Gulonate (BioDeep_00000014483)

 

Secondary id: BioDeep_00001869533

human metabolite Endogenous natural product


代谢物信息卡片


(2R,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

化学式: C6H12O7 (196.0583)
中文名称: 古龙酸
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 33.54%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Gulonate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/gulonate (retrieved 2025-02-03) (BioDeep RN: BioDeep_00000014483). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(C(C(=O)O)O)O)O)O)O
InChI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4-,5-/m0/s1

描述信息

Gulonic acid, also known as gulonate, belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain.It is a gulonic acid having D-configuration.
Reduction product of glucuronic acid; oxidation product of l-gulose [HMDB]

同义名列表

10 个代谢物同义名

(2R,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; Gulonic acid, monosodium salt, (L)-isomer; Gulonic acid, ion (1-), (L)-isomer; Gulonic acid, (L)-isomer; D-Gulonic acid; L-Gulonic acid; Gulonic acid; L-Gulonate; D-Gulonate; Gulonate



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Michelle R Denburg, Yunwen Xu, Alison G Abraham, Josef Coresh, Jingsha Chen, Morgan E Grams, Harold I Feldman, Paul L Kimmel, Casey M Rebholz, Eugene P Rhee, Ramachandran S Vasan, Bradley A Warady, Susan L Furth. Metabolite Biomarkers of CKD Progression in Children. Clinical journal of the American Society of Nephrology : CJASN. 2021 08; 16(8):1178-1189. doi: 10.2215/cjn.00220121. [PMID: 34362785]
  • Yong Jia, Crista A Burbidge, Crystal Sweetman, Emi Schutz, Kathy Soole, Colin Jenkins, Robert D Hancock, John B Bruning, Christopher M Ford. An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera. The Journal of biological chemistry. 2019 11; 294(44):15932-15946. doi: 10.1074/jbc.ra119.010196. [PMID: 31488549]
  • Jindan Yang, Xiaowei Sun, Zhijing Feng, Dongfang Hao, Maoqing Wang, Xiujuan Zhao, Changhao Sun. Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry. Toxicology letters. 2011 Oct; 206(3):306-13. doi: 10.1016/j.toxlet.2011.08.012. [PMID: 21889581]
  • Francisco J Fernandez, Fernando Garces, Miguel López-Estepa, Juan Aguilar, Laura Baldomà, Miquel Coll, Josefa Badia, M Cristina Vega. The UlaG protein family defines novel structural and functional motifs grafted on an ancient RNase fold. BMC evolutionary biology. 2011 Sep; 11(?):273. doi: 10.1186/1471-2148-11-273. [PMID: 21943130]
  • Lei Gong, Nelly Aranibar, Yong-Hae Han, Youcai Zhang, Lloyd Lecureux, Vasanthi Bhaskaran, Purnima Khandelwal, Curtis D Klaassen, Lois D Lehman-McKeeman. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Aug; 122(2):587-97. doi: 10.1093/toxsci/kfr114. [PMID: 21561886]
  • Diego H Sanchez, Fernando L Pieckenstain, Jedrzey Szymanski, Alexander Erban, Mariusz Bromke, Matthew A Hannah, Ute Kraemer, Joachim Kopka, Michael K Udvardi. Comparative functional genomics of salt stress in related model and cultivated plants identifies and overcomes limitations to translational genomics. PloS one. 2011 Feb; 6(2):e17094. doi: 10.1371/journal.pone.0017094. [PMID: 21347266]
  • Ariel A Bazzini, Carlos A Manacorda, Takayuki Tohge, Gabriela Conti, Maria C Rodriguez, Adriano Nunes-Nesi, Sofía Villanueva, Alisdair R Fernie, Fernando Carrari, Sebastian Asurmendi. Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes. PloS one. 2011; 6(12):e28466. doi: 10.1371/journal.pone.0028466. [PMID: 22174812]
