Tyrphostin B42 (BioDeep_00000172771)
human metabolite blood metabolite
代谢物信息卡片
N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
化学式: C17H14N2O3 (294.10043740000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OC1=C(O)C=C(C=C(C#N)C(=O)NCC2=CC=CC=C2)C=C1
InChI: InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinxin Yue, Wei Hao, Min Wang, Yang Fu. Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5/IGF-1 pathway.
Immunity, inflammation and disease.
2023 Nov; 11(11):e1071. doi:
10.1002/iid3.1071. [PMID: 38018587] - Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan. Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway.
Diagnostic pathology.
2023 Sep; 18(1):108. doi:
10.1186/s13000-023-01393-x. [PMID: 37759223] - Liang Shao, Yan Yan, Nansu Wang, Qiongfang Tan, Yuying Huang, Lei Lei, Dongmei Yang, Ling Liu. Betulonic acid regulates oviduct epithelial cell inflammation through the TLR4, MAPK, and JAK/STAT signalling pathways.
Reproduction, fertility, and development.
2023 May; 35(8):480-491. doi:
10.1071/rd21380. [PMID: 37142241] - Yiying Tao, Jianfang Han, Wenhua Liu, Ling An, Wenbo Hu, Ningning Wang, Yean Yu. MUC1 Promotes Mesangial Cell Proliferation and Kidney Fibrosis in Diabetic Nephropathy Through Activating STAT and β-Catenin Signal Pathway.
DNA and cell biology.
2021 Oct; 40(10):1308-1316. doi:
10.1089/dna.2021.0098. [PMID: 34520253] - Lingpeng Xie, Yuting Wu, Chuying Zhou, Zhangbin Tan, Honglin Xu, Guanghong Chen, Hongmei Chen, Guiqiong Huang, Huijie Fan, Lei Gao, Bin Liu, Yingchun Zhou. Piceatannol protects against sepsis-induced myocardial dysfunction via direct inhibition of JAK2.
International immunopharmacology.
2021 Jul; 96(?):107639. doi:
10.1016/j.intimp.2021.107639. [PMID: 34162128] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Li Zhang, Xuejun Wang, Hao Zhang, Mengwen Feng, Jingjing Ding, Bing Zhang, Zijie Cheng, Lingmei Qian. Exercise-induced peptide EIP-22 protect myocardial from ischaemia/reperfusion injury via activating JAK2/STAT3 signalling pathway.
Journal of cellular and molecular medicine.
2021 04; 25(7):3560-3572. doi:
10.1111/jcmm.16441. [PMID: 33710777] - Minghui Jiang, Jiahui Liu, Wenli Liu, Xiaoliang Zhu, Yasmeen Bano, Hongbing Liao, Haiyan Li, Hai-Hong Jiang. Bone marrow stem cells secretome accelerates simulated birth trauma-induced stress urinary incontinence recovery in rats.
Aging.
2021 03; 13(7):10517-10534. doi:
10.18632/aging.202812. [PMID: 33793419] - Yang Liu, Yushi Sun, Yuhui Zhou, Xiaojiang Tang, Ke Wang, Yu Ren, Jianjun He. Sinomenine hydrochloride inhibits the progression of plasma cell mastitis by regulating IL-6/JAK2/STAT3 pathway.
International immunopharmacology.
2020 Apr; 81(?):106025. doi:
10.1016/j.intimp.2019.106025. [PMID: 31810886] - Guangxing Tan, Lin Jiang, Gangqin Li, Kuan Bai. ESTAT3 Inhibitor AG-490 Inhibits the Growth of Prostate Cancer by miR-503-5p Both In Vivo and In Vitro.
Technology in cancer research & treatment.
2020 Jan; 19(?):1533033820948062. doi:
10.1177/1533033820948062. [PMID: 33063634] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Te-Chuan Chen, Manish Neupane, Shao-Ju Chien, Feng-Rong Chuang, Robert B Crawford, Norbert E Kaminski, Chia-Cheng Chang. Characterization of Adult Canine Kidney Epithelial Stem Cells That Give Rise to Dome-Forming Tubular Cells.
