MeCbl (BioDeep_00000015899)
Secondary id: BioDeep_00000027797, BioDeep_00000410657, BioDeep_00001893206
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate
化学式: C63H91CoN13O14P (1343.5877716)
中文名称: 甲钴胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: NC(C[C@H]1[C@@]2([H])[C@]3(C)[N]4=C([C@@H](CCC(N)=O)[C@]3(C)CC(N)=O)C(C)=C([C@](CC(N)=O)(C)[C@@H]5CCC(N)=O)[N]6=C5C=C(C(C)(C)[C@@H]7CCC(N)=O)[N]8=C7C(C)=C([C@@]1(CCC(NC[C@@H](C)O9)=O)C)[N-]2[Co+3]486([CH3-])[N](C\%10=CC(C)=C(C)C=C\%11\%10)=CN\%11[C@@H](O[C@@H]\%12CO)[C@@](O)([H])[C@@H]\%12OP9([O-])=O)=O
InChI: -1
描述信息
Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.
同义名列表
18 个代谢物同义名
[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate; Methyl-5,6-dimethylbenzimidazolylcobalamin; Methylcob(III)alamin; CO-METHYLCOBALAMIN; Methyl vitamin B12; Methyl cobalamine; Methylcobalamin; Hitocobamin M; Methylcobaz; Mecobalamin; Methycobal; Methyl-B12; cobalt(3+); carbanide; Algobaz; MeCbl; CH3-B12; Methylcobalamin
数据库引用编号
10 个数据库交叉引用编号
- KEGG: C06453
- PubChem: 24892769
- PubChem: 6436232
- Metlin: METLIN63586
- CAS: 13422-55-4
- ChEBI: CHEBI:28115
- PubChem: 8686
- NIKKAJI: J1.706.550E
- medchemexpress: HY-B0586
- KNApSAcK: 28115
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Margot Cooreman-Algoed, Lieselot Boone, Evelien Uitterhaegen, Sue Ellen Taelman, Wouter De Soete, Jo Dewulf. Environmental life cycle assessment of nutraceuticals: A case study on methylcobalamin in different packaging types.
The Science of the total environment.
2023 Oct; 893(?):164780. doi:
10.1016/j.scitotenv.2023.164780. [PMID: 37302605] - Chang-Woo Lee, Joon-Soo Jin, Seungwon Kwon, Chul Jin, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho. Are herbal medicines alone or in combination for diabetic peripheral neuropathy more effective than methylcobalamin alone? A systematic review and meta-analysis.
Complementary therapies in clinical practice.
2022 Nov; 49(?):101657. doi:
10.1016/j.ctcp.2022.101657. [PMID: 36007447] - Adela Čorejová, Tomáš Fazekaš, Daniela Jánošíková, Juraj Repiský, Veronika Pospíšilová, Maria Miková, Drahomíra Rauová, Daniela Ostatníková, Ján Kyselovič, Anna Hrabovská. Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration.
Nutrients.
2022 May; 14(10):. doi:
10.3390/nu14102035. [PMID: 35631176] - Betül Orhan Kiliç, Serhat Kiliç, Elif Şahin Eroğlu, Eylem Gül, Fatma Burcu Belen Apak. Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 0-3 years.
Hematology (Amsterdam, Netherlands).
2021 Dec; 26(1):1013-1017. doi:
10.1080/16078454.2021.2010877. [PMID: 34871525] - Rajdeep Kaur, Savita Verma Attri, Arushi Gahlot Saini, Naveen Sankhyan. A high frequency and geographical distribution of MMACHC R132* mutation in children with cobalamin C defect.
Amino acids.
2021 Feb; 53(2):253-264. doi:
10.1007/s00726-021-02942-8. [PMID: 33515116] - Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Eleni Margariti, Parthena Giannoulaki, Georgios Batanis, Solomon Tesfaye, Kοnstantinos Kantartzis. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020395. [PMID: 33513879] - Zhiyuan Deng, Manjia Wang, Yaohua Fan, Min Liu. Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with mecobalamin for treating diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.
Medicine.
2021 Jan; 100(3):e24103. doi:
10.1097/md.0000000000024103. [PMID: 33546016] - Weihua Mai, Aisheng Wei, Xiaoxuan Lin, Funeng Wang, Jianhong Ye, Ping Chen. Efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.
