Cyclohexaamylose (BioDeep_00000171734)
human metabolite blood metabolite
代谢物信息卡片
5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.2³,⁶.2⁸,¹¹.2¹³,¹⁶.2¹⁸,²¹.2²³,²⁶]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
化学式: C36H60O30 (972.316926)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(O2)C(C7O)O)CO)CO)CO)CO)CO)O)O)O
InChI: InChI=1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pavana Suresh, Erwin London. Using cyclodextrin-induced lipid substitution to study membrane lipid and ordered membrane domain (raft) function in cells.
Biochimica et biophysica acta. Biomembranes.
2022 02; 1864(1):183774. doi:
10.1016/j.bbamem.2021.183774. [PMID: 34534531] - S Paolacci, M C Ergoren, D De Forni, E Manara, B Poddesu, G Cugia, K Dhuli, G Camilleri, G Tuncel, H Kaya Suer, N Sultanoglu, M Sayan, M Dundar, T Beccari, M R Ceccarini, I S Gunsel, A Dautaj, T Sanlidag, S T Connelly, G M Tartaglia, M Bertelli. In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection.
European review for medical and pharmacological sciences.
2021 12; 25(1 Suppl):81-89. doi:
10.26355/eurrev_202112_27337. [PMID: 34890038] - S Paolacci, A K Kiani, P Shree, D Tripathi, Y B Tripathi, P Tripathi, G M Tartaglia, M Farronato, G Farronato, S T Connelly, M R Ceccarini, M Coatto, M C Ergoren, T Sanlidag, A Dautaj, M Bertelli. Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies.
European review for medical and pharmacological sciences.
2021 12; 25(1 Suppl):90-100. doi:
10.26355/eurrev_202112_27338. [PMID: 34890039] - Eunyoung Lee, Xilin Zhang, Tomoe Noda, Junki Miyamoto, Ikuo Kimura, Tomoaki Tanaka, Kenichi Sakurai, Ryo Hatano, Takashi Miki. Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910796. [PMID: 34639136] - Stefano Paolacci, Maria Rachele Ceccarini, Michela Codini, Elena Manara, Silvia Tezzele, Marcella Percio, Natale Capodicasa, Dorela Kroni, Munis Dundar, Mahmut Cerkez Ergoren, Tamer Sanlidag, Tommaso Beccari, Marco Farronato, Giampietro Farronato, Gianluca Martino Tartaglia, Matteo Bertelli. Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis.
Acta bio-medica : Atenei Parmensis.
2020 11; 91(13-S):e2020009. doi:
10.23750/abm.v91i13-s.10583. [PMID: 33170175] - Mahmut Cerkez Ergoren, Stefano Paolacci, Elena Manara, Astrit Dautaj, Kristjana Dhuli, Kyrylo Anpilogov, Giorgio Camilleri, Huseyin Kaya Suer, Murat Sayan, Gulten Tuncel, Nazife Sultanoglu, Marco Farronato, Gianluca Martino Tartaglia, Munis Dundar, Giampietro Farronato, Irfan Suat Gunsel, Matteo Bertelli, Tamer Sanlidag. A pilot study on the preventative potential of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 transmission.
Acta bio-medica : Atenei Parmensis.
2020 11; 91(13-S):e2020022. doi:
10.23750/abm.v91i13-s.10817. [PMID: 33170176] - Erica Bessell, Nicholas R Fuller, Tania P Markovic, Namson S Lau, Jessica Burk, Chelsea Hendy, Tegan Picone, Ang Li, Ian D Caterson. Effects of α-Cyclodextrin on Cholesterol Control and Hydrolyzed Ginseng Extract on Glycemic Control in People With Prediabetes: A Randomized Clinical Trial.
JAMA network open.
2020 11; 3(11):e2023491. doi:
10.1001/jamanetworkopen.2020.23491. [PMID: 33201232] - Aysha Sarfraz Rizvi, Ghulam Murtaza, Muhammad Irfan, Yin Xiao, Feng Qu. Determination of Kynurenine Enantiomers by Alpha-Cyclodextrin, Cationic-βeta-Cyclodextrin and Their Synergy Complemented with Stacking Enrichment in Capillary Electrophoresis.
Journal of chromatography. A.
2020 Jul; 1622(?):461128. doi:
10.1016/j.chroma.2020.461128. [PMID: 32331779] - Prabhat Tripathi, Liang Shuai, Himanshu Joshi, Hirohito Yamazaki, William H Fowle, Aleksei Aksimentiev, Hicham Fenniri, Meni Wanunu. Rosette Nanotube Porins as Ion Selective Transporters and Single-Molecule Sensors.
Journal of the American Chemical Society.
