14,15-Epoxyeicosa-5z-enoic acid (BioDeep_00000172809)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H36O3 (324.2664)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CCCCCC1C(O1)CCCCCCCC=CCCCC(=O)O
InChI: InChI=1S/C20H36O3/c1-2-3-12-15-18-19(23-18)16-13-10-8-6-4-5-7-9-11-14-17-20(21)22/h7,9,18-19H,2-6,8,10-17H2,1H3,(H,21,22)
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:197211
- PubChem: 53394468
- HMDB: HMDB0244590
- chemspider: 26458442
- CAS: 519038-92-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jan Neckář, Libor Kopkan, Zuzana Husková, František Kolář, František Papoušek, Herbert J Kramer, Sung Hee Hwang, Bruce D Hammock, John D Imig, Jiří Malý, Ivan Netuka, Bohuslav Ošťádal, Luděk Červenka. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Clinical science (London, England : 1979).
2012 Jun; 122(11):513-25. doi:
10.1042/cs20110622. [PMID: 22324471] - Sri N Batchu, Stephen B Lee, Victor Samokhvalov, Ketul R Chaudhary, Haitham El-Sikhry, Steven M Weldon, John M Seubert. Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress.
Canadian journal of physiology and pharmacology.
2012 Jun; 90(6):811-23. doi:
10.1139/y2012-082. [PMID: 22624559] - Rebecca L Charles, Joseph R Burgoyne, Manuel Mayr, Steven M Weldon, Norbert Hubner, Hua Dong, Christophe Morisseau, Bruce D Hammock, Aimee Landar, Philip Eaton. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation.
Circulation research.
2011 Feb; 108(3):324-34. doi:
10.1161/circresaha.110.235879. [PMID: 21164107] - Mohammed A Nayeem, Dovenia S Ponnoth, Matthew A Boegehold, Darryl C Zeldin, John R Falck, S Jamal Mustafa. High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Mar; 296(3):R567-74. doi:
10.1152/ajpregu.90798.2008. [PMID: 19109366] - Christiana Dimitropoulou, Lashondra West, Mary B Field, Richard E White, L Manmohan Reddy, John R Falck, John D Imig. Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.
Prostaglandins & other lipid mediators.
2007 Feb; 83(1-2):50-61. doi:
10.1016/j.prostaglandins.2006.09.008. [PMID: 17259072] - John M Seubert, Christopher J Sinal, Joan Graves, Laura M DeGraff, J Alyce Bradbury, Craig R Lee, Kerry Goralski, Michelle A Carey, Ayala Luria, John W Newman, Bruce D Hammock, John R Falck, Holly Roberts, Howard A Rockman, Elizabeth Murphy, Darryl C Zeldin. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.
Circulation research.
2006 Aug; 99(4):442-50. doi:
10.1161/01.res.0000237390.92932.37. [PMID: 16857962] - Dan Wang, Lillian J Borrego-Conde, John R Falck, Kamalesh K Sharma, Christopher S Wilcox, Jason G Umans. Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles.
Kidney international.
2003 Jun; 63(6):2187-93. doi:
10.1046/j.1523-1755.2003.00036.x. [PMID: 12753306] - Kathryn M Gauthier, Christina Deeter, U Murali Krishna, Y Krishna Reddy, Muralidhar Bondlela, J R Falck, William B Campbell. 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Circulation research.
2002 May; 90(9):1028-36. doi:
10.1161/01.res.0000018162.87285.f8. [PMID: 12016270]