Stem cells and development.
2019 11; 28(21):1424-1433. doi:
10.1089/scd.2019.0049. [PMID: 31495275] - Lei Zhang, Peng Lu, Xu Guo, Ting Liu, Xu Luo, Yi-Tang Zhu. Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2019 Sep; 68(9):751-760. doi:
10.1007/s00011-019-01258-4. [PMID: 31250048] - Z-D Liu, Z-X Mou, X-H Che, K Wang, H-X Li, X-Y Chen, X-M Guo. ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway.
European review for medical and pharmacological sciences.
2019 Jul; 23(13):5840-5850. doi:
10.26355/eurrev_201907_18326. [PMID: 31298335] - Hongmei Yin, Zhen Li, Jia Chen, Xiaobo Hu. Expression and the potential functions of TRIM32 in lung cancer tumorigenesis.
Journal of cellular biochemistry.
2019 04; 120(4):5232-5243. doi:
10.1002/jcb.27798. [PMID: 30378152] - Sheng Zuo, Zhen Zhu, Yi Liu, Hong Li, Shuang Song, Shaojun Yin. CXCL16 Induces the Progression of Pulmonary Fibrosis through Promoting the Phosphorylation of STAT3.
Canadian respiratory journal.
2019; 2019(?):2697376. doi:
10.1155/2019/2697376. [PMID: 31379980] - Mojca Gasparitsch, Alexandra Schieber, Teresa Schaubeck, Ursula Keller, Marco Cattaruzza, Bärbel Lange-Sperandio. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy.
PloS one.
2019; 14(12):e0226675. doi:
10.1371/journal.pone.0226675. [PMID: 31846485] - X-J Sun, J-R Mao. Role of Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in cardioprotection of exercise preconditioning.
European review for medical and pharmacological sciences.
2018 08; 22(15):4975-4986. doi:
10.26355/eurrev_201808_15638. [PMID: 30070334] - Jinghui Zhang, Chenchang Liu, Guofeng You. AG490, a JAK2-specific inhibitor, downregulates the expression and activity of organic anion transporter-3.
Journal of pharmacological sciences.
2018 Mar; 136(3):142-148. doi:
10.1016/j.jphs.2018.01.006. [PMID: 29487013] - Shanshan Wu, Xiaohua Chen, Yuyan Tang, Yi Zhang, Dan Li, Jie Chen, Jieling Wang, Zhenghao Tang, Guoqing Zang, Yongsheng Yu. Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo.
Acta biochimica et biophysica Sinica.
2018 Feb; 50(2):181-190. doi:
10.1093/abbs/gmx133. [PMID: 29340620] - Jing Yu, Hao Wu, Zi-Yu Liu, Qi Zhu, Chang Shan, Ke-Qin Zhang. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation.
International journal of molecular medicine.
2017 Oct; 40(4):1185-1193. doi:
10.3892/ijmm.2017.3098. [PMID: 28849106] - Yang Li, Xiaojing Shi, Jian Li, Minghui Zhang, Bo Yu. Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2.
Apoptosis : an international journal on programmed cell death.
2017 Apr; 22(4):510-518. doi:
10.1007/s10495-016-1327-1. [PMID: 27848055] - Bin Chen, Yi Liu, YuanQiang Zhang, JingKun Li, KaiYuan Cheng, Lei Cheng. IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway.
Inflammation.
