5b-Dihydrotestosterone (BioDeep_00000014578)
Main id: BioDeep_00000637506
human metabolite Endogenous
代谢物信息卡片
(5R,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
化学式: C19H30O2 (290.2246)
中文名称: 本胆烷-17β-醇-3-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C
InChI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14+,15+,16+,17+,18+,19+/m1/s1
描述信息
5beta-Dihydrotestosterone is an intermediate in Androgen and estrogen metabolism. 5beta-Dihydrotestosterone is generated from Testosterone via the enzyme 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6). [HMDB]
5beta-Dihydrotestosterone is an intermediate in Androgen and estrogen metabolism. 5beta-Dihydrotestosterone is generated from Testosterone via the enzyme 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6).
同义名列表
30 个代谢物同义名
(5R,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one; (1S,2S,7R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one; (5beta,8alpha,17beta)-17-Hydroxyandrostan-3-one; 17β-hydroxy-5β-androstan-3-one; (5beta,17beta)-17-Hydroxyandrostan-3-one; (5b,8a,17b)-17-Hydroxyandrostan-3-one; (5Β,8α,17β)-17-hydroxyandrostan-3-one; 17beta-hydroxy-5beta-androstan-3-one; 5beta,17beta-Hydroxyandrostan-3-one; (5Β,17β)-17-hydroxyandrostan-3-one; (5b,17b)-17-Hydroxyandrostan-3-one; 5beta-Androstan-17beta-ol-3-one; 17beta-Hydroxyetiocholan-3-one; 5Β,17β-hydroxyandrostan-3-one; 5b,17b-Hydroxyandrostan-3-one; 17Β-hydroxyetiocholan-3-one; 17b-Hydroxyetiocholan-3-one; 5β-Dihydrotestosterone; Etiocholan-17-beta-ol-3-one; 5Β-androstan-17β-ol-3-one; 5b-Androstan-17b-ol-3-one; 5beta-Dihydrotestosterone; Etiocholan-17-β-ol-3-one; Etiocholan-17-b-ol-3-one; 5β-dihydrotestosterone; 5b-Dihydrotestosterone; 5-beta-DHT; 5-Β-DHT; 5-b-DHT; 5beta-Dihydrotestosterone
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:2150
- KEGG: C05293
- PubChem: 11302
- HMDB: HMDB0006770
- Metlin: METLIN2792
- DrugBank: DB07447
- ChEMBL: CHEMBL373357
- foodb: FDB024072
- chemspider: 10827
- CAS: 571-22-2
- PubChem: 7677
- LipidMAPS: LMST02020069
- PDB-CCD: BDT
- 3DMET: B01835
- NIKKAJI: J16.844K
- KNApSAcK: 2150
- LOTUS: LTS0169858
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
13 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(1)
- Male steroid hormones in cardiomyocyte energy metabolism:
3 -Androstane-diol ⟶ Epiandrosterone
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(12)
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH - Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH - Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH - Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH - Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH - 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH - Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Hangjie Fu, Wenxia Li, Jinyuan Liu, Qiehao Tang, Zhiwei Weng, Lijian Zhu, Bin Ding. Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway.
Journal of ethnopharmacology.
2024 Aug; 330(?):118227. doi:
10.1016/j.jep.2024.118227. [PMID: 38685364] - Seong Min Lee, Sang Mok Lee, Jungbin Song. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats.
Nutrients.
2024 Apr; 16(8):. doi:
10.3390/nu16081189. [PMID: 38674879] - R Z Huang, Y W Wang, H Y Huang, R H Jiang, N N Xue, S P Yin, H Y Zhao. [Application effect of a dual release system of androgen and its antagonist in the repair of full-thickness burn wounds in mice].
Zhonghua shao shang yu chuang mian xiu fu za zhi.
2024 Feb; 40(2):180-189. doi:
10.3760/cma.j.cn501225-20230802-00033. [PMID: 38418180] - Rui-Rong Zheng, Qian-Xi Ouyang, Zi-Yao Liu, Lin-Nan Li, Li Yang, Zheng-Tao Wang. [Natural 5α-reductase inhibitors in treatment of benign prostatic hyperplasia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Feb; 49(4):858-867. doi:
10.19540/j.cnki.cjcmm.20231113.601. [PMID: 38621893] - Jiarui Wei, Tao Li, Shengyuan Lin, Bin Zhang, Xing Li. Dihydrotestosterone reduces neuroinflammation in spinal cord injury through NF-κB and MAPK pathway.
