1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane (BioDeep_00000172115)

   

human metabolite blood metabolite


代谢物信息卡片


1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane

化学式: C11H11Cl2N (227.02685060000002)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 31.58%

分子结构信息

SMILES: C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
InChI: InChI=1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2

描述信息

同义名列表

1 个代谢物同义名

1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh-Gyu Hahn. Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. Bioorganic & medicinal chemistry letters. 2014 Aug; 24(15):3234-7. doi: 10.1016/j.bmcl.2014.06.026. [PMID: 24974340]
  • J Prins, K G C Westphal, G A H Korte-Bouws, M S Quinton, R Schreiber, B Olivier, S M Korte. The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior. 2011 Jan; 97(3):444-52. doi: 10.1016/j.pbb.2010.10.001. [PMID: 20934452]
  • Joseph P Tizzano, D Sloan Stribling, Diego Perez-Tilve, Alison Strack, Andrea Frassetto, Richard Z Chen, Tung M Fong, Lauren Shearman, Philip A Krieter, Matthias H Tschöp, Phil Skolnick, Anthony S Basile. The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics. 2008 Mar; 324(3):1111-26. doi: 10.1124/jpet.107.133132. [PMID: 18089843]
  • Phil Skolnick, Philip Krieter, Joseph Tizzano, Anthony Basile, Piotr Popik, Pal Czobor, Arnold Lippa. Preclinical and clinical pharmacology of DOV 216,303, a 'triple' reuptake inhibitor. CNS drug reviews. 2006; 12(2):123-34. doi: 10.1111/j.1527-3458.2006.00123.x. [PMID: 16958986]
  • Bernard Beer, Jill Stark, Philip Krieter, Pal Czobor, Gary Beer, Arnold Lippa, Phil Skolnick. DOV 216,303, a 'triple' reuptake inhibitor: safety, tolerability, and pharmacokinetic profile. Journal of clinical pharmacology. 2004 Dec; 44(12):1360-7. doi: 10.1177/0091270004269560. [PMID: 15545306]
  • Phil Skolnick, Piotr Popik, Aaron Janowsky, Bernard Beer, Arnold S Lippa. 'Broad spectrum' antidepressants: is more better for the treatment of depression?. Life sciences. 2003 Nov; 73(25):3175-9. doi: 10.1016/j.lfs.2003.06.007. [PMID: 14561522]
  • Phil Skolnick, Piotr Popik, Aaron Janowsky, Bernard Beer, Arnold S Lippa. Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor. European journal of pharmacology. 2003 Feb; 461(2-3):99-104. doi: 10.1016/s0014-2999(03)01310-4. [PMID: 12586204]