Sorbitol (BioDeep_00000014330)

 

Secondary id: BioDeep_00000398093

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexol

化学式: C6H14O6 (182.079)
中文名称: 山梨醇, D-山梨醇, 山梨糖醇
谱图信息: 最多检出来源 Homo sapiens(plant) 14.37%

分子结构信息

SMILES: C(C(C(C(C(CO)O)O)O)O)O
InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6+

描述信息

Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. Ascorbic acid fermentation; in solution form for moisture-conditioning of cosmetic creams and lotions, toothpaste, tobacco, gelatin; bodying agent for paper, textiles, and liquid pharmaceuticals; softener for candy; sugar crystallization inhibitor; surfactants; urethane resins and rigid foams; plasticizer, stabilizer for vinyl resins; food additive (sweetener, humectant, emulsifier, thickener, anticaking agent); dietary supplement. (Hawleys Condensed Chemical Dictionary) Biological Source: Occurs widely in plants ranging from algae to the higher orders. Fruits of the plant family Rosaceae, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are the fruits of the Sorbus and Crataegus species Use/Importance: Used for manufacturing of sorbose, propylene glycol, ascorbic acid, resins, plasticizers and as antifreeze mixtures with glycerol or glycol. Tablet diluent, sweetening agent and humectant, other food uses. Sorbitol is used in photometric determination of Ru(VI) and Ru(VIII); in acid-base titration of borate (Dictionary of Organic Compounds).
Occurs widely in plants ranging from algae to the higher orders. Fruits of the plant family Rosaceae, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are the fruits of the Sorbus and Crataegus subspecies Sweetening agent and humectant and many other food uses. D-Glucitol is found in many foods, some of which are common salsify, other bread, wild rice, and common chokecherry.
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AD - Osmotically acting laxatives
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AG - Enemas
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions
V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CC - Tests for bile duct patency
Acquisition and generation of the data is financially supported in part by CREST/JST.
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents
D005765 - Gastrointestinal Agents > D002400 - Cathartics
D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].
D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

同义名列表

80 个代谢物同义名

(2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexol; Sorbitol 3\\% in plastic container; Trommsdorff brand OF sorbitol; Medefield brand OF sorbitol; Baxter brand OF sorbitol; Pfizer brand OF sorbitol; Sorbit kyowa powder 50m; Sorbitol pfizer brand; Sorbit W-powder 50; Sorbitol syrup C; Kyowa powder 50m; Sorbit W-powder; Neosorb 20/60dC; Sorbit D-powder; Neosorb p 20/60; Karion instant; D-(-)-Sorbitol; Neosorb p 60W; Neosorb 70/02; Klysma sorbit; Neosorb 70/70; Sorbit DP 50; Neosorb p 60; Sorbogem 712; (-)-Sorbitol; Sorbit L 70; Sorbitol FP; Sorbit D 70; Sorbit W 70; Sorbitol FK; Foodol D 70; Sorbit T 70; D-Sorbitol; Sorbitol F; Sorbitol S; Sorbilande; D-Glucitol; Sorbex RP; L-Gulitol; Sorbostyl; Sorbit DP; Sorbit WP; Glucarine; Diakarmon; Sorbex R; Sorbilax; D-Sorbit; Sorbex m; Sorbitol; Sionit K; Multitol; Sorbitur; D-Sorbol; Sorbex X; Sorbex S; Glucitol; Sorbit S; Sionite; Sorbite; Neosorb; Esasorb; Nivitin; Medevac; Resulax; GLC-Ol; Karion; Siosan; Sionit; Sorbit; Sionon; Sorbol; e 420; Sorbo; e-420; e420; g-Ol; Yal; Sorbitol; D-Sorbitol; Sorbitol



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(7)

PlantCyc(0)

代谢反应

155 个相关的代谢反应过程信息。

Reactome(69)

BioCyc(33)

WikiPathways(2)

Plant Reactome(0)

INOH(3)

PlantCyc(29)

COVID-19 Disease Map(0)

PathBank(19)

