Acetylcholine chloride (BioDeep_00000015071)
PANOMIX_OTCML-2023
代谢物信息卡片
Acetylcholine chloride
化学式: C7H16ClNO2 (181.08695060000002)
中文名称: 氯化乙酰胆碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 4.35%
分子结构信息
SMILES: CC(=O)OCC[N+](C)(C)C.[Cl-]
InChI: /p-1
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:2417
- KEGG: C08201
- KEGGdrug: D81773
- KEGGdrug: D00999
- PubChem: 6060
- Metlin: METLIN66848
- ChEMBL: CHEMBL1184
- MeSH: Acetylcholine
- CAS: 60-31-1
- PubChem: 10400
- NIKKAJI: J231.275A
- RefMet: Acetylcholine chloride
- medchemexpress: HY-B0282
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohsen Akbari, Salar Moardi, Homeyra Piri, Roonak Amiri, Farzaneh Aliaqabozorg, Elham Sadat Afraz. The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia.
Experimental gerontology.
2024 Jul; 192(?):112459. doi:
10.1016/j.exger.2024.112459. [PMID: 38740315] - Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulou. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila.
Cells.
2024 Apr; 13(9):. doi:
10.3390/cells13090746. [PMID: 38727282] - S K Johnsy Sugitha, Raja Venkatesan, R Gladis Latha, Alexandre A Vetcher, Bandar Ali Al-Asbahi, Seong-Cheol Kim. A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton).
Molecules (Basel, Switzerland).
2024 Mar; 29(7):. doi:
10.3390/molecules29071464. [PMID: 38611744] - Ying Yu, Li Yun Wang, Yan Chi Liu, Hao Cui, Cheng Yuan, Cheng Xiao Wang. Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng.
Pharmaceutical research.
2024 Mar; 41(3):513-529. doi:
10.1007/s11095-024-03670-w. [PMID: 38383935] - Fan Zhang, Lingnan Guo, Jingjing Shi, Hao Jiang, Feini Zhou, Yanlin Zhou, Bin Lv, Maosheng Xu. Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis.
Neurobiology of disease.
2024 Feb; 191(?):106390. doi:
10.1016/j.nbd.2023.106390. [PMID: 38145852] - Musa Dirak, Jefferson Chan, Safacan Kolemen. Optical imaging probes for selective detection of butyrylcholinesterase.
Journal of materials chemistry. B.
2024 Jan; 12(5):1149-1167. doi:
10.1039/d3tb02468g. [PMID: 38196348] - Guadalupe E Ángeles-López, Angélica Hernández-Ruíz, Ma Eva González-Trujano, Sol Cristians, Berenice Ovalle-Magallanes, Rosa Ventura-Martínez. Pharmacological disadvantages in the spasmolytic effects by using the mixture known as 'three toronjiles' in folk medicine.
Journal of ethnopharmacology.
2024 Jan; 318(Pt B):116978. doi:
10.1016/j.jep.2023.116978. [PMID: 37524233] - Baolei Zhan, Ting Zhou, Di Tong, Zile Xu, Xiaoyu Liang, Anqi Ma, Shumin Lü. Expression of the non-neuronal cholinergic system components in Malpighian tubules of Mythimna separata and evidence for non-neuronal acetylcholine synthesis.
Insect biochemistry and molecular biology.
2024 Jan; 164(?):104047. doi:
10.1016/j.ibmb.2023.104047. [PMID: 38072082] - Dominika Szadkowska, Magdalena Chłopecka, Jakub W Strawa, Katarzyna Jakimiuk, Daniel Augustynowicz, Michał Tomczyk, Marta Mendel. Effects of Cirsium palustre Extracts and Their Main Flavonoids on Colon Motility-An Ex Vivo Study.
International journal of molecular sciences.
2023 Dec; 24(24):. doi:
10.3390/ijms242417283. [PMID: 38139112] - Guzalia F Zakirjanova, Arthur R Giniatullin, Chulpan R Gafurova, Artem I Malomouzh, Nikita S Fedorov, Arthur N Khaziev, Andrei N Tsentsevitsky, Alexey M Petrov. Effects of cholesterol oxidase on neurotransmission and acetylcholine levels at the mice neuromuscular junctions.
Archives of biochemistry and biophysics.
2023 Nov; 749(?):109803. doi:
10.1016/j.abb.2023.109803. [PMID: 37955112] - Hu Chen, Na Wang, Shunli Wei, Xinjian Xu, Chunxiao Wu, Shugang Liu. Inhibition of Acetylcholine Expression in the Tumor Microenvironment by Mustard Oil: A Potential Strategy to Retard Colon Cancer Progression.
Alternative therapies in health and medicine.
