Labd-14-ene, 8,13-epoxy-, (13S)- (BioDeep_00000015636)

代谢物信息卡片

Labd-14-ene, 8,13-epoxy-, (13S)-

化学式: C20H34O (290.2609514)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CC1(CCCC2(C1CCC3(C2CCC(O3)(C)C=C)C)C)C
InChI: InChI=1S/C20H34O/c1-7-18(4)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)21-18/h7,15-16H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1

描述信息

同义名列表

1 个代谢物同义名

Labd-14-ene, 8,13-epoxy-, (13S)-

数据库引用编号

3 个数据库交叉引用编号

KEGG: C21725
PubChem: 6432025
PubChem: 350078302

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

1641247 - Achyranthemum paniculatum: 10.1016/0031-9422(89)80195-5
462376 - Acrisione denticulata: 10.1016/0031-9422(88)87031-6
42754 - Araucaria araucana: 10.1002/(SICI)1099-1565(200003/04)11:2<99::AID-PCA494>3.0.CO;2-9
1475379 - Casearia corymbosa: 10.1016/0031-9422(90)85282-K
183013 - Espeletia timotensis: 10.1016/S0031-9422(99)00346-5
241838 - Excoecaria agallocha: 10.1248/BPB.21.993
1114766 - Grindelia tarapacana: 10.1016/0031-9422(95)00419-8
155638 - Guarea macrophylla: 10.1016/S0031-9422(00)00302-2
261799 - Helichrysum retortum: 10.1016/0031-9422(89)80195-5
884033 - Juniperus comitana: 10.1021/NP50040A040
103973 - Juniperus drupacea: 10.1080/10412905.1997.9700773
2290789 - Juniperus standleyi: 10.1021/NP50040A040
120598 - Manoao colensoi:
130206 - Picea glehnii: 10.1021/NP0000217
224734 - Picea orientalis: 10.1007/BF00577187
88728 - Pinus koraiensis: 10.1007/BF00566335
29805 - Pinus luchuensis: 10.1021/NP000155K
71641 - Pinus merkusii: 10.1016/0031-9422(93)85408-J
58042 - Pinus nigra: 10.1007/S00107-001-0251-3
71649 - Pinus pumila: 10.1007/BF00567793
41228 - Plectranthus barbatus: 10.1016/0031-9422(89)80130-X
40031 - Rhizophora mangle: 10.1080/10412905.2001.9699622
268896 - Salvia candidissima:
268920 - Salvia palaestina: 10.1016/J.PHYTOCHEM.2007.11.002
268934 - Salvia staminea: 10.1055/S-2003-39705
511490 - Solidago rugosa: 10.1016/0031-9422(94)00625-4
54477 - Vitex agnus-castus: 10.1002/(SICI)1097-0231(199608)10:11<1345::AID-RCM631>3.0.CO;2-4
1489963 - Xylia xylocarpa: 10.1039/JR9630000644