PharmGKB(0)

260 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hongjian Li, Yajing Si, Hong Wang, Zhi Liu, Qian Lu, Li Liu, Tong Li, Aide Wang. The Ca2+-MdCRF4-MdWRKY9 module negatively affects apple fruit watercore formation by suppressing the transcription of MdSOT2. The Plant journal : for cell and molecular biology. 2024 Jun; 118(5):1358-1371. doi: 10.1111/tpj.16673. [PMID: 38341799]
  • Jing Wenguang, Lin Xiaoyu, L I Chu, Zhao Xiaoliang, Cheng Xianlong, Wang Penglong, Wei Feng, M A Shuangcheng. Anti-inflammatory mechanism of the non-volatile ingredients originated from Guanghuoxiang () based on high performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope and cell metabolomics. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):260-267. doi: 10.19852/j.cnki.jtcm.20240203.003. [PMID: 38504532]
  • Fan Yang, Jiawei Luo, Wenmeng Guo, Yuxin Zhang, Yunxiao Liu, Ze Yu, Yaqiang Sun, Mingjun Li, Fengwang Ma, Tao Zhao. Origin and early divergence of tandem duplicated sorbitol transporter genes in Rosaceae: insights from evolutionary analysis of the SOT gene family in angiosperms. The Plant journal : for cell and molecular biology. 2024 Feb; 117(3):856-872. doi: 10.1111/tpj.16533. [PMID: 37983569]
  • Huijuan Zhou, Mingshen Su, Jihong Du, Xianan Zhang, Xiongwei Li, Minghao Zhang, Yang Hu, Chen Huan, Zhengwen Ye. Crucial roles of sorbitol metabolism and energy status in the chilling tolerance of yellow peach. Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108092. doi: 10.1016/j.plaphy.2023.108092. [PMID: 37852068]
  • Shonit Nair Sharma, Ashkhan Hojati, Bhargavee Gnanasambandam, Rahul S Yerrabelli, Joshua Brozek. In-silico molecular designs to treat neurologic and ophthalmologic diseases caused by sorbitol excess: engineering the Agrobacterium vitis protein. BMC research notes. 2023 Jul; 16(1):129. doi: 10.1186/s13104-023-06367-2. [PMID: 37400926]
  • Dong Meng, Hongyan Cao, Qing Yang, Mengxia Zhang, Ewa Borejsza-Wysocka, Huicong Wang, Abhaya M Dandekar, Zhangjun Fei, Lailiang Cheng. SnRK1 kinase-mediated phosphorylation of transcription factor bZIP39 regulates sorbitol metabolism in apple. Plant physiology. 2023 07; 192(3):2123-2142. doi: 10.1093/plphys/kiad226. [PMID: 37067900]
  • Shengyuan Ye, Yang Cheng, Zheng Guo, Xingguo Wang, Wei Wei. A lipid toolbox of sugar alcohol fatty acid monoesters for single-component lipid nanoparticles with temperature-controlled release. Colloids and surfaces. B, Biointerfaces. 2023 Jun; 228(?):113426. doi: 10.1016/j.colsurfb.2023.113426. [PMID: 37399694]
  • Thi Thanh Le, Manh Tuan Ha, Thao Quyen Cao, Jeong Ah Kim, Jae Sue Choi, Byung Sun Min. 1,5-Anhydro-d-glucitol derivative and galloylated flavonoids isolated from the leaves of Acer ginnala Maxim. as dual inhibitors of PTP1B and α-glucosidase enzymes: In vitro and in silico studies. Phytochemistry. 2023 Jun; 213(?):113769. doi: 10.1016/j.phytochem.2023.113769. [PMID: 37343738]
  • Ziyu Yang, Juanxiu Qin, Lina Zhao, Tianchi Chen, Qian Huang, Ying Jian, Qi Zhao, Sheng Yang, Qi Li, Qian Liu, Michael Otto, Min Li. Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease. Gastroenterology. 2023 06; 164(7):1189-1201.e13. doi: 10.1053/j.gastro.2023.02.046. [PMID: 36898551]