2017 Apr; 40(2):612-622. doi:
10.1007/s10753-017-0508-6. [PMID: 28233079] - Sumin Gao, Leyun Zhan, Zhengchao Yang, Ruili Shi, Haobo Li, Zhengyuan Xia, Shiying Yuan, Qing-Ping Wu, Tingting Wang, Shanglong Yao. Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(3):1140-1151. doi:
10.1159/000481755. [PMID: 28977786] - Qing Wu, Xiaokang Zhou, Danqing Huang, Yingchen Ji, Feiwu Kang. IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(4):1360-1369. doi:
10.1159/000465455. [PMID: 28278513] - Hee Ja Kim, Jiwoo Lim, Young-Soon Jang, Eui-Cheol Shin, Hyung-Ran Kim, Ju-Young Seoh, Ji Soo Lee, Soon Nam Lee, Jihee Lee Kang, Youn-Hee Choi. Exogenous Hydrogen Peroxide Induces Lipid Raft-Mediated STAT-6 Activation in T Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 42(6):2467-2480. doi:
10.1159/000480210. [PMID: 28848115] - M López-Yoldi, R Castilla-Madrigal, M P Lostao, A Barber, J Prieto, J A Martínez, M Bustos, M J Moreno-Aliaga. Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells.
Acta physiologica (Oxford, England).
2016 07; 217(3):217-26. doi:
10.1111/apha.12674. [PMID: 26972986] - Min Zhang, Guangmin Nong, Min Jiang, Wenjie Zhan. [Lipid derivative of benzylidene malononitrile AG490 attenuates airway inflammation of mice with neutrophilic asthma].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2016 Jun; 32(6):730-3. doi:
". [PMID: 27371836] - Min Chul Park, Hyobin Jeong, Sung Hwa Son, YounHa Kim, Daeyoung Han, Peter C Goughnour, Taehee Kang, Nam Hoon Kwon, Hyo Eun Moon, Sun Ha Paek, Daehee Hwang, Ho Jun Seol, Do-Hyun Nam, Sunghoon Kim. Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function.
Cancer research.
2016 Mar; 76(5):1044-54. doi:
10.1158/0008-5472.can-14-2611. [PMID: 26676754] - Jian-Ying Luo, Dan Fu, Ya-Qin Wu, Ying Gao. Inhibition of the JAK2/STAT3/SOSC1 Signaling Pathway Improves Secretion Function of Vascular Endothelial Cells in a Rat Model of Pregnancy-Induced Hypertension.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 40(3-4):527-537. doi:
10.1159/000452566. [PMID: 27889763] - Haifeng Chen, Bingyu Shi, Xuebing Feng, Wei Kong, Weiwei Chen, Linyu Geng, Jinyun Chen, Rui Liu, Xia Li, WanJun Chen, Xiang Gao, Lingyun Sun. Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.).
2015 Sep; 67(9):2383-93. doi:
10.1002/art.39196. [PMID: 25989537] - Valeriya Gyurkovska, Nina Ivanovska. Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock.
European journal of pharmacology.
2015 Mar; 751(?):118-26. doi:
10.1016/j.ejphar.2015.01.045. [PMID: 25666385] - Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori, Masakazu Ishii. Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.
European journal of pharmacology.
2014 Nov; 742(?):22-30. doi:
10.1016/j.ejphar.2014.08.023. [PMID: 25179574] - Naohiro Nomura, Paula Nunes, Richard Bouley, Anil V Nair, Stanley Shaw, Erica Ueda, Nutthapoom Pathomthongtaweechai, Hua A Jenny Lu, Dennis Brown. High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
American journal of physiology. Cell physiology.
2014 Oct; 307(7):C597-605. doi:
10.1152/ajpcell.00154.2014. [PMID: 24944200] - Jeff M Sands, Mitsi A Blount. Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on 'High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration'.
American journal of physiology. Cell physiology.
2014 Oct; 307(7):C595-6. doi:
10.1152/ajpcell.00184.2014. [PMID: 24944199] - Jonathan Pratt, Borhane Annabi. Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells.
Cellular signalling.
2014 May; 26(5):917-24. doi:
10.1016/j.cellsig.2014.01.012. [PMID: 24462646] - Youcai Tang, Anping Chen. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling.
Laboratory investigation; a journal of technical methods and pathology.