2020 01; 142(4):1680-1685. doi:
10.1021/jacs.9b10993. [PMID: 31913034] - Riya Sett, Bijan K Paul, Nikhil Guchhait. Unsaturation of the phospholipid side-chain influences its interaction with cyclodextrins: A spectroscopic exploration using a phenazinium dye.
Colloids and surfaces. B, Biointerfaces.
2019 Aug; 180(?):150-158. doi:
10.1016/j.colsurfb.2019.04.046. [PMID: 31048240] - Erica Bessell, Nicholas R Fuller, Tania P Markovic, Jessica Burk, Tegan Picone, Chelsea Hendy, Michelle M C Tan, Ian D Caterson. Effects of alpha-cyclodextrin on cholesterol control and Compound K on glycaemic control in people with pre-diabetes: Protocol for a Phase III randomized controlled trial.
Clinical obesity.
2019 Aug; 9(4):e12324. doi:
10.1111/cob.12324. [PMID: 31172667] - Mohammad Hasanzadeh, Elnaz Javidi, Abolghasem Jouyban, Ahad Mokhtarzadeh, Nasrin Shadjou, Soltanali Mahboob. Electrochemical recognition of taurine biomarker in unprocessed human plasma samples using silver nanoparticlebased nanocomposite: A new platform for early stage diagnosis of neurodegenerative diseases of the nervous system.
Journal of molecular recognition : JMR.
2018 12; 31(12):e2739. doi:
10.1002/jmr.2739. [PMID: 29956394] - Amir E Kaziem, Yunhao Gao, Yuan Zhang, Xueying Qin, Yanan Xiao, Yanhui Zhang, Hong You, Jianhong Li, Shun He. α-Amylase triggered carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella.
Journal of hazardous materials.
2018 10; 359(?):213-221. doi:
10.1016/j.jhazmat.2018.07.059. [PMID: 30036751] - Kelli A Lytle, Debra A Harteneck, Anthony M Noble, Michael D Jensen. The Soluble Fiber α-Cyclodextrin Does Not Increase the Fecal Losses of Dietary Fat in Adults-A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial.
The Journal of nutrition.
2018 09; 148(9):1421-1425. doi:
10.1093/jn/nxy135. [PMID: 30107536] - Mohammad Hasanzadeh, Nasrin Razmi, Ahad Mokhtarzadeh, Nasrin Shadjou, Soltanali Mahboob. Aptamer based assay of plated-derived grow factor in unprocessed human plasma sample and MCF-7 breast cancer cell lysates using gold nanoparticle supported α-cyclodextrin.
International journal of biological macromolecules.
2018 Mar; 108(?):69-80. doi:
10.1016/j.ijbiomac.2017.11.149. [PMID: 29180051] - Amir E Kaziem, Yunhao Gao, Shun He, Jianhong Li. Synthesis and Insecticidal Activity of Enzyme-Triggered Functionalized Hollow Mesoporous Silica for Controlled Release.
Journal of agricultural and food chemistry.
2017 Sep; 65(36):7854-7864. doi:
10.1021/acs.jafc.7b02560. [PMID: 28809107] - Toshihiro Sakurai, Akiko Sakurai, Ye Chen, Boris L Vaisman, Marcelo J Amar, Milton Pryor, Seth G Thacker, Xue Zhang, Xujing Wang, Yubo Zhang, Jun Zhu, Zhi-Hong Yang, Lita A Freeman, Alan T Remaley. Dietary α-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice.
Molecular nutrition & food research.
2017 08; 61(8):. doi:
10.1002/mnfr.201600804. [PMID: 28102587] - Li-Yang Cheng, Min Fang, Ai-Min Bai, Yu Ouyang, Yan-Jun Hu. Insights into the interaction of methotrexate and human serum albumin: A spectroscopic and molecular modeling approach.
Luminescence : the journal of biological and chemical luminescence.
2017 Aug; 32(5):873-879. doi:
10.1002/bio.3267. [PMID: 28071855] - Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzon. Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment.
BMC complementary and alternative medicine.
2017 Jul; 17(1):362. doi:
10.1186/s12906-017-1876-z. [PMID: 28705212] - Li-Zhong Hu, Ning Wan, Xi-Xi Ma, Zi-Wei Jing, Ya-Xuan Zhang, Chen Li, Si-Yuan Zhou, Bang-Le Zhang. Enhanced gene transfection performance and biocompatibility of polyethylenimine through pseudopolyrotaxane formation with α-cyclodextrin.
Nanotechnology.
2017 Mar; 28(12):125102. doi:
10.1088/1361-6528/aa5e56. [PMID: 28163261] - Ling-hao Qin, Duan-wen Cao, Shi-rong Pan, Jian-hai Chen. [Construction of serum-resistant cationic polymer α-CD-PAMAM and evaluation of its performances as gene delivery vector].