  • Hong-Xia Xu, Dong Meng, Qing Yang, Ting Chen, Meng Qi, Xiao-Ying Li, Hang Ge, Jun-Wei Chen. Sorbitol induces flower bud formation via the MADS-box transcription factor EjCAL in loquat. Journal of integrative plant biology. 2023 May; 65(5):1241-1261. doi: 10.1111/jipb.13439. [PMID: 36541724]
  • Igor Rafael Sousa Costa, Francisco Lucas Pacheco Cavalcante, Fábio Rossi Cavalcanti, Cleberson de Freitas Fernandes, Enéas Gomes-Filho, Kirley Marques Canuto, Humberto Henrique de Carvalho. Metabolomic exhibits different profiles and potential biomarkers of Vitis sp co-cultivated with Fusarium oxysporum for short, medium, and long times. Physiologia plantarum. 2023 Apr; ?(?):e13918. doi: 10.1111/ppl.13918. [PMID: 37087574]
  • Canying Li, Chenyang Zhang, Jiaxin Liu, Linhong Qu, Yonghong Ge. l-Glutamate maintains the quality of apple fruit by mediating carotenoid, sorbitol and sucrose metabolisms. Journal of the science of food and agriculture. 2023 Mar; ?(?):. doi: 10.1002/jsfa.12566. [PMID: 36944028]
  • Ge Tian, Chunling Liu, Xinxiang Xu, Yue Xing, Jingquan Liu, Mengxue Lyu, Ziquan Feng, Xuelin Zhang, Hanhan Qin, Han Jiang, Zhanling Zhu, Yuanmao Jiang, Shunfeng Ge. Effects of Magnesium on nitrate uptake and sorbitol synthesis and translocation in apple seedlings. Plant physiology and biochemistry : PPB. 2023 Mar; 196(?):139-151. doi: 10.1016/j.plaphy.2023.01.033. [PMID: 36706693]
  • Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova. The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. Research in veterinary science. 2022 Dec; 152(?):261-269. doi: 10.1016/j.rvsc.2022.08.022. [PMID: 36063603]
  • Xiao Liu, Dong-He Liu, Yan Shen, Jing Liu, Jun Wei, Chun-Lei Wang. Transcriptome changes associated with boron applications in fruits of watercore-susceptible pear cultivar. Molecular biology reports. 2022 Dec; 49(12):12055-12061. doi: 10.1007/s11033-022-07934-9. [PMID: 36309610]
  • Letícia Souza Lima, Suellen Rodrigues Ramalho, Graziele Custódia Sandim, Eduardo Benedetti Parisotto, Janaina de Cássia Orlandi Sardi, Maria Lígia Rodrigues Macedo. Prevention of hospital pathogen biofilm formation by antimicrobial peptide KWI18. Microbial pathogenesis. 2022 Nov; 172(?):105791. doi: 10.1016/j.micpath.2022.105791. [PMID: 36150557]
  • Michail Michailidis, Vaia Styliani Titeli, Evangelos Karagiannis, Kyriaki Feidaki, Ioannis Ganopoulos, Georgia Tanou, Anagnostis Argiriou, Athanassios Molassiotis. Tissue-specific transcriptional analysis outlines calcium-induced core metabolic changes in sweet cherry fruit. Plant physiology and biochemistry : PPB. 2022 Oct; 189(?):139-152. doi: 10.1016/j.plaphy.2022.08.022. [PMID: 36087439]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Cryo-derived plants through embryogenesis showed same levels of vinblastine and vincristine (anticancer) in Catharanthus roseus and had normal genome size. Scientific reports. 2022 10; 12(1):16635. doi: 10.1038/s41598-022-20993-z. [PMID: 36198853]
  • Gözde Koşarsoy Ağçeli. A new approach to nanocomposite carbohydrate polymer films: Levan and chia seed mucilage. International journal of biological macromolecules. 2022 Oct; 218(?):751-759. doi: 10.1016/j.ijbiomac.2022.07.157. [PMID: 35905758]
  • Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Namba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito. Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure. Scientific reports. 2022 09; 12(1):15449. doi: 10.1038/s41598-022-19371-6. [PMID: 36104378]
  • Miranda Buseman, April E Blong, Rebecca A L Walton. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2022 Sep; 32(5):675-679. doi: 10.1111/vec.13203. [PMID: 35527394]
  • Mathias B Jørgensen, Jan H Christensen. Can analyte protectants compensate wastewater matrix induced enhancement effects in gas chromatography - mass spectrometry analysis?. Journal of chromatography. A. 2022 Aug; 1676(?):463280. doi: 10.1016/j.chroma.2022.463280. [PMID: 35785676]
  • Kristin D Gerson, Nancy Yang, Lauren Anton, Maayan Levy, Jacques Ravel, Michal A Elovitz, Heather H Burris. Second trimester short cervix is associated with decreased abundance of cervicovaginal lipid metabolites. American journal of obstetrics and gynecology. 2022 08; 227(2):273.e1-273.e18. doi: 10.1016/j.ajog.2022.04.031. [PMID: 35469813]
  • Leiting Li, Meng Li, Juyou Wu, Hao Yin, Jim M Dunwell, Shaoling Zhang. Genome-wide identification and comparative evolutionary analysis of sorbitol metabolism pathway genes in four Rosaceae species and three model plants. BMC plant biology. 2022 Jul; 22(1):341. doi: 10.1186/s12870-022-03729-z. [PMID: 35836134]
  • Celien Tigchelaar, Mark L van Zuylen, Abraham H Hulst, Benedikt Preckel, André P van Beek, Ido P Kema, Jeroen Hermanides, Anthony R Absalom. Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway. Diabetologia. 2022 07; 65(7):1098-1107. doi: 10.1007/s00125-022-05693-7. [PMID: 35380232]
  • Ming-Shan Chen, Kung-Ssu Yang, Wen-Chun Lin, Chien-Liang Fang, Hsin-Fu Chen, Shew-Meei Sheu. Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps. Molecular biology reports. 2022 Jul; 49(7):6517-6529. doi: 10.1007/s11033-022-07482-2. [PMID: 35637315]
  • Iveta Pleyerová, Jaromír Hamet, Hana Konrádová, Helena Lipavská. Versatile roles of sorbitol in higher plants: luxury resource, effective defender or something else?. Planta. 2022 Jun; 256(1):13. doi: 10.1007/s00425-022-03925-z. [PMID: 35713726]
  • Bianca R Grosz, Igor Stevanovski, Sara Negri, Melina Ellis, Stephanie Barnes, Stephen Reddel, Steve Vucic, Garth A Nicholson, Andrea Cortese, Kishore R Kumar, Ira W Deveson, Marina L Kennerson. Long read sequencing overcomes challenges in the diagnosis of SORD neuropathy. Journal of the peripheral nervous system : JPNS. 2022 06; 27(2):120-126. doi: 10.1111/jns.12485. [PMID: 35224818]
  • Xiao Liu, Yan Shen, Dong-He Liu, Jing Liu, Jing Zhang, Jun Wei, Chun-Lei Wang. A sorbitol transporter gene plays specific role in the occurrence of watercore by modulating the level of intercellular sorbitol in pear. Plant science : an international journal of experimental plant biology. 2022 Apr; 317(?):111179. doi: 10.1016/j.plantsci.2022.111179. [PMID: 35193736]
  • Zhengyang Wang, Baiquan Ma, Nanxiang Yang, Ling Jin, Lan Wang, Songya Ma, Yong-Ling Ruan, Fengwang Ma, Mingjun Li. Variation in the promoter of the sorbitol dehydrogenase gene MdSDH2 affects binding of the transcription factor MdABI3 and alters fructose content in apple fruit. The Plant journal : for cell and molecular biology. 2022 03; 109(5):1183-1198. doi: 10.1111/tpj.15624. [PMID: 34888978]