  • Kenneth H Gabbay, Kurt M Bohren, Roy Morello, Terry Bertin, Jeff Liu, Peter Vogel. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. The Journal of biological chemistry. 2010 Jun; 285(25):19510-20. doi: 10.1074/jbc.m110.110247. [PMID: 20410296]
  • Nelly Aranibar, Vasanthi Bhaskaran, Karl-Heinz Ott, Jeff Vassallo, David Nelson, Lloyd Lecureux, Lei Gong, Steve Stryker, Lois Lehman-McKeeman. Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling. Magnetic resonance in chemistry : MRC. 2009 Dec; 47 Suppl 1(?):S12-9. doi: 10.1002/mrc.2503. [PMID: 19768707]
  • Adaucto B Pereira-Netto, Ute Roessner, Shozo Fujioka, Antony Bacic, Tadao Asami, Shigeo Yoshida, Steven D Clouse. Shooting control by brassinosteroids: metabolomic analysis and effect of brassinazole on Malus prunifolia, the Marubakaido apple rootstock. Tree physiology. 2009 Apr; 29(4):607-20. doi: 10.1093/treephys/tpn052. [PMID: 19203977]
  • B Mohamed Khadeer Ahamed, Venkatarangaiah Krishna, Kumaraswamy H Malleshappa. In vivo wound healing activity of the methanolic extract and its isolated constituent, gulonic acid gamma-lactone, obtained from Grewia tiliaefolia. Planta medica. 2009 Apr; 75(5):478-82. doi: 10.1055/s-0029-1185315. [PMID: 19219758]
  • Consuelo Sánchez-Brunete, Beatriz Albero, Germán Martín, José L Tadeo. Determination of pesticide residues by GC-MS using analyte protectants to counteract the matrix effect. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Nov; 21(11):1291-6. doi: 10.2116/analsci.21.1291. [PMID: 16317896]
  • Oleg A Barski, Victor Z Papusha, Margarita M Ivanova, Dorene M Rudman, Milton J Finegold. Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. American journal of physiology. Renal physiology. 2005 Jul; 289(1):F200-7. doi: 10.1152/ajprenal.00411.2004. [PMID: 15769935]
  • A Xu, J Yao, L Yu, S Lv, J Wang, B Yan, Z Yu. Mutation of Gluconobacter oxydans and Bacillus megaterium in a two-step process of l-ascorbic acid manufacture by ion beam. Journal of applied microbiology. 2004; 96(6):1317-23. doi: 10.1111/j.1365-2672.2004.02270.x. [PMID: 15139924]
  • Cornelia Wagner, Michael Sefkow, Joachim Kopka. Construction and application of a mass spectral and retention time index database generated from plant GC/EI-TOF-MS metabolite profiles. Phytochemistry. 2003 Mar; 62(6):887-900. doi: 10.1016/s0031-9422(02)00703-3. [PMID: 12590116]
  • G Moeckel, J Hallbach, W G Guder. Purification of human and rat kidney aldose reductase. Enzyme & protein. 1994 199; 48(1):45-50. doi: 10.1159/000474968. [PMID: 7787970]
  • A K Daly, T J Mantle. The kinetic mechanism of the major form of ox kidney aldehyde reductase with D-glucuronic acid. The Biochemical journal. 1982 Aug; 205(2):381-8. doi: 10.1042/bj2050381. [PMID: 6814425]
  • A Warrander, R H Waring. An improved method for gas chromatographic determination of urinary xylitol and glucuronic, glucaric gulonic and ascorbic acids, with their values in the rat, rabbit, guinea-pig and marmoset. Xenobiotica; the fate of foreign compounds in biological systems. 1978 Oct; 8(10):605-9. doi: 10.3109/00498257809069572. [PMID: 102085]
  • J J BURNS, J KANFER, G ASHWELL. Formation of L-xylulose from L-gulonic acid in rat kidney. Biochimica et biophysica acta. 1959 Aug; 34(?):464-9. doi: 10.1016/0006-3002(59)90299-9. [PMID: 13806255]