AB-MECA (BioDeep_00000171889)
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H21N7O4 (399.1655)
中文名称:
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=CN=C32)NCC4=CC=C(C=C4)N)O)O
InChI: InChI=1S/C18H21N7O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-2-4-10(19)5-3-9/h2-5,7-8,12-14,18,26-27H,6,19H2,1H3,(H,20,28)(H,21,22,23)
描述信息
同义名列表
6 个代谢物同义名
5-(6-{[(4-aminophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboximidate; 5-(6-{[(4-aminophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide; 5-(6-{[(4-aminophenyl)methyl]amino}purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide; 5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide; N(6)-(4-Amino-3-iodobenzyl)adenosine-5-N-methyluronamide; AB-MECA
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Endre G Mikus, Kinga Boér, Géza Timári, Katalin Urbán-Szabó, Zoltán Kapui, Judit Szeredi, Katalin Gerber, Tibor Szabó, Sándor Bátori, Michel Finet, Péter Arányi, Anne-Marie Galzin. Interaction of SSR161421, a novel specific adenosine A(3) receptor antagonist with adenosine A(3) receptor agonists both in vitro and in vivo.
European journal of pharmacology.
2013 Jan; 699(1-3):62-6. doi:
10.1016/j.ejphar.2012.11.046. [PMID: 23219789] - Endre G Mikus, Judit Szeredi, Kinga Boer, Géza Tímári, Michel Finet, Péter Aranyi, Anne-Marie Galzin. Evaluation of SSR161421, a novel orally active adenosine A3 receptor antagonist on pharmacology models.
European journal of pharmacology.
2013 Jan; 699(1-3):172-9. doi:
10.1016/j.ejphar.2012.11.049. [PMID: 23219796] - James Fossetta, James Jackson, Gregory Deno, Xuedong Fan, Xixuan Karen Du, Loretta Bober, Anne Soudé-Bermejo, Odette de Bouteiller, Christophe Caux, Charles Lunn, Daniel Lundell, R Kyle Palmer. Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
Molecular pharmacology.
2003 Feb; 63(2):342-50. doi:
10.1124/mol.63.2.342. [PMID: 12527805] - Zhan-Guo Gao, Seong Gon Kim, Kelly A Soltysiak, Neli Melman, Adriaan P IJzerman, Kenneth A Jacobson. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.
Molecular pharmacology.
2002 Jul; 62(1):81-9. doi:
10.1124/mol.62.1.81. [PMID: 12065758] - Z G Gao, J E Van Muijlwijk-Koezen, A Chen, C E Müller, A P Ijzerman, K A Jacobson. Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives.
Molecular pharmacology.
2001 Nov; 60(5):1057-63. doi:
10.1124/mol.60.5.1057. [PMID: 11641434] - M L Trincavelli, D Tuscano, P Cecchetti, A Falleni, L Benzi, K N Klotz, V Gremigni, F Cattabeni, A Lucacchini, C Martini. Agonist-induced internalization and recycling of the human A(3) adenosine receptors: role in receptor desensitization and resensitization.
Journal of neurochemistry.
2000 Oct; 75(4):1493-501. doi:
10.1046/j.1471-4159.2000.0751493.x. [PMID: 10987829] - A H Li, S Moro, N Melman, X D Ji, K A Jacobson. Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry.
1998 Aug; 41(17):3186-201. doi:
10.1021/jm980093j. [PMID: 9703464] - K Varani, B Cacciari, P G Baraldi, S Dionisotti, E Ongini, P A Borea. Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Life sciences.
1998; 63(5):PL 81-7. doi:
10.1016/s0024-3205(98)00289-6. [PMID: 9714428] - K A Jacobson, K S Park, J L Jiang, Y C Kim, M E Olah, G L Stiles, X D Ji. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists.
Neuropharmacology.
1997 Sep; 36(9):1157-65. doi:
10.1016/s0028-3908(97)00104-4. [PMID: 9364471] - J Jiang, A M van Rhee, L Chang, A Patchornik, X D Ji, P Evans, N Melman, K A Jacobson. Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry.
1997 Aug; 40(16):2596-608. doi:
10.1021/jm970091j. [PMID: 9258367] - Y C Kim, X D Ji, K A Jacobson. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Journal of medicinal chemistry.
1996 Oct; 39(21):4142-8. doi:
10.1021/jm960482i. [PMID: 8863790] - H O Kim, X D Ji, N Melman, M E Olah, G L Stiles, K A Jacobson. Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Journal of medicinal chemistry.
1994 Sep; 37(20):3373-82. doi:
10.1021/jm00046a022. [PMID: 7932565]