Yao xue xue bao = Acta pharmaceutica Sinica.
2017 01; 52(1):139-45. doi:
NULL. [PMID: 29911813] - Richard Van Krieken, Guang Chen, Bo Gao, Jolene Read, Hassan A Al Saleh, Renzhong Li, Khalid Al-Nedawi, Joan C Krepinsky. Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.
Cellular signalling.
2017 01; 29(?):158-167. doi:
10.1016/j.cellsig.2016.11.004. [PMID: 27826032] - Guangtao Li, JiHyun Kim, Zhen Huang, Johnna R St Clair, Deborah A Brown, Erwin London. Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids.
Proceedings of the National Academy of Sciences of the United States of America.
2016 12; 113(49):14025-14030. doi:
10.1073/pnas.1610705113. [PMID: 27872310] - Sulong Xiao, Qi Wang, Longlong Si, Xiaoshu Zhou, Yongmin Zhang, Lihe Zhang, Demin Zhou. Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors.
European journal of medicinal chemistry.
2016 Nov; 124(?):1-9. doi:
10.1016/j.ejmech.2016.08.020. [PMID: 27565552] - Marcelo J A Amar, Maryann Kaler, Amber B Courville, Robert Shamburek, Maureen Sampson, Alan T Remaley. Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids.
Lipids in health and disease.
2016 Jul; 15(1):115. doi:
10.1186/s12944-016-0284-6. [PMID: 27405337] - Miriana Durante, Marcello Salvatore Lenucci, Pier Paolo Marrese, Vito Rizzi, Monica De Caroli, Gabriella Piro, Paola Fini, Gian Luigi Russo, Giovanni Mita. Α-Cyclodextrin encapsulation of supercritical CO₂ extracted oleoresins from different plant matrices: A stability study.
Food chemistry.
2016 May; 199(?):684-93. doi:
10.1016/j.foodchem.2015.12.073. [PMID: 26776025] - Hiroyuki Inagaki, Ryouichi Ito, Yuko Setoguchi, Yukihiro Oritani, Tatsuhiko Ito. Administration of Piceatannol Complexed with α-Cyclodextrin Improves Its Absorption in Rats.
Journal of agricultural and food chemistry.
2016 May; 64(18):3557-63. doi:
10.1021/acs.jafc.6b00398. [PMID: 27078058] - M A Guevara, L L Bauer, K A Garleb, G C Fahey, M R C de Godoy. In vitro fermentation characteristics, in vivo ileal and total tract nutrient digestibilities, and fecal microbiota responses of dogs to α-cyclodextrin.
Journal of animal science.
2016 May; 94(5):2004-13. doi:
10.2527/jas.2015-9925. [PMID: 27285698] - Sergey Shityakov, Ramin Ekhteiari Salmas, Ellaine Salvador, Norbert Roewer, Jens Broscheit, Carola Förster. Evaluation of the potential toxicity of unmodified and modified cyclodextrins on murine blood-brain barrier endothelial cells.
The Journal of toxicological sciences.
2016 Apr; 41(2):175-84. doi:
10.2131/jts.41.175. [PMID: 26961601] - Ayumu Ohyama, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima. In Vitro and In Vivo Tumor-Targeting siRNA Delivery Using Folate-PEG-appended Dendrimer (G4)/α-Cyclodextrin Conjugates.
Bioconjugate chemistry.
2016 Mar; 27(3):521-32. doi:
10.1021/acs.bioconjchem.5b00545. [PMID: 26715308] - Zhongjun Zhao, Bo Wang, Yixiang Duan. Exploration of Microplasma Probe Desorption/Ionization Mass Spectrometry (MPPDI-MS) for Biologically Related Analysis.
Analytical chemistry.
2016 Feb; 88(3):1667-73. doi:
10.1021/acs.analchem.5b03671. [PMID: 26758529] - Eszter Róka, Zoltán Ujhelyi, Mária Deli, Alexandra Bocsik, Éva Fenyvesi, Lajos Szente, Ferenc Fenyvesi, Miklós Vecsernyés, Judit Váradi, Pálma Fehér, Rudolf Gesztelyi, Caroline Félix, Florent Perret, Ildikó Katalin Bácskay. Evaluation of the Cytotoxicity of α-Cyclodextrin Derivatives on the Caco-2 Cell Line and Human Erythrocytes.
Molecules (Basel, Switzerland).
