1-Naphthyl isocyanate (BioDeep_00000172266)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H7NO (169.0527612)
中文名称: 异氰酸1-萘基酯, 异氰酸-1-萘酯
谱图信息:
最多检出来源 Homo sapiens(blood) 13.21%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC=C2N=C=O
InChI: InChI=1S/C11H7NO/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huiying Hua, Manyun Dai, Yishuang Luo, Hante Lin, Gangming Xu, Xiaowei Hu, Liping Xu, Haoyue Zhang, Zhiyuan Tang, Liming Chang, Aiming Liu, Julin Yang. Basal PPARα inhibits bile acid metabolism adaptation in chronic cholestatic model induced by α-naphthylisothiocyanate.
Toxicology letters.
2019 Jan; 300(?):31-39. doi:
10.1016/j.toxlet.2018.10.015. [PMID: 30352267] - Xiaomin Yao, Yue Li, Xiaoyan Cheng, Hongwei Li. ER stress contributes to alpha-naphthyl isothiocyanate-induced liver injury with cholestasis in mice.
Pathology, research and practice.
2016 Jun; 212(6):560-7. doi:
10.1016/j.prp.2016.05.001. [PMID: 27173049] - Hui Sun, Ai-Hua Zhang, Di-Xing Zou, Wen-Jun Sun, Xiu-Hong Wu, Xi-Jun Wang. Metabolomics coupled with pattern recognition and pathway analysis on potential biomarkers in liver injury and hepatoprotective effects of yinchenhao.
Applied biochemistry and biotechnology.
2014 Jun; 173(4):857-69. doi:
10.1007/s12010-014-0903-5. [PMID: 24728784] - F Belal, M Walash, N El-Enany, S Zayed. Highly sensitive HPLC method for assay of aliskiren in human plasma through derivatization with 1-naphthyl isocyanate using UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Aug; 933(?):24-9. doi:
10.1016/j.jchromb.2013.06.004. [PMID: 23872160] - Sofie Starckx, Ameesha Batheja, Geert R Verheyen, Sandra De Jonghe, Kristel Steemans, Bram Van Dijck, Monica Singer, Nancy Bogdan, Jan Snoeys, Petra Vinken, Jennifer C Sasaki, Jacky Van Gompel, Peggy Guzzie-Peck, Ann Lampo, Lieve Lammens. Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats.
Toxicologic pathology.
2013 Jul; 41(5):795-804. doi:
10.1177/0192623312464436. [PMID: 23143187] - Christopher J McEntyre, Sandy Slow, Michael Lever. Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate.
Analytica chimica acta.
2009 Jun; 644(1-2):90-4. doi:
10.1016/j.aca.2009.04.014. [PMID: 19463568] - Ying Zhao, Desheng Zhai, Xijing Chen, Jinnan Yang, Xiangfeng Song, Hui He, Qiaoling Yu, Yan Xing. Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.
Toxicology.
2007 Feb; 230(2-3):145-50. doi:
10.1016/j.tox.2006.11.008. [PMID: 17184895] - Desheng Zhai, Ying Zhao, Xijing Chen, Jiqiang Guo, Hui He, Qiaoling Yu, Jinnan Yang, Andrew K Davey, Jiping Wang. Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats.
Planta medica.
2007 Feb; 73(2):128-33. doi:
10.1055/s-2006-957067. [PMID: 17206559] - David E Amacher, Rick Adler, Athula Herath, R Reid Townsend. Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Clinical chemistry.
2005 Oct; 51(10):1796-803. doi:
10.1373/clinchem.2005.049908. [PMID: 16099942] - J Azmi, J L Griffin, R F Shore, E Holmes, J K Nicholson. Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products.
Xenobiotica; the fate of foreign compounds in biological systems.
2005 Aug; 35(8):839-52. doi:
10.1080/00498250500297940. [PMID: 16278195] - Yaping Liu, Jane Binz, Mary Jo Numerick, Steve Dennis, Guizhen Luo, Bhasha Desai, Kathleen I MacKenzie, Traci A Mansfield, Steven A Kliewer, Bryan Goodwin, Stacey A Jones. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
The Journal of clinical investigation.
2003 Dec; 112(11):1678-87. doi:
10.1172/jci18945. [PMID: 14623915] - Ke Hu, Marilyn E Morris. Determination of alpha-naphthylisothiocyanate and metabolites alpha-naphthylamine and alpha-naphthylisocyanate in rat plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 May; 788(1):17-28. doi:
10.1016/s1570-0232(02)01004-8. [PMID: 12668067]