(R)-N-(1-Methyl-2-phenylethyl)adenosine (BioDeep_00000172064)

   

human metabolite blood metabolite


代谢物信息卡片


2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol

化学式: C19H23N5O4 (385.17499580000003)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90.27%

分子结构信息

SMILES: CC(CC1=CC=CC=C1)NC1=NC=NC2=C1N=CN2C1OC(CO)C(O)C1O
InChI: InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)

描述信息

D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D020011 - Protective Agents

同义名列表

4 个代谢物同义名

2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol; 2-(hydroxymethyl)-5-{6-[(1-phenylpropan-2-yl)amino]-9H-purin-9-yl}oxolane-3,4-diol; 2-(hydroxymethyl)-5-{6-[(1-phenylpropan-2-yl)amino]purin-9-yl}oxolane-3,4-diol; (R)-N-(1-Methyl-2-phenylethyl)adenosine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • María Ángeles Ruiz, David Agustín León, José Luis Albasanz, Mairena Martín. Desensitization of adenosine A(1) receptors in rat immature cortical neurons. European journal of pharmacology. 2011 Nov; 670(2-3):365-71. doi: 10.1016/j.ejphar.2011.09.027. [PMID: 21946103]
  • Chong-Bin Zhu, Jennifer A Steiner, Jaclyn L Munn, Lynette C Daws, William A Hewlett, Randy D Blakely. Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. The Journal of pharmacology and experimental therapeutics. 2007 Jul; 322(1):332-40. doi: 10.1124/jpet.107.121665. [PMID: 17460150]
  • María Angeles Ruiz, José Luis Albasanz, David León, Manuel Ros, Antonio Andrés, Mairena Martín. Different modulation of inhibitory and stimulatory pathways mediated by adenosine after chronic in vivo agonist exposure. Brain research. 2005 Jan; 1031(2):211-21. doi: 10.1016/j.brainres.2004.10.040. [PMID: 15649446]
  • Craig A Whitworth, Vickram Ramkumar, Brett Jones, Naoki Tsukasaki, Leonard P Rybak. Protection against cisplatin ototoxicity by adenosine agonists. Biochemical pharmacology. 2004 May; 67(9):1801-7. doi: 10.1016/j.bcp.2004.01.010. [PMID: 15081879]
  • Sylvie Duflot, Bárbara Riera, Sonia Fernández-Veledo, Vicent Casadó, Robert I Norman, F Javier Casado, Carme Lluís, Rafael Franco, Marçal Pastor-Anglada. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Molecular and cellular biology. 2004 Apr; 24(7):2710-9. doi: 10.1128/mcb.24.7.2710-2719.2004. [PMID: 15024061]
  • J L Albasanz, D León, M A Ruíz, M Fernández, M Martín. Adenosine A1 receptor agonist treatment up-regulates rat brain metabotropic glutamate receptors. Biochimica et biophysica acta. 2002 Dec; 1593(1):69-75. doi: 10.1016/s0167-4889(02)00330-0. [PMID: 12431785]
  • Timothy J Martin, Kenneth J Broadley. Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways. British journal of pharmacology. 2002 Nov; 137(6):729-38. doi: 10.1038/sj.bjp.0704902. [PMID: 12411402]
  • Zhan-Guo Gao, Seong Gon Kim, Kelly A Soltysiak, Neli Melman, Adriaan P IJzerman, Kenneth A Jacobson. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Molecular pharmacology. 2002 Jul; 62(1):81-9. doi: 10.1124/mol.62.1.81. [PMID: 12065758]
  • I Yamawaki, J Tamaoki, Y Takeda, A Nagai. [Effect of adenosine and its analogues on microvascular leakage in the rat trachea]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 1998 Mar; 36(3):231-5. doi: NULL. [PMID: 9656668]
  • D Vendite, J M Sanz, D M López-Alañon, J Vacas, A Andrés, M Ros. Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells. Neurochemical research. 1998 Feb; 23(2):211-8. doi: 10.1023/a:1022437110269. [PMID: 9475516]
  • T Sumida, M A Smith, Y Maehara, J G Collins, L M Kitahata. Spinal R-phenyl-isopropyl adenosine inhibits spinal dorsal horn neurons responding to noxious heat stimulation in the absence and presence of sensitization. Pain. 1998 Feb; 74(2-3):307-13. doi: 10.1016/s0304-3959(97)00191-7. [PMID: 9520245]
  • E F Williams. Plasticity of cardiovascular nucleoside transporters following chronic dipyridamole treatment. SAAS bulletin, biochemistry and biotechnology. 1997; 10(?):19-24. doi: NULL. [PMID: 9274058]
  • A Ruiz, J M Sanz, G Gonzalez-Calero, M Fernández, A Andrés, A Cubero, M Ros. Desensitization and internalization of adenosine A1 receptors in rat brain by in vivo treatment with R-PIA: involvement of coated vesicles. Biochimica et biophysica acta. 1996 Jan; 1310(1):168-74. doi: 10.1016/0167-4889(95)00152-2. [PMID: 9244192]
  • A Olivera, J M Lopez-Novoa. Effect of adenosine and adenosine analogues on cyclic AMP accumulation in cultured mesangial cells and isolated glomeruli of the rat. British journal of pharmacology. 1992 Oct; 107(2):341-6. doi: 10.1111/j.1476-5381.1992.tb12748.x. [PMID: 1330173]
  • G C Rolband, E D Furth, J M Staddon, E M Rogus, A P Goldberg. Effects of age and adenosine in the modulation of insulin action on rat adipocyte metabolism. Journal of gerontology. 1990 Sep; 45(5):B174-8. doi: 10.1093/geronj/45.5.b174. [PMID: 2203845]