Medicine.
2021 Jan; 100(1):e23702. doi:
10.1097/md.0000000000023702. [PMID: 33429738] - Ayşe Tuğba-Kartal, Zeynep Çağla-Mutlu. Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion.
2020 12; 72(6):380-385. doi:
10.24875/ric.20000208. [PMID: 33053572] - Koichiro Hotta, Yue Wang, Yuji Mano. A sensitive bioanalytical assay for methylcobalamin, an endogenous and light-labile substance, in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2020 Nov; 191(?):113621. doi:
10.1016/j.jpba.2020.113621. [PMID: 32966937] - Timothy Kwok, Yuanyuan Wu, Jenny Lee, Ruby Lee, Cho Yiu Yung, Grace Choi, Vivian Lee, John Harrison, Linda Lam, Vincent Mok. A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients.
Clinical nutrition (Edinburgh, Scotland).
2020 08; 39(8):2399-2405. doi:
10.1016/j.clnu.2019.11.005. [PMID: 31787369] - Guo-Bin Sheng, Hang Su, Hui-Ling Li, Rui Bao, Gang Liu, Ying Kong, Ying Tang. [Effect of electro-nape-acupuncture on hearing in patients with refractory flat descending idiopathic sudden sensorineural hearing loss].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2020 Jul; 40(7):726-30. doi:
10.13703/j.0255-2930.20190614-k0002. [PMID: 32648396] - Chen Chen, Moxian Chen, Cong Cheng, Yun Chi, Zhiliang Hu, Yuan Liu, Shan Huang, Yanling Lv, Chongfeng Liang, Damin Jiao, Yongxiang Yi, Xia Zhang, Wenkui Sun, Hongxia Wei. A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases.
Journal of neurovirology.
2020 06; 26(3):456-458. doi:
10.1007/s13365-020-00849-w. [PMID: 32424616] - Jun Ni, Caifeng Zhu, Xiaoqiu Ni, Jiazhen Yin. IgA nephropathy associated with thalassemia: a case report.
BMC nephrology.
2020 05; 21(1):182. doi:
10.1186/s12882-020-01844-3. [PMID: 32410665] - Xuke Han, Yang Gao, Shengju Wang, Qiu Chen. Effect of electroacupuncture on diabetic neurogenic bladder: A randomized controlled trial protocol.
Medicine.
2020 Apr; 99(17):e19843. doi:
10.1097/md.0000000000019843. [PMID: 32332636] - Doreen Schmidl, Kinga Howorka, Stephan Szegedi, Kristina Stjepanek, Stefan Puchner, Ahmed Bata, Ulrike Scheschy, Gerold Aschinger, René M Werkmeister, Leopold Schmetterer, Gerhard Garhofer. A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.
Molecular vision.
2020; 26(?):326-333. doi:
. [PMID: 32355442] - Marjorie G Garrod, Heidi A Rossow, Christopher C Calvert, Joshua W Miller, Ralph Green, Bruce A Buchholz, Lindsay H Allen. 14C-Cobalamin Absorption from Endogenously Labeled Chicken Eggs Assessed in Humans Using Accelerator Mass Spectrometry.
Nutrients.
2019 Sep; 11(9):. doi:
10.3390/nu11092148. [PMID: 31500393] - Junling Cui, Yuanyuan Wang, Huifeng Zhang, Xiaopu Cui, Lihui Wang, Huacheng Zheng. Isolated subacute combined degeneration in late-onset cobalamin C deficiency in children: Two case reports and literature review.
Medicine.
2019 Sep; 98(39):e17334. doi:
10.1097/md.0000000000017334. [PMID: 31574870] - Wei Sun, Guangsheng Li, Zhaohui Lai, Zhijuan Lu, Ye Lin, Jidong Peng, Jinchang Huang, Kun Hu. Subacute Combined Degeneration of the Spinal Cord and Hydrocephalus Associated with Vitamin B12 Deficiency.
World neurosurgery.
2019 Aug; 128(?):277-283. doi:
10.1016/j.wneu.2019.05.008. [PMID: 31082549] - Kendice Ip, Daniel Banov, Gus Bassani, Latisha Morgan. Physicochemical Stability of Extemporaneously Prepared Methylcobalamin Injections in the Presence and Absence of Preservative and the Impact of Light Exposure.
