Dimethylguanidino valeric acid (BioDeep_00000169692)

   

human metabolite blood metabolite


代谢物信息卡片


(alpha-keto-dimethyl-delta-N,N-Dimethylguanidynol)valeric acid

化学式: C8H15N3O3 (201.111336)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 1.25%

分子结构信息

SMILES: CN(C)/C(=N/CCCC(=O)C(=O)O)/N
InChI: InChI=1S/C8H15N3O3/c1-11(2)8(9)10-5-3-4-6(12)7(13)14/h3-5H2,1-2H3,(H2,9,10)(H,13,14)

描述信息

Dimethylguanidino valeric acid or DMGV is a product formed from the transamination of asymmetric dimethylarginine (ADMA) via the enzyme alanine-glyoxylate aminotransferase 2 (AGXT2). This pathway is involved in nitric oxide regulation. DMGV has been detected in both blood and urine (PMID:  21945966 ). More recently DMGV has been identified as an independent plasma biomarker of nonalcoholic fatty liver disease (NAFLD). Furthermore, plasma DMGV levels are correlated with biopsy-proven nonalcoholic steatohepatitis (NASH). Plasma DMGV levels have also been found to decline in parallel with improvements in post-procedure cardiometabolic parameters. Plasma DMGV levels have been shown to be able to predict the development of type 2 diabetes up to 12 years before disease onset (PMID: 29083323). Baseline plasma levels of DMGV have been shown to be positively associated with body fat percentage, abdominal visceral fat, very low-density lipoprotein cholesterol (VLDL), and triglycerides. Plasma levels of DMGV are inversely associated with insulin sensitivity, low-density lipoprotein cholesterol, high-density lipoprotein size, and high-density lipoprotein cholesterol (HDL). Overall, DMGV is associated with partial resistance to metabolic health benefits of regular exercise (PMID: 31166569).

同义名列表

21 个代谢物同义名

(alpha-keto-dimethyl-delta-N,N-Dimethylguanidynol)valeric acid; alpha-​keto-​delta-​(NG,​NG-​dimethylguanidino)​valeric acid; αlpha-​keto-​delta-​(NG,​NG-​dimethylguanidino)​valeric acid; (alpha-Keto-dimethyl-delta-N,N-dimethylguanidynol) valerate; (a-Keto-dimethyl-delta-N,N-dimethylguanidynol) valeric acid; (alpha-keto-dimethyl-delta-N,N-Dimethylguanidynol)valerate; 5-[[(dimethylamino)iminomethyl]amino]-2-oxopentanoic acid; (a-Keto-dimethyl-delta-N,N-dimethylguanidynol) valerate; (Α-keto-dimethyl-δ-N,N-dimethylguanidynol) valeric acid; 5-[[(dimethylamino)iminomethyl]amino]-2-oxopentanoate; α-​keto-​δ-​(NG,​NG-​dimethylguanidino)​valeric acid; 5-(N,N-dimethylcarbamimidamido)-2-oxopentanoic acid; (Α-keto-dimethyl-δ-N,N-dimethylguanidynol) valerate; 2-oxo-5-(3,3-Dimethylguanidine-1-yl)pentanoic acid; α-​keto-​δ-​(NG,​NG-​dimethylguanidino)​valerate; 2-oxo-5-(3,3-Dimethylguanidine-1-yl)pentanoate; Dimethylguanidino valeric acid; Dimethylguanidinovaleric acid; Dimethylguanidino valerate; Dimethylguanidinovalerate; DMGV



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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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