Susan S Girdler, Monica Lindgren, Patrizia Porcu, David R Rubinow, Jacqueline L Johnson, A Leslie Morrow. A history of depression in women is associated with an altered GABAergic neuroactive steroid profile.
Psychoneuroendocrinology.
2012 Apr; 37(4):543-53. doi:
10.1016/j.psyneuen.2011.08.004. [PMID: 21890277] - Thangarasu Silambarasan, Boobalan Raja. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats.
European journal of pharmacology.
2012 Mar; 679(1-3):81-9. doi:
10.1016/j.ejphar.2011.12.040. [PMID: 22266490] - Simon Trent, Alison Dennehy, Heather Richardson, Obah A Ojarikre, Paul S Burgoyne, Trevor Humby, William Davies. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.
Psychoneuroendocrinology.
2012 Feb; 37(2):221-9. doi:
10.1016/j.psyneuen.2011.06.006. [PMID: 21723668] - María Paz Ocaranza, Jorge E Jalil. Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling.
International journal of hypertension.
2012; 2012(?):594361. doi:
10.1155/2012/594361. [PMID: 22315665] - Zhigang Song, Lei Liu, Ardashir Sheikhahmadi, Hongchao Jiao, Hai Lin. Effect of heat exposure on gene expression of feed intake regulatory peptides in laying hens.
Journal of biomedicine & biotechnology.
2012; 2012(?):484869. doi:
10.1155/2012/484869. [PMID: 22619495] - Carrie A Northcott, Jeremy P Glenn, Robert E Shade, Candace M Kammerer, Carmen Hinojosa-Laborde, Gregory D Fink, Joseph R Haywood, Laura A Cox. A custom rat and baboon hypertension gene array to compare experimental models.
Experimental biology and medicine (Maywood, N.J.).
2012 Jan; 237(1):99-110. doi:
10.1258/ebm.2011.011188. [PMID: 22228705] - Wolfram Kessler, Stephan Diedrich, Pia Menges, Tobias Ebker, Michael Nielson, Lars Ivo Partecke, Tobias Traeger, Katharina Cziupka, Julia van der Linde, Ralf Puls, Alexandra Busemann, Claus-Dieter Heidecke, Stefan Maier. The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis.
Mediators of inflammation.
2012; 2012(?):467620. doi:
10.1155/2012/467620. [PMID: 22547905] - Manuel Gómez-Guzmán, Rosario Jiménez, Manuel Sánchez, María José Zarzuelo, Pilar Galindo, Ana María Quintela, Rocío López-Sepúlveda, Miguel Romero, Juan Tamargo, Félix Vargas, Francisco Pérez-Vizcaíno, Juan Duarte. Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.
Free radical biology & medicine.
2012 Jan; 52(1):70-9. doi:
10.1016/j.freeradbiomed.2011.09.015. [PMID: 22001745] - Caitlin W Hicks, Daniel A Sweeney, Robert L Danner, Peter Q Eichacker, Anthony F Suffredini, Jing Feng, Junfeng Sun, Ellen N Behrend, Steven B Solomon, Charles Natanson. Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.
Critical care medicine.
2012 Jan; 40(1):199-207. doi:
10.1097/ccm.0b013e31822efa14. [PMID: 21926575] - Nadav Ben-Dov, Rafi Korenstein. Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface.
PloS one.
2012; 7(4):e35204. doi:
10.1371/journal.pone.0035204. [PMID: 22558127] - Wiebke Arlt, Michael Biehl, Angela E Taylor, Stefanie Hahner, Rossella Libé, Beverly A Hughes, Petra Schneider, David J Smith, Han Stiekema, Nils Krone, Emilio Porfiri, Giuseppe Opocher, Jerôme Bertherat, Franco Mantero, Bruno Allolio, Massimo Terzolo, Peter Nightingale, Cedric H L Shackleton, Xavier Bertagna, Martin Fassnacht, Paul M Stewart. Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors.
The Journal of clinical endocrinology and metabolism.
2011 Dec; 96(12):3775-84. doi:
10.1210/jc.2011-1565. [PMID: 21917861] - Yoshitaka Iwazu, Shigeaki Muto, Ichiro Hirahara, Genro Fujisawa, Shin-ichi Takeda, Eiji Kusano. Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/salt-induced hypertensive rats.
