1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (BioDeep_00000172123)
human metabolite blood metabolite
代谢物信息卡片
5-[(2-methylpiperazin-1-yl)sulfonyl]isoquinoline
化学式: C14H17N3O2S (291.1041422)
中文名称: 1-(5-异喹啉磺酰基)-2-甲基哌嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 6.84%
分子结构信息
SMILES: CC1CNCCN1S(=O)(=O)C1=C2C=CN=CC2=CC=C1
InChI: InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
描述信息
D004791 - Enzyme Inhibitors
同义名列表
9 个代谢物同义名
5-[(2-methylpiperazin-1-yl)sulfonyl]isoquinoline; 1-(5-Isoquinolinylsulphonyl)-2-methylpiperazine; 5-(2-Methylpiperazine-1-sulphonyl)isoquinoline; 1-(5-Isoquinolinesulphonyl)-2-methylpiperazine; 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline; 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine; 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine; H 7; H-7
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:43385
- ChEBI: CHEBI:83438
- PubChem: 3542
- HMDB: HMDB0243797
- DrugBank: DB07996
- ChEMBL: CHEMBL323556
- MeSH: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- chemspider: 3421
- CAS: 84477-87-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Phytochemistry.
2023 Oct; 214(?):113801. doi:
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International immunopharmacology.
2023 Aug; 124(Pt A):110791. doi:
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European journal of pharmacology.
2022 Mar; 919(?):174779. doi:
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Chemical biology & drug design.
2021 12; 98(6):1065-1078. doi:
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Brain and behavior.
2021 08; 11(8):e2266. doi:
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Neuroscience letters.
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Cell reports.
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International journal of molecular sciences.
2021 Feb; 22(4):. doi:
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Folia neuropathologica.
2021; 59(1):32-49. doi:
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PloS one.
2021; 16(3):e0248355. doi:
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Journal of pharmacological sciences.
2021 Jan; 145(1):6-15. doi:
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The Journal of toxicological sciences.
2021; 46(6):255-262. doi:
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Journal of integrative neuroscience.
2020 Dec; 19(4):651-662. doi:
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Biochemical and biophysical research communications.
2020 10; 531(4):622-627. doi:
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JCI insight.
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Cardiovascular toxicology.
2020 08; 20(4):351-360. doi:
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Biopharmaceutics & drug disposition.
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Chemico-biological interactions.
2020 Feb; 317(?):108944. doi:
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International journal of molecular sciences.
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Metabolic brain disease.
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Basic & clinical pharmacology & toxicology.
2019 Aug; 125(2):152-165. doi:
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CNS neuroscience & therapeutics.
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Toxicology and applied pharmacology.
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Clinical immunology (Orlando, Fla.).
2019 04; 201(?):35-47. doi:
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Cardiovascular therapeutics.
2018 Dec; 36(6):e12477. doi:
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Journal of cardiovascular pharmacology and therapeutics.
2018 09; 23(5):472-480. doi:
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Pulmonary pharmacology & therapeutics.
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Scientific reports.
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Basic & clinical pharmacology & toxicology.
2018 Feb; 122(2):278-287. doi:
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Artificial cells, nanomedicine, and biotechnology.
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2017 Dec; 33(12):1585-1593. doi:
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Renal failure.
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Molecular neurobiology.
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International journal of molecular sciences.
2017 Aug; 18(8):. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
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Proceedings of the National Academy of Sciences of the United States of America.
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Scientific reports.
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Journal of molecular neuroscience : MN.
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Renal failure.
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Molecular and cellular neurosciences.
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Luminescence : the journal of biological and chemical luminescence.
2016 Jun; 31(4):986-91. doi:
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2016 Mar; 41(3):225-32. doi:
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Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
2016 03; 24(2):317-27. doi:
10.1111/wrr.12407. [PMID: 26789651] - Lorenzo A Calò, Ugo Vertolli, Elisa Pagnin, Verdiana Ravarotto, Paul A Davis, Mario Lupia, Elena Naso, Giuseppe Maiolino, Agostino Naso. Increased rho kinase activity in mononuclear cells of dialysis and stage 3-4 chronic kidney disease patients with left ventricular hypertrophy: Cardiovascular risk implications.