2023 Nov; 29(8):246-251. doi:
". [PMID: 37573596] - Tokaa Mansour, Wafaa H Radwan, Menna Mansour, Mohamed Gomaa, Farouk Farouk, Mohamed Shepl, Ahmed G Soliman, Basma T Abd-Elhalim, Mohamed M K El-Senosy, Ashraf Bakry, Naglaa M Ebeed, Neima K Alsenosy, Hesham Elhariry, Ahmed Galal, Salwa M El-Sayed, Eslam Adly, Samah H Abu-Hussien. Larvicidal potential, toxicological assessment, and molecular docking studies of four Egyptian bacterial strains against Culex pipiens L. (Diptera: Culicidae).
Scientific reports.
2023 10; 13(1):17230. doi:
10.1038/s41598-023-44279-0. [PMID: 37821509] - S B Caine, S Plant, K Furbish, M Yerton, E Smaragdi, B Niclou, J M Lorusso, J Y Chang, C Bitter, A Basu, S Miller, C-Y Huang, R Komson, D Liu, S Behar, M Thomsen. Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs.
Psychopharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00213-023-06444-1. [PMID: 37580441] - Lin Yang, Xu Ma, Yuhan Guo, Yuman He, Yunwen Yang, Wenqiao Wang, Ziyi Xu, Zhaojiang Zuo, Ying Xue, Rui Yang, Bing Han, Jinsheng Sun. Acetylcholine (ACh) enhances Cd tolerance through transporting ACh in vesicles and modifying Cd absorption in duckweed (Lemna turionifera 5511).
Environmental pollution (Barking, Essex : 1987).
2023 Aug; 335(?):122305. doi:
10.1016/j.envpol.2023.122305. [PMID: 37580008] - Sheba R David, Penny Pei Ni Lai, Jestin Chellian, Srikumar Chakravarthi, Rajan Rajabalaya. Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes.
Scientific reports.
2023 08; 13(1):12423. doi:
10.1038/s41598-023-39442-6. [PMID: 37528147] - Jonnelle M Edwards-Glenn, Milene T Fontes, Emily W Waigi, Tiago J Costa, Andrei Maiseyeu, Clinton Webb, Cameron G McCarthy, Camilla F Wenceslau. Specialized pro-resolving mediator therapy improves vascular relaxation via formyl peptide-receptor-2.
American journal of hypertension.
2023 Jul; ?(?):. doi:
10.1093/ajh/hpad062. [PMID: 37439351] - Karelle Kouam Yacine Madjo, Marius Mbiantcha, Linda Zenab Njoya Fagni, Vanessa Mba Matah Marthe, Elvira Azanze Ngoufack, Gonzal Eric Tsafack, Stephanie Flore Djuichou Nguemnang, Carine Flore Adjouzem, Gilbert Ateufack. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats.
Journal of complementary & integrative medicine.
2023 Jun; ?(?):. doi:
10.1515/jcim-2023-0024. [PMID: 37382892] - Qin Zeng, Shuyi Wang, Mengyuan Li, Shuang Wang, Chaohuan Guo, Xinyuan Ruan, Ryu Watanabe, Yimei Lai, Yuefang Huang, Xiaoyu Yin, Chuanzhao Zhang, Binfeng Chen, Niansheng Yang, Hui Zhang. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses.
Cell metabolism.
2023 05; 35(5):837-854.e8. doi:
10.1016/j.cmet.2023.03.010. [PMID: 37019104] - Qing Wu, Ming Zhao, Dongling Li, Xi He, Weijin Zang. Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 05; 37(5):e22917. doi:
10.1096/fj.202202108r. [PMID: 37039813] - Yixi Zhang, Xiaoyong Xu, Jingting Wang, Xusheng Shao, Zewen Liu, Zhong Li. Molecular Mechanism of Action of Cycloxaprid, An Oxabridged cis-Nitromethylene Neonicotinoid.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24087511. [PMID: 37108674] - Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu. Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24087356. [PMID: 37108518] - Ayad A Alawadi, Vagner A Benedito, R Chris Skinner, Derek C Warren, Casey Showman, Janet C Tou. RNA-sequencing revealed apple pomace ameliorates expression of genes in the hypothalamus associated with neurodegeneration in female rats fed a Western diet during adolescence to adulthood.
Nutritional neuroscience.
2023 Apr; 26(4):332-344. doi:
10.1080/1028415x.2022.2050008. [PMID: 35296223] - Petar Šušnjara, Zrinka Mihaljević, Ana Stupin, Nikolina Kolobarić, Anita Matić, Ivana Jukić, Zlata Kralik, Gordana Kralik, Anđelina Miloloža, Tihana Pavošević, Vatroslav Šerić, Zdenko Lončarić, Darko Kerovec, Olivera Galović, Ines Drenjančević. Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.
Nutrients.
2023 Mar; 15(7):. doi:
10.3390/nu15071599. [PMID: 37049437] - Pilar Rodríguez-Rodríguez, Anuson Poasakate, Santiago Ruvira-Hernando, Perla Y Gutierrez-Arzapalo, Rainer Böger, Juliane Hannemann, Nicole Lüneburg, Silvia M Arribas. Vascular nitrosative stress in hypertension induced by fetal undernutrition in rats.