2015 Nov; 20(11):20269-85. doi:
10.3390/molecules201119694. [PMID: 26569209] - Qing Shi, Lin Zhang, Mengyu Liu, Xuelin Zhang, Xiangjun Zhang, Xiaoqiu Xu, Sha Chen, Xiaohui Li, Jianxiang Zhang. Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells.
Biomaterials.
2015 Oct; 67(?):169-82. doi:
10.1016/j.biomaterials.2015.07.023. [PMID: 26218743] - Keiichi Motoyama, Ryosuke Mitsuyasu, Chiho Akao, Irhan Ibrahim Abu Hashim, Nana Sato, Takahiro Tanaka, Taishi Higashi, Hidetoshi Arima. Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis.
Molecular pharmaceutics.
2015 Sep; 12(9):3129-36. doi:
10.1021/mp500814f. [PMID: 26270769] - M A Guevara, L L Bauer, K A Garleb, G C Fahey, M R C de Godoy. Serum lipid profiles, total tract nutrient digestibility, and gastrointestinal tolerance by dogs of α-cyclodextrin.
Journal of animal science.
2015 May; 93(5):2201-7. doi:
10.2527/jas.2014-8442. [PMID: 26020316] - Mohd Younis Rather, Eva Nordberg Karlsson, Patrick Adlercreutz. Complexation of alkyl glycosides with α-cyclodextrin can have drastically different effects on their conversion by glycoside hydrolases.
Journal of biotechnology.
2015 Apr; 200(?):52-8. doi:
10.1016/j.jbiotec.2015.02.019. [PMID: 25711178] - Bent O Petersen, Mohammed Saddik Motawie, Birger Lindberg Møller, Ole Hindsgaul, Sebastian Meier. NMR characterization of chemically synthesized branched α-dextrin model compounds.
Carbohydrate research.
2015 Feb; 403(?):149-56. doi:
10.1016/j.carres.2014.05.011. [PMID: 24957577] - Jing Yu, Wei Ha, Jian-nan Sun, Yan-ping Shi. Supramolecular hybrid hydrogel based on host-guest interaction and its application in drug delivery.
ACS applied materials & interfaces.
2014 Nov; 6(22):19544-51. doi:
10.1021/am505649q. [PMID: 25372156] - Xue Li, Haiyan Li, Qun Xiao, Liuyi Wang, Manli Wang, Xiaolong Lu, Peter York, Senlin Shi, Jiwen Zhang. Two-way effects of surfactants on Pickering emulsions stabilized by the self-assembled microcrystals of α-cyclodextrin and oil.
Physical chemistry chemical physics : PCCP.
2014 Jul; 16(27):14059-69. doi:
10.1039/c4cp00807c. [PMID: 24901107] - Ting Yang, Ran Ji, Xin-Xing Deng, Fu-Sheng Du, Zi-Chen Li. Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation.
Soft matter.
2014 Apr; 10(15):2671-8. doi:
10.1039/c3sm53059k. [PMID: 24647364] - Eneko Larrañeta, Cristina Martínez-Ohárriz, Itziar Vélaz, Arantza Zornoza, Rubén Machín, José Ramón Isasi. In Vitro release from reverse poloxamine/α-cyclodextrin matrices: modelling and comparison of dissolution profiles.
Journal of pharmaceutical sciences.
2014 Jan; 103(1):197-206. doi:
10.1002/jps.23774. [PMID: 24338752] - M C Hamoudi, A Bochot. Oil-cyclodextrin based beads for oral delivery of poorly-soluble drugs.
Current topics in medicinal chemistry.
2014; 14(4):510-7. doi:
10.2174/1568026613666131219124539. [PMID: 24354669] - Patricia A Jarosz, Evan Fletcher, Eman Elserafy, Joseph D Artiss, K-L Catherine Jen. The effect of α-cyclodextrin on postprandial lipid and glycemic responses to a fat-containing meal.
Metabolism: clinical and experimental.
2013 Oct; 62(10):1443-7. doi:
10.1016/j.metabol.2013.05.015. [PMID: 23806736] - M C Hamoudi, J Saunier, C Gueutin, E Fattal, A Bochot. Beads made of α-cyclodextrin and soybean oil: the drying method influences bead properties and drug release.
Drug development and industrial pharmacy.
2013 Sep; 39(9):1306-14. doi:
10.3109/03639045.2012.727830. [PMID: 23050693] - Chuan Liu, Yani Xu, Hui Ouyang, Tao Yi. [Preparation and in vitro evaluation of self-assembled beads drug delivery system of berberine hydrochloride].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Jun; 38(12):1924-8. doi:
". [PMID: 24066585] - Yuya Hayashi, Taishi Higashi, Keiichi Motoyama, Yoshimasa Mori, Hirofumi Jono, Yukio Ando, Hidetoshi Arima. Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo.
Journal of drug targeting.