2014 May; 94(5):503-16. doi:
10.1038/labinvest.2014.42. [PMID: 24614199] - Yushen Jiang, Tang Jiang, Juan Ouyang, Qingsong Zhou, Yanlan Liang, Yingpeng Cui, Peisong Chen, Bin Huang. Cell atavistic transition: Paired box 2 re-expression occurs in mature tubular epithelial cells during acute kidney injury and is regulated by Angiotensin II.
PloS one.
2014; 9(4):e93563. doi:
10.1371/journal.pone.0093563. [PMID: 24710423] - Youn Hee Joung, Eun Joung Lim, Pramod Darvin, Ju Woong Jang, Kyung Do Park, Hak Kyo Lee, Heui Soo Kim, Byung Wook Cho, Taekyu Park, Sumi Chung, Jong Hwan Park, Young Mok Yang. Hwanggeumchal sorghum extract enhances BMP7 and GH signaling through the activation of Jak2/STAT5B in MC3T3‑E1 osteoblastic cells.
Molecular medicine reports.
2013 Sep; 8(3):891-6. doi:
10.3892/mmr.2013.1593. [PMID: 23877734] - Z Merhi, E Buyuk, D S Berger, A Zapantis, D D Israel, S Chua, S Jindal. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF.
Human reproduction (Oxford, England).
2013 Jun; 28(6):1661-9. doi:
10.1093/humrep/det072. [PMID: 23503941] - A Ferlazzo, E S M Carvalho, S F Gregorio, D M Power, A V M Canario, F Trischitta, J Fuentes. Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream (Sparus aurata L.).
The Journal of experimental biology.
2012 Nov; 215(Pt 21):3836-44. doi:
10.1242/jeb.074906. [PMID: 22855618] - Shi-Hong Wen, Yi Li, Cai Li, Zhi-Qiu Xia, Wei-Feng Liu, Xu-Yu Zhang, Wan-Long Lei, Wen-Qi Huang, Ke-Xuan Liu. Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.
Shock (Augusta, Ga.).
2012 Oct; 38(4):411-9. doi:
10.1097/shk.0b013e3182662266. [PMID: 22777122] - Zohreh Hosseinzadeh, Manzar Shojaiefard, Shefalee K Bhavsar, Florian Lang. Up-regulation of the betaine/GABA transporter BGT1 by JAK2.
Biochemical and biophysical research communications.
2012 Mar; 420(1):172-7. doi:
10.1016/j.bbrc.2012.02.137. [PMID: 22405821] - Víctor H Olavarría, Jaime E Figueroa, Victoriano Mulero. Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C.
Developmental and comparative immunology.
2012 Jan; 36(1):216-21. doi:
10.1016/j.dci.2011.08.004. [PMID: 21884725] - R Fernández-Sánchez, S Berzal, María-Dolores Sánchez-Niño, F Neria, S Gonçalves, O Calabia, A Tejedor, M J Calzada, C Caramelo, J J P Deudero, A Ortiz. AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.
Current medicinal chemistry.
2012; 19(23):4014-23. doi:
10.2174/092986712802002554. [PMID: 22709000] - Xing-Xin Wu, Li-Mei Wu, Jing-Jing Fan, Yu Qin, Gong Chen, Xue-Feng Wu, Yan Shen, Yang Sun, Qiang Xu. Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice.
Journal of ethnopharmacology.
2011 Apr; 135(1):173-8. doi:
10.1016/j.jep.2011.03.010. [PMID: 21396998] - Qing-juan Liu, Yong-hong Shi, Shu-xia Liu, Jun Hao, Yan-ping Cao, Hang Li, Jin-ying Wei, Hui-jun Duan. [The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1β].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2010 Dec; 22(12):747-9. doi:
NULL. [PMID: 21190604] - Chen Wang, Yong-hong Shi, Yun-zhuo Ren, Jun Hao, Zan-hua Rong, Hui-jun Duan. [The expression of suppressor of cytokine signaling-1/3 in renal tubular epithelial cells induced by high glucose].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2010 Dec; 22(12):754-7. doi:
NULL. [PMID: 21190606] - S Wang, N Yang, L Zhang, B Huang, H Tan, Y Liang, Y Li, X Yu. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice.