Life sciences.
2016 Mar; 148(?):80-5. doi:
10.1016/j.lfs.2016.02.019. [PMID: 26872982] - Hui Peng, Yuanqing Li, Cheng Wang, Jun Zhang, Yanru Chen, Wenfang Chen, Jin Cao, Yanlin Wang, Zhaoyong Hu, Tanqi Lou. ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy.
Scientific reports.
2016 Feb; 6(?):20304. doi:
10.1038/srep20304. [PMID: 26842599] - Yihua Bei, Thong Hua-Huy, Carole Nicco, Sy Duong-Quy, Nhat-Nam Le-Dong, Kiet-Phong Tiev, Christiane Chéreau, Frédéric Batteux, Anh Tuan Dinh-Xuan. RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Experimental lung research.
2016; 42(1):44-55. doi:
10.3109/01902148.2016.1141263. [PMID: 26873329] - Qing He, Yan-hua Li, Si-si Guo, Ying Wang, Wei Lin, Qiong Zhang, Jian Wang, Cun-gen Ma, Bao-Guo Xiao. Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model.
The European journal of neuroscience.
2016 Jan; 43(1):41-52. doi:
10.1111/ejn.13132. [PMID: 26565388] - Chan Chen, Jie-Zhong Yu, Qiong Zhang, Yong-Fei Zhao, Chun-Yun Liu, Yan-Hua Li, Wan-Fang Yang, Cun-Gen Ma, Bao-Guo Xiao. Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.
Neuromolecular medicine.
2015 Dec; 17(4):454-65. doi:
10.1007/s12017-015-8374-6. [PMID: 26481340] - Itsuko Baba, Yasuhiro Egi, Hiroyuki Utsumi, Tetsuhiro Kakimoto, Kazuo Suzuki. Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Molecular medicine reports.
2015 Dec; 12(6):8010-20. doi:
10.3892/mmr.2015.4467. [PMID: 26498136] - Guobin Song, Guoping Xi, Jiezhong Yu, Ling Feng, Jianjun Huang, Baoguo Xiao, Yanhua Li, Cungen Ma. [Promoting effect of Fasudil on the proliferation and survival of bone marrow-derived neural stem cells in vitro].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2015 Nov; 31(11):1488-91, 1496. doi:
NULL. [PMID: 26522357] - Fatma Aydinoglu, Olcay Ergurhan Kiroglu, Erhan Astarci, Ebru Balli, Nuran Ogulener. Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
European journal of pharmacology.
2015 Oct; 764(?):318-327. doi:
10.1016/j.ejphar.2015.07.021. [PMID: 26169563] - Yan-hua Li, Jie-zhong Yu, Yan-le Xin, Ling Feng, Zhi Chai, Jian-chun Liu, Hong-zhen Zhang, Guang-Xian Zhang, Bao-guo Xiao, Cun-gen Ma. Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors.
Experimental and molecular pathology.
2015 Oct; 99(2):220-8. doi:
10.1016/j.yexmp.2015.06.016. [PMID: 26112093] - Yan-Le Xin, Jie-Zhong Yu, Xin-Wang Yang, Chun-Yun Liu, Yan-Hua Li, Ling Feng, Zhi Chai, Wan-Fang Yang, Qing Wang, Wei-Jia Jiang, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen Ma. FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity.
Bioscience reports.
2015 07; 35(5):. doi:
10.1042/bsr20150032. [PMID: 26223433] - Jing Jin, Chao Peng, Su-zhen Wu, Hong-min Chen, Bai-fang Zhang. Blocking VEGF/Caveolin-1 signaling contributes to renal protection of fasudil in streptozotocin-induced diabetic rats.
Acta pharmacologica Sinica.
2015 Jul; 36(7):831-40. doi:
10.1038/aps.2015.23. [PMID: 25937636] - Zhiming Li, Hua Lian, Qin Liang, Fanfang Zeng, Dongdan Zheng. Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia.
