(+)-Norgestrel (BioDeep_00000171510)
human metabolite blood metabolite
代谢物信息卡片
15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
化学式: C21H28O2 (312.2089188)
中文名称: 炔诺孕酮
谱图信息:
最多检出来源 Homo sapiens(blood) 5.26%
分子结构信息
SMILES: CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
InChI: InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3
描述信息
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:7630
- PubChem: 4542
- HMDB: HMDB0242257
- DrugBank: DB09389
- Wikipedia: Norgestrel
- MeSH: Norgestrel
- chemspider: 4383
- CAS: 6533-00-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Leo Han, Mitchell D Creinin, Agnes Hemon, Anna Glasier, Melissa J Chen, Alison Edelman. Mechanism of action of a 0.075 mg norgestrel progestogen-only pill 2. Effect on cervical mucus and theoretical risk of conception.
Contraception.
2022 Aug; 112(?):43-47. doi:
10.1016/j.contraception.2022.03.016. [PMID: 35367204] - Madhu Sanga, Subusola Vaughan, Julius Nangosyah, Veronika Scholz, Sergio Fonseca. Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life.
International journal of clinical pharmacology and therapeutics.
2022 Jan; 60(1):67-78. doi:
10.5414/cp204034. [PMID: 34779392] - Giovanni Grandi, Maria Chiara Del Savio, Fabio Facchinetti. The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism.
Expert review of clinical pharmacology.
2021 Feb; 14(2):211-224. doi:
10.1080/17512433.2021.1878876. [PMID: 33464138] - Concepción Guadarrama-García, Martiniano Bello, Marvin Soriano-Ursúa. Molecular insights into how SHBG dimerization exerts changes on ligand molecular recognition.
The Journal of steroid biochemistry and molecular biology.
2020 03; 197(?):105502. doi:
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CNS drugs.
2019 05; 33(5):513-522. doi:
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Ecotoxicology and environmental safety.
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Clinical pharmacology in drug development.
2017 Nov; 6(6):604-613. doi:
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2016 Jun; 30(6):287-94. doi:
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Talanta.
2016 May; 152(?):401-9. doi:
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2016 Apr; 1017-1018(?):1-9. doi:
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The Annals of pharmacotherapy.
2015 Jul; 49(7):784-9. doi:
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2014 Aug; 49(8):1175-80. doi:
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2014 Apr; 11(?):33. doi:
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Diabetes, obesity & metabolism.
2012 Dec; 14(12):1155-7. doi:
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2011 Apr; 36 Suppl 2(?):4-11. doi:
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Contraception.
2010 Mar; 81(3):209-14. doi:
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Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
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2006 Dec; 13(4):277-81. doi:
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Contraception.
2004 Nov; 70(5):371-7. doi:
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Fertility and sterility.
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Contraception.
2003 Jun; 67(6):467-71. doi:
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Contraception.
2003 Jun; 67(6):431-7. doi:
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The Journal of reproductive medicine.
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Contraception.
2003 Feb; 67(2):93-9. doi:
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Journal of endocrinological investigation.
2002 Oct; 25(9):765-8. doi:
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Contraception.
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