Cellular and molecular biology (Noisy-le-Grand, France).
2024 Jan; 70(1):213-218. doi:
10.14715/cmb/2024.70.1.29. [PMID: 38372091] - Y Y Han, Q H Zhang, W S Chen, Z L Li, D Xie, S L Zhang, H Lu, L W Wang, Z H Xu, L Z Zhang. Fermented rape pollen powder can alleviate benign prostatic hyperplasia in rats by reducing hormone content and changing gut microbiota.
Beneficial microbes.
2023 Nov; 14(5):503-524. doi:
10.1163/18762891-20230039. [PMID: 38656098] - Min Hu, Yuehui Zhang, Xu Zhang, XiuYing Zhang, Xinyue Huang, Yaxing Lu, Yijia Li, Mats Brännström, Amanda Nancy Sferruzzi-Perri, Linus R Shao, Håkan Billig. Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome.
The American journal of pathology.
2023 Sep; ?(?):. doi:
10.1016/j.ajpath.2023.08.008. [PMID: 37689383] - Glendis Shiko, Max-Jonas Paulmann, Felix Feistel, Maria Ntefidou, Vanessa Hermann-Ene, Walter Vetter, Benedikt Kost, Grit Kunert, Julie A Z Zedler, Michael Reichelt, Ralf Oelmüller, Jan Klein. Occurrence and conversion of progestogens and androgens are conserved in land plants.
The New phytologist.
2023 Aug; ?(?):. doi:
10.1111/nph.19163. [PMID: 37559351] - Rami M Mosaoa, Taha A Kumosani, Soonham S Yaghmoor, Shaimaa Rihan, Said S Moselhy. Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats.
Environmental science and pollution research international.
2023 May; ?(?):. doi:
10.1007/s11356-023-27802-8. [PMID: 37249771] - V A Filatova, R V Rozhivanov, I Z Bondarenko, V A Ioutsi, E N Andreeva, G A Mel'nichenko, N G Mokrysheva. [Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism].
Problemy endokrinologii.
2023 May; 69(2):80-91. doi:
10.14341/probl13226. [PMID: 37448275] - Mauricio D Dorfman, Thomas Monfeuga, Susan J Melhorn, Jenny E Kanter, Jeremy M Frey, Rachael D Fasnacht, Anandhakumar Chandran, Emaad Lala, Inmaculada Velasco, Katya B Rubinow, Thomas H Meek, Ellen A Schur, Karin E Bornfeldt, Joshua P Thaler. Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.
American journal of physiology. Endocrinology and metabolism.
2023 Apr; ?(?):. doi:
10.1152/ajpendo.00059.2023. [PMID: 37053049] - Biao Liu, Tian Fang, Lei Liang, Wen-Juan Hu, Min Dong, Li Chen, Wei Wu, Shi-Feng Yun. [Rauwolfia extract inhibits the proliferation of prostate cells in rats with benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2023 Mar; 29(3):195-201. doi:
". [PMID: 38597699] - April K Binder, Danielle L Peecher, Amanda J Qvigstad, Silvia D Gutierrez, Jennifer Magaña, David B Banks, Kenneth S Korach. Differential Strain-dependent Ovarian and Metabolic Responses in a Mouse Model of PCOS.
Endocrinology.
2023 02; 164(4):. doi:
10.1210/endocr/bqad024. [PMID: 36718579] - You-Jee Jang, Hye-Yeon Jung, Ju-Yeong Myeong, Kwang Hoon Song, Joseph Kwon, Duwoon Kim, Jae-Il Park. Effects of Alginate Oligosaccharide on Testosterone-Induced Benign Prostatic Hyperplasia in Orchiectomized Rats.
Nutrients.
2023 Jan; 15(3):. doi:
10.3390/nu15030682. [PMID: 36771389] - Rabab Ahmed Rasheed, A S Sadek, R T Khattab, Fatma Alzahraa A Elkhamisy, Heba Abdelrazak Abdelfattah, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Dina S Hussein, Azza Saleh Embaby, Mai A M Almoatasem. Diacerein provokes apoptosis, improves redox balance, and downregulates PCNA and TNF-α in a rat model of testosterone-induced benign prostatic hyperplasia: A new non-invasive approach.
PloS one.