International journal of pharmaceutical compounding.
2019 Mar; 23(2):167-175. doi:
NULL. [PMID: 31085783] - De-Qi Jiang, Shi-Hua Zhao, Ming-Xing Li, Li-Lin Jiang, Yong Wang, Yan Wang. Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials.
Medicine.
2018 Nov; 97(44):e13020. doi:
10.1097/md.0000000000013020. [PMID: 30383660] - Eva Greibe, Linda S Kornerup, Christian B Juul, Sergey N Fedosov, Christian W Heegaard, Ebba Nexo. The tissue profile of metabolically active coenzyme forms of vitamin B12 differs in vitamin B12-depleted rats treated with hydroxo-B12 or cyano-B12.
The British journal of nutrition.
2018 07; 120(1):49-56. doi:
10.1017/s000711451800123x. [PMID: 29936920] - J Y Xu, H Y Gao. Combined treatment of traditional Chinese medicine and western medicine in the treatment of diabetic peripheral neuropathy.
Journal of biological regulators and homeostatic agents.
2018 Jul; 32(4):945-949. doi:
". [PMID: 30043582] - Madelyn C Huang, Christelle Douillet, Ellen N Dover, Miroslav Stýblo. Prenatal arsenic exposure and dietary folate and methylcobalamin supplementation alter the metabolic phenotype of C57BL/6J mice in a sex-specific manner.
Archives of toxicology.
2018 06; 92(6):1925-1937. doi:
10.1007/s00204-018-2206-z. [PMID: 29721587] - Meixia Yuan, Beiyun Wang, Shijin Tan. Mecobalamin and early functional outcomes of ischemic stroke patients with H-type hypertension.
Revista da Associacao Medica Brasileira (1992).
2018 May; 64(5):428-432. doi:
10.1590/1806-9282.64.05.428. [PMID: 30304141] - Tsutomu Shishido, Yuki Hiroshima, Nozomu Uematsu, Hiroko Kazumoto, Hiroko Kaiume, Takehiko Kirihara, Wataru Takeda, Toshimitsu Ueki, Masahiko Sumi, Hikaru Kobayashi. [Successful treatment with mecobalamin in a pernicious anemia patient presenting with false-normal serum vitamin B12].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2018 ; 59(6):675-681. doi:
10.11406/rinketsu.59.675. [PMID: 29973442] - Guoping Ye, Meiling Su, Dingyu Zhu, Linyun Zhang, Wang Lin, Li Huang, Mingxia Wu. [Effect of joss stick moxibustion combined with pricking and cupping for acute herpes zoster and its mechanism of analgesia].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Dec; 37(12):1289-93. doi:
10.13703/j.0255-2930.2017.12.010. [PMID: 29354993] - Zi Yong Ju, Ke Wang, Hua Shun Cui, Yibo Yao, Shi Min Liu, Jia Zhou, Tong Yu Chen, Jun Xia. Acupuncture for neuropathic pain in adults.
The Cochrane database of systematic reviews.
2017 12; 12(?):CD012057. doi:
10.1002/14651858.cd012057.pub2. [PMID: 29197180] - Koji Suzuki, Hiroyuki Tanaka, Mitsuhiro Ebara, Koichiro Uto, Hozo Matsuoka, Shunsuke Nishimoto, Kiyoshi Okada, Tsuyoshi Murase, Hideki Yoshikawa. Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional recovery in a rat sciatic nerve crush injury model.
Acta biomaterialia.
2017 04; 53(?):250-259. doi:
10.1016/j.actbio.2017.02.004. [PMID: 28179161] - Robert L Hendren, S Jill James, Felicia Widjaja, Brittany Lawton, Abram Rosenblatt, Stephen Bent. Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism.
Journal of child and adolescent psychopharmacology.
2016 11; 26(9):774-783. doi:
10.1089/cap.2015.0159. [PMID: 26889605] - Amber Parry-Strong, Fali Langdana, Sylvan Haeusler, Mark Weatherall, Jeremy Krebs. Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial.
The New Zealand medical journal.
