Artesunate (BioDeep_00000017280)

 

Secondary id: BioDeep_00000399330

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


BUTANEDIOIC ACID, MONO(DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL) ESTER, (3R-(3.ALPHA.,5A.BETA.,6.BETA.,8A.BETA.,9.ALPHA.,10.BETA.,12.BETA.,12AR*))-

化学式: C19H28O8 (384.1784088)
中文名称: 二氢青蒿素-12-α-丁二酸单酯, 青蒿琥酯, 青蒿酯, 青蒿琥酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 38.36%

分子结构信息

SMILES: CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
InChI: InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1

描述信息

Artesunate is an artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria. It has a role as an antimalarial, a ferroptosis inducer and an antineoplastic agent. It is an artemisinin derivative, a sesquiterpenoid, a dicarboxylic acid monoester, a cyclic acetal, a semisynthetic derivative and a hemisuccinate.
Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin]. Artesunate was granted FDA approval on 26 May 2020.
Artesunic acid is a natural product found in Artemisia apiacea, Acronychia pubescens, and Artemisia carvifolia with data available.
Artesunate is a water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunates active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua.
artesunate is a mineral.
A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities
Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may, therefore, be given by injection. It is on the World Health Organizations List of Essential Medicines, the most effective and safe medicines needed in a health system (DrugBank).
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BE - Artemisinin and derivatives, plain
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
D000970 - Antineoplastic Agents
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

同义名列表

72 个代谢物同义名

BUTANEDIOIC ACID, MONO(DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL) ESTER, (3R-(3.ALPHA.,5A.BETA.,6.BETA.,8A.BETA.,9.ALPHA.,10.BETA.,12.BETA.,12AR*))-; BUTANEDIOIC ACID, MONO(DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL) ESTER, (3R-(3alpha,5Abeta,6beta,8Abeta,9alpha,10beta,12beta,12AR*))-; 4-oxo-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0?,(1)(3).0?,(1)(3)]hexadecan-10-yl]oxy}butanoic acid; 4-oxo-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-yl]oxy}butanoic acid; Butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid; Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester; Butanedioic acid, mono((5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10-yl hydrogen butanedioate; 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid; 4-OXO-4-(3R,5AS,6R,8AS,9R,10S,12R,12AR)-3,6,9-TRIMETHYLDECAHYDRO-3,12-EPOXYPYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL HYDROGEN BUTANEDIOATE; Butanedioate, 1-[(3R,5as,6R,8as,9R,10S,12R,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-J]-1,2-benzodioxepin-10-yl] ester; 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid; 3R,5AS,6R,8AS,9R,10S,12R,12AR)-3,6,9-TRIMETHYLDECAHYDRO-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL HYDROGEN BUTANEDIOATE; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate; DIHYDROARTEMISININE-12.ALPHA.-SUCCINATE; Dihydroartemisinine 12 alpha succinate; dihydroartemisinine-12-alpha-succinate; Dihydroartemisinine-12alpha-succinate; Quinghaosu reduced succinate ester; Dihydroqinghasu hemsuccinic acid; Dihydroqinghaosu hemisuccinate; Dihydroqinghasu hemsuccinate; Dihydroartemisinin, Succinyl; succinyl dihydroartemisinin; FIHJKUPKCHIPAT-AHIGJZGOSA-N; ARTESUNATUM [WHO-IP LATIN]; Artesunate [USAN:INN:BAN]; ARTESUNATE [ORANGE BOOK]; Artesunato (INN-Spanish); Artesunato [INN-Spanish]; Artesunatum (INN-Latin); Artesunatum [INN-Latin]; .alpha.-artesunic acid; ARTESUNATE (USP-RS); ARTESUNATE [USP-RS]; ARTESUNATE [WHO-DD]; ARTESUNATE [WHO-IP]; ARTESUNATE [MART.]; ARTESUNATE (MART.); ARTESUNATE [VANDF]; ARTESUNATE [HSDB]; Artesunate [USAN]; sodium artesunate; Artesunate [INN]; ARTESUNATE [MI]; UNII-60W3249T9M; Artesunic acid; Gsunate Forte; Artesunatum; Plasmotrim; Plasmotrin; Artesunato; Artesunata; 60W3249T9M; Artesunate; Qinghaozhi; Arsuamoon; cosunate; Saphnate; malartin; Cosinate; Zysunate; Nuartez; Arinate; Malacef; P01BE03; Arsumax; Artsuna; Asumax; D95; As