Journal of hypertension.
2011 Dec; 29(12):2440-53. doi:
10.1097/hjh.0b013e32834c31f5. [PMID: 22045122] - Peng Jiang, Weixing Dai, Shikai Yan, Zhongliang Chen, Ruilin Xu, Jianmi Ding, Li Xiang, Shuping Wang, Runhui Liu, Weidong Zhang. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method.
Journal of ethnopharmacology.
2011 Nov; 138(2):530-6. doi:
10.1016/j.jep.2011.09.049. [PMID: 22001859] - Tatsuya Sakamoto, Chie Mori, Shogo Minami, Hideya Takahashi, Tsukasa Abe, Daisuke Ojima, Maho Ogoshi, Hirotaka Sakamoto. Corticosteroids stimulate the amphibious behavior in mudskipper: potential role of mineralocorticoid receptors in teleost fish.
Physiology & behavior.
2011 Oct; 104(5):923-8. doi:
10.1016/j.physbeh.2011.06.002. [PMID: 21683725] - Vishal Gupta. Mineralocorticoid hypertension.
Indian journal of endocrinology and metabolism.
2011 Oct; 15 Suppl 4(?):S298-312. doi:
10.4103/2230-8210.86972. [PMID: 22145132] - Jagriti Bhatia, Fauzia Tabassum, Ashok Kumar Sharma, Saurabh Bharti, Mahaveer Golechha, Sujata Joshi, Md Sayeed Akhatar, Abhay Krishna Srivastava, Dharamvir Singh Arya. Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: role of (p) eNOS, NO and oxidative stress.
Cardiovascular toxicology.
2011 Sep; 11(3):272-9. doi:
10.1007/s12012-011-9122-2. [PMID: 21748534] - Po-Yin Chu, Amanda Zatta, Helen Kiriazis, Jaye Chin-Dusting, Xiao-Jun Du, Tanneale Marshall, David M Kaye. CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess.
Circulation. Heart failure.
2011 Sep; 4(5):651-8. doi:
10.1161/circheartfailure.110.960831. [PMID: 21685249] - Pravin Borde, Mahalaxmi Mohan, Sanjay Kasture. Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats.
Natural product research.
2011 Sep; 25(16):1549-59. doi:
10.1080/14786410903335190. [PMID: 21391110] - Aihua Zhang, Zhanjun Jia, Ningning Wang, Tyson J Tidwell, Tianxin Yang. Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice.
Kidney international.
2011 Jul; 80(1):51-60. doi:
10.1038/ki.2011.29. [PMID: 21368743] - Marco Bortolato, Paola Devoto, Paola Roncada, Roberto Frau, Giovanna Flore, Pierluigi Saba, Giuseppa Pistritto, Alessio Soggiu, Salvatore Pisanu, Agata Zappala, Maria Serafina Ristaldi, Maria Tattoli, Vincenzo Cuomo, Francesco Marrosu, Maria Luisa Barbaccia. Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.
Neuropharmacology.
2011 Jun; 60(7-8):1301-8. doi:
10.1016/j.neuropharm.2011.01.013. [PMID: 21256141] - Kazuaki Shimizu, Kengo Furuichi, Norihiko Sakai, Kiyoki Kitagawa, Kouji Matsushima, Naofumi Mukaida, Shuichi Kaneko, Takashi Wada. Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Jun; 34(6):747-52. doi:
10.1038/hr.2011.23. [PMID: 21451526] - B Seifi, Mehri Kadkhodaee, M Zahmatkesh. Effect of vitamin E therapy on serum uric acid in DOCA-salt-treated rats.
Acta physiologica Hungarica.
2011 Jun; 98(2):214-20. doi:
10.1556/aphysiol.98.2011.2.13. [PMID: 21616780] - Kodzue Kinoshita, Sayaka Inada, Kazuya Seki, Aiko Sasaki, Natsuki Hama, Hiroshi Kusunoki. Long-term monitoring of fecal steroid hormones in female snow leopards (Panthera uncia) during pregnancy or pseudopregnancy.
PloS one.
