N6-Carboxymethyllysine (BioDeep_00000169756)

   

human metabolite blood metabolite natural product


代谢物信息卡片


(2S)-2-amino-6-[(carboxymethyl)amino]hexanoic acid

  化学式: C8H16N2O4 (204.111)
中文名称: N-ε-羧甲基-L-赖氨酸, N6-(羧甲基)-L-赖氨酸
  谱图信息: 最多检出来源 Homo sapiens(blood) 39.79%

分子结构信息

SMILES: C(CCNCC(=O)O)CC(C(=O)O)N
InChI: InChI=1S/C8H16N2O4/c9-6(8(13)14)3-1-2-4-10-5-7(11)12/h6,10H,1-5,9H2,(H,11,12)(H,13,14)/t6-/m0/s1


描述信息

N6-Carboxymethyllysine (CML), also known as epsilon-(carboxymethyl)lysine, belongs to the class of organic compounds known as L-alpha-amino acids. These are alpha-amino acids which have the L-configuration of the alpha-carbon atom. CML is a Maillard reaction product, or dietary advanced glycation end-products (d-AGE), formed as a result of the thermal treatment of foods. Due to its chemical stability and its ubiquity in foods and in vivo, CML is used as a biomarker for the ingestion of thermally treated foods. CML is metabolized by intestinal bacteria under anaerobic conditions (PMID: 31091091).