Lupus.
2010 Sep; 19(10):1171-80. doi:
10.1177/0961203310367660. [PMID: 20501525] - Geber Peña, Bolin Cai, Edwin A Deitch, Luis Ulloa. JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.
Journal of molecular medicine (Berlin, Germany).
2010 Aug; 88(8):851-9. doi:
10.1007/s00109-010-0628-z. [PMID: 20393690] - M Tsutsui, H Yasuda, H Suto, H Imai, Y Isobe, M Sasaki, Y Kojima, K Oshimi, K Sugimoto. Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma.
International journal of laboratory hematology.
2010 Aug; 32(4):419-26. doi:
10.1111/j.1751-553x.2009.01204.x. [PMID: 19968719] - R K Singh, C Jia, F Garcia, G A Carrasco, G Battaglia, N A Muma. Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release.
Journal of psychopharmacology (Oxford, England).
2010 Jul; 24(7):1079-88. doi:
10.1177/0269881109103090. [PMID: 19304867] - Malika Faouzi, Valérie Chopin, Ahmed Ahidouch, Halima Ouadid-Ahidouch. Intermediate Ca2+-sensitive K+ channels are necessary for prolactin-induced proliferation in breast cancer cells.
The Journal of membrane biology.
2010 Mar; 234(1):47-56. doi:
10.1007/s00232-010-9238-5. [PMID: 20177667] - Mario B Marrero, Rudolf Lucas, Christina Salet, Terry A Hauser, Anatoly Mazurov, Patrick M Lippiello, Merouane Bencherif. An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes.
The Journal of pharmacology and experimental therapeutics.
2010 Jan; 332(1):173-80. doi:
10.1124/jpet.109.154633. [PMID: 19786623] - Satoru Shinriki, Mitsuharu Ueda, Kazutoshi Ota, Masaaki Nakamura, Mareina Kudo, Mutsuko Ibusuki, Jaemi Kim, Yoshihiro Yoshitake, Daiki Fukuma, Hirofumi Jono, Jun-Ichi Kuratsu, Masanori Shinohara, Yukio Ando. Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2010 Jan; 39(1):41-7. doi:
10.1111/j.1600-0714.2009.00777.x. [PMID: 19453393] - Chia Hung Chou, Pei-Jer Chen, Yung-Ming Jeng, Ann-Lii Cheng, Li-Rung Huang, Jason Chia-Hsien Cheng. Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway.
International journal of radiation oncology, biology, physics.
2009 Dec; 75(5):1545-52. doi:
10.1016/j.ijrobp.2008.12.072. [PMID: 19327909] - D Chen, G Zuo, C Li, X Hu, T Guan, R Jiang, J Li, X Lin, F Li, C Luo, H Wang, C Lei, X Long, Y Wang, J Wang. Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway.
Journal of ethnopharmacology.
2009 Nov; 126(2):215-20. doi:
10.1016/j.jep.2009.08.043. [PMID: 19735711] - Tang Jiang, Qing-song Zhou, Lei Pi, Bin Huang. [Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion].
Zhonghua bing li xue za zhi = Chinese journal of pathology.
2009 Jul; 38(7):466-71. doi:
. [PMID: 19781194] - Ana Canda-Sánchez, Francisco J Salgado, Amparo Pérez-Díaz, Carla Varela-González, Pilar Arias, Montserrat Nogueira. IL-12-dependent activation of ERK1/2 in human T lymphoblasts.
Immunobiology.
