8-Desoxygartanin (BioDeep_00000017220)

 

Secondary id: BioDeep_00000616458

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


1,3,5-Trihydroxy-2-(3-methyl-but-2-enyl)-4-((Z)-3-methyl-but-2-enyl)-xanthen-9-one

化学式: C23H24O5 (380.1624)
中文名称: 1,3,5-三羟基-2,4-双(3-甲基-2-丁烯基)氧杂蒽酮, 8-DESOXYGARTANIN
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 63.93%

分子结构信息

SMILES: C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O
InChI: InChI=1S/C23H24O5/c1-12(2)8-10-14-19(25)16(11-9-13(3)4)23-18(20(14)26)21(27)15-6-5-7-17(24)22(15)28-23/h5-9,24-26H,10-11H2,1-4H3

描述信息

8-Desoxygartanin is a member of xanthones.
8-Desoxygartanin is a natural product found in Garcinia merguensis, Garcinia intermedia, and other organisms with data available.
Isolated from Garcinia mangostana (mangosteen). 8-Desoxygartanin is found in fruits and purple mangosteen.
8-Desoxygartanin is found in fruits. 8-Desoxygartanin is isolated from Garcinia mangostana (mangosteen
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].

同义名列表

10 个代谢物同义名

1,3,5-Trihydroxy-2-(3-methyl-but-2-enyl)-4-((Z)-3-methyl-but-2-enyl)-xanthen-9-one; 1,3,5-Trihydroxy-2,4-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,5-trihydroxy-2,4-bis(3-methylbut-2-en-1-yl)-9h-xanthen-9-one; 9H-Xanthen-9-one, 1,3,5-trihydroxy-2,4-bis(3-methyl-2-butenyl)-; 1,3,5-Trihydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; 1,3,5-trihydroxy-2,4-bis(3-methylbut-2-enyl)xanthen-9-one; 1,3,5-Trihydroxy-2,4-bis(3-methyl-2-butenyl)xanthone; 8-Desoxygartanin; 8-deoxygartanin; Deoxygartinin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • K Y Khaw, S B Choi, S C Tan, H A Wahab, K L Chan, V Murugaiyah. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Sep; 21(11):1303-9. doi: 10.1016/j.phymed.2014.06.017. [PMID: 25172794]
  • Hyung Won Ryu, Marcus J Curtis-Long, Sunin Jung, Young Min Jin, Jung Keun Cho, Young Bae Ryu, Woo Song Lee, Ki Hun Park. Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorganic & medicinal chemistry. 2010 Sep; 18(17):6258-64. doi: 10.1016/j.bmc.2010.07.033. [PMID: 20696581]
  • Erasmienne Tambou Ngouamegne, René Soh Fongang, Silvère Ngouela, Fabrice Fekam Boyom, Michel Rohmer, Etienne Tsamo, Jiri Gut, Philip Jon Rosenthal. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chemical & pharmaceutical bulletin. 2008 Mar; 56(3):374-7. doi: 10.1248/cpb.56.374. [PMID: 18310952]
  • Vatcharin Rukachaisirikul, Mayuree Kamkaew, Dusadee Sukavisit, Souwalak Phongpaichit, Prakart Sawangchote, Walter C Taylor. Antibacterial xanthones from the leaves of Garcinia nigrolineata. Journal of natural products. 2003 Dec; 66(12):1531-5. doi: 10.1021/np0303254. [PMID: 14695790]
  • A Groweiss, J H Cardellina, M R Boyd. HIV-Inhibitory prenylated xanthones and flavones from Maclura tinctoria. Journal of natural products. 2000 Nov; 63(11):1537-9. doi: 10.1021/np000175m. [PMID: 11087602]