同义名列表

45 个代谢物同义名

(2S)-2-amino-6-[(carboxymethyl)amino]hexanoic acid; (2S)-2-Amino-6-(carboxymethylamino)hexanoic acid; N(epsilon)-Carboxymethyl-L-lysine; N(epsilon)-(Carboxymethyl)lysine; Nepsilon-Carboxymethyl-L-Lysine; N(epsilon)-Carboxymethyllysine; Nepsilon-(carboxymethyl)lysine; epsilon-(Carboxymethyl)lysine; N-epsilon-Carboxymethyllysine; N6-(Carboxymethyl)-L-lysine; N6-(Carboxymethyl)lysine; Nε-(carboxymethyl)lysine; N(6)-Carboxymethyllysine; N-Ε-carboxymethyllysine; Ε-(carboxymethyl)lysine; N6-Carboxymethyllysine; Carboxymethyl-lysine; Carboxymethyllysine; NECML; CML; NUXSIDPKKIEIMI-LURJTMIESA-N; UNII-70YDX3Z2O7; (2~{S})-2-azanyl-6-(2-hydroxy-2-oxoethylamino)hexanoic acid; (2S)-2-azaniumyl-6-(carboxylatomethylazaniumyl)hexanoate; (S)-2-Amino-6-((carboxymethyl)amino)hexanoic acid; (S)-2-Amino-6-((carboxymethyl)amino)hexanoicacid; (S)-2-Amino-6-(carboxymethylamino)hexanoic acid; 2-amino-6-((carboxymethyl)amino)hexanoic acid; 2-Amino-6-(carboxymethyk-amino)-hexanoic acid; 2-amino-6-[(carboxymethyl)amino]hexanoic acid; 70YDX3Z2O7; CML - carboxymethyl lysine; CML, N-epsilon-Carboxymethyl-L-lysine; L-Lysine, N6-(carboxymethyl)-; L-Lysine, N6-(carboxymethyl)-; Lysine, N6-(carboxymethyl)-, L- (8CI); N6-(Carboxymethyl)-L-lysine; N6-(Carboxymethyl)lysine; Ne-(Carboxymethyl)lysine; e-(Carboxymethyl)lysine; N epsilon -(1-Carboxymethyl)-L-lysine; N?-?(1-Carboxymethyl)-L-?lysine; N?-(1-Carboxymethyl)-L-lysine; N.EPSILON.-(CARBOXYMETHYL)LYSINE; n'-(carboxymethyl)lysine; N(6)-(carboxymethyl)-L-lysine; N(6)-carboxymethyl-L-lysine; N|A-(Carboxymethyl)-L-lysine; Ne-Carboxymethyl-L-lysine; NEpsilon-(1-Carboxymethyl)-L-lysine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Na Li, Xuan Wu, Hailong Liu, Diandong Xie, Shuqi Hao, Zeyu Lu, Wei Quan, Jie Chen, Huaide Xu, Mei Li. Effect of edible oil type on the formation of protein-bound Nε-(carboxymethyl)lysine in roasted pork patties. Food research international (Ottawa, Ont.). 2023 Dec; 174(Pt 1):113628. doi: 10.1016/j.foodres.2023.113628. [PMID: 37986479]
  • Silvia Tagliamonte, Antonio Dario Troise, Rosalia Ferracane, Paola Vitaglione. The Maillard reaction end product Nε-carboxymethyllysine is metabolized in humans and the urinary levels of the microbial metabolites are associated with individual diet. Food & function. 2023 Feb; 14(4):2074-2081. doi: 10.1039/d2fo03480h. [PMID: 36728638]
  • Le-Ying Li, Shuai Chen, Fei-Fei Li, Zhi-Ming Wu, Ying Shen, Feng-Hua Ding, Xiao-Qun Wang, Wei-Feng Shen, Qiu-Jing Chen, Yang Dai, Lin Lu. High serum levels of N-epsilon-carboxymethyllysine are associated with poor coronary collateralization in type 2 diabetic patients with chronic total occlusion of coronary artery. BMC cardiovascular disorders. 2022 06; 22(1):282. doi: 10.1186/s12872-022-02694-7. [PMID: 35733085]
  • Cynthia Helou, Matheus Thomaz Nogueira Silva Lima, Céline Niquet-Leridon, Philippe Jacolot, Eric Boulanger, Florian Delguste, Axel Guilbaud, Michael Genin, Pauline M Anton, Carine Delayre-Orthez, Tatiana Papazian, Michael Howsam, Frédéric J Tessier. Plasma Levels of Free NƐ-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091890. [PMID: 35565855]
  • Permal Deo, Varinderpal S Dhillon, Philip Thomas, Michael Fenech. The Association of Nε-Carboxymethyllysine With Polyunsaturated and Saturated Fatty Acids in Healthy Individuals. The journals of gerontology. Series A, Biological sciences and medical sciences. 2022 03; 77(3):462-470. doi: 10.1093/gerona/glab307. [PMID: 34628492]
