D-Proline (BioDeep_00000014495)

 

Secondary id: BioDeep_00000014866, BioDeep_00001868185

human metabolite PANOMIX_OTCML-2023 Endogenous natural product Volatile Flavor Compounds


代谢物信息卡片


(2R)-Pyrrolidine-2-carboxylic acid

化学式: C5H9NO2 (115.0633254)
中文名称: D-脯氨酸
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.03%

分子结构信息

SMILES: C1CC(NC1)C(=O)O
InChI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

描述信息

D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva (PMID: 16480744). These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity. (PMID: 1426150) [HMDB]
D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva (PMID: 16480744). These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity (PMID: 1426150).
(R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
(R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

同义名列表

17 个代谢物同义名

(2R)-Pyrrolidine-2-carboxylic acid; (R)-Pyrrolidine-2-carboxylic acid; (2R)-Pyrrolidine-2-carboxylate; (R)-Pyrrolidine-2-carboxylate; (R)-2-Carboxypyrrolidine; R)-2-Carboxypyrrolidine; H-D-Pro-OH; R-Proline; D-Proline; D-Prolin; Proline; Dpr; (+)-(R)-Proline; (R)-(+)-Proline; (R)-Proline; D-Proline; D-proline



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

38 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(38)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • David T Thwaites, Catriona M H Anderson. The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. British journal of pharmacology. 2011 Dec; 164(7):1802-16. doi: 10.1111/j.1476-5381.2011.01438.x. [PMID: 21501141]
  • Yoko Nagata, Masatoshi Higashi, Yutaka Ishii, Hiroaki Sano, Minoru Tanigawa, Kumiko Nagata, Kazuma Noguchi, Masahiro Urade. The presence of high concentrations of free D-amino acids in human saliva. Life sciences. 2006 Mar; 78(15):1677-81. doi: 10.1016/j.lfs.2005.08.009. [PMID: 16480744]
  • Y Nagata, R Masui, T Akino. The presence of free D-serine, D-alanine and D-proline in human plasma. Experientia. 1992 Oct; 48(10):986-8. doi: 10.1007/bf01919147. [PMID: 1426150]