Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (BioDeep_00000171866)

   

human metabolite blood metabolite


代谢物信息卡片


37,39,41,43,45,47,49-heptamethoxy-5,10,15,20,25,30,35-heptakis(methoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}.2^{28,31}]nonatetracontane-36,38,40,42,44,46,48-heptol

化学式: C56H98O35 (1330.5888358000002)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COCC1C2C(C(C(O1)OC3C(OC(C(C3O)OC)OC4C(OC(C(C4O)OC)OC5C(OC(C(C5O)OC)OC6C(OC(C(C6O)OC)OC7C(OC(C(C7O)OC)OC8C(OC(O2)C(C8O)OC)COC)COC)COC)COC)COC)COC)OC)O
InChI: InChI=1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Fugen Gu, Jia Ning, Huimin Fan, Chunzhi Wu, Yi Wang. Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats. Acta pharmaceutica (Zagreb, Croatia). 2018 Jun; 68(2):145-157. doi: 10.2478/acph-2018-0016. [PMID: 29702479]
  • Ya-Jing Ye, Yun Wang, Kai-Yan Lou, Yan-Zuo Chen, Rongjun Chen, Feng Gao. The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. International journal of nanomedicine. 2015; 10(?):4309-19. doi: 10.2147/ijn.s83508. [PMID: 26170666]
  • Francesca Rizzello, Angelo De Paolis, Miriana Durante, Federica Blando, Giovanni Mita, Sofia Caretto. Enhanced production of bioactive isoprenoid compounds from cell suspension cultures of Artemisia annua L. using β-cyclodextrins. International journal of molecular sciences. 2014 Oct; 15(10):19092-105. doi: 10.3390/ijms151019092. [PMID: 25338048]
  • Katja Klein, Jamie F S Mann, Paul Rogers, Robin J Shattock. Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines. Journal of controlled release : official journal of the Controlled Release Society. 2014 Jun; 183(?):43-50. doi: 10.1016/j.jconrel.2014.03.018. [PMID: 24657807]
  • Cristina Martin, Boiko Cohen, Issam Gaamoussi, Mustapha Ijjaali, Abderrazzak Douhal. Ultrafast dynamics of C30 in solution and within CDs and HSA protein. The journal of physical chemistry. B. 2014 May; 118(21):5760-71. doi: 10.1021/jp5026575. [PMID: 24773055]
  • Andreia Ascenso, Mariana Cruz, Carla Euletério, Filomena A Carvalho, Nuno C Santos, Helena C Marques, Sandra Simões. Novel tretinoin formulations: a drug-in-cyclodextrin-in-liposome approach. Journal of liposome research. 2013 Sep; 23(3):211-9. doi: 10.3109/08982104.2013.788026. [PMID: 23631723]
  • Hirofumi Shimomura, Kouichi Hosoda, Shunji Hayashi, Kenji Yokota, Yoshikazu Hirai. Phosphatidylethanolamine of Helicobacter pylori functions as a steroid-binding lipid in the assimilation of free cholesterol and 3β-hydroxl steroids into the bacterial cell membrane. Journal of bacteriology. 2012 May; 194(10):2658-67. doi: 10.1128/jb.00105-12. [PMID: 22408164]
  • Thitirat Mantim, Duangjai Nacapricha, Prapin Wilairat, Peter C Hauser. Enantiomeric separation of some common controlled stimulants by capillary electrophoresis with contactless conductivity detection. Electrophoresis. 2012 Jan; 33(2):388-94. doi: 10.1002/elps.201100370. [PMID: 22170109]
  • N Başaran Mutlu, Zelihagül Değim, Şükran Yilmaz, Dinç Eşsiz, Ahmet Nacar. New perspective for the treatment of Alzheimer diseases: liposomal rivastigmine formulations. Drug development and industrial pharmacy. 2011 Jul; 37(7):775-89. doi: 10.3109/03639045.2010.541262. [PMID: 21231901]