Lipids in health and disease.
2015 May; 14(?):52. doi:
10.1186/s12944-015-0050-1. [PMID: 26018523] - Yigit Akin, Aliseydi Bozkurt, Huseyin S Erol, Mesut Halici, Fikret Celebi, Kubra A T Kapakin, Hakan Gulmez, Mutlu Ates, Abdulkadir Coban, Baris Nuhoglu. Impact of Rho-Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder.
Lower urinary tract symptoms.
2015 May; 7(2):108-14. doi:
10.1111/luts.12058. [PMID: 26663691] - Yuji Nozaki, Koji Kinoshita, Shoichi Hino, Tomohiro Yano, Kaoru Niki, Yasuaki Hirooka, Kazuya Kishimoto, Masanori Funauchi, Itaru Matsumura. Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity.
American journal of physiology. Renal physiology.
2015 Apr; 308(8):F899-909. doi:
10.1152/ajprenal.00362.2014. [PMID: 25651561] - Haiyan Hu, Wei Chen, Jiarong Ding, Meng Jia, Jingjing Yin, Zhiyong Guo. Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.
Experimental and molecular pathology.
2015 Apr; 98(2):277-85. doi:
10.1016/j.yexmp.2015.02.006. [PMID: 25697583] - Noriaki Satoh, Yumiko Toyohira, Keita Takahashi, Nobuyuki Yanagihara. Effects of various pharmacological agents on the function of norepinephrine transporter.
Journal of UOEH.
2015 Mar; 37(1):33-42. doi:
10.7888/juoeh.37.33. [PMID: 25787100] - Tao Li, Guang-ming Yang, Yu Zhu, Yue Wu, Xiang-yun Chen, Dan Lan, Kun-lun Tian, Liang-ming Liu. Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
American journal of physiology. Endocrinology and metabolism.
2015 Feb; 308(4):E257-69. doi:
10.1152/ajpendo.00348.2014. [PMID: 25425000] - Carmen Kirchner, Bastian Lüer, Patrik Efferz, Jeremias Wohlschlaeger, Andreas Paul, Thomas Minor. Ex vivo use of a Rho-kinase inhibitor during renal preservation improves graft function upon reperfusion.
Cryobiology.
2015 Feb; 70(1):71-5. doi:
10.1016/j.cryobiol.2014.12.008. [PMID: 25555715] - Yongfei Zhao, Qiong Zhang, Jianying Xi, Baoguo Xiao, Yanhua Li, Cungen Ma. Neuroprotective effect of fasudil on inflammation through PI3K/Akt and Wnt/β-catenin dependent pathways in a mice model of Parkinson's disease.
International journal of clinical and experimental pathology.
2015; 8(3):2354-64. doi:
. [PMID: 26045742] - Yong-fei Zhao, Qiong Zhang, Jian-ying Xi, Yan-hua Li, Cun-gen Ma, Bao-guo Xiao. Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease.
Journal of the neurological sciences.
2015; 353(1-2):28-37. doi:
10.1016/j.jns.2015.03.022. [PMID: 25908255] - Lisa Jolly, Anastasios Stavrou, Gilles Vanderstoken, Victoria A Meliopoulos, Anthony Habgood, Amanda L Tatler, Joanne Porte, Alan Knox, Paul Weinreb, Shelia Violette, Tracy Hussell, Martin Kolb, Martin R Stampfli, Stacey Schultz-Cherry, Gisli Jenkins. Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.
The Journal of biological chemistry.
2014 Dec; 289(51):35246-63. doi:
10.1074/jbc.m114.582262. [PMID: 25339175] - Chan Chen, Yan-hua Li, Qiong Zhang, Jie-zhong Yu, Yong-fei Zhao, Cun-gen Ma, Bao-guo Xiao. Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis.
Acta pharmacologica Sinica.
2014 Nov; 35(11):1428-38. doi:
10.1038/aps.2014.68. [PMID: 25263338] - GuiFang Guo, Vandana Singh, Douglas W Zochodne. Growth and turning properties of adult glial cell-derived neurotrophic factor coreceptor α1 nonpeptidergic sensory neurons.