Journal of physiology and biochemistry.
2023 Feb; ?(?):. doi:
10.1007/s13105-023-00949-1. [PMID: 36821073] - Yuqiu Yang, Yufeng Gao, Chelimoge Wang. [Mongolian medicine Heisuga-25 promotes the expression of neuroskeletal protein, increases the content of neurotransmitter and improves the symptoms of Alzheimer's disease in mice].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2023 Feb; 39(2):153-158. doi:
. [PMID: 36872434] - Mohammad Asif, Kaneez Fatima, Sadaf Jamal Gilani, Mohamad Taleuzzaman, Syed Salman Ali, Samera Ali Siddiqui. Evaluation of Nootropic Potential of Aerva persica Roots against D-galactose-induced Memory Impairment.
Central nervous system agents in medicinal chemistry.
2023; 23(2):126-136. doi:
10.2174/1871524923666230822100016. [PMID: 37608652] - Wei Sun, Xuanyin Zhao, Yiwen Wan, Yang Yang, Xiaoliang Li, Xiao Chen, Yazi Mei, Lei An. Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats.
Human & experimental toxicology.
2023 Jan; 42(?):9603271231163477. doi:
10.1177/09603271231163477. [PMID: 36890733] - Xing Tian, Jiamin Guo, Xinxin Su, Baolei Zhan, Xiaoyu Liang, Anqi Ma, Yalin Zhang, Shumin Lü. Comparative transcriptome analysis reveals the non-neuronal cholinergic system in the ovary of the oriental armyworm, Mythimna separata Walker (Lepidoptera: Noctuidae).
Pest management science.
2022 Dec; 78(12):5220-5233. doi:
10.1002/ps.7141. [PMID: 36053883] - Cao Thi Hue, Vu Thanh Trung, Nguyen Thanh Hoa, Nguyen Thi Lan Huong, Pham Thanh Binh, Nguyen The Cuong, Nguyen Van Thanh, Nguyen Phuong Thao. Glycoside constituents from Miliusa sinensis leaves and their anti-inflammatory and acetylcholine protective effects.
Natural product research.
2022 Dec; 36(23):5967-5976. doi:
10.1080/14786419.2022.2050226. [PMID: 35275510] - M I Yousef, S Roychoudhury, K S Jafaar, P Slama, K K Kesari, M Ae-N Kamel. Aluminum oxide and zinc oxide induced nanotoxicity in rat brain, heart, and lung.
Physiological research.
2022 11; 71(5):677-694. doi:
10.33549/physiolres.934831. [PMID: 36121020] - Muhammad Junaid Rao, Mingzheng Duan, Xiaoshuang Wei, Hou Zuo, Li Ma, Muhammad Tahir Ul Qamar, Min Li, Shijian Han, Lihua Hu, Lingqiang Wang. LC-MS/MS-based metabolomics approach revealed novel phytocompounds from sugarcane rind with promising pharmacological value.
Journal of the science of food and agriculture.
2022 Nov; 102(14):6632-6642. doi:
10.1002/jsfa.12030. [PMID: 35603546] - Guo-Rui Yuan, Meng-Ling Chen, Meng-Lan Peng, Wei Lei, Li-Wei Meng, Wei Dou, Jin-Jun Wang. Knockdown of a Nicotinic Acetylcholine Receptor Subunit Gene Bdorβ1 Decreases Susceptibility to Oxa-Bridged trans- instead of cis-Nitromethylene Neonicotinoid Insecticides in Bactrocera dorsalis.
Journal of agricultural and food chemistry.
2022 Oct; 70(42):13554-13562. doi:
10.1021/acs.jafc.2c04709. [PMID: 36224100] - Marwa M Saeed, Álvaro Fernández-Ochoa, Fatema R Saber, Rabab H Sayed, María de la Luz Cádiz-Gurrea, Amira K Elmotayam, Francisco Javier Leyva-Jiménez, Antonio Segura-Carretero, Rania I Nadeem. The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27207118. [PMID: 36296710] - Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang. Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012064. [PMID: 36292919] - Yunting Xie, Linlin Cai, Zhiji Huang, Kai Shan, Xinglian Xu, Guanghong Zhou, Chunbao Li. Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice.
Journal of agricultural and food chemistry.
2022 Oct; 70(39):12442-12455. doi:
10.1021/acs.jafc.2c04246. [PMID: 36070521] - Zhi-Min Wang, Sha Li, Cheng-Cheng Shi, Lin-Jie Xie, Kai-Yun Fu, Wei-Hua Jiang. The actions of neonicotinoid insecticides on nicotinic acetylcholine subunits Ldα1 and Ldα8 of Leptinotarsa decemlineata and assembled receptors.
Insect science.
