Glycinexylidide (BioDeep_00000014824)
Secondary id: BioDeep_00001874341
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
2-Amino-N-(2,6-dimethyl-phenyl)-acetamide
化学式: C10H14N2O (178.1106074)
中文名称: 甘氨酸二甲基苯胺
谱图信息:
最多检出来源 Homo sapiens(blood) 5.84%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN
InChI: InChI=1S/C10H14N2O/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6,11H2,1-2H3,(H,12,13)
描述信息
Glycinexylidide is a metabolite of lidocaine. Lidocaine, Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. (Wikipedia)
同义名列表
11 个代谢物同义名
2-Amino-N-(2,6-dimethyl-phenyl)-acetamide; 2-amino-N-(2,6-dimethylphenyl)acetamide; N-(2,6-Dimethylphenyl)-2-aminoacetamide; N-(2,6-Dimethylphenyl)glycinamide; Glycinexylidide monohydrochloride; 2-Amino-2,6-dimethylacetoanilide; 2-Amino-2,6-acetoxylidide; Glycine xylidide; Glycinexylidide; Glycylxylidide; GX
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:357241
- KEGG: C16569
- PubChem: 87833
- HMDB: HMDB0060679
- Metlin: METLIN1001
- ChEMBL: CHEMBL1302
- CAS: 1217098-46-8
- CAS: 18865-38-8
- PubChem: 51090898
- NIKKAJI: J401.554A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
6 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(2)
- Lidocaine metabolism:
Lidocaine ⟶ 2,6-xylidine - Lidocaine metabolism:
Lidocaine ⟶ 2,6-xylidine
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(3)
- Lidocaine (Antiarrhythmic) Action Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline - Lidocaine (Local Anaesthetic) Action Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline - Lidocaine (Local Anaesthetic) Metabolism Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bridget Martell, Harvey Kushner, Elaine Richardson, Amy Mize, Philip Mayer. Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects.
Clinical pharmacology in drug development.
2017 Jan; 6(1):27-35. doi:
10.1002/cpdd.286. [PMID: 27297519] - Colleen K Lambertz, Christopher J Johnson, Paul G Montgomery, James R Maxwell, Stefanie J Fry. Toxicity of topical lidocaine applied to the breasts to reduce discomfort during screening mammography.
Journal of anaesthesiology, clinical pharmacology.
2012 Apr; 28(2):200-4. doi:
10.4103/0970-9185.94859. [PMID: 22557743] - Robert Werdehausen, David Kremer, Timo Brandenburger, Lukas Schlösser, Janusz Jadasz, Patrick Küry, Inge Bauer, Carmen Aragón, Volker Eulenburg, Henning Hermanns. Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?.
Anesthesiology.
2012 Jan; 116(1):147-58. doi:
10.1097/aln.0b013e31823cf233. [PMID: 22133759] - Samantha A Nelis, Catherine Sievers, Mark Jarrett, Lisa M Nissen, Carl M J Kirkpatrick, P Nicholas Shaw. Quantitative analysis of lignocaine and metabolites in equine urine and plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jul; 878(22):2018-22. doi:
10.1016/j.jchromb.2010.05.042. [PMID: 20566304] - Jin Xiang, Cheng Zhang, Qin Yu, Mao-Zhi Liang, Yong-Ping Qin, Feng Nan. [Determination of lidocaine and its metabolites in human plasma by liquid chromatography in combination with tandem mass spectrometry].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2010 Jul; 41(4):696-9. doi:
. [PMID: 20848799] - E J Dickey, H C McKenzie, K A Brown, C N de Solis. Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses.
Equine veterinary journal.
2008 Jun; 40(4):348-52. doi:
10.2746/042516408x284664. [PMID: 18267881] - Satish Balkrishna Bhise, Remeth Jacky Dias. Effect of erythromycin and rifampicin on monoethylglycinexylidide test.
Indian journal of pharmacology.
2008 Mar; 40(2):84-6. doi:
10.4103/0253-7613.41044. [PMID: 21279172] - A Maes, L Weiland, C Sandersen, F Gasthuys, P De Backer, S Croubels. Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):180-7. doi:
10.1016/j.jchromb.2007.01.010. [PMID: 17296334] - Sara De Martin, Rocco Orlando, Massimo Bertoli, Paola Pegoraro, Pietro Palatini. Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis.