  • Delphine Castagne, Georges Dive, Brigitte Evrard, Michel Frédérich, Géraldine Piel. Spectroscopic studies and molecular modeling for understanding the interactions between cholesterol and cyclodextrins. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2010; 13(3):362-77. doi: 10.18433/j3bs34. [PMID: 21092709]
  • Keiichi Motoyama, Kazuhisa Kameyama, Risako Onodera, Norie Araki, Fumitoshi Hirayama, Kaneto Uekama, Hidetoshi Arima. Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-beta-cyclodextrin, not 2,6-di-O-methyl-alpha-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2009 Oct; 38(3):249-61. doi: 10.1016/j.ejps.2009.07.010. [PMID: 19664706]
  • Anita Zamboni, Pamela Gatto, Alessandro Cestaro, Stefania Pilati, Roberto Viola, Fulvio Mattivi, Claudio Moser, Riccardo Velasco. Grapevine cell early activation of specific responses to DIMEB, a resveratrol elicitor. BMC genomics. 2009 Aug; 10(?):363. doi: 10.1186/1471-2164-10-363. [PMID: 19660119]
  • F Karamustafa, N Celebi, Z Değim, N Unal. Transport evaluation of alendronate across Caco-2 cell monolayers. Die Pharmazie. 2009 Feb; 64(2):98-103. doi: NULL. [PMID: 19320282]
  • Pranav Shah, Viral Jogani, Pushpa Mishra, Anil Kumar Mishra, Tamishraha Bagchi, Ambikanandan Misra. In vitro assessment of acyclovir permeation across cell monolayers in the presence of absorption enhancers. Drug development and industrial pharmacy. 2008 Mar; 34(3):279-88. doi: 10.1080/03639040701655952. [PMID: 18363143]
  • Pranav Shah, Viral Jogani, Pushpa Mishra, Anil Kumar Mishra, Tamishraha Bagchi, Ambikanandan Misra. Modulation of ganciclovir intestinal absorption in presence of absorption enhancers. Journal of pharmaceutical sciences. 2007 Oct; 96(10):2710-22. doi: 10.1002/jps.20888. [PMID: 17680662]
  • Yen-Ling Chen, Yuh-Jyh Jong, Shou-Mei Wu. Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma. Journal of chromatography. A. 2006 Jun; 1119(1-2):176-82. doi: 10.1016/j.chroma.2006.02.054. [PMID: 16530777]
  • Koichi Yokogawa, Katsuhiro Toshima, Kayo Yamoto, Tatsuo Nishioka, Naoki Sakura, Ken-ichi Miyamoto. Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol. Biological & pharmaceutical bulletin. 2006 Jun; 29(6):1229-33. doi: 10.1248/bpb.29.1229. [PMID: 16755022]
  • Roque Bru, Susana Sellés, Juan Casado-Vela, Sarai Belchí-Navarro, Maria Angeles Pedreño. Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures. Journal of agricultural and food chemistry. 2006 Jan; 54(1):65-71. doi: 10.1021/jf051485j. [PMID: 16390179]
  • Li-Bin Liu, Zhi-Xia Zheng, Jin-Ming Lin. Application of dimethyl-beta-cyclodextrin as a chiral selector in capillary electrophoresis for enantiomer separation of ephedrine and related compounds in some drugs. Biomedical chromatography : BMC. 2005 Jul; 19(6):447-53. doi: 10.1002/bmc.504. [PMID: 16037931]
  • Tianzhi Yang, Fatima Mustafa, Shuhua Bai, Fakhrul Ahsan. Pulmonary delivery of low molecular weight heparins. Pharmaceutical research. 2004 Nov; 21(11):2009-16. doi: 10.1023/b:pham.0000048191.69098.d6. [PMID: 15587922]
  • Alamdar Hussain, Tianzhi Yang, Abdel-Azim Zaghloul, Fakhrul Ahsan. Pulmonary absorption of insulin mediated by tetradecyl-beta-maltoside and dimethyl-beta-cyclodextrin. Pharmaceutical research. 2003 Oct; 20(10):1551-7. doi: 10.1023/a:1026118813943. [PMID: 14620506]