2016 Jun; 129(1436):67-75. doi:
NULL. [PMID: 27355231] - J David Spence. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke.
Nutrition research (New York, N.Y.).
2016 Feb; 36(2):109-16. doi:
10.1016/j.nutres.2015.10.003. [PMID: 26597770] - Dongqiang Wang, Pingping Zhang, Zhijun Li, Ying Liu. [Effects of mecobalamin on Bax and Bcl-2 in neurons after peripheral nerve injury].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2015 Nov; 33(11):841-3. doi:
". [PMID: 26887269] - Ken Ikeda, Yasuo Iwasaki, Ryuji Kaji. Neuroprotective effect of ultra-high dose methylcobalamin in wobbler mouse model of amyotrophic lateral sclerosis.
Journal of the neurological sciences.
2015 Jul; 354(1-2):70-4. doi:
10.1016/j.jns.2015.04.052. [PMID: 25982504] - Kaifeng Hu, Williard J Werner, Kylie D Allen, Susan C Wang. Investigation of enzymatic C-P bond formation using multiple quantum HCP nuclear magnetic resonance spectroscopy.
Magnetic resonance in chemistry : MRC.
2015 Apr; 53(4):267-72. doi:
10.1002/mrc.4190. [PMID: 25594737] - Anantharajappa Kumudha, Sagaya Selvakumar, Pullancheri Dilshad, Gopal Vaidyanathan, Munna Singh Thakur, Ravi Sarada. Methylcobalamin--a form of vitamin B12 identified and characterised in Chlorella vulgaris.
Food chemistry.
2015 Mar; 170(?):316-20. doi:
10.1016/j.foodchem.2014.08.035. [PMID: 25306351] - Jie Liu, Bing Sun, Bo Ban, Mei Zhang, Hai-Ling Sun, Ping Li, Yan-Ying Li, Yan-Hong Zhang. [Treatment of type 2 diabetic peripheral neuropathy patients of qi-yin deficiency complicated phlegm-dampness blocking collaterals syndrome by internal application of qigui mixture and external application of qigui huoxue lotion: a clinical study].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2014 Sep; 34(9):1053-8. doi:
NULL. [PMID: 25335327] - Ling-Lian Yuan, Lian-Xin Wang, Yan-Ming Xie, Wei Yang, Zhi-Xin Yang, Yan Zhuang, Yun-Bi Zhang. [Analysis on clinical features and treatment of herpes zoster patients hospitalized in real world].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Sep; 39(18):3469-73. doi:
". [PMID: 25532379] - Shabnam Garg, Ashit Syngle, Kanchan Vohra. Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study.
The Clinical journal of pain.
2013 Aug; 29(8):717-24. doi:
10.1097/ajp.0b013e318272ebec. [PMID: 23354008] - Bridget Wilcken. Leukoencephalopathies associated with disorders of cobalamin and folate metabolism.
Seminars in neurology.
2012 Feb; 32(1):68-74. doi:
10.1055/s-0032-1306389. [PMID: 22422209] - Ashit Syngle, Kanchan Vohra, Nidhi Garg, Ladbans Kaur, Prem Chand. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis.
International journal of rheumatic diseases.
2012 Feb; 15(1):45-55. doi:
10.1111/j.1756-185x.2011.01679.x. [PMID: 22324946] - Hyoung-Il Kim, Woo Jin Hyung, Ki Jun Song, Seung Ho Choi, Choong-Bai Kim, Sung Hoon Noh. Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients.
Annals of surgical oncology.
2011 Dec; 18(13):3711-7. doi:
10.1245/s10434-011-1764-6. [PMID: 21556950] - Pei-ji Huang, Xiao-hong Mao, Yan-ping Wang. [Electrophysiological changes in diabetic peripheral neuropathy patients of different Chinese medicine syndrome types intervened by naoxintong and mecobalamin].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Aug; 31(8):1051-6. doi:
". [PMID: 21910333] - T Kwok, J Lee, C B Law, P C Pan, C Y Yung, K C Choi, L C Lam. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people.
Clinical nutrition (Edinburgh, Scotland).
2011 Jun; 30(3):297-302. doi:
10.1016/j.clnu.2010.12.004. [PMID: 21216507] - David Watkins, David S Rosenblatt. Inborn errors of cobalamin absorption and metabolism.