2023; 18(11):e0293682. doi:
10.1371/journal.pone.0293682. [PMID: 37943844] - Ruan Pimenta, Juliana A Camargo, Patrícia Candido, Vitória Ghazarian, Guilherme L Gonçalves, Vanessa R Guimarães, Poliana Romão, Caroline Chiovatto, Carolina M Mioshi, Gabriel A Dos Santos, Iran A Silva, Alexander Birbrair, Miguel Srougi, William C Nahas, Kátia R Leite, Nayara I Viana, Sabrina T Reis. Cholesterol Triggers Nuclear Co-Association of Androgen Receptor, p160 Steroid Coactivators, and p300/CBP-Associated Factor Leading to Androgenic Axis Transactivation in Castration-Resistant Prostate Cancer.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2022 Dec; 56(S4):1-15. doi:
10.33594/000000592. [PMID: 36458578] - Henrique J Cardoso, Marília I Figueira, Tiago M A Carvalho, Catarina D M Serra, Cátia V Vaz, Patrícia A Madureira, Sílvia Socorro. Androgens and low density lipoprotein-cholesterol interplay in modulating prostate cancer cell fate and metabolism.
Pathology, research and practice.
2022 Dec; 240(?):154181. doi:
10.1016/j.prp.2022.154181. [PMID: 36327818] - Inês L Pereira, Célia Lopes, Eduardo Rocha, Tânia V Madureira. Establishing brown trout primary hepatocyte spheroids as a new alternative experimental model-Testing the effects of 5α-dihydrotestosterone on lipid pathways.
Aquatic toxicology (Amsterdam, Netherlands).
2022 Dec; 253(?):106331. doi:
10.1016/j.aquatox.2022.106331. [PMID: 36327687] - Jiyoung You, Jieun Woo, Kyung-Baeg Roh, Dehun Ryu, Youngsu Jang, Eunae Cho, Deokhoon Park, Eunsun Jung. Assessment of the anti-hair loss potential of Camellia japonica fruit shell extract in vitro.
International journal of cosmetic science.
2022 Nov; ?(?):. doi:
10.1111/ics.12827. [PMID: 36411959] - Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C Edwards, Blake J Cochran, William L Ledger, Robert B Gilchrist, Michael J Bertoldo, Lindsay E Wu, Kirsty A Walters. Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation.
Molecular metabolism.
2022 11; 65(?):101583. doi:
10.1016/j.molmet.2022.101583. [PMID: 36096453] - Young-Jin Choi, Meiqi Fan, Nishala Erandi Wedamulla, Yujiao Tang, Sung Mun Bae, Ji-Young Hwang, Eun-Kyung Kim. Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways.
Food & function.
2022 Oct; 13(19):10235-10247. doi:
10.1039/d2fo00841f. [PMID: 36124918] - Menglu Yang, Haakon K Fjærvoll, Ketil A Fjærvoll, Nicholas H Wang, Tor P Utheim, Charles N Serhan, Darlene A Dartt. Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators.
Scientific reports.
2022 09; 12(1):16305. doi:
10.1038/s41598-022-20177-9. [PMID: 36175572] - Ling Ma, Huchi Shen, Chengge Fang, Timson Chen, Jing Wang. Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196443. [PMID: 36234980] - Ting Xiong, Valentina Rodriguez Paris, Melissa C Edwards, Ying Hu, Blake J Cochran, Kerry-Anne Rye, William L Ledger, Vasantha Padmanabhan, David J Handelsman, Robert B Gilchrist, Kirsty A Walters. Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model.
American journal of physiology. Endocrinology and metabolism.
2022 08; 323(2):E145-E158. doi:
10.1152/ajpendo.00418.2021. [PMID: 35658542] - Andrew J McGovern, Janneth González, David Ramírez, George E Barreto. Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology.
International immunopharmacology.
2022 Jul; 108(?):108721. doi:
10.1016/j.intimp.2022.108721. [PMID: 35344815] - Taratorn Fainanta, Sukanya Jaroenporn, Patteera Wititsuwankul, Suchinda Malaivijitnond. Comparison of neuroprotective effects of dihydrotestosterone, 17β-estradiol, and Pueraria mirifica herb extract on cognitive impairment in androgen deficient male rats.
Hormones and behavior.
2022 07; 143(?):105198. doi:
10.1016/j.yhbeh.2022.105198. [PMID: 35609404] - Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis.
Journal of agricultural and food chemistry.
2022 May; 70(18):5561-5569. doi:
10.1021/acs.jafc.1c07955. [PMID: 35466676] - Min Hu, Yuehui Zhang, Lingjing Lu, Yu Zhou, Denghui Wu, Mats Brännström, Linus R Shao, Håkan Billig. Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway.