Clinical pharmacology and therapeutics.
2006 Dec; 80(6):597-606. doi:
10.1016/j.clpt.2006.08.020. [PMID: 17178261] - Shin Nakayama, Masayuki Miyabe, Yoshihiro Kakiuchi, Shinichi Inomata, Yoshiko Osaka, Taeko Fukuda, Yukinao Kohda, Hidenori Toyooka. Propofol does not inhibit lidocaine metabolism during epidural anesthesia.
Anesthesia and analgesia.
2004 Oct; 99(4):1131-1135. doi:
10.1213/01.ane.0000131508.39939.86. [PMID: 15385363] - Alexander Valverde, Thomas J Doherty, Jorge Hernández, Wendy Davies. Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
Veterinary anaesthesia and analgesia.
2004 Oct; 31(4):264-71. doi:
10.1111/j.1467-2995.2004.00165.x. [PMID: 15509291] - Magnus S Anderson, Bing Lu, Mohamed Abdel-Rehim, Sverker Blomberg, Lars G Blomberg. Utility of nonaqueous capillary electrophoresis for the determination of lidocaine and its metabolites in human plasma: a comparison of ultraviolet and mass spectrometric detection.
Rapid communications in mass spectrometry : RCM.
2004; 18(22):2612-8. doi:
10.1002/rcm.1666. [PMID: 15481095] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Maura Floreani, Pietro Palatini. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Clinical pharmacology and therapeutics.
2004 Jan; 75(1):80-8. doi:
10.1016/j.clpt.2003.09.007. [PMID: 14749694] - Taeko Fukuda, Yoshihiro Kakiuchi, Masayuki Miyabe, Shinichi Kihara, Yukinao Kohda, Hidenori Toyooka. Free lidocaine concentrations during continuous epidural anesthesia in geriatric patients.
Regional anesthesia and pain medicine.
2003 May; 28(3):215-20. doi:
10.1053/rapm.2003.50131. [PMID: 12772139] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Pietro Palatini. Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
British journal of clinical pharmacology.
2003 Jan; 55(1):86-93. doi:
10.1046/j.1365-2125.2003.01718.x. [PMID: 12534644] - Y Kakiuchi, T Fukuda, M Miyabe, M Homma, H Toyooka, Y Kohda. Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia.
International journal of clinical pharmacology and therapeutics.
2002 Nov; 40(11):493-8. doi:
10.5414/cpp40493. [PMID: 12698986] - T Fukuda, Y Kakiuchi, M Miyabe, N Okubo, Y Yaguchi, Y Kohda, H Toyooka. Plasma lidocaine, monoethylglycinexylidide, and glycinexylidide concentrations after epidural administration in geriatric patients.
Regional anesthesia and pain medicine.
2000 May; 25(3):268-73. doi:
10.1016/s1098-7339(00)90009-9. [PMID: 10834781] - Y Kakiuchi, Y Kohda, M Miyabe, Y Momose. Effect of plasma alpha1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children.
International journal of clinical pharmacology and therapeutics.
1999 Oct; 37(10):493-8. doi:
NULL. [PMID: 10543316] - K T Lê, H Maurice, P du Souich. First-pass metabolism of lidocaine in the anesthetized rabbit. Contribution of the small intestine.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jul; 24(7):711-6. doi:
NULL. [PMID: 8818566] - C L O'Neal, A Poklis. Sensitive HPLC for simultaneous quantification of lidocaine and its metabolites monoethylglycinexylidide and glycinexylidide in serum.
Clinical chemistry.
1996 Feb; 42(2):330-1. doi:
10.1093/clinchem/42.2.330. [PMID: 8595734] - M Chamelian, A Lécrivain, A Robichaud, P du Souich. Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits.
British journal of pharmacology.
1994 Sep; 113(1):317-23. doi:
10.1111/j.1476-5381.1994.tb16211.x. [PMID: 7812627] - Y Chen, J M Potter. Fluorescence polarization immunoassay and HPLC assays compared for measuring monoethylglycinexylidide in liver-transplant patients.