2013 May; 21(5):487-96. doi:
10.3109/1061186x.2013.769105. [PMID: 23570609] - Chuan Liu, Tao Yi. [Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils].
Yao xue xue bao = Acta pharmaceutica Sinica.
2012 Dec; 47(12):1582-6. doi:
". [PMID: 23460961] - Jianan Zhan, Anirudha Singh, Zhe Zhang, Ling Huang, Jennifer H Elisseeff. Multifunctional aliphatic polyester nanofibers for tissue engineering.
Biomatter.
2012 Oct; 2(4):202-12. doi:
10.4161/biom.22723. [PMID: 23507886] - M C Hamoudi, F Bourasset, V Domergue-Dupont, C Gueutin, V Nicolas, E Fattal, A Bochot. Formulations based on alpha cyclodextrin and soybean oil: an approach to modulate the oral release of lipophilic drugs.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Aug; 161(3):861-7. doi:
10.1016/j.jconrel.2012.05.032. [PMID: 22634090] - Hao Fan, Kun Zhao, Yan Lin, Xiaoyun Wang, Bo Wu, Qianggen Li, Lin Cheng. A new electrochemical biosensor for DNA detection based on molecular recognition and lead sulfide nanoparticles.
Analytical biochemistry.
2011 Dec; 419(2):168-72. doi:
10.1016/j.ab.2011.08.005. [PMID: 21871430] - Hidetoshi Arima, Toshihito Tsutsumi, Ayumi Yoshimatsu, Haruna Ikeda, Keiichi Motoyama, Taishi Higashi, Fumitoshi Hirayama, Kaneto Uekama. Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) on endogenous gene expression.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Oct; 44(3):375-84. doi:
10.1016/j.ejps.2011.08.019. [PMID: 21896329] - Diana Gentilcore, Lora Vanis, Jasmine C Teng, Judith M Wishart, Jonathan D Buckley, Christopher K Rayner, Michael Horowitz, Karen L Jones. The oligosaccharide α-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults.
The British journal of nutrition.
2011 Aug; 106(4):583-7. doi:
10.1017/s0007114511000444. [PMID: 21554816] - Kevin B Comerford, Joseph D Artiss, K L Catherine Jen, Sidika E Karakas. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans.
Obesity (Silver Spring, Md.).
2011 Jun; 19(6):1200-4. doi:
10.1038/oby.2010.280. [PMID: 21127475] - Edmond Kahn, Mauhamad Baarine, Aurélien Dauphin, Kévin Ragot, Nicolas Tissot, Alix Seguin, Franck Ménétrier, Zilal Kattan, Claude-Marie Bachelet, Frédérique Frouin, Gérard Lizard. Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2011 Apr; 79(4):293-305. doi:
10.1002/cyto.a.21017. [PMID: 21381190] - Dong Ma, Kai Tu, Li-Ming Zhang. Bioactive supramolecular hydrogel with controlled dual drug release characteristics.
Biomacromolecules.
2010 Sep; 11(9):2204-12. doi:
10.1021/bm100676a. [PMID: 20831271] - Srinivas Maddi, Madhusudan Rao Yamsani, Andreas Seeling, Gerhard K E Scriba. Stereoselective plasma protein binding of amlodipine.
Chirality.
2010 Feb; 22(2):262-6. doi:
10.1002/chir.20738. [PMID: 19496159] - Keiichi Motoyama, Kazuhisa Kameyama, Risako Onodera, Norie Araki, Fumitoshi Hirayama, Kaneto Uekama, Hidetoshi Arima. Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-beta-cyclodextrin, not 2,6-di-O-methyl-alpha-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2009 Oct; 38(3):249-61. doi:
10.1016/j.ejps.2009.07.010. [PMID: 19664706] - Motoki Inoue, Kaname Hashizaki, Hiroyuki Taguchi, Yoshihiro Saito. Preparation and characterization of n-alkane/water emulsion stabilized by cyclodextrin.
Journal of oleo science.
2009; 58(2):85-90. doi:
10.5650/jos.58.85. [PMID: 19145062] - Elke Maria Wagner, Kai-Lin Catherine Jen, Joseph Donald Artiss, Alan Thomas Remaley. Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty acid profile in low-density lipoprotein receptor knockout mice on a high-fat diet.
Metabolism: clinical and experimental.
2008 Aug; 57(8):1046-51. doi:
10.1016/j.metabol.2008.02.020. [PMID: 18640380] - Carolyn M Klinge, Nalinie S Wickramasinghe, Margarita M Ivanova, Susan M Dougherty. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2008 Jul; 22(7):2185-97. doi:
10.1096/fj.07-103366. [PMID: 18296501] - L Trichard, E Fattal, G Le Bas, D Duchêne, J-L Grossiord, A Bochot. Formulation and characterisation of beads prepared from natural cyclodextrins and vegetable, mineral or synthetic oils.