American journal of medical genetics. Part C, Seminars in medical genetics.
2011 Feb; 157C(1):33-44. doi:
10.1002/ajmg.c.30288. [PMID: 21312325] - Anantharajappa Kumudha, Sagaya Selva Kumar, Munna Singh Thakur, Gokare Aswathanarayana Ravishankar, Ravi Sarada. Purification, identification, and characterization of methylcobalamin from Spirulina platensis.
Journal of agricultural and food chemistry.
2010 Sep; 58(18):9925-30. doi:
10.1021/jf102159j. [PMID: 20799700] - Katsushi Koyama, Akinori Ito, Jun Yamamoto, Takae Nishio, Junko Kajikuri, Yasuaki Dohi, Nobuyuki Ohte, Akira Sano, Hiroshi Nakamura, Hiromichi Kumagai, Takeo Itoh. Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2010 Jun; 55(6):1069-78. doi:
10.1053/j.ajkd.2009.12.035. [PMID: 20430500] - D S Froese, S Healy, M McDonald, G Kochan, U Oppermann, F H Niesen, R A Gravel. Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder.
Molecular genetics and metabolism.
2010 May; 100(1):29-36. doi:
10.1016/j.ymgme.2010.02.005. [PMID: 20219402] - Ying Yuan, Hongmei Shen, Jian Yao, Nan Hu, Fei Ding, Xiaosong Gu. The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury.
Brain research bulletin.
2010 Jan; 81(1):25-32. doi:
10.1016/j.brainresbull.2009.07.013. [PMID: 19646511] - S Jill James, Stepan Melnyk, George Fuchs, Tyra Reid, Stefanie Jernigan, Oleksandra Pavliv, Amanda Hubanks, David W Gaylor. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.
The American journal of clinical nutrition.
2009 Jan; 89(1):425-30. doi:
10.3945/ajcn.2008.26615. [PMID: 19056591] - Gu Weijun, Lu Juming, Yang Guoqing, Dou Jingtao, Guo Qinghua, Mu Yiming, Pan Changyu. Effects of plasma homocysteine levels on serum HTase/PON activity in patients with type 2 diabetes.
Advances in therapy.
2008 Sep; 25(9):884-93. doi:
10.1007/s12325-008-0095-x. [PMID: 18781288] - B Fowler, J V Leonard, M R Baumgartner. Causes of and diagnostic approach to methylmalonic acidurias.
Journal of inherited metabolic disease.
2008 Jun; 31(3):350-60. doi:
10.1007/s10545-008-0839-4. [PMID: 18563633] - Yi-Fei Zhang, Guang Ning. Mecobalamin.
Expert opinion on investigational drugs.
2008 Jun; 17(6):953-64. doi:
10.1517/13543784.17.6.953. [PMID: 18491996] - Wei-jun Gu, Ju-ming Lu, Guo-qing Yang, Qing-hua Guo, Jing-tao Dou, Yi-ming Mu, Chang-yu Pan. [Effects of intervention therapy of methylcobalamin and folic acid on plasma homocysteine concentration and homocysteine thiolactonases/paraoxonase activity in patients with type 2 diabetes mellitus].
Zhonghua yi xue za zhi.
2007 Jan; 87(4):256-8. doi:
NULL. [PMID: 17425871] - R J Kelly, T M Gruner, J M Furlong, A R Sykes. Analysis of corrinoids in ovine tissues.
Biomedical chromatography : BMC.
2006 Aug; 20(8):806-14. doi:
10.1002/bmc.604. [PMID: 16345011] - Lodewijk Thomas Vlasveld, Gerard M J Bos, Anton A M Ermens, Jaap A Bakker, Jan Lindemans. Hyperhomocysteinemia and functional cobalamin deficiency due to granulocytosis-induced alterations in the cobalamin-binding protein.
Haematologica.
2006 Mar; 91(3):394-6. doi:
NULL. [PMID: 16531264] - Charlotte M Poloschek, Brian Fowler, Renate Unsold, Birgit Lorenz. Disturbed visual system function in methionine synthase deficiency.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2005 May; 243(5):497-500. doi:
10.1007/s00417-004-1044-2. [PMID: 15931548] - R J Kelly, T M Gruner, A R Sykes. Development of a method for the separation of corrinoids in ovine tissues by HPLC.