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Denis Ponomarev, Maria Lvova, Viatcheslav Mordvinov, Irina Chidunchi, Alexander Dushkin, Damira Avgustinovich. Anti-Opisthorchis felineus effects of artemisinin derivatives: An in vitro study. Acta tropica. 2024 Jun; 254(?):107196. doi: 10.1016/j.actatropica.2024.107196. [PMID: 38521124]
  • Jingsi Liu, Yingyi Huang, Tinglin Qian, Jinyu Chen, Yuewen Ding, Zhaohui Lai, Xinghua Zhong, Mingjun Lai, Huili Zhang, Yuanyuan Wang, Honghao Wang, Yu Peng. Exploring the neuroprotective role of artesunate in mouse models of anti-NMDAR encephalitis: insights from molecular mechanisms and transmission electron microscopy. Cell communication and signaling : CCS. 2024 May; 22(1):269. doi: 10.1186/s12964-024-01652-4. [PMID: 38745240]
  • Pamela Weathers, Melissa Towler, Bushra Hafeez Kiani, David Dolivo, Tanja Dominko. Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to Artemisia sp., Artemisinin, and Its Derivatives. Molecules (Basel, Switzerland). 2024 May; 29(9):. doi: 10.3390/molecules29092107. [PMID: 38731597]
  • Yu Xia, Yixin Tang, Zhixin Huang, Nantian Ke, Yue Zheng, Wanzhen Zhuang, Yi Zhang, Xiaoqing Yin, Mingshu Tu, Jianlin Chen, Yingshu Wang, Yi Huang. Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling. Cellular signalling. 2024 05; 117(?):111108. doi: 10.1016/j.cellsig.2024.111108. [PMID: 38369266]
  • Lulu Chen, Jialin Wang, Yanshuang Ren, Yujin Ma, Jie Liu, Hongwei Jiang, Chuanxin Liu. Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155382. doi: 10.1016/j.phymed.2024.155382. [PMID: 38382280]
  • Bingmin Wu, Ruiyan Zheng, Minhua Ouyang, Yong Zhu, Huanjun Lu, Kaihao Liao, Yuhe Dong, Bolun Su, Junying Huang, Tian Zhong, Zhongqiu Liu, Jingyan Li. The water extract of Amydrium sinense (Engl.) H. Li ameliorates Isoproterenol-induced cardiac hypertrophy through inhibiting the NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116241. doi: 10.1016/j.biopha.2024.116241. [PMID: 38330711]
  • Paul N Newton, Lesley A Chesson, Mayfong Mayxay, Arjen Dondorp, Patricia Tabernero, John D Howa, Thure E Cerling. Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation. Scientific reports. 2024 02; 14(1):3995. doi: 10.1038/s41598-024-54168-9. [PMID: 38369604]
  • Jinhui Sun, Chunli Chen, Jingwei Wang. Artesunate Inhibits Lipid Accumulation and Inflammation by Regulating the NLRP3 Inflammasome in Nonalcoholic Fatty Liver Disease. Discovery medicine. 2024 Feb; 36(181):385-392. doi: 10.24976/discov.med.202436181.36. [PMID: 38409843]
  • Herwig Strik, Thomas Efferth, Bernd Kaina. Artesunate in glioblastoma therapy: Case reports and review of clinical studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155274. doi: 10.1016/j.phymed.2023.155274. [PMID: 38142662]
  • Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang. The update and transport of aluminum nanoparticles in plants and their biochemical and molecular phototoxicity on plant growth and development: A systematic review. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 340(Pt 1):122875. doi: 10.1016/j.envpol.2023.122875. [PMID: 37931678]
  • Jiao Wang, Jin Zhang, Zeyu Guo, Hui Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155156. doi: 10.1016/j.phymed.2023.155156. [PMID: 37897861]
  • Jiaxing Zhang, Liwei Gu, Yumao Jiang, Yun Ma, Ziyue Zhang, Shengnan Shen, Shuo Shen, Qing Peng, Wei Xiao. Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects. International journal of nanomedicine. 2024; 19(?):1385-1408. doi: 10.2147/ijn.s444076. [PMID: 38371457]
