(E)-Tamoxifen (BioDeep_00000172045)
human metabolite blood metabolite
代谢物信息卡片
{2-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl}dimethylamine
化学式: C26H29NO (371.2249)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 0.74%
分子结构信息
SMILES: CCC(=C(C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1
InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Cell reports.
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Molecular pharmacology.
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Journal of cancer research and clinical oncology.
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Therapeutic drug monitoring.
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Molecular & cellular proteomics : MCP.
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The Journal of nutritional biochemistry.
2012 Jul; 23(7):725-32. doi:
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Breast cancer research and treatment.
2012 Jul; 134(2):693-700. doi:
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BMC cancer.
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Breast cancer research and treatment.
2012 Jun; 133(2):677-83. doi:
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European journal of nutrition.
2012 Jun; 51(4):465-76. doi:
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Hepato-gastroenterology.
2012 Jun; 59(116):994-6. doi:
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Breast cancer research and treatment.
2012 Jun; 133(3):1077-88. doi:
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Journal of biomedical materials research. Part A.
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2012 Jun; 133(2):793-8. doi:
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European journal of pharmacology.
2012 May; 683(1-3):270-5. doi:
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Cellular and molecular life sciences : CMLS.
2012 May; 69(10):1625-34. doi:
10.1007/s00018-012-0971-z. [PMID: 22481437] - M Moegele, S Buchholz, S Seitz, Olaf Ortmann. Vaginal estrogen therapy in postmenopausal breast cancer patients treated with aromatase inhibitors.
Archives of gynecology and obstetrics.
2012 May; 285(5):1397-402. doi:
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European journal of clinical pharmacology.
2012 May; 68(5):811-9. doi:
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Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
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Journal of proteome research.
2012 Apr; 11(4):2193-205. doi:
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BMC cancer.
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Climacteric : the journal of the International Menopause Society.
2012 Apr; 15(2):115-24. doi:
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Journal of lipid research.
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Archives of gynecology and obstetrics.
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Calcified tissue international.
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ACS chemical neuroscience.
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Breast cancer research and treatment.
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Cancer prevention research (Philadelphia, Pa.).
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Journal of hematology & oncology.
2012 Jan; 5(?):1. doi:
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International journal of pharmaceutics.
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2012 Jan; 30(2):151-7. doi:
10.1200/jco.2011.35.2237. [PMID: 22162577] - Melissa L Sokolosky, Michael J Wargovich. Homeostatic imbalance and colon cancer: the dynamic epigenetic interplay of inflammation, environmental toxins, and chemopreventive plant compounds.
Frontiers in oncology.
2012; 2(?):57. doi:
10.3389/fonc.2012.00057. [PMID: 22675672] - Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu, Man-Jiang Xie. Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells.
PloS one.
2012; 7(5):e37451. doi:
10.1371/journal.pone.0037451. [PMID: 22655048] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069. [PMID: 22557968] - Taishi Miyashita, Yasuyuki Toyoda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models.
The Journal of toxicological sciences.
2012; 37(5):931-42. doi:
10.2131/jts.37.931. [PMID: 23038002] - Francis Jacob, Kristjan Ukegjini, Sheri Nixdorf, Caroline E Ford, Jake Olivier, Rosmarie Caduff, James P Scurry, Rea Guertler, Daniela Hornung, Renato Mueller, Daniel A Fink, Neville F Hacker, Viola A Heinzelmann-Schwarz. Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients.
PloS one.
2012; 7(2):e31885. doi:
10.1371/journal.pone.0031885. [PMID: 22363760] - Subhasree Ashok Nag, Jiang-Jiang Qin, Wei Wang, Ming-Hai Wang, Hui Wang, Ruiwen Zhang. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action.
Frontiers in pharmacology.
2012; 3(?):25. doi:
10.3389/fphar.2012.00025. [PMID: 22403544] - Dong Hoe Koo, Cheol-Young Park, Eun Sook Lee, Jungsil Ro, Sang Woo Oh. Progranulin as a prognostic biomarker for breast cancer recurrence in patients who had hormone receptor-positive tumors: a cohort study.
PloS one.
2012; 7(6):e39880. doi:
10.1371/journal.pone.0039880. [PMID: 22761921] - Mandy Ka Man Kam, King Yiu Lee, Paul Kwong Hang Tam, Vincent Chi Hang Lui. Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons.
PloS one.
2012; 7(5):e35799. doi:
10.1371/journal.pone.0035799. [PMID: 22586451] - Kazuma Kiyotani, Taisei Mushiroda, Chiyo K Imamura, Yusuke Tanigawara, Naoya Hosono, Michiaki Kubo, Mitsunori Sasa, Yusuke Nakamura, Hitoshi Zembutsu. Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients.
Breast cancer research and treatment.
2012 Jan; 131(1):137-45. doi:
10.1007/s10549-011-1777-7. [PMID: 21947681] - Syed M Meeran, Shweta N Patel, Yuanyuan Li, Samriddhi Shukla, Trygve O Tollefsbol. Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.
PloS one.
2012; 7(5):e37748. doi:
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Menopause (New York, N.Y.).
2012 Jan; 19(1):96-103. doi:
10.1097/gme.0b013e318223e82a. [PMID: 21926925] - Hetal N Prajapati, Damon M Dalrymple, Abu T M Serajuddin. A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development.