FEBS letters.
2022 03; 596(6):806-825. doi:
10.1002/1873-3468.14289. [PMID: 35038776] - Ye-Eun Kwon, Sun-Eun Choi, Kwang-Hyun Park. Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana.
Molecules (Basel, Switzerland).
2022 Feb; 27(4):. doi:
10.3390/molecules27041419. [PMID: 35209207] - Basma H Marghani, Alaa Fehaid, Ahmed I Ateya, Mohamed Aboul Ezz, Rasha M Saleh. Photothermal therapeutic potency of plasmonic silver nanoparticles for apoptosis and anti-angiogenesis in testosterone induced benign prostate hyperplasia in rats.
Life sciences.
2022 Feb; 291(?):120240. doi:
10.1016/j.lfs.2021.120240. [PMID: 34942164] - Ehsan Shabani, Heibatullah Kalantari, Mojtaba Kalantar, Mehdi Goudarzi, Esrafil Mansouri, Hadi Kalantar. Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.
BMC complementary medicine and therapies.
2021 Dec; 21(1):301. doi:
10.1186/s12906-021-03472-2. [PMID: 34930229] - Min Hu, Yuehui Zhang, Shuting Ma, Juanli Li, Xu Wang, Mengmeng Liang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Hongxia Ma, Mats Brännström, Linus R Shao, Håkan Billig. Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome.
Molecular human reproduction.
2021 11; 27(12):. doi:
10.1093/molehr/gaab067. [PMID: 34850077] - Eszter Csikós, Adrienn Horváth, Kamilla Ács, Nóra Papp, Viktória Lilla Balázs, Marija Sollner Dolenc, Maša Kenda, Nina Kočevar Glavač, Milan Nagy, Michele Protti, Laura Mercolini, Györgyi Horváth, Ágnes Farkas, On Behalf Of The Oemonom. Treatment of Benign Prostatic Hyperplasia by Natural Drugs.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237141. [PMID: 34885733] - Yani Zhao, Yan Zhang, Yao Li, Min Yang, Jiani Yuan, Yu Cao, Lu Xu, Xuexinyu Ma, Sisong Lin, Junming An, Siwang Wang. Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5α-reductase type 2.
European journal of pharmacology.
2021 Oct; 908(?):174334. doi:
10.1016/j.ejphar.2021.174334. [PMID: 34265299] - Yuehui Zhang, Min Hu, Fan Yang, Yizhuo Zhang, Shuting Ma, Dongqi Zhang, Xu Wang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Mats Brännström, Linus R Shao, Håkan Billig. Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance.
Journal of molecular medicine (Berlin, Germany).
2021 10; 99(10):1427-1446. doi:
10.1007/s00109-021-02104-z. [PMID: 34180022] - Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, Stanley Andrisse. DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice.
The Journal of endocrinology.
2021 06; 250(2):49-65. doi:
10.1530/joe-21-0040. [PMID: 34060475] - Hyo-Jung Kim, Bo-Ram Jin, Hyo-Jin An. Psoralea corylifolia L. extract ameliorates benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis.
Journal of ethnopharmacology.
2021 Jun; 273(?):113844. doi:
10.1016/j.jep.2021.113844. [PMID: 33485982] - Célia Lopes, Eduardo Rocha, Inês L Pereira, Tânia V Madureira. Deciphering influences of testosterone and dihydrotestosterone on lipid metabolism genes using brown trout primary hepatocytes.
Aquatic toxicology (Amsterdam, Netherlands).
2021 Jun; 235(?):105819. doi:
10.1016/j.aquatox.2021.105819. [PMID: 33873058] - Yanhua Zheng, Jingwei Yu, Chengjie Liang, Shuna Li, Xiaohui Wen, Yanmei Li. Characterization on gut microbiome of PCOS rats and its further design by shifts in high-fat diet and dihydrotestosterone induction in PCOS rats.
Bioprocess and biosystems engineering.
2021 May; 44(5):953-964. doi:
10.1007/s00449-020-02320-w. [PMID: 32157446] - Danijela Vojnović Milutinović, Ana Teofilović, Nataša Veličković, Jelena Brkljačić, Sanja Jelača, Ana Djordjevic, Djuro Macut. Glucocorticoid signaling and lipid metabolism disturbances in the liver of rats treated with 5α-dihydrotestosterone in an animal model of polycystic ovary syndrome.