  • Omar Mossad, Bérénice Batut, Bahtiyar Yilmaz, Nikolaos Dokalis, Charlotte Mezö, Elisa Nent, Lara Susann Nabavi, Melanie Mayer, Feres José Mocayar Maron, Joerg M Buescher, Mercedes Gomez de Agüero, Antal Szalay, Tim Lämmermann, Andrew J Macpherson, Stephanie C Ganal-Vonarburg, Rolf Backofen, Daniel Erny, Marco Prinz, Thomas Blank. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine. Nature neuroscience. 2022 03; 25(3):295-305. doi: 10.1038/s41593-022-01027-3. [PMID: 35241804]
  • Armand M A Linkens, Alfons J H M Houben, Abraham A Kroon, Miranda T Schram, Tos T J M Berendschot, Carroll A B Webers, Marleen van Greevenbroek, Ronald M A Henry, Bastiaan de Galan, Coen D A Stehouwer, Simone J M P Eussen, Casper G Schalkwijk. Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. The American journal of clinical nutrition. 2022 02; 115(2):444-455. doi: 10.1093/ajcn/nqab302. [PMID: 34581759]
  • Svetlana Baskal, Stefanos A Tsikas, Olga Begou, Alexander Bollenbach, Sigurd Lenzen, Anne Jörns, Dimitrios Tsikas. Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031541. [PMID: 35163462]
  • Boopathi Sowndhar Rajan, Kalaiselvi Krishnan, Elangovan Vellaichamy. Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin. Cardiovascular toxicology. 2022 01; 22(1):35-51. doi: 10.1007/s12012-021-09697-4. [PMID: 34655413]
  • Wenjun Liu, Yuqiang Ji, Weiwei Zhang, Fei Fang, Qin Cai, Ying Li. Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease. Computational intelligence and neuroscience. 2022; 2022(?):8970860. doi: 10.1155/2022/8970860. [PMID: 35720930]
  • Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpień-Golder. Advanced Glycation End-Products (AGEs) and Their Soluble Receptor (sRAGE) in Women Suffering from Systemic Lupus Erythematosus (SLE). Cells. 2021 12; 10(12):. doi: 10.3390/cells10123523. [PMID: 34944030]
  • Nani Wang, Pingcui Xu, Weixuan Yao, Jiali Zhang, Shufen Liu, Yongjun Wang, Yan Zhang. Structural elucidation and anti-diabetic osteoporotic activity of an arabinogalactan from Phellodendron chinense Schneid. Carbohydrate polymers. 2021 Nov; 271(?):118438. doi: 10.1016/j.carbpol.2021.118438. [PMID: 34364577]
  • Svetlana Baskal, Adrian Post, Daan Kremer, Alexander Bollenbach, Stephan J L Bakker, Dimitrios Tsikas. Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality. Amino acids. 2021 Nov; 53(11):1679-1693. doi: 10.1007/s00726-021-03091-8. [PMID: 34693489]
  • Qian Wu, Yuanyuan Chen, Yu Ouyang, Yi He, Juan Xiao, Liang Zhang, Nianjie Feng. Effect of catechin on dietary AGEs absorption and cytotoxicity in Caco-2 cells. Food chemistry. 2021 Sep; 355(?):129574. doi: 10.1016/j.foodchem.2021.129574. [PMID: 33799251]
  • Yong Li, Chaoyi Xue, Wei Quan, Fang Qin, Zhaojun Wang, Zhiyong He, Maomao Zeng, Jie Chen. Assessment the influence of salt and polyphosphate on protein oxidation and Nε-(carboxymethyl)lysine and Nε-(carboxyethyl)lysine formation in roasted beef patties. Meat science. 2021 Jul; 177(?):108489. doi: 10.1016/j.meatsci.2021.108489. [PMID: 33714683]
  • Elom K Aglago, Casper G Schalkwijk, Heinz Freisling, Veronika Fedirko, David J Hughes, Li Jiao, Christina C Dahm, Anja Olsen, Anne Tjønneland, Verena Katzke, Theron Johnson, Matthias B Schulze, Krasimira Aleksandrova, Giovanna Masala, Sabina Sieri, Vittorio Simeon, Rosario Tumino, Alessandra Macciotta, Bas Bueno-de-Mesquita, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, Paula Jakszyn, Maria-Jose Sánchez, Pilar Amiano, Sandra M Colorado-Yohar, Aurelio Barricarte Gurrea, Aurora Perez-Cornago, Ana-Lucia Mayén, Elisabete Weiderpass, Marc J Gunter, Alicia K Heath, Mazda Jenab. Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study. Carcinogenesis. 2021 05; 42(5):705-713. doi: 10.1093/carcin/bgab026. [PMID: 33780524]
