Tryprostatin A (BioDeep_00000013560)
natural product
代谢物信息卡片
化学式: C22H27N3O3 (381.20523120000007)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 20.17%
分子结构信息
SMILES: c1(ccc2c(c1)[nH]c(c2C[C@H]1C(=O)N2[C@H](C(=O)N1)CCC2)CC=C(C)C)OC
InChI: InChI=1S/C22H27N3O3/c1-13(2)6-9-17-16(15-8-7-14(28-3)11-18(15)23-17)12-19-22(27)25-10-4-5-20(25)21(26)24-19/h6-8,11,19-20,23H,4-5,9-10,12H2,1-3H3,(H,24,26)/t19-,20-/m0/s1
描述信息
A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:72761
- KEGG: C20607
- PubChem: 9929833
- PubChem: 45934456
- ChEMBL: CHEMBL289159
- KNApSAcK: C00016145
- CAS: 171864-80-5
- PMhub: MS000028046
- MetaboLights: MTBLC72761
- PubChem: 172232334
- RefMet: Tryprostatin A
- LOTUS: LTS0091627
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- fumitremorgin C biosynthesis:
6-hydroxytryprostatin B + SAM ⟶ H+ + SAH + tryprostatin A - superpathway of fumitremorgin biosynthesis:
DMAPP + verruculogen ⟶ diphosphate + fumitremorgin A
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
23 个相关的物种来源信息
- 4890 - Ascomycota: LTS0091627
- 1131492 - Aspergillaceae: LTS0091627
- 5052 - Aspergillus: LTS0091627
- 746128 - Aspergillus fumigatus:
- 746128 - Aspergillus fumigatus: 10.1016/0040-4020(96)00737-5
- 746128 - Aspergillus fumigatus: 10.1016/J.TET.2008.06.013
- 746128 - Aspergillus fumigatus: 10.1021/JF300146N
- 746128 - Aspergillus fumigatus: 10.1021/NP800700E
- 746128 - Aspergillus fumigatus: 10.7164/ANTIBIOTICS.48.1382
- 746128 - Aspergillus fumigatus: 10.7164/ANTIBIOTICS.49.527
- 746128 - Aspergillus fumigatus: 10.7164/ANTIBIOTICS.49.534
- 746128 - Aspergillus fumigatus: LTS0091627
- 34397 - Clavicipitaceae: LTS0091627
- 45234 - Cordyceps: LTS0091627
- 45847 - Cordyceps tenuipes: 10.1021/NP800702C
- 45847 - Cordyceps tenuipes: LTS0091627
- 474943 - Cordycipitaceae: LTS0091627
- 2759 - Eukaryota: LTS0091627
- 147545 - Eurotiomycetes: LTS0091627
- 4751 - Fungi: LTS0091627
- 72232 - Isaria: LTS0091627
- 147550 - Sordariomycetes: LTS0091627
- 28568 - Trichocomaceae: LTS0091627
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuwei Fang, Jianglian She, Xi Zhang, Tanwei Gu, Danni Xie, Xiaowei Luo, Xiangxi Yi, Chenghai Gao, Yonghong Liu, Cuixian Zhang, Lan Tang, Xuefeng Zhou. Discovery of Anti-Hypercholesterolemia Agents Targeting LXRα from Marine Microorganism-Derived Natural Products.
Journal of natural products.
2024 02; 87(2):322-331. doi:
10.1021/acs.jnatprod.3c01029. [PMID: 38334086] - Xiao-Jun Li, Qiang Zhang, An-Ling Zhang, Jin-Ming Gao. Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
Journal of agricultural and food chemistry.
2012 Apr; 60(13):3424-31. doi:
10.1021/jf300146n. [PMID: 22409377] - Chunhe Wang, David C Buck, Rui Yang, Tara A Macey, Kim A Neve. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
Journal of neurochemistry.
2005 May; 93(4):899-909. doi:
10.1111/j.1471-4159.2005.03055.x. [PMID: 15857393] - Holger Woehlecke, Antje Pohl, Nele Alder-Baerens, Hermann Lage, Andreas Herrmann. Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2).
The Biochemical journal.
2003 Dec; 376(Pt 2):489-95. doi:
10.1042/bj20030886. [PMID: 12946267]