2011 May; 6(5):e19314. doi:
10.1371/journal.pone.0019314. [PMID: 21559303] - Pia Kiilerich, Sylvain Milla, Armin Sturm, Claudiane Valotaire, Sylvie Chevolleau, Franck Giton, Xavier Terrien, Jean Fiet, Alexis Fostier, Laurent Debrauwer, Patrick Prunet. Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation.
The Journal of endocrinology.
2011 May; 209(2):221-35. doi:
10.1530/joe-10-0371. [PMID: 21343325] - Sachin S Kandlikar, Gregory D Fink. Mild DOCA-salt hypertension: sympathetic system and role of renal nerves.
American journal of physiology. Heart and circulatory physiology.
2011 May; 300(5):H1781-7. doi:
10.1152/ajpheart.00972.2010. [PMID: 21357502] - Patrizia Porcu, Todd K O'Buckley, Soomin C Song, Jo Lynne Harenza, Lu Lu, Xusheng Wang, Robert W Williams, Michael F Miles, A Leslie Morrow. Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation.
PloS one.
2011 Apr; 6(4):e18405. doi:
10.1371/journal.pone.0018405. [PMID: 21494628] - Hiroe Toba, Mamiko Yoshida, Chisato Tojo, Arisa Nakano, Yuko Oshima, Yushi Kojima, Kazuki Noda, Jiahong Wang, Miyuki Kobara, Tetsuo Nakata. L/N-type calcium channel blocker cilnidipine ameliorates proteinuria and inhibits the renal renin-angiotensin-aldosterone system in deoxycorticosterone acetate-salt hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Apr; 34(4):521-9. doi:
10.1038/hr.2010.279. [PMID: 21270815] - Justin L Grobe, Beth A Buehrer, Aline M Hilzendeger, Xuebo Liu, Deborah R Davis, Di Xu, Curt D Sigmund. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice.
Hypertension (Dallas, Tex. : 1979).
2011 Mar; 57(3):600-7. doi:
10.1161/hypertensionaha.110.165829. [PMID: 21263123] - Nicole Schupp, Peter Kolkhof, Nina Queisser, Sabine Gärtner, Ursula Schmid, Axel Kretschmer, Elke Hartmann, Rajaraman G Oli, Stefan Schäfer, Helga Stopper. Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2011 Mar; 25(3):968-78. doi:
10.1096/fj.10-173286. [PMID: 21135038] - Noboru Toda, Kikuo Arakawa. Salt-induced hemodynamic regulation mediated by nitric oxide.
Journal of hypertension.
2011 Mar; 29(3):415-24. doi:
10.1097/hjh.0b013e328341d19e. [PMID: 21150639] - Nour-Eddine Rhaleb, Saraswati Pokharel, Umesh Sharma, Oscar A Carretero. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice.
Journal of hypertension.
2011 Feb; 29(2):330-8. doi:
10.1097/hjh.0b013e32834103ee. [PMID: 21052020] - Flaminia Fanelli, Ilaria Belluomo, Valentina D Di Lallo, Gaia Cuomo, Rosaria De Iasio, Margherita Baccini, Elena Casadio, Bruno Casetta, Valentina Vicennati, Alessandra Gambineri, Gabriele Grossi, Renato Pasquali, Uberto Pagotto. Serum steroid profiling by isotopic dilution-liquid chromatography-mass spectrometry: comparison with current immunoassays and reference intervals in healthy adults.
Steroids.
2011 Feb; 76(3):244-53. doi:
10.1016/j.steroids.2010.11.005. [PMID: 21112348] - Youping Wang, Donna H Wang. Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-β/Smad signaling in DOCA-salt hypertension.
Molecular medicine (Cambridge, Mass.).
2011; 17(11-12):1204-12. doi:
10.2119/molmed.2011.00063. [PMID: 21792478] - Brigid Gregg, Larry K Kociolek, Kenan Qin, Robert L Rosenfield, Christine Yu. P450c17 deficiency caused by compound heterozygosity for two novel mutations presenting as hypotension in early infancy.
Hormone research in paediatrics.
2011; 76(6):434-41. doi:
10.1159/000329857. [PMID: 21822006] - Megan M Greenlee, I Jeanette Lynch, Michelle L Gumz, Brian D Cain, Charles S Wingo. Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.
Journal of the American Society of Nephrology : JASN.