Biomedical chromatography : BMC.
2005 May; 19(4):329-33. doi:
10.1002/bmc.444. [PMID: 15828057] - Yoshihiro Sato, Yoshiaki Honda, Jun Iwamoto, Tomohiro Kanoko, Kei Satoh. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial.
JAMA.
2005 03; 293(9):1082-8. doi:
10.1001/jama.293.9.1082. [PMID: 15741530] - Hernán Trimarchi, Pablo Young, María L Díaz, Juan Schropp, Mariano Forrester, Emilio Freixas. [Hyperhomocysteinemia as a vascular risk factor in chronic hemodialysis patients].
Medicina.
2005; 65(6):513-7. doi:
NULL. [PMID: 16433478] - S Jill James, Paul Cutler, Stepan Melnyk, Stefanie Jernigan, Laurette Janak, David W Gaylor, James A Neubrander. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
The American journal of clinical nutrition.
2004 Dec; 80(6):1611-7. doi:
10.1093/ajcn/80.6.1611. [PMID: 15585776] - Emmanuel Roze, David Gervais, Sophie Demeret, Hélène Ogier de Baulny, Jacqueline Zittoun, Jean-François Benoist, Gérard Said, Charles Pierrot-Deseilligny, Francis Bolgert. Neuropsychiatric disturbances in presumed late-onset cobalamin C disease.
Archives of neurology.
2003 Oct; 60(10):1457-62. doi:
10.1001/archneur.60.10.1457. [PMID: 14568819] - Akiko Nagaishi, Hiroshi Takashima, Yasuo Fukuda, Yasuo Kuroda. [A case of subacute combined degeneration with normal serum vitamin B12 level].
Rinsho shinkeigaku = Clinical neurology.
2003 Sep; 43(9):552-5. doi:
NULL. [PMID: 14727562] - Yoshihiro Sato, Masahide Kaji, Izumi Kondo, Hidemi Yoshida, Kei Satoh, Norifumi Metoki. Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: effect of combined therapy with folic acid and mecobalamine.
Journal of the neurological sciences.
2002 Oct; 202(1-2):65-8. doi:
10.1016/s0022-510x(02)00210-1. [PMID: 12220694] - Katsushi Koyama, Takeshi Usami, Oki Takeuchi, Kunio Morozumi, Genjiro Kimura. Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002 May; 17(5):916-22. doi:
10.1093/ndt/17.5.916. [PMID: 11981084] - Hernán Trimarchi, Amalia Schiel, Emilio Freixas, Marisa Díaz. Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients.
Nephron.
2002 May; 91(1):58-63. doi:
10.1159/000057605. [PMID: 12021520] - Yumi Takasaki, Yukiyoshi Moriuchi, Hideki Tsushima, Eiichirou Ikeda, Setsuko Koura, Jun Taguchi, Takuya Fukushima, Masao Tomonaga, Shuichi Ikeda. [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2002 Mar; 43(3):165-9. doi:
NULL. [PMID: 11979747] - Hernán Trimarchi, Valeria Genoud, Amalia Schiel, Maria Castañon, Emilio Freixas, Maria Luisa Diaz, Juan Schropp, Diana Martino, Horacio Pereyra, Lucia Kordich. The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center.
Medicina.
2002; 62(2):149-53. doi:
NULL. [PMID: 12038037] - Hiroshi Tomita, Kenji Ohtuka. Taste disturbance after tonsillectomy.
Acta oto-laryngologica. Supplementum.
2002; ?(546):164-72. doi:
10.1080/00016480260046571. [PMID: 12132617] - M Pogribna, S Melnyk, I Pogribny, A Chango, P Yi, S J James. Homocysteine metabolism in children with Down syndrome: in vitro modulation.
American journal of human genetics.
2001 Jul; 69(1):88-95. doi:
10.1086/321262. [PMID: 11391481] - R Biancheri, R Cerone, M C Schiaffino, U Caruso, E Veneselli, M V Perrone, A Rossi, R Gatti. Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases.
Neuropediatrics.