International journal of pharmaceutics.
2008 Apr; 354(1-2):88-94. doi:
10.1016/j.ijpharm.2007.10.029. [PMID: 18063325] - Laury Trichard, M Begoña Delgado-Charro, Richard H Guy, Elias Fattal, Amélie Bochot. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug.
Pharmaceutical research.
2008 Feb; 25(2):435-40. doi:
10.1007/s11095-007-9395-0. [PMID: 17671830] - Toshihito Tsutsumi, Fumitoshi Hirayama, Kaneto Uekama, Hidetoshi Arima. Evaluation of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA).
Journal of controlled release : official journal of the Controlled Release Society.
2007 Jun; 119(3):349-59. doi:
10.1016/j.jconrel.2007.03.013. [PMID: 17477999] - Manuel Ferrer, Ana Beloqui, Olga V Golyshina, Francisco J Plou, Alexander Neef, Tatyana N Chernikova, Lucia Fernández-Arrojo, Iraj Ghazi, Antonio Ballesteros, Kieran Elborough, Kenneth N Timmis, Peter N Golyshin. Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome.
Biotechnology journal.
2007 Feb; 2(2):207-13. doi:
10.1002/biot.200600183. [PMID: 17238236] - Hidetoshi Arima, Yuko Chihara, Masayo Arizono, Shogo Yamashita, Koki Wada, Fumitoshi Hirayama, Kaneto Uekama. Enhancement of gene transfer activity mediated by mannosylated dendrimer/alpha-cyclodextrin conjugate (generation 3, G3).
Journal of controlled release : official journal of the Controlled Release Society.
2006 Nov; 116(1):64-74. doi:
10.1016/j.jconrel.2006.08.026. [PMID: 17083992] - Roy Ziblat, Vladislav Lirtsman, Dan Davidov, Benjamin Aroeti. Infrared surface plasmon resonance: a novel tool for real time sensing of variations in living cells.
Biophysical journal.
2006 Apr; 90(7):2592-9. doi:
10.1529/biophysj.105.072090. [PMID: 16399831] - Joseph D Artiss, Kathryn Brogan, Michelle Brucal, Marjan Moghaddam, K-L Catherine Jen. The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats.
Metabolism: clinical and experimental.
2006 Feb; 55(2):195-202. doi:
10.1016/j.metabol.2005.08.012. [PMID: 16423626] - Jonathan D Buckley, Alicia A Thorp, Karen J Murphy, Peter R C Howe. Dose-dependent inhibition of the post-prandial glycaemic response to a standard carbohydrate meal following incorporation of alpha-cyclodextrin.
Annals of nutrition & metabolism.
2006; 50(2):108-14. doi:
10.1159/000090498. [PMID: 16373993] - Catherine Vial, Richard J Evans. Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction.
The Journal of biological chemistry.
2005 Sep; 280(35):30705-11. doi:
10.1074/jbc.m504256200. [PMID: 16006561] - Koki Wada, Hidetoshi Arima, Toshihito Tsutsumi, Yuko Chihara, Kenjiro Hattori, Fumitoshi Hirayama, Kaneto Uekama. Improvement of gene delivery mediated by mannosylated dendrimer/alpha-cyclodextrin conjugates.
Journal of controlled release : official journal of the Controlled Release Society.
2005 May; 104(2):397-413. doi:
10.1016/j.jconrel.2005.02.016. [PMID: 15907588] - Koki Wada, Hidetoshi Arima, Toshihito Tsutsumi, Fumitoshi Hirayama, Kaneto Uekama. Enhancing effects of galactosylated dendrimer/alpha-cyclodextrin conjugates on gene transfer efficiency.
Biological & pharmaceutical bulletin.
2005 Mar; 28(3):500-5. doi:
10.1248/bpb.28.500. [PMID: 15744077] - V Monnaert, S Tilloy, H Bricout, L Fenart, R Cecchelli, E Monflier. Behavior of alpha-, beta-, and gamma-cyclodextrins and their derivatives on an in vitro model of blood-brain barrier.
The Journal of pharmacology and experimental therapeutics.
2004 Aug; 310(2):745-51. doi:
10.1124/jpet.104.067512. [PMID: 15082751] - B A R Lina, A Bär. Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs.
Regulatory toxicology and pharmacology : RTP.
2004 Jun; 39 Suppl 1(?):S27-33. doi:
10.1016/j.yrtph.2004.05.005. [PMID: 15265612] - B Van Ommen, A T H J De Bie, A Bär. Disposition of 14C-alpha-cyclodextrin in germ-free and conventional rats.
