N-Hydroxy-L-proline (BioDeep_00000172212)

   

human metabolite blood metabolite natural product


代谢物信息卡片


1-hydroxypyrrolidine-2-carboxylic acid

化学式: C5H9NO3 (131.0582404)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 4.02%

分子结构信息

SMILES: C1CC(N(C1)O)C(=O)O
InChI: InChI=1S/C5H9NO3/c7-5(8)4-2-1-3-6(4)9/h4,9H,1-3H2,(H,7,8)

描述信息

同义名列表

4 个代谢物同义名

1-hydroxypyrrolidine-2-carboxylic acid; 1-Hydroxypyrrolidine-2-carboxylate; N-Hydroxy-L-proline; Hydroxyproline



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Laura K Schnackenberg, Jinchun Sun, Lisa M Pence, Sudeepa Bhattacharyya, Gonçalo Gamboa da Costa, Richard D Beger. Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Nov; 50(11):3978-83. doi: 10.1016/j.fct.2012.08.010. [PMID: 22902825]
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  • Ximin Zhou, Wenjuan Lü, Li Su, Yalei Dong, Qianfeng Li, Xingguo Chen. The binding affinity of amino acid-protein: hydroxyproline binding site I on human serum albumin. Organic & biomolecular chemistry. 2012 Oct; 10(41):8314-21. doi: 10.1039/c2ob25967b. [PMID: 22976452]
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  • Travis J Riedel, John Knight, Michael S Murray, Dawn S Milliner, Ross P Holmes, W Todd Lowther. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. Biochimica et biophysica acta. 2012 Oct; 1822(10):1544-52. doi: 10.1016/j.bbadis.2012.06.014. [PMID: 22771891]
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  • Jong-Min Han, Hyeong-Geug Kim, Min-Kyung Choi, Jin-Suk Lee, Hye-Jung Park, Jing-Hua Wang, Jong-Suk Lee, Seung-Wan Son, Seock-Yeon Hwang, Chang-Gue Son. Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Oct; 50(10):3505-13. doi: 10.1016/j.fct.2012.07.018. [PMID: 22824087]
  • Guo-Dung Hung, Ping-Chia Li, Hsuan-Shu Lee, Huei-Min Chang, Chiang-Ting Chien, Kuang-Lun Lee. Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat. Journal of the Formosan Medical Association = Taiwan yi zhi. 2012 Oct; 111(10):550-9. doi: 10.1016/j.jfma.2011.06.026. [PMID: 23089690]
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  • Soma Ghosh, Amalesh Samanta, Nirup Bikash Mandal, Sukdeb Bannerjee, Debprasad Chattopadhyay. Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. Journal of ethnopharmacology. 2012 Aug; 142(3):714-22. doi: 10.1016/j.jep.2012.05.048. [PMID: 22683906]
  • Eric Nguema-Ona, Sílvia Coimbra, Maïté Vicré-Gibouin, Jean-Claude Mollet, Azeddine Driouich. Arabinogalactan proteins in root and pollen-tube cells: distribution and functional aspects. Annals of botany. 2012 Jul; 110(2):383-404. doi: 10.1093/aob/mcs143. [PMID: 22786747]
  • Shuang Lu, Ming-liang Cheng, Hong Li, Jun Wu. [Study of potential protective effects of blueberry on hepatic cytochrome P450 2E1 expression in rats with immune hepatic fibrosis]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2012 Jul; 20(7):497-502. doi: 10.3760/cma.j.issn.1007-3418.2012.07.004. [PMID: 23044233]
  • Chandana Choudhury Barua, Archana Talukdar, Shameem Ara Begum, Debesh Chandra Pathak, Dilip Kumar Sarma, Rumi Saikia Borah, Asheesh Gupta. In vivo wound-healing efficacy and antioxidant activity of Achyranthes aspera in experimental burns. Pharmaceutical biology. 2012 Jul; 50(7):892-9. doi: 10.3109/13880209.2011.642885. [PMID: 22480137]
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  • Ipek Süntar, Esra Küpeli Akkol, Hikmet Keles, Erdem Yesilada, Satyajit D Sarker, Randolph Arroo, Turhan Baykal. Efficacy of Daphne oleoides subsp. kurdica used for wound healing: identification of active compounds through bioassay guided isolation technique. Journal of ethnopharmacology. 2012 Jun; 141(3):1058-70. doi: 10.1016/j.jep.2012.04.001. [PMID: 22521733]
  • José M González-Pérez, Emilio González-Reimers, María José DeLaVega-Prieto, María del Carmen Durán-Castellón, José Viña-Rodríguez, Luis Galindo-Martín, Julio Alvisa-Negrín, Francisco Santolaria-Fernández. Relative and combined effects of ethanol and protein deficiency on bone manganese and copper. Biological trace element research. 2012 Jun; 147(1-3):226-32. doi: 10.1007/s12011-011-9296-2. [PMID: 22190260]
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  • Paichit Inpanya, Atchariya Faikrua, Anan Ounaroon, Anuphan Sittichokechaiwut, Jarupa Viyoch. Effects of the blended fibroin/aloe gel film on wound healing in streptozotocin-induced diabetic rats. Biomedical materials (Bristol, England). 2012 Jun; 7(3):035008. doi: 10.1088/1748-6041/7/3/035008. [PMID: 22418946]