Pharmaceutical research.
2012 Jan; 29(1):285-305. doi:
10.1007/s11095-011-0541-3. [PMID: 21861203] - Kazuma Kiyotani, Taisei Mushiroda, Yusuke Nakamura, Hitoshi Zembutsu. Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters.
Drug metabolism and pharmacokinetics.
2012; 27(1):122-31. doi:
10.2133/dmpk.dmpk-11-rv-084. [PMID: 22041137] - Walckiria G Romero, Fabrício B Da Silva, Mariana V Borgo, Nazaré S Bissoli, Sonia A Gouvêa, Gláucia R Abreu. Tamoxifen alters the plasma concentration of molecules associated with cardiovascular risk in women with breast cancer undergoing chemotherapy.
The oncologist.
2012; 17(4):499-507. doi:
10.1634/theoncologist.2011-0369. [PMID: 22491005] - Paola Sánchez-Moreno, Houria Boulaiz, Juan Luis Ortega-Vinuesa, José Manuel Peula-García, Antonia Aránega. Novel drug delivery system based on docetaxel-loaded nanocapsules as a therapeutic strategy against breast cancer cells.
International journal of molecular sciences.
2012; 13(4):4906-4919. doi:
10.3390/ijms13044906. [PMID: 22606019] - Hidesuke Fukazawa, Tetsuro Suzuki, Takaji Wakita, Yuko Murakami. A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus.
Biological & pharmaceutical bulletin.
2012; 35(8):1320-7. doi:
10.1248/bpb.b12-00251. [PMID: 22863932] - Humberto Dellê, José Roberto C Rocha, Rita C Cavaglieri, José Mauro Vieira, Denise M A C Malheiros, Irene L Noronha. Antifibrotic effect of tamoxifen in a model of progressive renal disease.
Journal of the American Society of Nephrology : JASN.
2012 Jan; 23(1):37-48. doi:
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ISRN pharmacology.
2012; 2012(?):590626. doi:
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Renal failure.
2012; 34(3):387-9. doi:
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Zhonghua nan ke xue = National journal of andrology.
2012 Jan; 18(1):3-10. doi:
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PloS one.
2012; 7(2):e30604. doi:
10.1371/journal.pone.0030604. [PMID: 22363452] - N T Telang, G Li, D W Sepkovic, H L Bradlow, G Y C Wong. Anti-proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer.
Molecular medicine reports.
2012 01; 5(1):22-8. doi:
10.3892/mmr.2011.617. [PMID: 21971582] - Na Wei, Stephanie S Liu, Karen K L Chan, Hextan Y S Ngan. Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer.
PloS one.
2012; 7(1):e30311. doi:
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Journal of oncology.
2012; 2012(?):879623. doi:
10.1155/2012/879623. [PMID: 21977033] - Monika Merkle, Markus Wörnle. Sclerosing peritonitis: a rare but fatal complication of peritoneal inflammation.
Mediators of inflammation.
2012; 2012(?):709673. doi:
10.1155/2012/709673. [PMID: 22619486] - Anna-Clara E Spetz Holm, Jessica Frisk, Mats L Hammar. Acupuncture as treatment of hot flashes and the possible role of calcitonin gene-related Peptide.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):579321. doi:
10.1155/2012/579321. [PMID: 22110545] - Greg L Harris, Michael B Creason, Greg B Brulte, Deron R Herr. In vitro and in vivo antagonism of a G protein-coupled receptor (S1P3) with a novel blocking monoclonal antibody.
PloS one.
2012; 7(4):e35129. doi:
10.1371/journal.pone.0035129. [PMID: 22496900] - Gabriella Garruti, Helen H Wang, Leonilde Bonfrate, Ornella de Bari, David Q-H Wang, Piero Portincasa. A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.
Journal of lipids.
2012; 2012(?):304292. doi:
10.1155/2012/304292. [PMID: 22577560] - Efrat Eliyahu, Nataly Shtraizent, Ruth Shalgi, Edward H Schuchman. Construction of conditional acid ceramidase knockout mice and in vivo effects on oocyte development and fertility.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(3):735-48. doi:
10.1159/000341453. [PMID: 22854249] - Guangrui Yang, Zhanjun Jia, Toshinori Aoyagi, Donald McClain, Richard M Mortensen, Tianxin Yang. Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism.
PloS one.
2012; 7(8):e38117. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):258434. doi:
10.1155/2012/258434. [PMID: 22242040] - Simone M Tchu, Kara L Lynch, Alan H B Wu. Therapeutic drug monitoring of tamoxifen using LC-MS/MS.
Methods in molecular biology (Clifton, N.J.).
2012; 902(?):211-22. doi:
10.1007/978-1-61779-934-1_19. [PMID: 22767121] - Edy Meiyanto, Adam Hermawan, Anindyajati. Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.
Asian Pacific journal of cancer prevention : APJCP.
2012; 13(2):427-36. doi:
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TheScientificWorldJournal.
2012; 2012(?):439479. doi:
10.1100/2012/439479. [PMID: 22666123] - Remona Gopaul, Helen E Knaggs, Edwin D Lephart. Biochemical investigation and gene analysis of equol: a plant and soy-derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications.
BioFactors (Oxford, England).
2012 Jan; 38(1):44-52. doi:
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