  • Arvind M Korwar, Qibin Zhang. Comprehensive Quantification of Carboxymethyllysine-Modified Peptides in Human Plasma. Journal of the American Society for Mass Spectrometry. 2021 Mar; 32(3):744-752. doi: 10.1021/jasms.0c00443. [PMID: 33512994]
  • Wei Quan, Ye Jiao, Chaoyi Xue, Yong Li, Guoping Liu, Zhiyong He, Fang Qin, Maomao Zeng, Jie Chen. The Effect of Exogenous Free Nε-(Carboxymethyl)Lysine on Diabetic-Model Goto-Kakizaki Rats: Metabolomics Analysis in Serum and Urine. Journal of agricultural and food chemistry. 2021 Jan; 69(2):783-793. doi: 10.1021/acs.jafc.0c06445. [PMID: 33401897]
  • Hong Jin, Jing-Jing Ji, Yi Zhu, Xiao-Dong Wang, Yi-Ping Li, Qiu-Yin Shi, Yi-Fei Chen. Brain-Derived Neurotrophic Factor, a New Predictor of Coronary Artery Calcification. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2021 Jan; 27(?):1076029621989813. doi: 10.1177/1076029621989813. [PMID: 33523719]
  • Masaki Nakano, Yukio Nakamura, Takako Suzuki, Akiko Miyazaki, Jun Takahashi, Mitsuru Saito, Masataka Shiraki. Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers. Scientific reports. 2020 12; 10(1):22090. doi: 10.1038/s41598-020-78993-w. [PMID: 33328494]
  • Wei Zhang, Beibei Zhang, Yang Ye, Hongkai Zhu. Methylglyoxal-hydroimidazolones (MG-Hs) instead of Nɛ-(carboxymethyl)-l-lysine (CML) is the major advanced glycation end-product during drying process in black tea. Food chemistry. 2020 Dec; 333(?):127499. doi: 10.1016/j.foodchem.2020.127499. [PMID: 32673957]
  • Yuri Nomi, Hitomi Kudo, Kurenai Miyamoto, Tsuyoshi Okura, Kazuhiro Yamamoto, Hisashi Shimohiro, Sonoko Kitao, Yuichi Ito, Shigenobu Egawa, Kazuo Kawahara, Yuzuru Otsuka, Etsuko Ueta. Free advanced glycation end product distribution in blood components and the effect of genetic polymorphisms. Biochimie. 2020 Dec; 179(?):69-76. doi: 10.1016/j.biochi.2020.09.010. [PMID: 32946992]
  • Yoona Kim, Jennifer B Keogh, Permal Deo, Peter M Clifton. Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061767. [PMID: 32545555]
  • Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai, Tadashi Nishio. Immunohistochemistry of advanced glycation end product Nε-(carboxymethyl)lysine in coronary arteries in relation to cardiac fibrosis and serum N-terminal-pro basic natriuretic peptide in forensic autopsy cases. BMC research notes. 2020 May; 13(1):239. doi: 10.1186/s13104-020-05082-6. [PMID: 32398121]
  • Tianying Wu, Susan Kasper, Ronnie Meiyi Wong, Bruce Bracken. Identification of Differential Patterns of Oxidative Biomarkers in Prostate Cancer Progression. Clinical genitourinary cancer. 2020 04; 18(2):e174-e179. doi: 10.1016/j.clgc.2019.09.014. [PMID: 31899150]
  • Elaheh Foroumandi, Mohammad Alizadeh, Sorayya Kheirouri. Dietary quality index is negatively associated with serum advanced glycation end products in healthy adults. Clinical nutrition ESPEN. 2020 04; 36(?):111-115. doi: 10.1016/j.clnesp.2020.01.007. [PMID: 32220353]
  • Sarah Prestel, Bruna de Falco, Slim Blidi, Alberto Fiore, Keith Sturrock. Evaluation of the effect of berry extracts on carboxymethyllysine and lysine in ultra-high temperature treated milk. Food research international (Ottawa, Ont.). 2020 04; 130(?):108923. doi: 10.1016/j.foodres.2019.108923. [PMID: 32156371]
  • Dianwei Zhang, Yuzhen Wang, Huilin Liu. Corn silk extract inhibit the formation of Nε-carboxymethyllysine by scavenging glyoxal/methyl glyoxal in a casein glucose-fatty acid model system. Food chemistry. 2020 Mar; 309(?):125708. doi: 10.1016/j.foodchem.2019.125708. [PMID: 31683151]