2022 Oct; 29(5):1387-1400. doi:
10.1111/1744-7917.13005. [PMID: 35038787] - Xue Mei Fang, Ying Liu, Ji Wang, Xin Zhang, Lei Wang, Li Zhang, Hong Ping Zhang, Lei Liu, Dan Huang, Dan Liu, Ke Deng, Feng Ming Luo, Hua Jing Wan, Wei Min Li, Gang Wang, Brian G Oliver. Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations.
Lung.
2022 10; 200(5):579-589. doi:
10.1007/s00408-022-00570-x. [PMID: 36156139] - Eman A Mohamed, Hebatalla I Ahmed, Heba S Zaky, Amira M Badr. Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway.
Environmental science and pollution research international.
2022 Oct; 29(50):76135-76143. doi:
10.1007/s11356-022-20611-5. [PMID: 35668264] - Suman Manandhar, Runali Sankhe, Keerthi Priya, Gangadhar Hari, Harish Kumar B, Chetan H Mehta, Usha Y Nayak, K Sreedhara Ranganath Pai. Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer's disease.
Molecular diversity.
2022 Oct; 26(5):2793-2811. doi:
10.1007/s11030-022-10395-8. [PMID: 35146638] - Min Ji Go, Jong Min Kim, Jin Yong Kang, Seon Kyeong Park, Chang Jun Lee, Min Ji Kim, Hyo Rim Lee, Tae Yoon Kim, Seung Gyum Joo, Dae-Ok Kim, Ho Jin Heo. Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation.
Journal of microbiology and biotechnology.
2022 Sep; 32(9):1154-1167. doi:
10.4014/jmb.2207.07015. [PMID: 36039041] - Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Cheng. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911311. [PMID: 36232612] - Minji Kang, Jin Ryeol An, Hongliang Li, Wenwen Zhuang, Ryeon Heo, Seojin Park, Seo-Yeong Mun, Minju Park, Mi Seon Seo, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Won Sun Park. Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2022 09; 189(2):260-267. doi:
10.1093/toxsci/kfac083. [PMID: 35944222] - Xiu-Min Wang, Li-Xia Lv, Yue-Si Qin, Yu-Zhu Zhang, Ni Yang, Shu Wu, Xiu-Wen Xia, Hong Yang, Hong Xu, Ying Liu, Wei-Jun Ding. Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis.
World journal of gastroenterology.
2022 Sep; 28(34):5007-5022. doi:
10.3748/wjg.v28.i34.5007. [PMID: 36160643] - Muhammad Afzal, Sami I Alzarea, Khalid Saad Alharbi, Abdulaziz I Alzarea, Sattam Khulaif Alenezi, Mohammed Salem Alshammari, Ali H Alquraini, Imran Kazmi. Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF-α Signaling Pathways.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185888. [PMID: 36144623] - Hulya Guven, Nergiz Durmus, Nil Hocaoglu, Ozge Guner, Selin Acar, Pınar Akan, Ozlem Gursoy Calan. Protective effects of wheat germ oil against erectile and endothelial dysfunction in streptozotocin-induced diabetic rats.
International journal of impotence research.
2022 Sep; 34(6):581-587. doi:
10.1038/s41443-021-00453-4. [PMID: 34108653] - Deniz Kantar, Alev Duygu Acun, Betül Danışman. Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment.
Behavioural brain research.
2022 08; 431(?):113972. doi:
10.1016/j.bbr.2022.113972. [PMID: 35718231] - Dario Pellegrini, Regina Konst, Stijn van den Oord, Aukelien Dimitriu-Leen, Jan-Quinten Mol, Tijn Jansen, Angela Maas, Helmut Gehlmann, Robert-Jan van Geuns, Suzette Elias-Smale, Niels van Royen, Peter Damman. Features of atherosclerosis in patients with angina and no obstructive coronary artery disease.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
2022 Aug; 18(5):e397-e404. doi:
10.4244/eij-d-21-00875. [PMID: 35082112] - Maëlle Jospin, Benjamin Bonneau, Viviane Lainé, Jean-Louis Bessereau. An extracellular scaffolding complex confers unusual rectification upon an ionotropic acetylcholine receptor in C. elegans.
Proceedings of the National Academy of Sciences of the United States of America.
2022 07; 119(29):e2113545119. doi:
10.1073/pnas.2113545119. [PMID: 35858330] - Ze-Xing Wang, Wen-Wen Lian, Jun He, Xiao-Li He, Yu-Ming Wang, Chen-Hao Pan, Mei Li, Wei-Ku Zhang, Lian-Qi Liu, Jie-Kun Xu. Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress.
Journal of ethnopharmacology.