  • Yukihiro Chino, Masanari Kuwabara, Ichiro Hisatome. Factors Influencing Change in Serum Uric Acid After Administration of the Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus. Journal of clinical pharmacology. 2022 03; 62(3):366-375. doi: 10.1002/jcph.1970. [PMID: 34545949]
  • Meng Qi, Rui Wu, Zhihua Song, Biying Dong, Ting Chen, Mengying Wang, Hongyan Cao, Tingting Du, Shengjie Wang, Na Li, Qing Yang, Yujie Fu, Dong Meng. Sorbitol Reduces Sensitivity to Alternaria by Promoting Ceramide Kinases (CERK) Expression through Transcription Factor Pswrky25 in Populus (Populus simonii Carr.). Genes. 2022 02; 13(3):. doi: 10.3390/genes13030405. [PMID: 35327959]
  • Yang Wang, Jun Chen, Jiekang Tian, Guanchen Wang, Weikang Luo, Zebing Huang, Yan Huang, Ning Li, Mingming Guo, Xuegong Fan. Tryptophan-sorbitol based carbon quantum dots for theranostics against hepatocellular carcinoma. Journal of nanobiotechnology. 2022 Feb; 20(1):78. doi: 10.1186/s12951-022-01275-2. [PMID: 35164792]
  • Bhavya Srivastava, Souvik Sen, Kamalika Sen. Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy. Biotechnology and applied biochemistry. 2022 Feb; 69(1):77-91. doi: 10.1002/bab.2083. [PMID: 33264452]
  • Mitsutaka Nakashima, Toru Miyoshi, Kentaro Ejiri, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Nanba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito. Effects of luseogliflozin on estimated plasma volume in patients with heart failure with preserved ejection fraction. ESC heart failure. 2022 02; 9(1):712-720. doi: 10.1002/ehf2.13683. [PMID: 35267246]
  • Shaoxun Wang, Feng Jiao, Jane J Border, Xing Fang, Reece F Crumpler, Yedan Liu, Huawei Zhang, Joshua Jefferson, Ya Guo, Parker S Elliott, Kirby N Thomas, Luke B Strong, Austin H Urvina, Baoying Zheng, Arjun Rijal, Stanley V Smith, Hongwei Yu, Richard J Roman, Fan Fan. Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals. American journal of physiology. Heart and circulatory physiology. 2022 02; 322(2):H246-H259. doi: 10.1152/ajpheart.00438.2021. [PMID: 34951541]
  • Heung-Shick Lee, Younhee Kim. Myricetin Disturbs the Cell Wall Integrity and Increases the Membrane Permeability of Candida albicans. Journal of microbiology and biotechnology. 2022 Jan; 32(1):37-45. doi: 10.4014/jmb.2110.10014. [PMID: 34750288]
  • Lee Mei Ng, Shinichiro Komaki, Hideyuki Takahashi, Takashi Yamano, Hideya Fukuzawa, Takashi Hashimoto. Hyperosmotic stress-induced microtubule disassembly in Chlamydomonas reinhardtii. BMC plant biology. 2022 Jan; 22(1):46. doi: 10.1186/s12870-022-03439-6. [PMID: 35065609]
  • Yongxin Li, Hua Huang, Xinshuai Zhang. Identification of catabolic pathway for 1-deoxy-D-sorbitol in Bacillus licheniformis. Biochemical and biophysical research communications. 2022 01; 586(?):81-86. doi: 10.1016/j.bbrc.2021.11.072. [PMID: 34837836]
  • Zhisi Zhang, Xueping Liu, Zhibin Shen, Yanfen Chen, Cong Chen, Ying SiTu, Chunping Tang, Tao Jiang. Isoflavaspidic Acid PB Extracted from Dryopteris fragrans (L.) Schott Inhibits Trichophyton rubrum Growth via Membrane Permeability Alternation and Ergosterol Biosynthesis Disruption. BioMed research international. 2022; 2022(?):6230193. doi: 10.1155/2022/6230193. [PMID: 35782069]