2011 Jan; 22(1):49-58. doi:
10.1681/asn.2010030311. [PMID: 21164026] - Seyhan Sahan-Firat, Brett L Jennings, Fariborz A Yaghini, Chi Young Song, Anne M Estes, Xiao R Fang, Nasreen Farjana, Amir I Khan, Kafait U Malik. 2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1.
American journal of physiology. Heart and circulatory physiology.
2010 Dec; 299(6):H1891-901. doi:
10.1152/ajpheart.00655.2010. [PMID: 20852048] - Asada Leelahavanichkul, Qin Yan, Xuzhen Hu, Christoph Eisner, Yuning Huang, Richard Chen, Diane Mizel, Hua Zhou, Elizabeth C Wright, Jeffrey B Kopp, Jürgen Schnermann, Peter S T Yuen, Robert A Star. Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.
Kidney international.
2010 Dec; 78(11):1136-53. doi:
10.1038/ki.2010.287. [PMID: 20736988] - Theodora Szasz, A Elizabeth Linder, Robert P Davis, Robert Burnett, Gregory D Fink, Stephanie W Watts. Allopurinol does not decrease blood pressure or prevent the development of hypertension in the deoxycorticosterone acetate-salt rat model.
Journal of cardiovascular pharmacology.
2010 Dec; 56(6):627-34. doi:
10.1097/fjc.0b013e3181f80194. [PMID: 20881613] - Marcos S Neres, Richard J Auchus, Cedric H L Shackleton, Claudio E Kater. Distinctive profile of the 17-hydroxylase and 17,20-lyase activities revealed by urinary steroid metabolomes of patients with CYP17 deficiency.
Arquivos brasileiros de endocrinologia e metabologia.
2010 Dec; 54(9):826-32. doi:
10.1590/s0004-27302010000900009. [PMID: 21340176] - John W Funder. Minireview: Aldosterone and mineralocorticoid receptors: past, present, and future.
Endocrinology.
2010 Nov; 151(11):5098-102. doi:
10.1210/en.2010-0465. [PMID: 20861235] - Brittany L Mason, Carmine M Pariante, Sara Jamel, Sarah A Thomas. Central nervous system (CNS) delivery of glucocorticoids is fine-tuned by saturable transporters at the blood-CNS barriers and nonbarrier regions.
Endocrinology.
2010 Nov; 151(11):5294-305. doi:
10.1210/en.2010-0554. [PMID: 20881247] - James D Stockand, Elena Mironova, Vladislav Bugaj, Timo Rieg, Paul A Insel, Volker Vallon, Janos Peti-Peterdi, Oleh Pochynyuk. Purinergic inhibition of ENaC produces aldosterone escape.
Journal of the American Society of Nephrology : JASN.
2010 Nov; 21(11):1903-11. doi:
10.1681/asn.2010040377. [PMID: 20813869] - Erika I Boesen, Douglas L Williams, Jennifer S Pollock, David M Pollock. Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats.
Clinical and experimental pharmacology & physiology.
2010 Oct; 37(10):1016-22. doi:
10.1111/j.1440-1681.2010.05428.x. [PMID: 20626757] - Cheryl A Frye, Alicia A Walf, Jason J Paris. Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats.
Behavioural pharmacology.
2010 Sep; 21(5-6):530-9. doi:
10.1097/fbp.0b013e32833e0a23. [PMID: 20679892] - Kornelia Kędziora-Kornatowska, Jolanta Czuczejko, Jadwiga Motyl, Karolina Szewczyk-Golec, Mariusz Kozakiewicz, Hanna Pawluk, Józef Kędziora, Robert Błaszczak, Maciej Banach, Jacek Rysz. Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study.
Archives of medical science : AMS.
2010 Aug; 6(4):513-8. doi:
10.5114/aoms.2010.14461. [PMID: 22371793] - Ming-Ho Tsai, Meei Jyh Jiang. Reactive oxygen species are involved in regulating alpha1-adrenoceptor-activated vascular smooth muscle contraction.
Journal of biomedical science.
2010 Aug; 17(?):67. doi:
10.1186/1423-0127-17-67. [PMID: 20727219] - Joseph Fomusi Ndisang, Ashok Jadhav. Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension.
The Journal of pharmacology and experimental therapeutics.