  • Lidia Mateus-Avois, Patrice Mangin, Martial Saugy. Development and validation of a capillary zone electrophoresis method for the determination of ephedrine and related compounds in urine without extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):203-16. doi: 10.1016/s1570-0232(03)00222-8. [PMID: 12798180]
  • Prapasri Sinswat, Parkpoom Tengamnuay. Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins. International journal of pharmaceutics. 2003 May; 257(1-2):15-22. doi: 10.1016/s0378-5173(03)00090-5. [PMID: 12711157]
  • F Ahsan, J J Arnold, E Meezan, D J Pillion. Mutual inhibition of the insulin absorption-enhancing properties of dodecylmaltoside and dimethyl-beta-cyclodextrin following nasal administration. Pharmaceutical research. 2001 May; 18(5):608-14. doi: 10.1023/a:1011073008325. [PMID: 11465415]
  • N Albertson, I Wenngren, J E Sjöström. Growth and survival of Helicobacter pylori in defined medium and susceptibility to Brij 78. Journal of clinical microbiology. 1998 May; 36(5):1232-5. doi: 10.1128/jcm.36.5.1232-1235.1998. [PMID: 9574682]
  • P Y Grosse, F Pinguet, J M Joulia, C Astre, F Bressolle. High-performance liquid chromatographic assay for methyl-beta-cyclodextrin in plasma and cell lysate. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 694(1):219-26. doi: 10.1016/s0378-4347(97)00103-5. [PMID: 9234866]
  • M Siluveru, J T Stewart. Stereoselective determination of R-(-)- and S-(+)-prilocaine in human serum by capillary electrophoresis using a derivatized cyclodextrin and ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 May; 693(1):205-10. doi: 10.1016/s0378-4347(97)00017-0. [PMID: 9200536]
  • A Rawyler, P A Siegenthaler. Cyclodextrins: a new tool for the controlled lipid depletion of thylakoid membranes. Biochimica et biophysica acta. 1996 Jan; 1278(1):89-97. doi: 10.1016/0005-2736(95)00190-5. [PMID: 8611612]
  • M Vakily, F M Pasutto, M Daneshtalab, F Jamali. Inclusion complexation of heptakis(2,6-di-O-ethyl)-beta-cyclodextrin with tiaprofenic acid: pharmacokinetic consequences of a pH-dependent release and stereoselective dissolution. Journal of pharmaceutical sciences. 1995 Aug; 84(8):1014-9. doi: 10.1002/jps.2600840819. [PMID: 7500270]
  • U Vollmer, B W Müller, J Peeters, J Mesens, B Wilffert, T Peters. A study of the percutaneous absorption-enhancing effects of cyclodextrin derivatives in rats. The Journal of pharmacy and pharmacology. 1994 Jan; 46(1):19-22. doi: 10.1111/j.2042-7158.1994.tb03713.x. [PMID: 8201522]
  • N G Schipper, S G Romeijn, J C Verhoef, F W Merkus. Nasal insulin delivery with dimethyl-beta-cyclodextrin as an absorption enhancer in rabbits: powder more effective than liquid formulations. Pharmaceutical research. 1993 May; 10(5):682-6. doi: 10.1023/a:1018999414088. [PMID: 8321831]
  • Y Watanabe, Y Matsumoto, M Yamaguchi, R Kikuchi, K Takayama, H Nomura, K Maruyama, M Matsumoto. Absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and blood leukocyte dynamics following intranasal administration in rabbits. Biological & pharmaceutical bulletin. 1993 Jan; 16(1):93-5. doi: 10.1248/bpb.16.93. [PMID: 7690293]
  • P Ibsen, C Schou, M Au-Jensen, I Heron. The effect of cyclodextrin on lipopolysaccharide production in cultures of Bordetella pertussis. Journal of biological standardization. 1989 Oct; 17(4):321-30. doi: 10.1016/s0092-1157(89)80003-4. [PMID: 2559082]