  • Hsin-Jung Ho, Koichi Kikuchi, Daiki Oikawa, Shun Watanabe, Yoshitomi Kanemitsu, Daisuke Saigusa, Ryota Kujirai, Wakako Ikeda-Ohtsubo, Mariko Ichijo, Yukako Akiyama, Yuichi Aoki, Eikan Mishima, Yoshiaki Ogata, Yoshitsugu Oikawa, Tetsuro Matsuhashi, Takafumi Toyohara, Chitose Suzuki, Takehiro Suzuki, Nariyasu Mano, Yoshiteru Kagawa, Yuji Owada, Takane Katayama, Toru Nakayama, Yoshihisa Tomioka, Takaaki Abe. SGLT-1-specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine-induced renal failure. Physiological reports. 2021 12; 9(24):e15092. doi: 10.14814/phy2.15092. [PMID: 34921520]
  • Michael Bekhit, Waldemar Gorski. Determination of sorbitol dehydrogenase in microsamples of human serum. Talanta. 2021 Dec; 235(?):122730. doi: 10.1016/j.talanta.2021.122730. [PMID: 34517598]
  • Anna N Ligezka, Silvia Radenkovic, Mayank Saraswat, Kishore Garapati, Wasantha Ranatunga, Wirginia Krzysciak, Hitoshi Yanaihara, Graeme Preston, William Brucker, Renee M McGovern, Joel M Reid, David Cassiman, Karthik Muthusamy, Christin Johnsen, Saadet Mercimek-Andrews, Austin Larson, Christina Lam, Andrew C Edmondson, Bart Ghesquière, Peter Witters, Kimiyo Raymond, Devin Oglesbee, Akhilesh Pandey, Ethan O Perlstein, Tamas Kozicz, Eva Morava. Sorbitol Is a Severity Biomarker for PMM2-CDG with Therapeutic Implications. Annals of neurology. 2021 12; 90(6):887-900. doi: 10.1002/ana.26245. [PMID: 34652821]
  • Hideaki Jinnouchi, Akira Yoshida, Hiromi Tsuyuno, Kiyoko Iwamoto, Seigo Sugiyama, Kunio Hieshima, Keizo Kajiwara, Noboru Kurinami, Tomoko Suzuki, Katsunori Jinnouchi, Tomio Jinnouchi. Changes in urinary glucose concentration and body weight in patients treated with the selective SGLT2 inhibitor luseogliflozin. Diabetes research and clinical practice. 2021 Dec; 182(?):108916. doi: 10.1016/j.diabres.2021.108916. [PMID: 34119556]
  • Filipa Mota, Patricia De Jesus, Sanjay K Jain. Kit-based synthesis of 2-deoxy-2-[18F]-fluoro-D-sorbitol for bacterial imaging. Nature protocols. 2021 11; 16(11):5274-5286. doi: 10.1038/s41596-021-00613-2. [PMID: 34686858]
  • Yi Chen, Xiaowen Jiang, Junnan Wang, Zhengxiu Wu, Yuchen Wu, Zhonghua Ni, Hong Yi, Rongsheng Lu. Sensitive Oxidation of Sorbitol-Mediated Fe2+ by H2O2: A Reliable TD-NMR Method for Clinical Blood Glucose Detection. Analytical chemistry. 2021 10; 93(42):14153-14160. doi: 10.1021/acs.analchem.1c02616. [PMID: 34637275]
  • Yasushi Honda, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Masato Yoneda, Satoru Saito, Yoji Nagashima, Atsushi Nakajima. Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice. Journal of pharmacological sciences. 2021 Oct; 147(2):176-183. doi: 10.1016/j.jphs.2021.07.002. [PMID: 34384565]
  • Anqi Zhang, Daisuke Nakano, Wararat Kittikulsuth, Yuka Yamashita, Akira Nishiyama. Luseogliflozin, a SGLT2 Inhibitor, Does Not Affect Glucose Uptake Kinetics in Renal Proximal Tubules of Live Mice. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158169. [PMID: 34360935]
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