2022 Jul; 293(?):115252. doi:
10.1016/j.jep.2022.115252. [PMID: 35405255] - Malena M Pérez, Vinícius E Pimentel, Carlos A Fuzo, Pedro V da Silva-Neto, Diana M Toro, Thais F C Fraga-Silva, Luiz G Gardinassi, Camilla N S Oliveira, Camila O S Souza, Nicola T Torre-Neto, Jonatan C S de Carvalho, Thais C De Leo, Viviani Nardini, Marley R Feitosa, Rogerio S Parra, José J R da Rocha, Omar Feres, Fernando C Vilar, Gilberto G Gaspar, Leticia F Constant, Fátima M Ostini, Augusto M Degiovani, Alessandro P Amorim, Angelina L Viana, Ana P M Fernandes, Sandra R Maruyama, Elisa M S Russo, Isabel K F M Santos, Vânia L D Bonato, Cristina R B Cardoso, Carlos A Sorgi, Marcelo Dias-Baruffi, Lúcia H Faccioli. Acetylcholine, Fatty Acids, and Lipid Mediators Are Linked to COVID-19 Severity.
Journal of immunology (Baltimore, Md. : 1950).
2022 07; 209(2):250-261. doi:
10.4049/jimmunol.2200079. [PMID: 35768148] - Mengxiao Zhou, Lijuan Wang, Zihan Wang, Xiaotong Chang, Xiaobo Zhu. Celiac vagus nerve mediates expression of the acetylcholine receptor α7nAChR on monocytes in the spleen.
Biochemical and biophysical research communications.
2022 07; 613(?):174-179. doi:
10.1016/j.bbrc.2022.05.005. [PMID: 35597124] - Anna K Whitehead, Nicholas D Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S Pearson, Kyle B LaPenna, Thomas E Sharp, David J Lefer, Eric Lazartigues, Jason D Gardner, Xinping Yue. Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.
Clinical science (London, England : 1979).
2022 06; 136(12):973-987. doi:
10.1042/cs20220083. [PMID: 35678315] - Geoffrey Alan Watson, Enrique Sanz-Garcia, Wen-Jiang Zhang, Zhihui Amy Liu, Sy Cindy Yang, Ben Wang, Shaofeng Liu, Shawn Kubli, Hal Berman, Thomas Pfister, Sofia Genta, Anna Spreafico, Aaron R Hansen, Philippe L Bedard, Stephanie Lheureux, Albiruni Abdul Razak, Dave Cescon, Marcus O Butler, Wei Xu, Tak W Mak, Lillian L Siu, Eric Chen. Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab.
Journal for immunotherapy of cancer.
2022 06; 10(6):. doi:
10.1136/jitc-2021-004378. [PMID: 35705312] - Wanlin Zhong, Jiaqing Zhu, Juanjuan Yi, Changcheng Zhao, Yanling Shi, Qiaozhen Kang, Jinyong Huang, Limin Hao, Jike Lu. Biochemical analysis reveals the systematic response of motion sickness mice to ginger (Zingiber officinale) extract's amelioration effect.
Journal of ethnopharmacology.
2022 May; 290(?):115077. doi:
10.1016/j.jep.2022.115077. [PMID: 35131339] - Tomasz Tuzimski, Anna Petruczynik. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103222. [PMID: 35630702] - Eun-Jung Yoon, Yunseo Choi, Dongsun Park. Improvement of Cognitive Function in Ovariectomized Rats by Human Neural Stem Cells Overexpressing Choline Acetyltransferase via Secretion of NGF and BDNF.
International journal of molecular sciences.
2022 May; 23(10):. doi:
10.3390/ijms23105560. [PMID: 35628371] - Jody L Greaney, Erika F H Saunders, Lacy M Alexander. Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder.
American journal of physiology. Heart and circulatory physiology.
2022 05; 322(5):H880-H889. doi:
10.1152/ajpheart.00643.2021. [PMID: 35363580] - Yajun Shi, Jingliu Liu, Dan Zhu, Likui Lu, Mengshu Zhang, Weisheng Li, Hongtao Zeng, Xi Yu, Jun Guo, Yingying Zhang, Xiuwen Zhou, Qinqin Gao, Fei Xia, Youguo Chen, Min Li, Miao Sun. Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
Biology of reproduction.
2022 04; 106(4):687-698. doi:
10.1093/biolre/ioab234. [PMID: 34935917] - Miguel A Matilla, Félix Velando, Ana Tajuelo, David Martín-Mora, Wenhao Xu, Victor Sourjik, José A Gavira, Tino Krell. Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine.
mBio.
2022 04; 13(2):e0345821. doi:
10.1128/mbio.03458-21. [PMID: 35254130] - Eryn Donovan, Cassandra Avila, Sarah Klausner, Vinay Parikh, Cristina Fenollar-Ferrer, Randy D Blakely, Martin Sarter. Disrupted Choline Clearance and Sustained Acetylcholine Release In Vivo by a Common Choline Transporter Coding Variant Associated with Poor Attentional Control in Humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2022 04; 42(16):3426-3444. doi:
10.1523/jneurosci.1334-21.2022. [PMID: 35232764] - Weilin Liu, Jianhong Li, Minguang Yang, Xiaohua Ke, Yaling Dai, Huawei Lin, Sinuo Wang, Lidian Chen, Jing Tao. Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease.