Clinical chemistry.
1992 Dec; 38(12):2426-30. doi:
. [PMID: 1458579] - P du Souich, C Saunier, D Hartemann, M Allam. Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow.
Pulmonary pharmacology.
1992; 5(1):9-16. doi:
10.1016/0952-0600(92)90012-6. [PMID: 1591467] - W A Watson, M F Sands, J C Barlow, M E Lener, J H Wilton. Lidocaine absorption and metabolism after oropharyngeal application in young and young-elderly adults.
DICP : the annals of pharmacotherapy.
1991 May; 25(5):463-5. doi:
10.1177/106002809102500503. [PMID: 2068827] - Y K Tam, J Ke, R T Coutts, D G Wyse, M R Gray. Quantification of three lidocaine metabolites and their conjugates.
Pharmaceutical research.
1990 May; 7(5):504-7. doi:
10.1023/a:1015868800614. [PMID: 2367319] - J Yamane. [Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion].
Nichidai koku kagaku = Nihon University journal of oral science.
1989 Sep; 15(3):183-95. doi:
NULL. [PMID: 2489793] - N A Estes, A S Manolis, D J Greenblatt, H Garan, J N Ruskin. Therapeutic serum lidocaine and metabolite concentrations in patients undergoing electrophysiologic study after discontinuation of intravenous lidocaine infusion.
American heart journal.
1989 May; 117(5):1060-4. doi:
10.1016/0002-8703(89)90862-4. [PMID: 2711965] - B G Heinzow, A Somogyi, A J McLean. Influence of hydralazine on the pharmacokinetics of orally administered d-propranolol and lidocaine in conscious dogs.
Archives internationales de pharmacodynamie et de therapie.
1987 Mar; 286(1):5-14. doi:
NULL. [PMID: 3592861] - J R Powell, J Foster, J H Patterson, R Cross, W Wargin. Effect of duration of lidocaine infusion and route of cimetidine administration on lidocaine pharmacokinetics.
Clinical pharmacy.
1986 Dec; 5(12):993-8. doi:
NULL. [PMID: 3802729] - Y Saegusa, M Watanabe, H Ohno, Y Hasegawa, T Kawamoto, K Hanawa. [High-performance liquid chromatographic method for plasma or serum level monitoring of lidocaine and its active metabolites].
Rinsho byori. The Japanese journal of clinical pathology.
1986 Oct; 34(10):1193-7. doi:
NULL. [PMID: 3543441] - B R Kuhnert, E H Philipson, R Pimental, P M Kuhnert, K J Zuspan, C D Syracuse. Lidocaine disposition in mother, fetus, and neonate after spinal anesthesia.
Anesthesia and analgesia.
1986 Feb; 65(2):139-44. doi:
NULL. [PMID: 3942301] - R Lindberg, J Kanto, M Hovi-Viander, E Laurikainen. Serum concentrations and urinary excretion of lidocaine and its two desethylated metabolites after spinal anaesthesia using lidocaine or lidocaine with phenylephrine.
Acta anaesthesiologica Scandinavica.
1985 Nov; 29(8):811-3. doi:
10.1111/j.1399-6576.1985.tb02305.x. [PMID: 3841252] - R Inoue, T Suganuma, H Echizen, T Ishizaki, K Kushida, Y Tomono. Plasma concentrations of lidocaine and its principal metabolites during intermittent epidural anesthesia.
Anesthesiology.
1985 Sep; 63(3):304-10. doi:
10.1097/00000542-198509000-00011. [PMID: 4025891] - D J Greenblatt, D M Benjamin, C R Willis, J S Harmatz, M A Zinny. Lidocaine plasma concentrations following administration of intraoral lidocaine solution.
Archives of otolaryngology (Chicago, Ill. : 1960).
1985 May; 111(5):298-300. doi:
10.1001/archotol.1985.00800070050005. [PMID: 3985850] - J Cusson, S Nattel, C Matthews, M Talajic, S Lawand. Age-dependent lidocaine disposition in patients with acute myocardial infarction.
Clinical pharmacology and therapeutics.