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hans Wilhelm Rauwald, Tobias Liebold, Kristina Grötzinger, Jörg Lehmann, Kenny Kuchta. Labdanum and Labdanes of Cistus creticus and C. ladanifer: Anti-Borrelia activity and its phytochemical profiling✰. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jul; 60(?):152977. doi: 10.1016/j.phymed.2019.152977. [PMID: 31474477]
Victor Forman, Niels Bjerg-Jensen, Jane D Dyekjær, Birger Lindberg Møller, Irini Pateraki. Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast. Microbial cell factories. 2018 Nov; 17(1):181. doi: 10.1186/s12934-018-1027-3. [PMID: 30453976]
Kyle J Lauersen, Julian Wichmann, Thomas Baier, Sotirios C Kampranis, Irini Pateraki, Birger Lindberg Møller, Olaf Kruse. Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii. Metabolic engineering. 2018 09; 49(?):116-127. doi: 10.1016/j.ymben.2018.07.005. [PMID: 30017797]
Konstantinos Vavitsas, Emil Østergaard Rue, Lára Kristín Stefánsdóttir, Thiyagarajan Gnanasekaran, Andreas Blennow, Christoph Crocoll, Steinn Gudmundsson, Poul Erik Jensen. Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways. Microbial cell factories. 2017 Aug; 16(1):140. doi: 10.1186/s12934-017-0757-y. [PMID: 28806958]
Irini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen, Sileshi Gizachew Wubshet, Allison Maree Heskes, Victor Forman, Björn Hallström, Britta Hamberger, Mohammed Saddik Motawia, Carl Erik Olsen, Dan Staerk, Jørgen Hansen, Birger Lindberg Møller, Björn Hamberger. Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii. eLife. 2017 03; 6(?):. doi: 10.7554/elife.23001. [PMID: 28290983]
Codruta Ignea, Efstathia Ioannou, Panagiota Georgantea, Fotini A Trikka, Anastasia Athanasakoglou, Sofia Loupassaki, Vassilios Roussis, Antonios M Makris, Sotirios C Kampranis. Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. Microbial cell factories. 2016 Feb; 15(?):46. doi: 10.1186/s12934-016-0440-8. [PMID: 26920948]
Elias Englund, Johan Andersen-Ranberg, Rui Miao, Björn Hamberger, Pia Lindberg. Metabolic Engineering of Synechocystis sp. PCC 6803 for Production of the Plant Diterpenoid Manoyl Oxide. ACS synthetic biology. 2015 Dec; 4(12):1270-8. doi: 10.1021/acssynbio.5b00070. [PMID: 26133196]
Mi Jung Kim, Jingjing Jin, Junshi Zheng, Limsoon Wong, Nam-Hai Chua, In-Cheol Jang. Comparative Transcriptomics Unravel Biochemical Specialization of Leaf Tissues of Stevia for Diterpenoid Production. Plant physiology. 2015 Dec; 169(4):2462-80. doi: 10.1104/pp.15.01353. [PMID: 26438788]
Morten T Nielsen, Johan Andersen Ranberg, Ulla Christensen, Hanne Bjerre Christensen, Scott J Harrison, Carl Erik Olsen, Björn Hamberger, Birger Lindberg Møller, Morten H H Nørholm. Microbial Synthesis of the Forskolin Precursor Manoyl Oxide in an Enantiomerically Pure Form. Applied and environmental microbiology. 2014 Dec; 80(23):7258-65. doi: 10.1128/aem.02301-14. [PMID: 25239892]
Philipp Zerbe, Angela Chiang, Harpreet Dullat, Mark O'Neil-Johnson, Courtney Starks, Björn Hamberger, Jörg Bohlmann. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. The Plant journal : for cell and molecular biology. 2014 Sep; 79(6):914-27. doi: 10.1111/tpj.12589. [PMID: 24990389]
Irini Pateraki, Johan Andersen-Ranberg, Britta Hamberger, Allison Maree Heskes, Helle Juel Martens, Philipp Zerbe, Søren Spanner Bach, Birger Lindberg Møller, Jörg Bohlmann, Björn Hamberger. Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii. Plant physiology. 2014 Mar; 164(3):1222-36. doi: 10.1104/pp.113.228429. [PMID: 24481136]
P Mackin, T Waton, H M Watkinson, P Gallagher. A four-year naturalistic prospective study of cardiometabolic disease in antipsychotic-treated patients. European psychiatry : the journal of the Association of European Psychiatrists. 2012 Jan; 27(1):50-5. doi: 10.1016/j.eurpsy.2010.08.011. [PMID: 21036552]
Wildson Max B da Silva, Edilberto R Silveira, Otilia Deusdênia L Pessoa. Acylated manoyl oxide diterpenes of Stemodia trifoliata. Magnetic resonance in chemistry : MRC. 2010 Jun; 48(6):486-9. doi: 10.1002/mrc.2597. [PMID: 20474028]
Christina Matsingou, Costas Demetzos. Effect of the nature of the 3beta-substitution in manoyl oxides on the thermotropic behavior of DPPC lipid bilayer and on DPPC liposomes. Journal of liposome research. 2007; 17(2):89-105. doi: 10.1080/08982100701375076. [PMID: 17613699]
María Inés Ybarra, Susana Popich, Susana A Borkosky, Yoshinori Asakawa, Alicia Bardón. Manoyl oxide diterpenoids from Grindelia scorzonerifolia. Journal of natural products. 2005 Apr; 68(4):554-8. doi: 10.1021/np040174k. [PMID: 15844947]
Costas Demetzos, Antonios Kolocouris, Thalia Anastasaki. A simple and rapid method for the differentiation of C-13 manoyl oxide epimers in biologically important samples using GC-MS analysis supported with NMR spectroscopy and computational chemistry results. Bioorganic & medicinal chemistry letters. 2002 Dec; 12(24):3605-9. doi: 10.1016/s0960-894x(02)00792-8. [PMID: 12443786]