  • Permal Deo, Caitlin L McCullough, Theodora Almond, Emma L Jaunay, Leigh Donnellan, Varinderpal S Dhillon, Michael Fenech. Dietary sugars and related endogenous advanced glycation end-products increase chromosomal DNA damage in WIL2-NS cells, measured using cytokinesis-block micronucleus cytome assay. Mutagenesis. 2020 03; 35(2):169-177. doi: 10.1093/mutage/geaa002. [PMID: 31971590]
  • Axel Guilbaud, Michael Howsam, Céline Niquet-Léridon, Florian Delguste, Marc Fremont, Sophie Lestavel, Patrice Maboudou, Anne Garat, Susanna Schraen, Brigitte Onraed, Benoît Foligné, Éric Boulanger, Frédéric J Tessier. The Effect of Lactobacillus fermentum ME-3 Treatment on Glycation and Diabetes Complications. Molecular nutrition & food research. 2020 03; 64(6):e1901018. doi: 10.1002/mnfr.201901018. [PMID: 31991062]
  • Jangho Lee, Ju-Yong Hyon, Jin Young Min, Yang Hoon Huh, Hyo Jung Kim, Hayoung Lee, Sung Ho Yun, Chi-Won Choi, Su Jeong Ha, Joon Park, Young-Ho Chung, Hye Gwang Jeong, Sang Keun Ha, Sung Keun Jung, YoonSook Kim, Eun Hee Han. Mitochondrial carnitine palmitoyltransferase 2 is involved in Nε-(carboxymethyl)-lysine-mediated diabetic nephropathy. Pharmacological research. 2020 02; 152(?):104600. doi: 10.1016/j.phrs.2019.104600. [PMID: 31838081]
  • Silvia de la Cruz-Ares, Magdalena P Cardelo, Francisco M Gutiérrez-Mariscal, José D Torres-Peña, Antonio García-Rios, Niki Katsiki, María M Malagón, José López-Miranda, Pablo Pérez-Martínez, Elena M Yubero-Serrano. Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study. Nutrients. 2020 Jan; 12(1):. doi: 10.3390/nu12010238. [PMID: 31963378]
  • Shahnawaz Rehman, Mohammad Faisal, Abdulrahman A Alatar, Saheem Ahmad. Physico-chemical Changes Induced in the Serum Proteins Immunoglobulin G and Fibrinogen Mediated by Methylglyoxal. Current protein & peptide science. 2020; 21(9):916-923. doi: 10.2174/1389203720666190618095719. [PMID: 31244422]
  • Patricia Budihartanti Liman, Rina Agustina, Ratna Djuwita, Jahja Umar, Inge Permadhi, Helmizar, Adi Hidayat, Edith J M Feskens, Murdani Abdullah. Dietary and Plasma Carboxymethyl Lysine and Tumor Necrosis Factor-α as Mediators of Body Mass Index and Waist Circumference among Women in Indonesia. Nutrients. 2019 Dec; 11(12):. doi: 10.3390/nu11123057. [PMID: 31847322]
  • Claudia V Quintanilla-García, Jaime Uribarri, Martha Eugenia Fajardo-Araujo, José Juan Barrientos-Romero, Gustavo Romero-Gutiérrez, Ma Guadalupe Reynaga-Ornelas, Ma Eugenia Garay-Sevilla. Changes in circulating levels of carboxymethyllysine, soluble receptor for advanced glycation end products (sRAGE), and inflammation markers in women during normal pregnancy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2019 Dec; 32(24):4102-4107. doi: 10.1080/14767058.2018.1481948. [PMID: 29804482]
  • Zongshuai Zhu, Yiqun Cheng, Suhong Huang, Mingjun Yao, Yang Lei, Iftikhar Ali Khan, Ming Huang, Xinghu Zhou. Formation of Nϵ-Carboxymethyllysine and Nϵ-Carboxyethyllysine in Prepared Chicken Breast by Pan Frying. Journal of food protection. 2019 Dec; 82(12):2154-2160. doi: 10.4315/0362-028x.jfp-19-319. [PMID: 31742439]
  • Alma Martinez Fernandez, Luca Regazzoni, Maura Brioschi, Erica Gianazza, Piergiuseppe Agostoni, Giancarlo Aldini, Cristina Banfi. Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes. Free radical biology & medicine. 2019 11; 144(?):245-255. doi: 10.1016/j.freeradbiomed.2019.06.023. [PMID: 31260731]
  • Enric Sánchez, Àngels Betriu, Andree Yeramian, Elvira Fernández, Francesc Purroy, Manuel Sánchez-de-la-Torre, Reinald Pamplona, Eva Miquel, Mohsen Kerkeni, Cristina Hernández, Rafael Simó, Albert Lecube, Marta Hernández, Ferran Rius, Dinora Polanco, Ferran Barbé, Gerard Torres, Guillermo Suárez, Manuel Portero-Otin, Mariona Jové, Laura Colàs-Campàs, Ikram Benabdelhak, Cristina Farràs, Marta Ortega, José Manuel Valdivielso, Marcelino Bermúdez-López, Montse Martínez-Alonso. Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project. Journal of atherosclerosis and thrombosis. 2019 Oct; 26(10):879-889. doi: 10.5551/jat.47498. [PMID: 30842389]