2009; 214(3):187-96. doi:
10.1016/j.imbio.2008.07.006. [PMID: 19215801] - Fernando Neria, Maria A Castilla, Ruth Fernandez Sanchez, Francisco R Gonzalez Pacheco, Juan J P Deudero, Olalla Calabia, Alberto Tejedor, Felix Manzarbeitia, Alberto Ortiz, Carlos Caramelo. Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity.
Kidney international.
2009 Jan; 75(2):227-34. doi:
10.1038/ki.2008.487. [PMID: 18818682] - Jun Ren, Bang-Hao Zhu, David P Relling, Lucy B Esberg, Asli F Ceylan-Isik. High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response.
Obesity (Silver Spring, Md.).
2008 Nov; 16(11):2417-23. doi:
10.1038/oby.2008.381. [PMID: 18719678] - Petya Dimitrova, Nina Ivanovska. Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation.
International immunopharmacology.
2008 Nov; 8(11):1567-77. doi:
10.1016/j.intimp.2008.06.013. [PMID: 18656556] - Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hong. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.
Journal of nephrology.
2008 Nov; 21(6):919-23. doi:
NULL. [PMID: 19034877] - Petya Dimitrova, Martin Yordanov, Svetla Danova, Nina Ivanovska. Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA.
FEMS immunology and medical microbiology.
2008 Jul; 53(2):231-6. doi:
10.1111/j.1574-695x.2008.00421.x. [PMID: 18507679] - Abdulla K Salahudeen, Naeem Haider, John Jenkins, Manish Joshi, Harnish Patel, Hong Huang, Ming Yang, He Zhe. Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury.
American journal of physiology. Renal physiology.
2008 Jun; 294(6):F1354-65. doi:
10.1152/ajprenal.00131.2008. [PMID: 18385271] - Ikuhiro Yamada, Takashi Goto, Satoko Takeuchi, Shigetoshi Ohshima, Kazuo Yoneyama, Tomomi Shibuya, Ei Kataoka, Daisuke Segawa, Wataru Sato, Takahiro Dohmen, Yumiko Anezaki, Hajime Ishii, Hirohide Ohnishi. Mao (Ephedra sinica Stapf) protects against D-galactosamine and lipopolysaccharide-induced hepatic failure.
Cytokine.
2008 Mar; 41(3):293-301. doi:
10.1016/j.cyto.2007.12.003. [PMID: 18218321] - Sheng-Li Tian, Yong-Ming Zhou, Tao Huang, Zhi-Zhong Xue, Wei He. [Effects of Yisui Jiedu Recipe on JAK2-STAT5 signal transduction pathway in bone marrow hematopoietic cells from patients with myelodysplastic syndrome-refractory anemia].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2008 Feb; 6(2):185-9. doi:
10.3736/jcim20080216. [PMID: 18241656] - Niansheng Yang, Mingqian Luo, Rong Li, Yuefang Huang, Rui Zhang, Qingqing Wu, Fang Wang, Youji Li, Xueqing Yu. Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Jan; 23(1):91-100. doi:
10.1093/ndt/gfm509. [PMID: 17670769] - Roser Gorina, Coral Sanfeliu, Aida Galitó, Angel Messeguer, Anna M Planas. Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.
Glia.
2007 Oct; 55(13):1313-24. doi:
10.1002/glia.20542. [PMID: 17607690] - Margarita Martinez-Moczygemba, David P Huston, Jonathan T Lei. JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.
Journal of leukocyte biology.
2007 Apr; 81(4):1137-48. doi:
10.1189/jlb.0706465. [PMID: 17227823] - E Mrak, I Villa, R Lanzi, M Losa, F Guidobono, A Rubinacci. Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.
The Journal of endocrinology.
2007 Mar; 192(3):639-45. doi:
10.1677/joe.1.07073. [PMID: 17332531] - Fernando Neria, Carlos Caramelo, Héctor Peinado, Francisco R González-Pacheco, Juan J P Deudero, Alain J de Solis, Ruth Fernández-Sánchez, Silvia Peñate, Amparo Cano, María Angeles Castilla. Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.
American journal of physiology. Cell physiology.
