Bicuculline (+) (BioDeep_00000015568)

PANOMIX_OTCML-2023

代谢物信息卡片

Bicuculline (+)

化学式: C20H17NO6 (367.1055822)
中文名称: 咖喏定, 右旋比扣扣灵碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
InChI: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18-/m1/s1

描述信息

Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) [1][2][3].
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice[1][2][3][4].
Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) [1][2][3].

同义名列表

5 个代谢物同义名

CAPNOIDINE; Bicuculline (+); (+)-Bicuculline; d-Bicuculline; Bicuculline

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:68991
KEGG: C09372
PubChem: 120698
Metlin: METLIN44019
ChEMBL: CHEMBL1437488
CAS: 485-50-7
CAS: 485-49-4
MetaboLights: MTBLC68991
PubChem: 11563
KNApSAcK: C00001830
3DMET: B02906
NIKKAJI: J1.238.125E
medchemexpress: HY-N0219

分类词条

生物碱

代谢反应

0 个相关的代谢反应过程信息。

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17 个相关的物种来源信息

581246 Corydalis cava:
1464626 Fumaria petteri: 10.3109/13880208809053890
1053349 Fumaria capreolata:
367484 Fumaria vaillantii:
3464 Capnoides sempervirens:
1464625 Fumaria parviflora: 10.1021/NP50016A014
581246 Corydalis cava:
1464626 Fumaria petteri: 10.3109/13880208809053890
1053349 Fumaria capreolata:
367484 Fumaria vaillantii:
3464 Capnoides sempervirens:
1464625 Fumaria parviflora: 10.1021/NP50016A014
1238147 Corydalis bungeana Turcz.: -
38904 Corydalis decumbens (Thunb.) Pers.: -
458692 Corydalis yanhusuo W.T.Wang: -
404569 Corydalis ambigua var. amurensis [Syn. Corydalis ambigua]: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Anthony C Willis, Sumalee Kamchonwongpaisan. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. Journal of ethnopharmacology. 2012 Aug; 143(1):310-3. doi: 10.1016/j.jep.2012.06.037. [PMID: 22796506]
R Storb, E D Thomas, P L Weiden, C D Buckner, R A Clift, A Fefer, L P Fernando, E R Giblett, B W Goodell, F L Johnson, K G Lerner, P E Neiman, J E Sanders. Aplastic anemia treated by allogeneic bone marrow transplantation: a report on 49 new cases from Seattle. Blood. 1976 Dec; 48(6):817-41. doi: NULL. [PMID: 11859]