1985 Apr; 37(4):381-6. doi:
10.1038/clpt.1985.58. [PMID: 3978999] - F A Luzzi, T L Wenger, J K Klinger, A Barchowsky, H C Strauss. Simultaneous determination of lidocaine and its metabolites in plasma and myocardium.
Journal of chromatography.
1984 Nov; 311(2):291-9. doi:
10.1016/s0378-4347(00)84722-2. [PMID: 6520176] - A Broughton, A O Grant, C F Starmer, J K Klinger, B S Stambler, H C Strauss. Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.
Circulation research.
1984 Oct; 55(4):513-23. doi:
10.1161/01.res.55.4.513. [PMID: 6478555] - E H Philipson, B R Kuhnert, C D Syracuse. Maternal, fetal, and neonatal lidocaine levels following local perineal infiltration.
American journal of obstetrics and gynecology.
1984 Jun; 149(4):403-7. doi:
10.1016/0002-9378(84)90154-6. [PMID: 6731519] - K Kushida, K Oka, T Suganuma, T Ishizaki. Simultaneous determination of lidocaine and its principal metabolites by liquid chromatography on silica gel, with aqueous eluent.
Clinical chemistry.
1984 May; 30(5):637-40. doi:
10.1093/clinchem/30.5.637. [PMID: 6370497] - M K Halbert, R P Baldwin. Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection.
Journal of chromatography.
1984 Mar; 306(?):269-77. doi:
10.1016/s0378-4347(00)80889-0. [PMID: 6715465] - D E Drayer, B Lorenzo, S Werns, M M Reidenberg. Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages.
Clinical pharmacology and therapeutics.
1983 Jul; 34(1):14-22. doi:
10.1038/clpt.1983.122. [PMID: 6861434] - F Handel, F A Luzzi, T L Wenger, A Barchowsky, D G Shand, H C Strauss. Lidocaine and its metabolites in canine plasma and myocardium.
Journal of cardiovascular pharmacology.
1983 Jan; 5(1):44-50. doi:
10.1097/00005344-198301000-00006. [PMID: 6186858] - E Laurikainen, R Marttila, R Lindberg, J Kanto. Penetration of lidocaine and its active desethylated metabolite into cerebrospinal fluid in man.
European journal of clinical pharmacology.
1983; 25(5):639-41. doi:
10.1007/bf00542352. [PMID: 6662163] - C A Neff-Davis, J C Wilcke, L E Davis. A rapid analytical procedure for the determination of concentrations of lidocaine and its two active metabolites in canine serum.
Journal of veterinary pharmacology and therapeutics.
1982 Dec; 5(4):289-92. doi:
10.1111/j.1365-2885.1982.tb00445.x. [PMID: 7183798] - D A Jones, A McBurney, P J Stanley, C Tovey, J W Ward. Plasma concentrations of lignocaine and its metabolites during fibreoptic bronchoscopy.
British journal of anaesthesia.
1982 Aug; 54(8):853-7. doi:
10.1093/bja/54.8.853. [PMID: 7104134] - A Barchowsky, W W Stargel, D G Shand, P A Routledge. Saliva concentrations of lidocaine and its metabolites in man.
Therapeutic drug monitoring.
1982; 4(4):335-9. doi:
10.1097/00007691-198212000-00002. [PMID: 7157457] - E S Waller. Pharmacokinetic principles of lidocaine dosing in relation to disease state.
Journal of clinical pharmacology.
1981 Apr; 21(4):181-94. doi:
10.1002/j.1552-4604.1981.tb05698.x. [PMID: 7240439] - K A Collinsworth, J M Strong, A J Atkinson, R A Winkle, F Perlroth, D C Harrison. Pharmacokinetics and metabolism of lidocaine in patients with renal failure.
Clinical pharmacology and therapeutics.
1975 Jul; 18(1):59-64. doi:
10.1002/cpt197518159. [PMID: 1149363] - K K Adjepon-Yamoah, L F Prescott. Gas-liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4-hydroxyxylidine in plasma and urine.
The Journal of pharmacy and pharmacology.
1974 Nov; 26(11):889-93. doi:
10.1111/j.2042-7158.1974.tb09198.x. [PMID: 4156560]