Journal of neuropathology and experimental neurology.
2014 Sep; 73(9):820-36. doi:
10.1097/nen.0000000000000101. [PMID: 25101700] - Min-Fang Guo, Jian Meng, Yan-Hua Li, Jie-Zhong Yu, Chun-Yun Liu, Ling Feng, Wan-Fang Yang, Jun-Lian Li, Qian-Jin Feng, Bao-Guo Xiao, Cun-Gen Ma. The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes.
Journal of the neurological sciences.
2014 Aug; 343(1-2):69-75. doi:
10.1016/j.jns.2014.05.034. [PMID: 24952673] - Lars Tatenhorst, Lars Tönges, Kim-Ann Saal, Jan C Koch, Éva M Szegő, Mathias Bähr, Paul Lingor. Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Journal of neuropathology and experimental neurology.
2014 Aug; 73(8):770-9. doi:
10.1097/nen.0000000000000095. [PMID: 25003236] - Junko Taniguchi, Chie Seki, Hiroyuki Takuwa, Hiroshi Kawaguchi, Yoko Ikoma, Masayuki Fujinaga, Iwao Kanno, Ming-Rong Zhang, Satoshi Kuwabara, Hiroshi Ito. Evaluation of Rho-kinase activity in mice brain using N-[11C]methyl-hydroxyfasudil with positron emission tomography.
Molecular imaging and biology.
2014 Jun; 16(3):395-402. doi:
10.1007/s11307-013-0695-y. [PMID: 24155033] - Koh Meng Aw Yong, Yu Zeng, Donald Vindivich, Jude M Phillip, Pei-Hsun Wu, Denis Wirtz, Robert H Getzenberg. Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.
Journal of cellular physiology.
2014 Mar; 229(3):362-73. doi:
10.1002/jcp.24458. [PMID: 23996089] - Takuro Kobori, Shinichi Harada, Kazuo Nakamoto, Shogo Tokuyama. Involvement of PtdIns(4,5)P2 in the regulatory mechanism of small intestinal P-glycoprotein expression.
Journal of pharmaceutical sciences.
2014 Feb; 103(2):743-51. doi:
10.1002/jps.23811. [PMID: 24311454] - Koichiro Homma, Koichi Hayashi, Shu Wakino, Hirobumi Tokuyama, Takeshi Kanda, Satoru Tatematsu, Kazuhiro Hasegawa, Seitaro Fujishima, Shingo Hori, Takao Saruta, Hiroshi Itoh. Rho-kinase contributes to pressure-induced constriction of renal microvessels.
The Keio journal of medicine.
2014; 63(1):1-12. doi:
10.2302/kjm.2013-0001-oa. [PMID: 24429483] - Yanhua Li, Xingwang Yang, Hui Zhang, Jiezhong Yu, Chunyun Liu, Ling Feng, Junlian Li, Baoguo Xiao, Cungen Ma. [Inhibition of Fasudil on lipopolysaccharide-induced TNF-α and IL-1β expressions through TLR4 pathway in murine BV-2 cells in vitro].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2014 Jan; 30(1):11-4. doi:
". [PMID: 24405591] - Magdalena Jasińska-Stroschein, Jacek Owczarek, Paulina Plichta, Daria Orszulak-Michalak. Concurrent rho-kinase and tyrosine kinase platelet-derived growth factor inhibition in experimental pulmonary hypertension.
Pharmacology.
2014; 93(3-4):145-50. doi:
10.1159/000360182. [PMID: 24662671] - Charles D Anderson, Derek M Kendig, Mohammad Al-Qudah, Sunila Mahavadi, Karnam S Murthy, John R Grider. Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2014; 50(?):103-19. doi:
10.1540/jsmr.50.103. [PMID: 25891767] - Keiichiro Matoba, Daiji Kawanami, Rina Okada, Masami Tsukamoto, Jun Kinoshita, Tomoko Ito, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Noriyuki Murai, Senya Matsufuji, Junko Takahashi-Fujigasaki, Kazunori Utsunomiya. Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α.