2007 Mar; 292(3):C1123-31. doi:
10.1152/ajpcell.00548.2005. [PMID: 17035297] - Rong Li, Niansheng Yang, Lili Zhang, Yuefang Huang, Rui Zhang, Fang Wang, Mingqian Luo, Yingjie Liang, Xueqing Yu. Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome.
American journal of nephrology.
2007; 27(6):580-9. doi:
10.1159/000108102. [PMID: 17823504] - Ji Hoon Yu, Kyung Hwan Kim, Hyeyoung Kim. Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells.
Biochemical pharmacology.
2006 Nov; 72(11):1555-62. doi:
10.1016/j.bcp.2006.07.008. [PMID: 16934228] - Michael Fritzenwanger, Katharina Meusel, Martin Foerster, Friedhelm Kuethe, Andreas Krack, Hans R Figulla. Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.
Cytokine.
2006 Nov; 36(3-4):101-6. doi:
10.1016/j.cyto.2006.10.015. [PMID: 17197193] - I Arany, J K Megyesi, B D Nelkin, R L Safirstein. STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.
Kidney international.
2006 Aug; 70(4):669-74. doi:
10.1038/sj.ki.5001604. [PMID: 16788692] - K Moriwaki, H Kiyomoto, H Hitomi, G Ihara, K Kaifu, K Matsubara, T Hara, N Kondo, K Ohmori, A Nishiyama, T Fukui, M Kohno. Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway.
Kidney international.
2006 Aug; 70(4):788-93. doi:
10.1038/sj.ki.5001639. [PMID: 16820786] - Angela Graness, Valeria Poli, Margarete Goppelt-Struebe. STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.
Biochemical pharmacology.
2006 Jun; 72(1):32-41. doi:
10.1016/j.bcp.2006.04.001. [PMID: 16707113] - Masanori Nakata, Ikuro Maruyama, Toshihiko Yada. Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line.
Diabetes research and clinical practice.
2005 Dec; 70(3):209-16. doi:
10.1016/j.diabres.2005.03.036. [PMID: 15927298] - G Rega, C Kaun, T W Weiss, S Demyanets, G Zorn, S P Kastl, S Steiner, D Seidinger, C W Kopp, M Frey, R Roehle, G Maurer, K Huber, J Wojta. Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue.
Circulation.
2005 Apr; 111(15):1938-45. doi:
10.1161/01.cir.0000161823.55935.be. [PMID: 15837947] - Sung Gook Cho, Seh Yoon Yi, Young Sook Yoo. IFNgamma and TNFalpha synergistically induce neurite outgrowth on PC12 cells.
Neuroscience letters.
2005 Apr; 378(1):49-54. doi:
10.1016/j.neulet.2004.12.073. [PMID: 15763171] - Yi-lei Mao, Zhuo Yu, Xin Lu, Xin-ting Sang, Zhi-ying Yang, Shou-xian Zhong. [Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2005 Feb; 27(1):73-6. doi:
NULL. [PMID: 15782497] - Shao-Ling Zhang, Jun Guo, Babak Moini, Julie R Ingelfinger. Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis.
Kidney international.
2004 Dec; 66(6):2181-92. doi:
10.1111/j.1523-1755.2004.66008.x. [PMID: 15569307] - Alexandre I Belenkov, George Shenouda, Ekatarina Rizhevskaya, Denis Cournoyer, Jean-Philippe Belzile, Luis Souhami, Slobodan Devic, Terry Y K Chow. Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin.
Molecular cancer therapeutics.
2004 Dec; 3(12):1525-32. doi:
NULL. [PMID: 15634645] - Patricia Gomez-Bougie, Régis Bataille, Martine Amiot. The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.
European journal of immunology.
2004 Nov; 34(11):3156-64. doi:
10.1002/eji.200424981. [PMID: 15459900] - Shao-Ling Zhang, Babak Moini, Julie R Ingelfinger. Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Journal of the American Society of Nephrology : JASN.