Alzheimer's research & therapy.
2022 04; 14(1):53. doi:
10.1186/s13195-022-00994-w. [PMID: 35418161] - Pankaj Bhatia, Nirmal Singh. Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia.
The International journal of neuroscience.
2022 Apr; 132(4):384-396. doi:
10.1080/00207454.2020.1817009. [PMID: 32859137] - Mi Cheng, Yang-Lin Shi, Pan-Pan Shang, Yan-Jiao Chen, Yu-Dong Xu. Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness.
Current medical science.
2022 Apr; 42(2):333-340. doi:
10.1007/s11596-022-2559-7. [PMID: 35419674] - Stephanie M Mutchler, Thomas R Kleyman. Effects of amiloride on acetylcholine-dependent arterial vasodilation evolve over time in mice on a high salt diet.
Physiological reports.
2022 04; 10(7):e15255. doi:
10.14814/phy2.15255. [PMID: 35384364] - Ghazala Ashraf, Muhammad Asif, Ayesha Aziz, Tayyaba Iftikhar, Zi-Tao Zhong, Shujie Zhang, Bo Liu, Wei Chen, Yuan-Di Zhao. Advancing interfacial properties of carbon cloth via anodic-induced self-assembly of MOFs film integrated with α-MnO2: A sustainable electrocatalyst sensing acetylcholine.
Journal of hazardous materials.
2022 03; 426(?):128133. doi:
10.1016/j.jhazmat.2021.128133. [PMID: 34968843] - Akshi Deshwal, Arshdeep Kaur Gill, Surajmal Nain, Debabrata Patra, Subhabrata Maiti. Inhibitory effect of nucleotides on acetylcholine esterase activity and its microflow-based actuation in blood plasma.
Chemical communications (Cambridge, England).
2022 Mar; 58(21):3501-3504. doi:
10.1039/d2cc00029f. [PMID: 35194626] - Anna Szeliga, Ewa Rudnicka, Marzena Maciejewska-Jeske, Marek Kucharski, Anna Kostrzak, Marta Hajbos, Olga Niwczyk, Roman Smolarczyk, Blazej Meczekalski. Neuroendocrine Determinants of Polycystic Ovary Syndrome.
International journal of environmental research and public health.
2022 03; 19(5):. doi:
10.3390/ijerph19053089. [PMID: 35270780] - Concetta Cafiero, Alessandra Micera, Agnese Re, Beniamino Schiavone, Giulio Benincasa, Raffaele Palmirotta. Comment on Kopańska et al. Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research. Int. J. Mol. Sci. 2022, 23, 672.
International journal of molecular sciences.
2022 Mar; 23(5):. doi:
10.3390/ijms23052818. [PMID: 35269960] - Marta Kuczeriszka, Leszek Dobrowolski, Agnieszka Walkowska, Iwona Baranowska, Joanna D Sitek, Elżbieta Kompanowska-Jezierska. Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats.
Clinical and experimental pharmacology & physiology.
2022 03; 49(3):432-441. doi:
10.1111/1440-1681.13618. [PMID: 34870864] - Shohei Yamaguchi, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, Kozo Nakamura. Antihypertensive Mechanism of Orally Administered Acetylcholine in Spontaneously Hypertensive Rats.
Nutrients.
2022 Feb; 14(4):. doi:
10.3390/nu14040905. [PMID: 35215556] - Nikola M Stojanović, Marko Z Mladenović, Aleksandra Maslovarić, Nenad I Stojiljković, Pavle J Randjelović, Niko S Radulović. Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms - In vitro and in vivo studies.
Journal of ethnopharmacology.
2022 Feb; 284(?):114788. doi:
10.1016/j.jep.2021.114788. [PMID: 34718102] - Yang Sun, Chen Liang, Lihua Zheng, Lei Liu, Zhijin Li, Guang Yang, Yuxin Li. Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Journal of ethnopharmacology.
2022 Feb; 284(?):114767. doi:
10.1016/j.jep.2021.114767. [PMID: 34710555] - Mohammed Y Emran, Mohamed A Shenashen, Ayman El Sabagh, Mahmoud M Selim, Sherif A El-Safty. Enzymeless copper microspheres@carbon sensor design for sensitive and selective acetylcholine screening in human serum.
Colloids and surfaces. B, Biointerfaces.
2022 Feb; 210(?):112228. doi:
10.1016/j.colsurfb.2021.112228. [PMID: 34839049] - Yoshinori Nishijima, Shelby N Hader, Alena J Hanson, David X Zhang, Rodney Sparapani, David D Gutterman, Andreas M Beyer. Prolonged endothelial-dysfunction in human arterioles following infection with SARS-CoV-2.
Cardiovascular research.