Regulatory toxicology and pharmacology : RTP.
2004 Jun; 39 Suppl 1(?):57-66. doi:
10.1016/j.yrtph.2004.05.011. [PMID: 15265616] - B A R Lina, A Bär. Subchronic oral toxicity studies with alpha-cyclodextrin in rats.
Regulatory toxicology and pharmacology : RTP.
2004 Jun; 39 Suppl 1(?):S14-26. doi:
10.1016/j.yrtph.2004.05.006. [PMID: 15265611] - M L Calabrò, S Tommasini, P Donato, D Raneri, R Stancanelli, P Ficarra, R Ficarra, C Costa, S Catania, C Rustichelli, G Gamberini. Effects of alpha- and beta-cyclodextrin complexation on the physico-chemical properties and antioxidant activity of some 3-hydroxyflavones.
Journal of pharmaceutical and biomedical analysis.
2004 Apr; 35(2):365-77. doi:
10.1016/j.jpba.2003.12.005. [PMID: 15063469] - José Antonio Castro-Hermida, Isabelle Pors, Francisco Otero-Espinar, Asteria Luzardo-Alvarez, Elvira Ares-Mazás, Christophe Chartier. Efficacy of alpha-cyclodextrin against experimental cryptosporidiosis in neonatal goats.
Veterinary parasitology.
2004 Feb; 120(1-2):35-41. doi:
10.1016/j.vetpar.2003.12.012. [PMID: 15019141] - Fumihiro Kihara, Hidetoshi Arima, Toshihito Tsutsumi, Fumitoshi Hirayama, Kaneto Uekama. In vitro and in vivo gene transfer by an optimized alpha-cyclodextrin conjugate with polyamidoamine dendrimer.
Bioconjugate chemistry.
2003 Mar; 14(2):342-50. doi:
10.1021/bc025613a. [PMID: 12643744] - Soichiro Nakamura, Akikazu Hatanaka. Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria.
Journal of agricultural and food chemistry.
2002 Dec; 50(26):7639-44. doi:
10.1021/jf025808c. [PMID: 12475283] - Kouji Kowari, Iori Hirosawa, Hirono Kurai, Naoki Utoguchi, Makiko Fujii, Yoshiteru Watanabe. Pharmacokinetics and pharmacodynamics of human chorionic gonadotropin (hCG) after rectal administration of hollow-type suppositories containing hCG.
Biological & pharmaceutical bulletin.
2002 May; 25(5):678-81. doi:
10.1248/bpb.25.678. [PMID: 12033516] - Hideki Yano, Fumitoshi Hirayama, Makoto Kamada, Hidetoshi Arima, Kaneto Uekama. Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration.
Journal of controlled release : official journal of the Controlled Release Society.
2002 Feb; 79(1-3):103-12. doi:
10.1016/s0168-3659(01)00532-6. [PMID: 11853922] - S Kaewprasert, M Okada, Y Aoyama. Nutritional effects of cyclodextrins on liver and serum lipids and cecal organic acids in rats.
Journal of nutritional science and vitaminology.
2001 Oct; 47(5):335-9. doi:
10.3177/jnsv.47.335. [PMID: 11814148] - M T Chiang, S Y Chang, C W Whang. Chiral analysis of baclofen by alpha-cyclodextrin-modified capillary electrophoresis and laser-induced fluorescence detection.
Electrophoresis.
2001 Jan; 22(1):123-7. doi:
10.1002/1522-2683(200101)22:1<123::aid-elps123>3.0.co;2-4. [PMID: 11197160] - L N Alfazema, S Howells, D Perrett. Optimised separation of endogenous urinary components using cyclodextrin-modified micellar electrokinetic capillary chromatography.
Electrophoresis.
2000 Jul; 21(12):2503-8. doi:
10.1002/1522-2683(20000701)21:12<2503::aid-elps2503>3.0.co;2-8. [PMID: 10939465] - Z E Jouni, J Zamora, M Snyder, W R Montfort, A Weichsel, M A Wells. alpha-cyclodextrin extracts diacylglycerol from insect high density lipoproteins.
Journal of lipid research.
2000 Jun; 41(6):933-9. doi:
10.1016/s0022-2275(20)32035-6. [PMID: 10828085] - W Hammes, C Bourscheidt, U Büchsler, G Stodt, H Bökens. Quantitative determination of alpha-cyclodextrin in human plasma by liquid chromatography/positive ion electrospray mass spectrometry.
Journal of mass spectrometry : JMS.
