(2-Hydroxyethoxy)acetic acid (BioDeep_00000171699)

   

human metabolite blood metabolite


代谢物信息卡片


2-(2-hydroxyethoxy)acetic acid

化学式: C4H8O4 (120.0422568)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 79.27%

分子结构信息

SMILES: C(COCC(=O)O)O
InChI: InChI=1S/C4H8O4/c5-1-2-8-3-4(6)7/h5H,1-3H2,(H,6,7)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Tomáš Hložek, Miroslava Bursová, Pavel Coufal, Radomír Čabala. Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):16-21. doi: 10.1016/j.jpba.2015.04.039. [PMID: 26001161]
  • J G Schier, D R Hunt, A Perala, K E McMartin, M J Bartels, L S Lewis, M A McGeehin, W D Flanders. Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. Clinical toxicology (Philadelphia, Pa.). 2013 Dec; 51(10):923-9. doi: 10.3109/15563650.2013.850504. [PMID: 24266434]
  • Elisabeth Eckert, Wolfgang Gries, Thomas Göen, Gabriele Leng. Reliable quantitation of β-hydroxyethoxyacetic acid in human urine by an isotope-dilution GC-MS procedure. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Sep; 935(?):80-4. doi: 10.1016/j.jchromb.2013.07.017. [PMID: 23954659]
  • Christopher O Hoyte, Jerrold B Leikin. Management of diethylene glycol ingestion. Clinical toxicology (Philadelphia, Pa.). 2012 Jul; 50(6):525-7. doi: 10.3109/15563650.2012.696199. [PMID: 22694101]
  • Greg M Landry, Sarah Martin, Kenneth E McMartin. Diglycolic acid is the nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Nov; 124(1):35-44. doi: 10.1093/toxsci/kfr204. [PMID: 21856646]
  • Lauren M Besenhofer, Marie C McLaren, Brian Latimer, Michael Bartels, Mark J Filary, Adam W Perala, Kenneth E McMartin. Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Oct; 123(2):374-83. doi: 10.1093/toxsci/kfr197. [PMID: 21804082]
  • Leo J Schep, Robin J Slaughter, Wayne A Temple, D Michael G Beasley. Diethylene glycol poisoning. Clinical toxicology (Philadelphia, Pa.). 2009 Jul; 47(6):525-35. doi: 10.1080/15563650903086444. [PMID: 19586352]
  • Lisa M Sweeney, Karla D Thrall, Torka S Poet, Richard A Corley, Thomas J Weber, Betty J Locey, Jacquelyn Clarkson, Shawn Sager, Michael L Gargas. Physiologically based pharmacokinetic modeling of 1,4-Dioxane in rats, mice, and humans. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Jan; 101(1):32-50. doi: 10.1093/toxsci/kfm251. [PMID: 17897969]
  • J M Mathews, M K Parker, H B Matthews. Metabolism and disposition of diethylene glycol in rat and dog. Drug metabolism and disposition: the biological fate of chemicals. 1991 Nov; 19(6):1066-70. doi: NULL. [PMID: 1687012]
  • A Puigvert, D Ruano. [Etiopathogenesis of so-called congenital hydronephrosis]. Journal d'urologie et de nephrologie. 1979 Jan; 85(1-2):1-12. doi: NULL. [PMID: 439196]
  • W H Braun. Rapid method for the simultaneous determination of 1,4-dioxan and its major metabolite, beta-hydroxyethoxyacetic acid, concentrations in plasma and urine. Journal of chromatography. 1977 Mar; 133(2):263-6. doi: 10.1016/s0021-9673(00)83482-2. [PMID: 838808]
  • J D Young, W H Braun, P J Gehring, B S Horvath, R L Daniel. 1,4-Dioxane and beta-hydroxyethoxyacetic acid excretion in urine of humans exposed to dioxane vapors. Toxicology and applied pharmacology. 1976 Dec; 38(3):643-6. doi: 10.1016/0041-008x(76)90195-2. [PMID: 1014018]