2004 Jun; 15(6):1452-65. doi:
10.1097/01.asn.0000130567.76794.58. [PMID: 15153556] - Amy K Banes, Séan Shaw, John Jenkins, Heather Redd, Farhad Amiri, David M Pollock, Mario B Marrero. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.
American journal of physiology. Renal physiology.
2004 Apr; 286(4):F653-9. doi:
10.1152/ajprenal.00163.2003. [PMID: 14678947] - Chongren Tang, Ashley M Vaughan, John F Oram. Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.
The Journal of biological chemistry.
2004 Feb; 279(9):7622-8. doi:
10.1074/jbc.m312571200. [PMID: 14668333] - Keisuke Hagihara, Teppei Nishikawa, Tomoyasu Isobe, Jian Song, Yasuhiro Sugamata, Kazuyuki Yoshizaki. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.
Biochemical and biophysical research communications.
2004 Feb; 314(2):363-9. doi:
10.1016/j.bbrc.2003.12.096. [PMID: 14733913] - Jianghong Li, Rhona E Feltzer, Kevin L Dawson, Elizabeth A Hudson, Barbara J Clark. Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.
The Journal of biological chemistry.
2003 Dec; 278(52):52355-62. doi:
10.1074/jbc.m305232200. [PMID: 14565954] - Renate Burger, Frank Bakker, Andreas Guenther, Wolfgang Baum, Dirk Schmidt-Arras, Teru Hideshima, Yu-Tzu Tai, Reshma Shringarpure, Laurence Catley, Giorgio Senaldi, Martin Gramatzki, Kenneth C Anderson. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.
British journal of haematology.
2003 Dec; 123(5):869-78. doi:
10.1046/j.1365-2141.2003.04686.x. [PMID: 14632778] - K K Hintz, N S Aberle, J Ren. Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
2003 Oct; 27(10):1196-203. doi:
10.1038/sj.ijo.0802389. [PMID: 14513067] - Yukiyo Ogata, Masafumi Takahashi, Shuichi Ueno, Koichi Takeuchi, Takashi Okada, Hiroyuki Mano, Shigeo Ookawara, Keiya Ozawa, Bradford C Berk, Uichi Ikeda, Kazuyuki Shimada, Eiji Kobayashi. Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.
Hypertension (Dallas, Tex. : 1979).
2003 May; 41(5):1156-63. doi:
10.1161/01.hyp.0000064342.30653.24. [PMID: 12668584] - Song-bai Wang, Yong-ming Yao, Ning Dong, Yan Yu, Guo-cai Tao. [Role of Janus kinase/signal transducer and activator of transcription pathway in mediating mRNA expression of high mobility group box1 protein in the liver in septic rats].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2003 Mar; 15(3):147-9. doi:
NULL. [PMID: 12831616] - Li Li, Peter E Shaw. Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
The Journal of biological chemistry.
2002 May; 277(20):17397-405. doi:
10.1074/jbc.m109962200. [PMID: 11859072] - Akio Horiguchi, Mototsugu Oya, Ken Marumo, Masaru Murai. STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.
Kidney international.
2002 Mar; 61(3):926-38. doi:
10.1046/j.1523-1755.2002.00206.x. [PMID: 11849447] - Loren E Wold, David P Relling, Jinhong Duan, Faye L Norby, Jun Ren. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.
Hypertension (Dallas, Tex. : 1979).
2002 Jan; 39(1):69-74. doi:
10.1161/hy0102.100777. [PMID: 11799081] - C Mazière, M A Conte, J C Mazière. Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein.
Free radical biology & medicine.
2001 Dec; 31(11):1334-40. doi:
10.1016/s0891-5849(01)00649-9. [PMID: 11728804] - T Watanabe, R Pakala, T Katagiri, C R Benedict. Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.
Journal of vascular research.
2001 Jul; 38(4):341-9. doi:
10.1159/000051065. [PMID: 11455205]