Glycinexylidide (BioDeep_00000014824)
Secondary id: BioDeep_00001874341
human metabolite Endogenous blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
2-Amino-N-(2,6-dimethyl-phenyl)-acetamide
化学式: C10H14N2O (178.1106074)
中文名称: 甘氨酸二甲基苯胺, 甘氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 5.84%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN
InChI: InChI=1S/C10H14N2O/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6,11H2,1-2H3,(H,12,13)
描述信息
Glycinexylidide is a metabolite of lidocaine. Lidocaine, Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. (Wikipedia)
同义名列表
13 个代谢物同义名
2-Amino-N-(2,6-dimethyl-phenyl)-acetamide; 2-amino-N-(2,6-dimethylphenyl)acetamide; N-(2,6-Dimethylphenyl)-2-aminoacetamide; N-(2,6-Dimethylphenyl)glycinamide; Glycinexylidide monohydrochloride; 2-Amino-2,6-dimethylacetoanilide; 2-Amino-2,6-acetoxylidide; Glycine xylidide; Glycinexylidide; Glycylxylidide; GX; Glycinexylidide; Glycinexylidide
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:357241
- KEGG: C16569
- PubChem: 87833
- HMDB: HMDB0060679
- Metlin: METLIN1001
- ChEMBL: CHEMBL1302
- CAS: 1217098-46-8
- CAS: 18865-38-8
- PubChem: 51090898
- NIKKAJI: J401.554A
- KNApSAcK: 357241
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
6 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(2)
- Lidocaine metabolism:
Lidocaine ⟶ 2,6-xylidine - Lidocaine metabolism:
Lidocaine ⟶ 2,6-xylidine
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(3)
- Lidocaine (Antiarrhythmic) Action Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline - Lidocaine (Local Anaesthetic) Action Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline - Lidocaine (Local Anaesthetic) Metabolism Pathway:
Lidocaine ⟶ 2,6-Dimethylaniline
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Clinical pharmacology in drug development.
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Journal of anaesthesiology, clinical pharmacology.
2012 Apr; 28(2):200-4. doi:
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Anesthesiology.
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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
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Indian journal of pharmacology.
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2007 Jun; 852(1-2):180-7. doi:
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2006 Dec; 80(6):597-606. doi:
10.1016/j.clpt.2006.08.020. [PMID: 17178261] - Shin Nakayama, Masayuki Miyabe, Yoshihiro Kakiuchi, Shinichi Inomata, Yoshiko Osaka, Taeko Fukuda, Yukinao Kohda, Hidenori Toyooka. Propofol does not inhibit lidocaine metabolism during epidural anesthesia.
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Veterinary anaesthesia and analgesia.
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Rapid communications in mass spectrometry : RCM.
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10.1002/rcm.1666. [PMID: 15481095] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Maura Floreani, Pietro Palatini. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Clinical pharmacology and therapeutics.
2004 Jan; 75(1):80-8. doi:
10.1016/j.clpt.2003.09.007. [PMID: 14749694] - Taeko Fukuda, Yoshihiro Kakiuchi, Masayuki Miyabe, Shinichi Kihara, Yukinao Kohda, Hidenori Toyooka. Free lidocaine concentrations during continuous epidural anesthesia in geriatric patients.
Regional anesthesia and pain medicine.
2003 May; 28(3):215-20. doi:
10.1053/rapm.2003.50131. [PMID: 12772139] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Pietro Palatini. Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
British journal of clinical pharmacology.
2003 Jan; 55(1):86-93. doi:
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International journal of clinical pharmacology and therapeutics.
2002 Nov; 40(11):493-8. doi:
10.5414/cpp40493. [PMID: 12698986] - T Fukuda, Y Kakiuchi, M Miyabe, N Okubo, Y Yaguchi, Y Kohda, H Toyooka. Plasma lidocaine, monoethylglycinexylidide, and glycinexylidide concentrations after epidural administration in geriatric patients.
Regional anesthesia and pain medicine.
2000 May; 25(3):268-73. doi:
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International journal of clinical pharmacology and therapeutics.
1999 Oct; 37(10):493-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1996 Jul; 24(7):711-6. doi:
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Clinical chemistry.
1996 Feb; 42(2):330-1. doi:
10.1093/clinchem/42.2.330. [PMID: 8595734] - M Chamelian, A Lécrivain, A Robichaud, P du Souich. Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits.
British journal of pharmacology.
1994 Sep; 113(1):317-23. doi:
10.1111/j.1476-5381.1994.tb16211.x. [PMID: 7812627] - Y Chen, J M Potter. Fluorescence polarization immunoassay and HPLC assays compared for measuring monoethylglycinexylidide in liver-transplant patients.
Clinical chemistry.
1992 Dec; 38(12):2426-30. doi:
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Pulmonary pharmacology.
1992; 5(1):9-16. doi:
10.1016/0952-0600(92)90012-6. [PMID: 1591467] - W A Watson, M F Sands, J C Barlow, M E Lener, J H Wilton. Lidocaine absorption and metabolism after oropharyngeal application in young and young-elderly adults.
DICP : the annals of pharmacotherapy.
1991 May; 25(5):463-5. doi:
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Pharmaceutical research.
1990 May; 7(5):504-7. doi:
10.1023/a:1015868800614. [PMID: 2367319] - J Yamane. [Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion].
Nichidai koku kagaku = Nihon University journal of oral science.
1989 Sep; 15(3):183-95. doi:
NULL. [PMID: 2489793] - N A Estes, A S Manolis, D J Greenblatt, H Garan, J N Ruskin. Therapeutic serum lidocaine and metabolite concentrations in patients undergoing electrophysiologic study after discontinuation of intravenous lidocaine infusion.
American heart journal.
1989 May; 117(5):1060-4. doi:
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Archives internationales de pharmacodynamie et de therapie.
1987 Mar; 286(1):5-14. doi:
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Clinical pharmacy.
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Rinsho byori. The Japanese journal of clinical pathology.
1986 Oct; 34(10):1193-7. doi:
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Anesthesia and analgesia.
1986 Feb; 65(2):139-44. doi:
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Acta anaesthesiologica Scandinavica.
1985 Nov; 29(8):811-3. doi:
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