2001 Feb; 32(1):14-22. doi:
10.1055/s-2001-12217. [PMID: 11315197] - K Yamada, T Kawata, M Wada, T Isshiki, J Onoda, T Kawanishi, A Kunou, T Tadokoro, T Tobimatsu, A Maekawa, T Toraya. Extremely low activity of methionine synthase in vitamin B-12-deficient rats may be related to effects on coenzyme stabilization rather than to changes in coenzyme induction.
The Journal of nutrition.
2000 Aug; 130(8):1894-900. doi:
10.1093/jn/130.8.1894. [PMID: 10917899] - U Funada, M Wada, T Kawata, K Mori, H Tamai, T Kawanishi, A Kunou, N Tanaka, T Tadokoro, A Maekawa. Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2000 Jul; 70(4):167-71. doi:
10.1024/0300-9831.70.4.167. [PMID: 10989765] - S Kuwabara, R Nakazawa, N Azuma, M Suzuki, K Miyajima, T Fukutake, T Hattori. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients.
Internal medicine (Tokyo, Japan).
1999 Jun; 38(6):472-5. doi:
10.2169/internalmedicine.38.472. [PMID: 10411351] - J Tamura, K Kubota, H Murakami, M Sawamura, T Matsushima, T Tamura, T Saitoh, H Kurabayshi, T Naruse. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment.
Clinical and experimental immunology.
1999 Apr; 116(1):28-32. doi:
10.1046/j.1365-2249.1999.00870.x. [PMID: 10209501] - B Merinero, C Pérez-Cerdá, M J Garcia, B Chadefaux-Vekemans, P Kamoun, C Tonetti, J Zittoun, C Jakobs, M Ugarte. Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria.
Prenatal diagnosis.
1998 Sep; 18(9):947-52. doi:
10.1002/(sici)1097-0223(199809)18:9<947::aid-pd363>3.0.co;2-l. [PMID: 9793978] - A Wilson, D Leclerc, F Saberi, E Campeau, H Y Hwang, B Shane, J A Phillips, D S Rosenblatt, R A Gravel. Functionally null mutations in patients with the cblG-variant form of methionine synthase deficiency.
American journal of human genetics.
1998 Aug; 63(2):409-14. doi:
10.1086/301976. [PMID: 9683607] - M Wada, T Kawata, K Yamada, U Funada, M Kuwamori, M Endo, N Tanaka, T Tadokoro, A Maekawa. Serum C3 content in vitamin B(12)-deficient rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
1998; 68(2):94-7. doi:
NULL. [PMID: 9565823] - B Fowler, R B Schutgens, D S Rosenblatt, G P Smit, J Lindemans. Folate-responsive homocystinuria and megaloblastic anaemia in a female patient with functional methionine synthase deficiency (cblE disease).
Journal of inherited metabolic disease.
1997 Nov; 20(6):731-41. doi:
10.1023/a:1005372730310. [PMID: 9427140] - K Koyama, A Yoshida, A Takeda, K Morozumi, T Fujinami, N Tanaka. Abnormal cyanide metabolism in uraemic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1997 Aug; 12(8):1622-8. doi:
10.1093/ndt/12.8.1622. [PMID: 9269639] - G Mayer, M Kröger, K Meier-Ewert. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1996 Nov; 15(5):456-64. doi:
10.1016/s0893-133x(96)00055-3. [PMID: 8914118] - A Tomoda, T Miike, M Matsukura. Circadian rhythm abnormalities in adrenoleukodystrophy and methyl B12 treatment.
Brain & development.
1995 Nov; 17(6):428-31. doi:
10.1016/0387-7604(95)00083-6. [PMID: 8747422] - B Chadefaux-Vekemans, M O Rolland, S Lyonnet, D Rabier, P Divry, P Kamoun. Prenatal diagnosis of combined methylmalonic aciduria and homocystinuria (cobalamin CblC or CblD mutant).
Prenatal diagnosis.
1994 May; 14(5):417-8. doi:
10.1002/pd.1970140517. [PMID: 7916155] - J Kira, S Tobimatsu, I Goto. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis.
Internal medicine (Tokyo, Japan).
1994 Feb; 33(2):82-6. doi:
10.2169/internalmedicine.33.82. [PMID: 8019047] - S M Frisbie, M R Chance. Human cobalophilin: the structure of bound methylcobalamin and a functional role in protecting methylcobalamin from photolysis.