2022 01; 118(1):18-19. doi:
10.1093/cvr/cvab339. [PMID: 34755839] - Yumo Li, Binbin Wu, Cong Hu, Jie Hu, Qingquan Lian, Jun Li, Daqing Ma. The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats.
European journal of pharmacology.
2022 Jan; 914(?):174668. doi:
10.1016/j.ejphar.2021.174668. [PMID: 34863997] - You Kyoung Shin, Soonho Kwon, Yu Shan Hsieh, A Young Han, Geun Hee Seol. Linalyl acetate restores colon contractility and blood pressure in repeatedly stressed-ulcerative colitis rats.
Environmental health and preventive medicine.
2022; 27(0):27. doi:
10.1265/ehpm.22-00041. [PMID: 35753805] - Simon Haunhorst, Wilhelm Bloch, Miriam Ringleb, Lena Fennen, Heiko Wagner, Holger H W Gabriel, Christian Puta. Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review.
Exercise immunology review.
2022; 28(?):36-52. doi:
. [PMID: 35452397] - Fuding Guo, Yueyi Wang, Jun Wang, Zhihao Liu, Yanqiu Lai, Zhen Zhou, Zihan Liu, Yuyang Zhou, Xiao Xu, Zeyan Li, Meng Wang, Fu Yu, Ruijie Hu, Liping Zhou, Hong Jiang. Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway.
Oxidative medicine and cellular longevity.
2022; 2022(?):4740931. doi:
10.1155/2022/4740931. [PMID: 35422894] - Sulè Gunter, Frederic S Michel, Serena S Fourie, Mikayra Singh, Regina le Roux, Ashmeetha Manilall, Lebogang P Mokotedi, Aletta M E Millen. The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis.
PloS one.
2022; 17(2):e0264558. doi:
10.1371/journal.pone.0264558. [PMID: 35213638] - Andressa Kely Pinheiro, Dalila Andrade Pereira, Jean Leandro Dos Santos, Fabiano Beraldi Calmasini, Eduardo Costa Alexandre, Leonardo Oliveira Reis, Arthur L Burnett, Fernando Ferreira Costa, Fábio Henrique Silva. Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse.
PloS one.
2022; 17(6):e0269310. doi:
10.1371/journal.pone.0269310. [PMID: 35653352] - Jing Gao, Mingyin Lai, Wen Fu, Mengyu Wang, Thi Thanh Tam Mai, Baile Ning, Wenbin Fu. Electroacupuncture Ameliorates Depressive-Like State and Synaptic Deficits Induced by Hyper-Cholinergic Tone During Chronic Stress in Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Dec; 27(?):e933833. doi:
10.12659/msm.933833. [PMID: 34924558] - Danish Iqbal, M Salman Khan, Mohd Waiz, Md Tabish Rehman, Mohammed Alaidarous, Azfar Jamal, Abdulaziz S Alothaim, Mohamed F AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Mohammed Alsaweed, Yahya Madkhali, Abdulrahman Algarni, Suliman A Alsagaby, Wael Alturaiki. Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123533. [PMID: 34944045] - Adela Della Marina, Annabelle Arlt, Ulrike Schara-Schmidt, Christel Depienne, Andrea Gangfuß, Heike Kölbel, Albert Sickmann, Erik Freier, Nicolai Kohlschmidt, Andreas Hentschel, Joachim Weis, Artur Czech, Anika Grüneboom, Andreas Roos. Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123481. [PMID: 34943989] - Irina Zelinskaya, Oleg Kornushin, Elizaveta Savochkina, Vyacheslav Dyachuk, Marina Vasyutina, Michael Galagudza, Yana Toropova. Vascular region-specific changes in arterial tone in rats with type 2 diabetes mellitus: Opposite responses of mesenteric and femoral arteries to acetylcholine and 5-hydroxytryptamine.
Life sciences.
2021 Dec; 286(?):120011. doi:
10.1016/j.lfs.2021.120011. [PMID: 34606853] - Jian-Fang Li, Xiao-Yu Zhang, Xue Bai, Hong-Ai Su, Ya-Lan Liu, Yong-Yue Lu, Yi-Xiang Qi. Identification of putative muscarinic acetylcholine receptor genes in Bactrocera dorsalis and functional analysis of Bdor-mAChR-B.
Insect biochemistry and molecular biology.
2021 12; 139(?):103657. doi:
10.1016/j.ibmb.2021.103657. [PMID: 34582990] - Haruka Sasaki, Yi Zhang, Charles W Emala, Kentaro Mizuta. Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology.
2021 12; 321(6):L991-L1005. doi:
10.1152/ajplung.00273.2021. [PMID: 34612067] - Yang Gao, Jun-Feng Liu, Chao Zhang. The effects of acetylcholine on intracellular calcium fluorescence in smooth muscle cells of human esophagogastric junction cultured in vitro.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2021 11; 33(11):e14252. doi:
10.1111/nmo.14252. [PMID: 34532931] - Shachi Shuchi Smita, Mashu Trivedi, Deepika Tripathi, Shashi Pandey-Rai, Rakesh Pandey. Neuromodulatory potential of Asparagus racemosus and its bioactive molecule Shatavarin IV by enhancing synaptic acetylcholine level and nAChR activity.