  • Fengping Chen, Jiexia Lu, Biaolin Zheng, Nan Yi, Chunxiao Xie, Feiran Chen, Dafu Wei, Haixing Jiang, Shanyu Qin. Artesunate Inhibits the Growth of Insulinoma Cells via SLC7A11/ GPX4-mediated Ferroptosis. Current pharmaceutical design. 2024; 30(3):230-239. doi: 10.2174/0113816128289372240105041038. [PMID: 38243946]
  • Kristen S Hill, Erin E Schuler, Sally R Ellingson, Jill M Kolesar. Artesunate acts through cytochrome c to inhibit growth of pediatric AML cells. Scientific reports. 2023 12; 13(1):22383. doi: 10.1038/s41598-023-49928-y. [PMID: 38104159]
  • Emmanuel Kofi Kumatia, Felix Kwame Zoiku, Alex Asase, Nguyen Huu Tung. In vitro and in silico anti-malarial activity and cytotoxicity of n-hexyl 1-O-rutinoside (a glycoside) isolated from Annickia polycarpa (DC.) Setten and Maas ex I.M. turner. (Annonaceae). Journal of ethnopharmacology. 2023 Oct; ?(?):117287. doi: 10.1016/j.jep.2023.117287. [PMID: 37827299]
  • Jingsai Gu, Yishuang Xu, Dihao Hua, Zhen Chen. Role of artesunate in autoimmune diseases and signaling pathways. Immunotherapy. 2023 10; 15(14):1183-1193. doi: 10.2217/imt-2023-0052. [PMID: 37431601]
  • Qun-Fa Huang, Yan-Hong Li, Zeng-Jin Huang, Mei Jun, Wei Wang, Xiao-Li Chen, Guan-Hai Wang. Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Sep; 190(?):284-293. doi: 10.1016/j.ejpb.2023.07.014. [PMID: 37532638]
  • Xuwang Pan, Jinsong Huang, Shourong Liu, Yidan Shao, Jianjun Xi, Ruoyu He, Tingting Shi, Rangxiao Zhuang, Wenying Yu. pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma. Drug development and industrial pharmacy. 2023 Jul; ?(?):1-12. doi: 10.1080/03639045.2023.2239342. [PMID: 37470495]
  • Solomon E Owumi, Angel O Umez, Uche Arunsi, Chioma E Irozuru. Dietary aflatoxin B1 and antimalarial-a lumefantrine/artesunate-therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms. Scientific reports. 2023 07; 13(1):12172. doi: 10.1038/s41598-023-39455-1. [PMID: 37500724]
  • Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Jia. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. 2023 Jul; 50(1):. doi: 10.3892/or.2023.8584. [PMID: 37326033]
  • Jingyuan Liu, Zheng Pan, Boding Tong, Cong Wang, Jia Yang, Jingling Zou, Jikuan Jiang, Lusi Zhang, Bing Jiang. Artesunate protects against ocular fibrosis by suppressing fibroblast activation and inducing mitochondria-dependent ferroptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 06; 37(6):e22954. doi: 10.1096/fj.202201867r. [PMID: 37159329]
  • Yu Zhang, Jun Zhou, Ling Hua, Pan Li, Jiaqi Wu, Shenglan Shang, Fei Deng, Jing Luo, Mengling Liao, Nuoyan Wang, Xichun Pan, Yue Yuan, Yue Zheng, Yonglin Lu, Yasi Huang, Jiang Zheng, Xin Liu, Xiaoli Li, Hong Zhou. Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance. Cell communication and signaling : CCS. 2023 05; 21(1):124. doi: 10.1186/s12964-023-01137-w. [PMID: 37248534]
  • Kun Chen, Liying Tang, Xiaolin Nong. Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023 May; 72(5):1037-1050. doi: 10.1007/s00011-023-01729-9. [PMID: 37024544]
  • Yuchen Tao, Wenhang Li, Jianying Yang, Tingting Xue, Yanlu Wang, Xiaojie Dong, Hao Xu, Jianye Ren, Jiahui Lu. Exploring underlying mechanism of artesunate in treatment of acute myeloid leukemia using network pharmacology and molecular docking. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2023 Mar; ?(?):. doi: 10.1007/s12094-023-03125-5. [PMID: 36952106]