Biochemistry.
1993 Dec; 32(50):13886-92. doi:
10.1021/bi00213a018. [PMID: 8268164] - R H Allen, S P Stabler, J Lindenbaum. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Metabolism: clinical and experimental.
1993 Nov; 42(11):1448-60. doi:
10.1016/0026-0495(93)90198-w. [PMID: 7694037] - A Araki, Y Sako, H Ito. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment.
Atherosclerosis.
1993 Nov; 103(2):149-57. doi:
10.1016/0021-9150(93)90258-v. [PMID: 8292092] - T Shiraishi, T Kubo, S Okumura, H Naramura, M Nishimura, M Okusa, T Matsunaga. Hearing recovery in sudden deafness patients using a modified defibrinogenation therapy.
Acta oto-laryngologica. Supplementum.
1993; 501(?):46-50. doi:
10.3109/00016489309126213. [PMID: 7680521] - E S Tsukerman, T L Korsova, A A Poznanskaia. [Vitamin B 12 metabolism and the status of sulfhydryl groups in protein-choline deficiency in rats. Effects of methyl- and adenosylcobalamins].
Voprosy pitaniia.
1992 Jan; ?(1):40-4. doi:
NULL. [PMID: 1621377] - D S Rosenblatt. Vitamin B12 (Cbl)-responsive disorders.
Journal of nutritional science and vitaminology.
1992; Spec No(?):593-6. doi:
10.3177/jnsv.38.special_593. [PMID: 1297820] - T Ohta, K Ando, T Iwata, N Ozaki, Y Kayukawa, M Terashima, T Okada, Y Kasahara. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12).
Sleep.
1991 Oct; 14(5):414-8. doi:
NULL. [PMID: 1759094] - O D Golenko, N I Ryzhova, N V Miasishcheva. [The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid].
Biulleten' eksperimental'noi biologii i meditsiny.
1991 Mar; 111(3):292-4. doi:
NULL. [PMID: 2054508] - K Murayama, T Katsumi, T Asai. [Clinical evaluation of micturitional dysfunction after the operation for rectal cancer and effects of mecobalamin on that dysfunction].
Hinyokika kiyo. Acta urologica Japonica.
1989 Nov; 35(11):1853-7. doi:
NULL. [PMID: 2694825] - T L Korsova, N A Morozova, A A Poznanskaia, B I Kurganov. [Comparative study of the effect of vitamin B12 coenzymes on monooxygenase system and lipid peroxidation in the liver of rabbits poisoned with phenylhydrazine].
Voprosy meditsinskoi khimii.
1989 Mar; 35(2):97-102. doi:
. [PMID: 2741423] - E S Tsukerman, T Ia Pomerantseva, A A Poznanskaia, T L Korsova, I V Klement'eva. [Effect of methylcobalamin and adenosylcobalamin on the process of hematopoiesis and vitamin B12 exchange in experimental phenylhydrazine-induced anemia in rabbits].
Voprosy meditsinskoi khimii.
1989 Jan; 35(1):106-11. doi:
. [PMID: 2741387] - Y Mitsuyama, H Kogoh. Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-B12 treatment--preliminary study.
The Japanese journal of psychiatry and neurology.
1988 Mar; 42(1):65-71. doi:
NULL. [PMID: 3398357] - K Ejiri, H Taniguchi, S Baba. [Treatment of autonomic nerve dysfunction in uremia with special reference to its normalisation by methylcobalamin].
Nihon Jinzo Gakkai shi.
1987 Jun; 29(6):695-9. doi:
NULL. [PMID: 3682337] - D S Rosenblatt, I T Thomas, D Watkins, B A Cooper, R W Erbe. Vitamin B12 responsive homocystinuria and megaloblastic anemia: heterogeneity in methylcobalamin deficiency.
American journal of medical genetics.
1987 Feb; 26(2):377-83. doi:
10.1002/ajmg.1320260216. [PMID: 3812589] - H Ide, S Fujiya, Y Asanuma, M Tsuji, H Sakai, Y Agishi. Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy.
Clinical therapeutics.
1987; 9(2):183-92. doi:
NULL. [PMID: 3568063]