Neuroscience letters.
2021 11; 764(?):136294. doi:
10.1016/j.neulet.2021.136294. [PMID: 34655710] - Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J Tracey, Sangeeta S Chavan. Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension.
Molecular medicine (Cambridge, Mass.).
2021 10; 27(1):133. doi:
10.1186/s10020-021-00380-6. [PMID: 34674633] - Jiaqi Lv, Xiaoxiao Ji, Zhen Li, Huiqin Hao. The role of the cholinergic anti-inflammatory pathway in autoimmune rheumatic diseases.
Scandinavian journal of immunology.
2021 Oct; 94(4):e13092. doi:
10.1111/sji.13092. [PMID: 34780075] - Yana G Toropova, Irina A Zelinskaya, Mariya N Gorshkova, Daria S Motorina, Dmitriy V Korolev, Fedor S Velikonivtsev, Kamil G Gareev. Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats.
Journal of biomedical materials research. Part A.
2021 10; 109(10):2017-2026. doi:
10.1002/jbm.a.37193. [PMID: 33811797] - Anubhav Chakraborty, Vishwam Sankaran, Ramar Murugan, David Raj Chellappan. Comparative spasmolytic effect between Cinnamomum tamala and Cinnamomum verum leaf essential oils and eugenol through in vitro and in silico approaches.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2021 Sep; 76(9-10):383-391. doi:
10.1515/znc-2020-0153. [PMID: 33872476] - Francesca Leo, Tatsiana Suvorava, Sophia K Heuser, Junjie Li, Anthea LoBue, Frederik Barbarino, Eugenia Piragine, Rebekka Schneckmann, Beate Hutzler, Miranda E Good, Bernadette O Fernandez, Lukas Vornholz, Stephen Rogers, Allan Doctor, Maria Grandoch, Johannes Stegbauer, Eddie Weitzberg, Martin Feelisch, Jon O Lundberg, Brant E Isakson, Malte Kelm, Miriam M Cortese-Krott. Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure.
Circulation.
2021 09; 144(11):870-889. doi:
10.1161/circulationaha.120.049606. [PMID: 34229449] - Qing Wu, Ming Zhao, Xi He, Runqing Xue, Dongling Li, Xiaojiang Yu, Shengpeng Wang, Weijin Zang. Acetylcholine reduces palmitate-induced cardiomyocyte apoptosis by promoting lipid droplet lipolysis and perilipin 5-mediated lipid droplet-mitochondria interaction.
Cell cycle (Georgetown, Tex.).
2021 09; 20(18):1890-1906. doi:
10.1080/15384101.2021.1965734. [PMID: 34424820] - Tsuyoshi Inoue. Neuroimmune system-mediated renal protection mechanisms.
Clinical and experimental nephrology.
2021 Sep; 25(9):915-924. doi:
10.1007/s10157-021-02062-3. [PMID: 33877485] - Amanda Jiménez-Pompa, Sara Sanz-Lázaro, Arik J Hone, Lola Rueda-Ruzafa, José Medina-Polo, Carmen González-Enguita, Jesús Blázquez, Cristóbal de Los Ríos, J Michael McIntosh, Almudena Albillos. Therapeutic concentrations of varenicline increases exocytotic release of catecholamines from human and rat adrenal chromaffin cells in the presence of nicotine.
Neuropharmacology.
2021 09; 195(?):108632. doi:
10.1016/j.neuropharm.2021.108632. [PMID: 34097947] - Ji-Hye Choi, Eun-Byeol Lee, Hwan-Hee Jang, Youn-Soo Cha, Yong-Soon Park, Sung-Hyen Lee. Allium hookeri Extracts Improve Scopolamine-Induced Cognitive Impairment via Activation of the Cholinergic System and Anti-Neuroinflammation in Mice.
Nutrients.
2021 Aug; 13(8):. doi:
10.3390/nu13082890. [PMID: 34445062] - Anurag Kumar Singh, Saumitra Sen Singh, Aaina Singh Rathore, Surya Pratap Singh, Gaurav Mishra, Rajendra Awasthi, Sunil Kumar Mishra, Vibhav Gautam, Santosh Kumar Singh. Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation.
ACS biomaterials science & engineering.
2021 08; 7(8):3737-3753. doi:
10.1021/acsbiomaterials.1c00514. [PMID: 34297529] - Hye Ju Han, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo, Dae-Ok Kim, Gun-Hee Kim, Ho Jin Heo. Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation.
Marine drugs.
2021 Jul; 19(8):. doi:
10.3390/md19080434. [PMID: 34436273]