  • Chuan-Wei Yang, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Wen-Yuan Lin, Tsai-Chung Li, Cheng-Chieh Lin. Relationship among urinary advanced glycation-end products, skeletal muscle mass and physical performance in community-dwelling older adults. Geriatrics & gerontology international. 2019 Oct; 19(10):1017-1022. doi: 10.1111/ggi.13762. [PMID: 31522460]
  • Motetelo Alfred Mogale, Catherine Martha Mhlanga, Stanley Sechene Gololo, Agustine Adu. Ellisras Longitudinal Study 2017: elevated serum levels of carboxymethyl-lysine, an advanced glycation end-product, are associated with higher odds of developing endothelial dysfunction in black South African patients with type 2 diabetes mellitus (ELS 29). Cardiovascular journal of Africa. 2019 Jul; 30(4):193-197. doi: 10.5830/cvja-2018-060. [PMID: 31469381]
  • Ye Jiao, Jialiang He, Zhiyong He, Daming Gao, Fang Qin, Mingyong Xie, Maomao Zeng, Jie Chen. Formation of Nε-(carboxymethyl)lysine and Nε-(carboxyethyl)lysine during black tea processing. Food research international (Ottawa, Ont.). 2019 07; 121(?):738-745. doi: 10.1016/j.foodres.2018.12.051. [PMID: 31108804]
  • Zhongqun Wang, Zhengyang Bao, Yingpeng Ding, Suining Xu, Rongzeng Du, Jinchuan Yan, Lihua Li, Zhen Sun, Chen Shao, Wen Gu. Nε-carboxymethyl-lysine-induced PI3K/Akt signaling inhibition promotes foam cell apoptosis and atherosclerosis progression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jul; 115(?):108880. doi: 10.1016/j.biopha.2019.108880. [PMID: 31035012]
  • Yi-Xin Wang, Hao Xu, Xin Liu, Liang Liu, Yong-Ning Wu, Zhi-Yong Gong. Studies on mechanism of free Nε-(carboxymethyl)lysine-induced toxic injury in mice. Journal of biochemical and molecular toxicology. 2019 Jul; 33(7):e22322. doi: 10.1002/jbt.22322. [PMID: 30924232]
  • K Janšáková, E Lengyelová, N Pribulová, V Somoza, P Celec, K Šebeková, D Ostatníková, Ľ Tóthová. Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study. Physiological research. 2019 06; 68(3):467-479. doi: 10.33549/physiolres.934102. [PMID: 30904014]
  • Thi Phuong Nam Bui, Antonio Dario Troise, Vincenzo Fogliano, Willem M de Vos. Anaerobic Degradation of N-ε-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria. Journal of agricultural and food chemistry. 2019 Jun; 67(23):6594-6602. doi: 10.1021/acs.jafc.9b02208. [PMID: 31091091]
  • Emanuela Valle, Liviana Prola, Diana Vergnano, Roberta Borghi, Fiammetta Monacelli, Nicola Traverso, Natascia Bruni, Andrea Bovero, Achille Schiavone, Joana Nery, Domenico Bergero, Patrizio Odetti. Investigation of hallmarks of carbonyl stress and formation of end products in feline chronic kidney disease as markers of uraemic toxins. Journal of feline medicine and surgery. 2019 06; 21(6):465-474. doi: 10.1177/1098612x18783858. [PMID: 30015556]
  • Pei-Ying Pai, Mei-Chin Mong, Ya-Cheng Yang, Yin-Tso Liu, Zhi-Hong Wang, Mei-Chin Yin. Anti-Diabetic Effects of Gynura Bicolor Aqueous Extract in Mice. Journal of food science. 2019 Jun; 84(6):1631-1637. doi: 10.1111/1750-3841.14607. [PMID: 31059127]
  • Naomi J Rankin, Karl Burgess, Stefan Weidt, Goya Wannamethee, Naveed Sattar, Paul Welsh. High-throughput quantification of carboxymethyl lysine in serum and plasma using high-resolution accurate mass Orbitrap mass spectrometry. Annals of clinical biochemistry. 2019 05; 56(3):397-407. doi: 10.1177/0004563219830432. [PMID: 30832481]
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