Kidney international.
2013 Sep; 84(3):545-54. doi:
10.1038/ki.2013.130. [PMID: 23615507] - James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly, Mikiyasu Shirai. Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.
Cardiovascular diabetology.
2013 Aug; 12(?):111. doi:
10.1186/1475-2840-12-111. [PMID: 24059472] - Taketoshi Kushiyama, Takashi Oda, Kojiro Yamamoto, Keishi Higashi, Atsushi Watanabe, Hanako Takechi, Takahiro Uchida, Naoki Oshima, Yutaka Sakurai, Soichiro Miura, Hiroo Kumagai. Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.
American journal of physiology. Renal physiology.
2013 Jun; 304(11):F1325-34. doi:
10.1152/ajprenal.00447.2012. [PMID: 23552860] - Vivek Gupta, Nilesh Gupta, Imam H Shaik, Reza Mehvar, Ivan F McMurtry, Masahiko Oka, Eva Nozik-Grayck, Masanobu Komatsu, Fakhrul Ahsan. Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension.
Journal of controlled release : official journal of the Controlled Release Society.
2013 Apr; 167(2):189-99. doi:
10.1016/j.jconrel.2013.01.011. [PMID: 23353807] - Satoshi Ikemura, Takuaki Yamamoto, Goro Motomura, Ryosuke Yamaguchi, Garida Zhao, Kenyu Iwasaki, Yukihide Iwamoto. Preventive effects of the anti-vasospasm agent via the regulation of the Rho-kinase pathway on the development of steroid-induced osteonecrosis in rabbits.
Bone.
2013 Apr; 53(2):329-35. doi:
10.1016/j.bone.2012.12.050. [PMID: 23313282] - Norma B Ojeda, Thomas P Royals, Barbara T Alexander. Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.
American journal of physiology. Renal physiology.
2013 Apr; 304(7):F900-7. doi:
10.1152/ajprenal.00687.2012. [PMID: 23344570] - Takuro Kobori, Shinichi Harada, Kazuo Nakamoto, Shogo Tokuyama. Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia.
Journal of pharmaceutical sciences.
2013 Mar; 102(3):1095-105. doi:
10.1002/jps.23441. [PMID: 23303573] - Yoshihiro Fukumoto, Norikazu Yamada, Hiromi Matsubara, Minori Mizoguchi, Kazuaki Uchino, Atsushi Yao, Yasuki Kihara, Mitsuhiro Kawano, Hiroshi Watanabe, Yutaka Takeda, Takeshi Adachi, Shinobu Osanai, Nobuhiro Tanabe, Teruo Inoue, Akihiro Kubo, Yuri Ota, Koichiro Fukuda, Takeshi Nakano, Hiroaki Shimokawa. Double-blind, placebo-controlled clinical trial with a rho-kinase inhibitor in pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(10):2619-25. doi:
10.1253/circj.cj-13-0443. [PMID: 23912836] - Magdalena Jasińska-Stroschein, Jacek Owczarek, Anna Łuczak, Daria Orszulak-Michalak. The beneficial impact of fasudil and sildenafil on monocrotaline-induced pulmonary hypertension in rats: a hemodynamic and biochemical study.
Pharmacology.
2013; 91(3-4):178-84. doi:
10.1159/000346921. [PMID: 23428587] - Jan M Williams, Ashley C Johnson, Cary Stelloh, Albert W Dreisbach, Nora Franceschini, Kevin R Regner, Raymond R Townsend, Richard J Roman, Michael R Garrett. Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Hypertension (Dallas, Tex. : 1979).
2012 Nov; 60(5):1157-68. doi:
10.1161/hypertensionaha.112.199240. [PMID: 22987919] - Kensuke Suzuki, Kayo Nemoto, Norifumi Ninomiya, Masamune Kuno, Minoru Kubota, Hiroyuki Yokota. Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.
The Journal of surgical research.
2012 Nov; 178(1):352-7. doi:
10.1016/j.jss.2012.01.043. [PMID: 22487385]