2010 Jul; 334(1):87-98. doi:
10.1124/jpet.109.164871. [PMID: 20392817] - Mohsen Imenshahidi, Hossein Hosseinzadeh, Yaser Javadpour. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats.
Phytotherapy research : PTR.
2010 Jul; 24(7):990-4. doi:
10.1002/ptr.3044. [PMID: 20013822] - Cheryl A Frye, Carolyn J Koonce, Alicia A Walf. Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP.
Neuroreport.
2010 Jun; 21(8):590-5. doi:
10.1097/wnr.0b013e32833a7e14. [PMID: 20431492] - Jie Hu, Zhonghua Zhang, Wen-Jun Shen, Salman Azhar. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.
Nutrition & metabolism.
2010 Jun; 7(?):47. doi:
10.1186/1743-7075-7-47. [PMID: 20515451] - Morag J Young, James Morgan, Kim Brolin, Peter J Fuller, John W Funder. Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats.
Endocrinology.
2010 Jun; 151(6):2622-8. doi:
10.1210/en.2009-1476. [PMID: 20410198] - Juan J Tarín, Toshio Hamatani, Antonio Cano. Acute stress may induce ovulation in women.
Reproductive biology and endocrinology : RB&E.
2010 May; 8(?):53. doi:
10.1186/1477-7827-8-53. [PMID: 20504303] - Behjat Seifi, Mehri Kadkhodaee, Jie Xu, Manoocher Soleimani. Pro-inflammatory cytokines of rat vasculature in DOCA-salt treatment.
Molecular biology reports.
2010 Apr; 37(4):2111-5. doi:
10.1007/s11033-009-9676-2. [PMID: 19669669] - Eun Hui Bae, In Jin Kim, Jeong Woo Park, Seong Kwon Ma, Jong Un Lee, Soo Wan Kim. Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Apr; 25(4):1051-9. doi:
10.1093/ndt/gfp604. [PMID: 19948880] - Michael J Morris, Elisa S Na, Alan Kim Johnson. Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite.
Behavioral neuroscience.
2010 Apr; 124(2):211-24. doi:
10.1037/a0018910. [PMID: 20364881] - Yu-Yun Chen, Wei Ji, Jun-Rong Du, Dong-Ke Yu, Yao He, Chuan-Xing Yu, De-Shan Li, Chang-yi Zhao, Kui-yun Qiao. Preventive effects of low molecular mass potassium alginate extracted from brown algae on DOCA salt-induced hypertension in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2010 Apr; 64(4):291-5. doi:
10.1016/j.biopha.2009.09.004. [PMID: 19932586] - Daniel O'Brien, Prasad Chunduri, Abishek Iyer, Lindsay Brown. L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats.
Basic & clinical pharmacology & toxicology.
2010 Apr; 106(4):296-301. doi:
10.1111/j.1742-7843.2009.00480.x. [PMID: 20041879] - Abishek Iyer, Andrew Fenning, Junxian Lim, Giang T Le, Robert C Reid, Maria A Halili, David P Fairlie, Lindsay Brown. Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.
British journal of pharmacology.
2010 Apr; 159(7):1408-17. doi:
10.1111/j.1476-5381.2010.00637.x. [PMID: 20180942] - Susana Cavallero, Germán E González, Ignacio M Seropian, Carolina S Cerrudo, Federico Matorra, Celina Morales, Cecilia M Hertig, Ana M Puyó, Belisario E Fernández, Ricardo J Gelpi. Ventricular function and natriuretic peptides in sequentially combined models of hypertension.
American journal of physiology. Heart and circulatory physiology.
2010 Apr; 298(4):H1290-9. doi:
10.1152/ajpheart.00911.2009. [PMID: 20139323] - Nívia M Santiago, Priscila S Guimarães, Raquel A Sirvente, Laser A M Oliveira, Maria C Irigoyen, Robson A S Santos, Maria J Campagnole-Santos. Lifetime overproduction of circulating Angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling.
Hypertension (Dallas, Tex. : 1979).
2010 Apr; 55(4):889-96. doi:
10.1161/hypertensionaha.110.149815. [PMID: 20212262] - Patrizia Porcu, Todd K O'Buckley, Sarah E Alward, Soomin C Song, Kathleen A Grant, Harriet de Wit, A Leslie Morrow. Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
Alcoholism, clinical and experimental research.
