12-Hydroperoxy-icosatetraenoic acid (BioDeep_00000172684)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H32O4 (336.2300472)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCC(CCC=CC=CC=CC=CC(O)=O)OO
InChI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h6-9,11-12,15,18-19,23H,2-5,10,13-14,16-17H2,1H3,(H,21,22)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chaoqin Xie, Donna H Wang. Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.
Endocrinology.
2011 Oct; 152(10):3811-9. doi:
10.1210/en.2011-0141. [PMID: 21846804] - Maria-Patapia Zafiriou, Laura Cecilia Zelarayan, Claudia Noack, Anke Renger, Santosh Nigam, Athanassia Siafaka-Kapadai. Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid.
Biochimica et biophysica acta.
2011 Jun; 1811(6):361-9. doi:
10.1016/j.bbalip.2011.03.002. [PMID: 21420506] - Yael Riahi, Guy Cohen, Ofer Shamni, Shlomo Sasson. Signaling and cytotoxic functions of 4-hydroxyalkenals.
American journal of physiology. Endocrinology and metabolism.
2010 Dec; 299(6):E879-86. doi:
10.1152/ajpendo.00508.2010. [PMID: 20858748] - Mohamed D Morsy, Ossama A Mostafa, Waleed N Hassan. A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats.
Journal of biomedical science.
2010 Jul; 17(?):55. doi:
10.1186/1423-0127-17-55. [PMID: 20609232] - Yael Riahi, Yoav Sin-Malia, Guy Cohen, Evgenia Alpert, Arie Gruzman, Juergen Eckel, Bart Staels, Michel Guichardant, Shlomo Sasson. The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta.
Diabetes.
2010 Apr; 59(4):808-18. doi:
10.2337/db09-1207. [PMID: 20107107] - Afaf M Hassan. Selenium status in patients with aspirin-induced asthma.
Annals of clinical biochemistry.
2008 Sep; 45(Pt 5):508-12. doi:
10.1258/acb.2008.008030. [PMID: 18753425] - M Guichardant, S Bacot, P Molière, M Lagarde. Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites.
Prostaglandins, leukotrienes, and essential fatty acids.
2006 Sep; 75(3):179-82. doi:
10.1016/j.plefa.2006.05.006. [PMID: 16828271] - Lei Zhao, Tilo Grosser, Susanne Fries, Leena Kadakia, He Wang, Jonathan Zhao, Robert Falotico. Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.
Expert review of clinical immunology.
2006 Jul; 2(4):649-58. doi:
10.1586/1744666x.2.4.649. [PMID: 20477620] - Toralf Senger, Thomas Wichard, Susan Kunze, Cornelia Göbel, Jens Lerchl, Georg Pohnert, Ivo Feussner. A multifunctional lipoxygenase with fatty acid hydroperoxide cleaving activity from the moss Physcomitrella patens.
The Journal of biological chemistry.
2005 Mar; 280(9):7588-96. doi:
10.1074/jbc.m411738200. [PMID: 15611050] - Michiharu Tanabe, Sadaharu Tabuchi, Masato Iwatsuki, Masamichi Kurosaki, Hideki Kamitani, Masayuki Yokota, Takashi Watanabe. Incorporation of arachidonic and linoleic acid hydroperoxides into cultured human umbilical vein endothelial cells.
Prostaglandins, leukotrienes, and essential fatty acids.
2004 Jun; 70(6):485-9. doi:
10.1016/j.plefa.2003.10.003. [PMID: 15120710] - M Guichardant, B Chantegrel, C Deshayes, A Doutheau, P Moliere, M Lagarde. Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids.
Biochemical Society transactions.
2004 Feb; 32(Pt 1):139-40. doi:
10.1042/bst0320139. [PMID: 14748733] - David M Aronoff, Olivier Boutaud, Lawrence J Marnett, John A Oates. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
The Journal of pharmacology and experimental therapeutics.
2003 Feb; 304(2):589-95. doi:
10.1124/jpet.102.042853. [PMID: 12538810] - M Guichardant, N Bernoud-Hubac, B Chantegrel, C Deshayes, M Lagarde. Aldehydes from n-6 fatty acid peroxidation. Effects on aminophospholipids.
Prostaglandins, leukotrienes, and essential fatty acids.
2002 Aug; 67(2-3):147-9. doi:
10.1054/plef.2002.0412. [PMID: 12324234] - J Gu, Y Liu, Y Wen, R Natarajan, L Lanting, J L Nadler. Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts.
Journal of cellular physiology.
2001 Mar; 186(3):357-65. doi:
10.1002/1097-4652(200103)186:3<357::aid-jcp1034>3.0.co;2-e. [PMID: 11169974]