(18E)-20-Methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid (BioDeep_00000171548)

   

human metabolite blood metabolite natural product


代谢物信息卡片


(18E)-20-Methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid

化学式: C25H30O4 (394.214398)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: COC(=O)/C=C/C(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC(=O)O
InChI: InChI=1S/C25H30O4/c1-20(12-8-14-22(3)16-18-24(26)27)10-6-7-11-21(2)13-9-15-23(4)17-19-25(28)29-5/h6-19H,1-5H3,(H,26,27)

描述信息

同义名列表

4 个代谢物同义名

(18E)-20-Methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid; (18E)-20-Methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoate; 20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid; 20-Methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoate



数据库引用编号

6 个数据库交叉引用编号

  • PubChem: 91556
  • HMDB: HMDB0242302
  • chemspider: 82669
  • LOTUS: LTS0142408
  • wikidata: Q105232576
  • LOTUS: LTS0062824

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kleiton Lima de Godoy Machado, Daniele Vidal Faria, Marcos Bruno Silva Duarte, Lázara Aline Simões Silva, Tadeu Dos Reis de Oliveira, Thais Castilho Arruda Falcão, Diego Silva Batista, Marcio Gilberto Cardoso Costa, Claudete Santa-Catarina, Vanildo Silveira, Elisson Romanel, Wagner Campos Otoni, Fabio Tebaldi Silveira Nogueira. Plant age-dependent dynamics of annatto pigment (bixin) biosynthesis in Bixa orellana L. Journal of experimental botany. 2023 Nov; ?(?):. doi: 10.1093/jxb/erad458. [PMID: 37975812]
  • Asma Ashraf, Muhammad Umar Ijaz, Saima Muzammil, Muhammad Muzammil Nazir, Saima Zafar, S M Neamul Kabir Zihad, Shaikh Jamal Uddin, Md Saquib Hasnain, Amit Kumar Nayak. The role of bixin as antioxidant, anti-inflammatory, anticancer, and skin protecting natural product extracted from Bixa orellana L. Fitoterapia. 2023 Jul; 169(?):105612. doi: 10.1016/j.fitote.2023.105612. [PMID: 37454777]
  • Ayesheh Enayati, Atefe Rezaei, Seid Reza Falsafi, Hadis Rostamabadi, Narjes Malekjani, Sahar Akhavan-Mahdavi, Mohammad Saeed Kharazmi, Seid Mahdi Jafari. Bixin-loaded colloidal nanodelivery systems, techniques and applications. Food chemistry. 2023 Jan; 412(?):135479. doi: 10.1016/j.foodchem.2023.135479. [PMID: 36709686]
  • Lia Kusmita, Yuvianti Dwi Franyoto, Mutmainah Mutmainah, Ika Puspitaningrum, Agustina D R Nurcahyanti. Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro. Natural product research. 2022 Dec; 36(24):6421-6427. doi: 10.1080/14786419.2022.2036144. [PMID: 35133226]
  • Alexia Thamara Gasparin, Evelize Stacoviaki Rosa, Carlos Henrique Alves Jesus, Izonete Cristina Guiloski, Helena Cristina da Silva de Assis, Olair Carlos Beltrame, Rosângela Locatelli Dittrich, Samanta Daliana Golin Pacheco, Janaina Menezes Zanoveli, Joice Maria da Cunha. Bixin attenuates mechanical allodynia, anxious and depressive-like behaviors associated with experimental diabetes counteracting oxidative stress and glycated hemoglobin. Brain research. 2021 09; 1767(?):147557. doi: 10.1016/j.brainres.2021.147557. [PMID: 34107278]
  • Qian Lou, Xiangdong Pu, Jingyuan Song. [Advances in the biosynthesis and application of bixin]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2021 Jun; 37(6):1986-1997. doi: 10.13345/j.cjb.200724. [PMID: 34227289]
  • Darío R Gómez-Linton, Silvestre Alavez, Arturo Navarro-Ocaña, Angélica Román-Guerrero, Luis Pinzón-López, Laura J Pérez-Flores. Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ-tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans. Planta medica. 2021 Apr; 87(5):368-374. doi: 10.1055/a-1266-6674. [PMID: 33124008]
  • Ana María Naranjo-Durán, Julián Quintero-Quiroz, John Rojas-Camargo, Gelmy Luz Ciro-Gómez. Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques. Scientific reports. 2021 01; 11(1):1317. doi: 10.1038/s41598-020-80119-1. [PMID: 33446706]