2010 Mar; 34(3):432-42. doi:
10.1111/j.1530-0277.2009.01123.x. [PMID: 20028362] - Cornelius Schüle, Thomas C Baghai, Flavia di Michele, Daniela Eser, Augusto Pasini, Elena Romeo, Rainer Rupprecht. Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2010 Mar; 11(2 Pt 2):308-13. doi:
10.3109/15622970701639429. [PMID: 20218794] - Eun Hui Bae, In Jin Kim, Seong Kwon Ma, Soo Wan Kim. Rosiglitazone prevents the progression of renal injury in DOCA-salt hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Mar; 33(3):255-62. doi:
10.1038/hr.2009.217. [PMID: 20057489] - Donald R Dunbar, Hiba Khaled, Louise C Evans, Emad A S Al-Dujaili, Linda J Mullins, John J Mullins, Christopher J Kenyon, Matthew A Bailey. Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney.
Physiological genomics.
2010 Feb; 40(3):158-66. doi:
10.1152/physiolgenomics.00088.2009. [PMID: 19920212] - Zhanjun Jia, Toshinori Aoyagi, Tianxin Yang. mPGES-1 protects against DOCA-salt hypertension via inhibition of oxidative stress or stimulation of NO/cGMP.
Hypertension (Dallas, Tex. : 1979).
2010 Feb; 55(2):539-46. doi:
10.1161/hypertensionaha.109.144840. [PMID: 20065149] - Takehiro Ko, Yutaka Kakizoe, Naoki Wakida, Manabu Hayata, Kohei Uchimura, Naoki Shiraishi, Taku Miyoshi, Masataka Adachi, Shizuka Aritomi, Tomoyuki Konda, Kimio Tomita, Kenichiro Kitamura. Regulation of adrenal aldosterone production by serine protease prostasin.
Journal of biomedicine & biotechnology.
2010; 2010(?):793843. doi:
10.1155/2010/793843. [PMID: 20204133] - Saurabh Gupta, Jose Melendez, Apurv Khanna. Deoxycorticosterone producing tumor as a cause of resistant hypertension.
Case reports in medicine.
2010; 2010(?):372719. doi:
10.1155/2010/372719. [PMID: 20671982] - Ravinder J Singh. Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH).
Methods in molecular biology (Clifton, N.J.).
2010; 603(?):271-7. doi:
10.1007/978-1-60761-459-3_25. [PMID: 20077078] - Fernanda R Giachini, Jennifer C Sullivan, Victor V Lima, Fernando S Carneiro, Zuleica B Fortes, David M Pollock, Maria Helena C Carvalho, R Clinton Webb, Rita C Tostes. Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity.
Hypertension (Dallas, Tex. : 1979).
2010 Jan; 55(1):172-9. doi:
10.1161/hypertensionaha.109.140459. [PMID: 19901158] - Joseph Fomusi Ndisang, Ashok Jadhav. The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Jan; 298(1):R211-23. doi:
10.1152/ajpregu.91000.2008. [PMID: 19864334] - Mohammad Nasir Uddin, Enoch Agunanne, Darijana Horvat, Jules B Puschett. Alterations in the renin-angiotensin system in a rat model of human preeclampsia.
American journal of nephrology.
2010; 31(2):171-7. doi:
10.1159/000267099. [PMID: 20016143] - Chinnadurai Veeramani, Balakrishnan Aristatle, Ganesan Pushpavalli, Kodukkur Viswanathan Pugalendi. Antihypertensive efficacy of Melothria maderaspatana leaf extract on sham-operated and uninephrectomized DOCA-salt hypertensive rats.
Journal of basic and clinical physiology and pharmacology.
2010; 21(1):27-41. doi:
10.1515/jbcpp.2010.21.1.27. [PMID: 20506687] - Behjat Seifi, Mehri Kadkhodaee, Seyed M Karimian, Maryam Zahmatkesh, Jie Xu, Manoocher Soleimani. Evaluation of renal oxidative stress in the development of DOCA-salt induced hypertension and its renal damage.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010 Jan; 32(2):90-7. doi:
10.3109/10641960902993111. [PMID: 20374182] - Youping Wang, Donna H Wang. Aggravated renal inflammatory responses in TRPV1 gene knockout mice subjected to DOCA-salt hypertension.
