Manumycin A (BioDeep_00000171857)

   

human metabolite blood metabolite


代谢物信息卡片


N-(5-Hydroxy-5-{6-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)-C-hydroxycarbonimidoyl]hexa-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2,4,6-trimethyldeca-2,4-dienimidate

化学式: C31H38N2O7 (550.2678877999999)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 71.43%

分子结构信息

SMILES: CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(O)(C=CC=CC=CC(=O)NC2=C(O)CCC2=O)C2OC2C1=O
InChI: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)

描述信息

同义名列表

5 个代谢物同义名

N-(5-Hydroxy-5-{6-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)-C-hydroxycarbonimidoyl]hexa-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2,4,6-trimethyldeca-2,4-dienimidate; N-(5-hydroxy-5-{6-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)carbamoyl]hexa-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2,4,6-trimethyldeca-2,4-dienamide; Manumycin A; manumycin; Ucfi-C



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jianjun Qiao, Yan Song, Zongxin Ling, Xia Liu, Hong Fang. ram1 gene, encoding a subunit of farnesyltransferase, contributes to growth, antifungal susceptibility to amphotericin B of Aspergillus fumigatus. Medical mycology. 2017 Nov; 55(8):883-889. doi: 10.1093/mmy/myx002. [PMID: 28159997]
  • Xiangjun Zhou, Wei Zhang, Qisheng Yao, Hao Zhang, Guie Dong, Ming Zhang, Yutao Liu, Jian-Kang Chen, Zheng Dong. Exosome production and its regulation of EGFR during wound healing in renal tubular cells. American journal of physiology. Renal physiology. 2017 06; 312(6):F963-F970. doi: 10.1152/ajprenal.00078.2017. [PMID: 28356285]
  • Shinichi Nishimura, Masato Tokukura, Junko Ochi, Minoru Yoshida, Hideaki Kakeya. Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics. Chemistry & biology. 2014 Dec; 21(12):1690-9. doi: 10.1016/j.chembiol.2014.10.014. [PMID: 25500221]
  • Rebecca R Miles, William Perry, Joseph V Haas, Marian K Mosior, Mathias N'Cho, Jian W J Wang, Peng Yu, John Calley, Yong Yue, Quincy Carter, Bomie Han, Patricia Foxworthy, Mark C Kowala, Timothy P Ryan, Patricia J Solenberg, Laura F Michael. Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretion. The Journal of biological chemistry. 2013 Mar; 288(9):6386-96. doi: 10.1074/jbc.m112.410092. [PMID: 23322769]
  • Tao Yu, Hideaki Yamaguchi, Toshiro Noshita, Yumi Kidachi, Hironori Umetsu, Kazuo Ryoyama. Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation. Toxicology letters. 2010 Feb; 192(3):425-30. doi: 10.1016/j.toxlet.2009.11.021. [PMID: 19958823]
  • Banishree Saha, Dipankar Nandi. Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice. Hepatology (Baltimore, Md.). 2009 Nov; 50(5):1547-57. doi: 10.1002/hep.23180. [PMID: 19739265]
  • Michiko Sugita, Hiroki Sugita, Masao Kaneki. Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2007 Jun; 27(6):1390-5. doi: 10.1161/atvbaha.107.140673. [PMID: 17363690]
  • C-L Lin, F-S Wang, Y-R Kuo, Y-T Huang, H-C Huang, Y-C Sun, Y-H Kuo. Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney international. 2006 May; 69(9):1593-600. doi: 10.1038/sj.ki.5000329. [PMID: 16572112]
  • M A Frassanito, L Mastromauro, A Cusmai, F Dammacco. Blockade of the Ras pathway by manumycin, a farnesyltransferase inhibitor, overcomes the resistance of myeloma plasma cells to Fas-induced apoptosis. Clinical and experimental medicine. 2005 Mar; 4(4):174-82. doi: 10.1007/s10238-004-0053-0. [PMID: 15750764]
  • Joanne Gonzales, Sai-Ching Jim Yeung, Judith A Smith. High-performance liquid chromatographic assay validation of Manumycin A in mouse plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Sep; 776(2):177-82. doi: 10.1016/s1570-0232(02)00334-3. [PMID: 12137999]
  • J M Xuereb, P Sié, B Boneu, J Constans. Inhibition of tissue factor synthesis by disruption of ERK kinases and PKC signaling pathways in human vascular SMCs. Thrombosis and haemostasis. 2000 Jul; 84(1):129-36. doi: 10.1055/s-0037-1613980. [PMID: 10928483]
  • B R Ali, A Pal, S L Croft, R J Taylor, M C Field. The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria. Molecular and biochemical parasitology. 1999 Oct; 104(1):67-80. doi: 10.1016/s0166-6851(99)00131-0. [PMID: 10589982]
  • O Kainuma, T Asano, M Hasegawa, K Isono. [Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor]. Gan to kagaku ryoho. Cancer & chemotherapy. 1996 Oct; 23(12):1657-9. doi: . [PMID: 8886038]