  • Y Chen, C Liang, J Li, L Ma, B Wang, Z Yuan, S Yang, X Nong. Effect of artesunate on cardiovascular complications in periodontitis in a type I diabetes rat model and related mechanisms. Journal of endocrinological investigation. 2023 Mar; ?(?):. doi: 10.1007/s40618-023-02052-0. [PMID: 36892740]
  • San-Yuan Chen, Chun-Nun Chao, Hsin-Yi Huang, Pei-Wen Zhao, Chiung-Yao Fang. Artesunate Exhibits Synergy With Cisplatin and Cytotoxicity for Upper Tract and Bladder Urothelial Carcinoma Cells. Anticancer research. 2023 Mar; 43(3):1175-1184. doi: 10.21873/anticanres.16263. [PMID: 36854526]
  • Guanfeng Xie, Yubing Liang, Wen Gao, Liya Wu, Yan Zhang, Ziming Ye, Chao Qin. Artesunate alleviates intracerebral hemorrhage secondary injury by inducing ferroptosis in M1-polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway. Basic & clinical pharmacology & toxicology. 2023 Feb; ?(?):. doi: 10.1111/bcpt.13848. [PMID: 36815716]
  • Yuanqing Jin, Shuguang Wu, Lingyan Zhang, Gang Yao, Hai Zhao, Penghai Qiao, Jian Zhang. Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload-induced bone loss. Basic & clinical pharmacology & toxicology. 2023 Feb; 132(2):144-153. doi: 10.1111/bcpt.13817. [PMID: 36433916]
  • Laoqi Liang, Yang Liu, Xiaoyan Wu, Yan Chen. Artesunate induces ferroptosis by inhibiting the nuclear localization of SREBP2 in myeloma cells. International journal of medical sciences. 2023; 20(12):1535-1550. doi: 10.7150/ijms.86409. [PMID: 37859702]
  • Dai Cao, Die Chen, Jiang-Nan Xia, Wen-Yan Wang, Guo-Yuan Zhu, Li-Wen Chen, Chuantao Zhang, Bo Tan, Hui Li, Ying-Wei Li. Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113705. doi: 10.1016/j.biopha.2022.113705. [PMID: 36271541]
  • Joyce Hernandez Maldonado, Oliver Grundmann. Drug-Drug Interactions of Artemisinin-Based Combination Therapies in Malaria Treatment: A Narrative Review of the Literature. Journal of clinical pharmacology. 2022 10; 62(10):1197-1205. doi: 10.1002/jcph.2073. [PMID: 35543380]
  • Guoliang Xiong, Dakun Huang, Lingfei Lu, Xiuxian Luo, Yadong Wang, Shangwen Liu, Mianxiong Chen, Shaolong Yu, Marie Kappen, Changjiang You, Sheng Lu, Yingjie Yu, Jiandong Lu, Feng Lin. Near-Infrared-II Light Induced Mild Hyperthermia Activate Cisplatin-Artemisinin Nanoparticle for Enhanced Chemo/Chemodynamic Therapy and Immunotherapy. Small methods. 2022 09; 6(9):e2200379. doi: 10.1002/smtd.202200379. [PMID: 35978419]
  • Liwei Gu, Jiaxing Zhang, Dandan Liu, Jiayun Chen, Shuzhi Liu, Qing Peng, Ya Tian, Maobo Du, Junzhe Zhang, Wei Xiao, Shuo Shen, Jigang Wang. Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy. Journal of nanobiotechnology. 2022 Aug; 20(1):376. doi: 10.1186/s12951-022-01569-5. [PMID: 35964052]
  • Zhiying Huang, Shu Gan, Xuerong Zhuang, Yao Chen, Linlin Lu, Ying Wang, Xiaoxiao Qi, Qian Feng, Qiuju Huang, Biaoyan Du, Rong Zhang, Zhongqiu Liu. Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy. Cells. 2022 08; 11(16):. doi: 10.3390/cells11162472. [PMID: 36010550]
  • Shuoqiu Bai, Jingjing Zhou, Xiaolin Nong, Rongkang Shi, Zhong Yuan, Chubin Ma, Jiaquan Li. Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis. Canadian journal of physiology and pharmacology. 2022 Aug; 100(8):741-754. doi: 10.1139/cjpp-2021-0665. [PMID: 35500287]
  • Bahman Amani, Sara Zareei, Behnam Amani, Mahsa Zareei, Neda Zareei, Rouhollah Shabestan, Arash Akbarzadeh. Artesunate, imatinib, and infliximab in COVID-19: A rapid review and meta-analysis of current evidence. Immunity, inflammation and disease. 2022 06; 10(6):e628. doi: 10.1002/iid3.628. [PMID: 35634954]
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