American journal of physiology. Renal physiology.
2009 Dec; 297(6):F1550-9. doi:
10.1152/ajprenal.00012.2009. [PMID: 19794112] - LaShon C Sturgis, Joseph G Cannon, Derek A Schreihofer, Michael W Brands. The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Dec; 297(6):R1742-8. doi:
10.1152/ajpregu.90995.2008. [PMID: 19812355] - Joseph T Azzarello, Hsueh-Kung Lin, Awet Gherezghiher, Vladislav Zakharov, Zhongxin Yu, Bradley P Kropp, Daniel J Culkin, Trevor M Penning, Kar-Ming Fung. Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor.
International journal of clinical and experimental pathology.
2009 Nov; 3(2):147-55. doi:
. [PMID: 20126582] - Emad A S Al-Dujaili, Linda J Mullins, Matthew A Bailey, Ruth Andrew, Christopher J Kenyon. Physiological and pathophysiological applications of sensitive ELISA methods for urinary deoxycorticosterone and corticosterone in rodents.
Steroids.
2009 Nov; 74(12):938-44. doi:
10.1016/j.steroids.2009.06.009. [PMID: 19577584] - Bing Yao, Raymond C Harris, Ming-Zhi Zhang. Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway.
Hypertension (Dallas, Tex. : 1979).
2009 Nov; 54(5):1077-83. doi:
10.1161/hypertensionaha.109.137174. [PMID: 19770404] - Boleslaw Rutkowski, Janusz Ostrowski. Tadeusz Reichstein: from description of coffee aroma to discoveries of cortisone and aldosterone.
Journal of nephrology.
2009 Nov; 22 Suppl 14(?):80-5. doi:
". [PMID: 20013737] - Chih-Sen Kang, Nen-Chung Chang, Shen-Tien Chang, Chih-Chan Lin, Tsung-Ming Lee. Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hypertensive rats.
Journal of hypertension.
2009 Nov; 27(11):2232-43. doi:
10.1097/hjh.0b013e32833097bb. [PMID: 19812503] - Eun Hui Bae, In Jin Kim, Seong Kwon Ma, Soo Wan Kim. Altered regulation of renal sodium transporters and natriuretic peptide system in DOCA-salt hypertensive rats.
Regulatory peptides.
2009 Oct; 157(1-3):76-83. doi:
10.1016/j.regpep.2009.04.015. [PMID: 19422859] - John H Tinsley, Valorie L Chiasson, Sanique South, Ashutosh Mahajan, Brett M Mitchell. Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.
American journal of hypertension.
2009 Oct; 22(10):1107-14. doi:
10.1038/ajh.2009.125. [PMID: 19617880] - Behjat Seifi, Mehri Kadkhodaee, Seyed Morteza Karimian, Maryam Zahmatkesh, Sedighe Shams, Enayatolla Bakhshi. Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension.
Iranian journal of kidney diseases.
2009 Oct; 3(4):197-202. doi:
. [PMID: 19841522] - Bharti Sapra, Subheet Jain, Ashok K Tiwary. Transdermal delivery of carvedilol in rats: probing the percutaneous permeation enhancement mechanism of soybean extract-chitosan mixture.
Drug development and industrial pharmacy.
2009 Oct; 35(10):1230-41. doi:
10.1080/03639040902882272. [PMID: 19555244] - Po-Ling Yu, Hsu-Li Chao, Shyi-Wu Wang, Paulus S Wang. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.
Journal of cellular biochemistry.
2009 Oct; 108(2):469-75. doi:
10.1002/jcb.22276. [PMID: 19639602] - B Seifi, M Kadkhodaee, M Zahmatkesh, F Golab, E Bakhshi. Changes in serum and renal vitamin E levels in deoxycorticosterone acetate-salt hypertensive rats.
Transplantation proceedings.
2009 Sep; 41(7):2910-1. doi:
10.1016/j.transproceed.2009.07.007. [PMID: 19765471] - Marlina Manhiani, Jeffrey E Quigley, Sarah F Knight, Shiva Tasoobshirazi, TarRhonda Moore, Michael W Brands, Bruce D Hammock, John D Imig. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F740-8. doi:
10.1152/ajprenal.00098.2009. [PMID: 19553349]