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  • Hong-Ying Gao, Guo-Yu Li, Meng-Meng Lou, Xiao-Yu Li, Xiu-Yan Wei, Jin-Hui Wang. Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis. Journal of inflammation (London, England). 2012 May; 9(1):16. doi: 10.1186/1476-9255-9-16. [PMID: 22559721]
  • Qing-lan Wang, Yan-yan Tao, Li Shen, Hong-yan Cui, Cheng-hai Liu. [Chinese herbal medicine Fuzheng Huayu recipe inhibits liver fibrosis by mediating the transforming growth factor-β1/Smads signaling pathway]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2012 May; 10(5):561-8. doi: 10.3736/jcim20120512. [PMID: 22587979]
  • Sutchin R Patel, Kristina L Penniston, Lauren Iwicki, Ibrahim Saeed, Thomas D Crenshaw, Stephen Y Nakada. Dietary induction of long-term hyperoxaluria in the porcine model. Journal of endourology. 2012 May; 26(5):433-8. doi: 10.1089/end.2011.0182. [PMID: 21923275]
  • Ying-Ying Yang, Tung-Hu Tsai, Yi-Tsau Huang, Tzung-Yan Lee, Che-Chang Chan, Kuei-Chuan Lee, Han-Chieh Lin. Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinemia in nonalcoholic steatohepatitis-cirrhotic rats. Hepatology (Baltimore, Md.). 2012 May; 55(5):1540-50. doi: 10.1002/hep.25534. [PMID: 22183953]
  • Xiao-peng Yuan, Long-shan Liu, Qian Fu, Chang-xi Wang. Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis. Phytotherapy research : PTR. 2012 May; 26(5):697-703. doi: 10.1002/ptr.3630. [PMID: 22006851]
  • Georg Hierl, Ute Vothknecht, Christine Gietl. Programmed cell death in Ricinus and Arabidopsis: the function of KDEL cysteine peptidases in development. Physiologia plantarum. 2012 May; 145(1):103-13. doi: 10.1111/j.1399-3054.2012.01580.x. [PMID: 22268582]
  • Ilhan Gecit, Mehmet Aslan, Mustafa Gunes, Necip Pirincci, Ramazan Esen, Halit Demir, Kadir Ceylan. Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. Journal of cancer research and clinical oncology. 2012 May; 138(5):739-43. doi: 10.1007/s00432-011-1136-4. [PMID: 22258852]
  • Hui Yang, Long-Feng Zhao, Zhong-Fu Zhao, Yan Wang, Jing-Jing Zhao, Li Zhang. Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARγ and NF-κB. World journal of gastroenterology. 2012 Apr; 18(14):1680-8. doi: 10.3748/wjg.v18.i14.1680. [PMID: 22529699]
  • Ya-lei Dong, Na Yan, Xi Li, Xi-min Zhou, Lei Zhou, Hai-juan Zhang, Xing-guo Chen. Rapid and sensitive determination of hydroxyproline in dairy products using micellar electrokinetic chromatography with laser-induced fluorescence detection. Journal of chromatography. A. 2012 Apr; 1233(?):156-60. doi: 10.1016/j.chroma.2012.02.030. [PMID: 22398383]
  • Karin Benz, Claudia Stippich, Claudia Osswald, Christoph Gaissmaier, Nicolas Lembert, Andreas Badke, Eric Steck, Wilhelm K Aicher, Juergen A Mollenhauer. Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair. BMC musculoskeletal disorders. 2012 Apr; 13(?):54. doi: 10.1186/1471-2474-13-54. [PMID: 22490206]
  • Zhang Yang, Damian P Drew, Bodil Jørgensen, Ulla Mandel, Søren S Bach, Peter Ulvskov, Steven B Levery, Eric P Bennett, Henrik Clausen, Bent L Petersen. Engineering mammalian mucin-type O-glycosylation in plants. The Journal of biological chemistry. 2012 Apr; 287(15):11911-23. doi: 10.1074/jbc.m111.312918. [PMID: 22334671]
  • Jin-Xing Du, Ming-Yu Sun, Guang-Li Du, Feng-Hua Li, Cheng Liu, Yong-Ping Mu, Gao-Feng Chen, Ai-Hua Long, Yan-Qin Bian, Jia Liu, Cheng-Hai Liu, Yi-Yang Hu, Lie-Ming Xu, Ping Liu. Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-beta signaling pathway. BMC complementary and alternative medicine. 2012 Apr; 12(?):33. doi: 10.1186/1472-6882-12-33. [PMID: 22471627]
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  • T A Wani, H H Chandrashekara, D Kumar, R Prasad, A Gopal, K K Sardar, S K Tandan, D Kumar. Wound healing activity of ethanolic extract of Shorea robusta Gaertn. f. resin. Indian journal of experimental biology. 2012 Apr; 50(4):277-81. doi: ". [PMID: 22611916]
  • Ryushiro Yamaguchi, Hideo Terashima, Satoshi Yoneyama, Sosuke Tadano, Nobuhiro Ohkohchi. Effects of platelet-rich plasma on intestinal anastomotic healing in rats: PRP concentration is a key factor. The Journal of surgical research. 2012 Apr; 173(2):258-66. doi: 10.1016/j.jss.2010.10.001. [PMID: 21074782]
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