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  • Jianzhong Li, Youjing Yang, Shuhui Wei, Ling Chen, Lian Xue, Hailin Tian, Shasha Tao. Bixin Confers Prevention against Ureteral Obstruction-Caused Renal Interstitial Fibrosis through Activation of the Nuclear Factor Erythroid-2-Related Factor2 Pathway in Mice. Journal of agricultural and food chemistry. 2020 Aug; 68(31):8321-8329. doi: 10.1021/acs.jafc.0c03674. [PMID: 32706966]
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  • Anissa Algara Beni, Renata Fritzsche Rodrigues, Lisiane Conte, Isabella Ferreira Costa, Érika Aparecida Delalibera, Miguel Roehrs, Cristine Rampelotto, Tatiana Emanuelli, Sabrina Somacal. Dietary supplementation with annatto food-coloring extracts increases the resistance of human erythrocytes to hemolysis. Nutrition research (New York, N.Y.). 2020 04; 76(?):71-81. doi: 10.1016/j.nutres.2020.02.003. [PMID: 32217378]
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  • Raimundo Gonçalves de Oliveira Júnior, Antoine Bonnet, Estelle Braconnier, Hugo Groult, Grégoire Prunier, Laureen Beaugeard, Raphäel Grougnet, Jackson Roberto Guedes da Silva Almeida, Christiane Adrielly Alves Ferraz, Laurent Picot. Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Mar; 125(?):549-561. doi: 10.1016/j.fct.2019.02.013. [PMID: 30738990]
  • Ana Delia Pinzón-García, Laura Alejandra Ariza Orellano, Marcela Guimarães Takahashi de Lazari, Paula Peixoto Campos, Maria Esperanza Cortes, Ruben Dario Sinisterra. Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the Bixin and Bixin: β-CD inclusion compound in high-fat-fed obese mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):363-372. doi: 10.1016/j.biopha.2018.06.144. [PMID: 29966982]
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  • Sankari Mohan, Hridya Hemachandran, P Sneha, C George Priya Doss, J Godwin Christopher, Gurunathan Jayaraman, Siva Ramamoorthy. Structural insights into the binding mode and conformational changes of BSA induced by bixin and crocin. Journal of biomolecular structure & dynamics. 2018 Jun; 36(8):2085-2098. doi: 10.1080/07391102.2017.1342565. [PMID: 28665186]
  • Montserrat Rojo de la Vega, Andrea Krajisnik, Donna D Zhang, Georg T Wondrak. Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients. 2017 Dec; 9(12):. doi: 10.3390/nu9121371. [PMID: 29258247]
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  • Miguel Roehrs, Lisiane Conte, Dariane Trivisiol da Silva, Thiago Duarte, Luana Haselein Maurer, José Antonio Mainardi de Carvalho, Rafael Noal Moresco, Sabrina Somacal, Tatiana Emanuelli. Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects. Food research international (Ottawa, Ont.). 2017 10; 100(Pt 1):771-779. doi: 10.1016/j.foodres.2017.08.005. [PMID: 28873749]
  • Sylvia C Alcázar-Alay, J Felipe Osorio-Tobón, Tânia Forster-Carneiro, M Angela A Meireles. Obtaining bixin from semi-defatted annatto seeds by a mechanical method and solvent extraction: Process integration and economic evaluation. Food research international (Ottawa, Ont.). 2017 09; 99(Pt 1):393-402. doi: 10.1016/j.foodres.2017.05.032. [PMID: 28784497]
  • Renata Pires Assis, Carlos Alberto Arcaro, Vânia Ortega Gutierres, Juliana Oriel Oliveira, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunetti. Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. International journal of molecular sciences. 2017 Mar; 18(4):. doi: 10.3390/ijms18040332. [PMID: 28333071]
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  • Madipatla Prathyusha Rao, Kopparam Manjunath, Siddalingappa Tippanna Bhagawati, Boreddy Shivanandappa Thippeswamy. Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation. International journal of pharmaceutics. 2014 Oct; 473(1-2):485-92. doi: 10.1016/j.ijpharm.2014.07.027. [PMID: 25066077]
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