Endocrine.
2021 05; 72(2):562-572. doi:
10.1007/s12020-020-02600-1. [PMID: 33449293] - Henrique J Cardoso, Marília I Figueira, Cátia V Vaz, Tiago M A Carvalho, Luís A Brás, Patrícia A Madureira, Paulo J Oliveira, Vilma A Sardão, Sílvia Socorro. Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.
Cellular oncology (Dordrecht).
2021 Apr; 44(2):385-403. doi:
10.1007/s13402-020-00575-9. [PMID: 33464483] - Peng Cui, Wei Hu, Tong Ma, Min Hu, Xiaoyu Tong, Feifei Zhang, Jiemei Shi, Xiaoqing Xu, Xin Li, Linus Ruijin Shao, Håkan Billig, Yi Feng. Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats.
The Journal of steroid biochemistry and molecular biology.
2021 04; 208(?):105829. doi:
10.1016/j.jsbmb.2021.105829. [PMID: 33513383] - Huda Mando, Ahmad Hassan, Sajjad Gharaghani. Novel and Predictive QSAR Model for Steroidal and Nonsteroidal 5α- Reductase Type II Inhibitors.
Current drug discovery technologies.
2021; 18(2):317-332. doi:
10.2174/1570163817666200324170457. [PMID: 32208118] - Mohammad Ali Farshid, Mehdi Fazeli, Tahoora Shomali, Saeed Nazifi, Fatemeh Namazi. Protective effect of black mulberry (Morus nigra L.) fruit hydroalcoholic extract against testosterone-induced benign prostatic hyperplasia in rats.
Revista internacional de andrologia.
2021 Jan; 19(1):53-61. doi:
10.1016/j.androl.2019.09.003. [PMID: 31899187] - Yihua Xu, Li Wang, Siyuan Cao, Ruihua Hu, Rui Liu, Ke Hua, Zhigang Guo, Hong-Jie Di, Zhigang Hu. Genipin improves reproductive health problems caused by circadian disruption in male mice.
Reproductive biology and endocrinology : RB&E.
2020 Dec; 18(1):122. doi:
10.1186/s12958-020-00679-9. [PMID: 33308222] - Yeon Ju An, Jeong Yoon Lee, Yulha Kim, Woojin Jun, Yoo-Hyun Lee. Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats.
Journal of medicinal food.
2020 Dec; 23(12):1296-1302. doi:
10.1089/jmf.2020.4779. [PMID: 33136465] - Junsheng Liu, Juntong Yu, Xichun Peng. Poria cocos Polysaccharides Alleviates Chronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating Hormone Production, Modifying Gut Microbiota, and Remodeling the DNA Methylome.
Journal of agricultural and food chemistry.
2020 Nov; 68(45):12661-12670. doi:
10.1021/acs.jafc.0c05943. [PMID: 33119288] - Na-Hyun Kim, Jonghwan Jegal, Yun Na Kim, Jeong-Doo Heo, Jung-Rae Rho, Min Hye Yang, Eun Ju Jeong. The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions.
Nutrients.
2020 May; 12(6):. doi:
10.3390/nu12061575. [PMID: 32481550] - Geum-Lan Hong, Se-Ra Park, Da-Young Jung, Shanika Karunasagara, Kyu Pil Lee, Eun-Jeong Koh, Kyoungwon Cho, Sung Sun Park, Ju-Young Jung. The therapeutic effects of Stauntonia hexaphylla in benign prostate hyperplasia are mediated by the regulation of androgen receptors and 5α-reductase type 2.
Journal of ethnopharmacology.
2020 Mar; 250(?):112446. doi:
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American journal of physiology. Endocrinology and metabolism.
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Scientific reports.
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Pharmaceutical biology.
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Scientific reports.
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The journal of sexual medicine.
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JCI insight.
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Journal of cosmetic dermatology.
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The Journal of physiology.
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Hormones & cancer.
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Reproduction, fertility, and development.
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American journal of physiology. Endocrinology and metabolism.
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Journal of ethnopharmacology.
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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Molecules (Basel, Switzerland).
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Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.
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Aging.
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Endocrine.
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Biotechnology letters.
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Steroids.
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The Journal of clinical endocrinology and metabolism.
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Laboratory investigation; a journal of technical methods and pathology.
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Canadian journal of physiology and pharmacology.
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PloS one.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
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The Journal of clinical endocrinology and metabolism.
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