2000 Mar; 35(3):378-84. doi:
10.1002/(sici)1096-9888(200003)35:3<378::aid-jms945>3.0.co;2-m. [PMID: 10767767] - C Créminon, F Djedaïni-Pilard, R Vienet, C Péan, J M Grognet, J Grassi, B Perly, P Pradelles. A new specific enzyme immunoassay allowing an efficient pharmacokinetic evaluation of gamma-cyclodextrin after intravenous administration to rats.
Pharmaceutical research.
1999 Sep; 16(9):1407-11. doi:
10.1023/a:1018903109564. [PMID: 10496657] - M Egloff, D Léglise, L Duvillard, J Steinmetz, M J Boyer, A Ruelland, R Agher, I Beucler. [Multicenter evaluation on different analyzers of three methods for direct HDL-cholesterol assay].
Annales de biologie clinique.
1999 Sep; 57(5):561-72. doi:
NULL. [PMID: 10518058] - M Pajatsch, C Andersen, A Mathes, A Böck, R Benz, H Engelhardt. Properties of a cyclodextrin-specific, unusual porin from Klebsiella oxytoca.
The Journal of biological chemistry.
1999 Aug; 274(35):25159-66. doi:
10.1074/jbc.274.35.25159. [PMID: 10455198] - N Rifai, T G Cole, E Iannotti, T Law, M Macke, R Miller, D Dowd, D A Wiebe. Assessment of interlaboratory performance in external proficiency testing programs with a direct HDL-cholesterol assay.
Clinical chemistry.
1998 Jul; 44(7):1452-8. doi:
NULL. [PMID: 9665423] - M Ichimura, M Okamoto, S Mori, H Tohge, K Ochi, H Harada. Affinity isoelectric focusing of human serum apolipoprotein B-containing lipoproteins on agarose gels with cyclodextrins.
Electrophoresis.
1998 May; 19(5):687-91. doi:
10.1002/elps.1150190514. [PMID: 9629899] - H Sugiuchi, T Irie, Y Uji, T Ueno, T Chaen, K Uekama, H Okabe. Homogeneous assay for measuring low-density lipoprotein cholesterol in serum with triblock copolymer and alpha-cyclodextrin sulfate.
Clinical chemistry.
1998 Mar; 44(3):522-31. doi:
. [PMID: 9510857] - R Kizu, T Nakanishi, S Yamamoto, K Hayakawa, A Matsuzawa, M Eriguchi, Y Takeda, N Akiyama, Y Kidani. Significance of water solubility in the gastrointestinal absorption of trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)platinum(IV), an orally active antitumor platinum complex, and its analogs.
Anti-cancer drugs.
1998 Feb; 9(2):167-74. doi:
10.1097/00001813-199802000-00008. [PMID: 9510503] - N Yui, T Ooya, T Kumeno. Effect of biodegradable polyrotaxanes on platelet activation.
Bioconjugate chemistry.
1998 Jan; 9(1):118-25. doi:
10.1021/bc970189c. [PMID: 9460554] - J C Debouzy, F Fauvelle, S Crouzy, L Girault, Y Chapron, M Göschl, A Gadelle. Mechanism of alpha-cyclodextrin induced hemolysis. 2. A study of the factors controlling the association with serine-, ethanolamine-, and choline-phospholipids.
Journal of pharmaceutical sciences.
1998 Jan; 87(1):59-66. doi:
10.1021/js970180j. [PMID: 9452969] - F Fauvelle, J C Debouzy, S Crouzy, M Göschl, Y Chapron. Mechanism of alpha-cyclodextrin-induced hemolysis. 1. The two-step extraction of phosphatidylinositol from the membrane.
Journal of pharmaceutical sciences.
1997 Aug; 86(8):935-43. doi:
10.1021/js9602453. [PMID: 9269872] - C Kim, W C MacKellar, N M Cho, S R Byrn, D J Morré. Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture. Identification of binding proteins from sera of cancer patients.
Biochimica et biophysica acta.
1997 Mar; 1324(2):171-81. doi:
10.1016/s0005-2736(96)00219-2. [PMID: 9092704] - J Liu, S F Li. Systematic multivariate optimization of separation of auxins by capillary electrophoresis based on overlapping resolution mapping scheme.
Biomedical chromatography : BMC.
1997 Jan; 11(1):1-6. doi:
10.1002/(sici)1099-0801(199701)11:1<1::aid-bmc606>3.0.co;2-#. [PMID: 9051206] - L Koetzner, R L Riggs, J Mastropaolo, S I Deutsch. Selective cyclodextrin inhibition of alfaxolone-induced ataxia.
The Journal of pharmacy and pharmacology.
1996 May; 48(5):529-31. doi:
10.1111/j.2042-7158.1996.tb05968.x. [PMID: 8799881]