latrunculin B (BioDeep_00000013124)

   

Volatile Flavor Compounds


代谢物信息卡片


(4R)-4-[(1R,4E,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one

化学式: C20H29NO5S (395.17663440000007)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 16.67%

分子结构信息

SMILES: CC1(C)C=CCCC=CC(=O)OC2CC(CC1)OC(O)(C1CSC(O)=N1)C2
InChI: InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9+/t13-,15-,16-,17+,20-/m1/s1

描述信息

A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.

同义名列表

5 个代谢物同义名

latrunculin B; (4R)-4-[(1R,4E,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one; 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone; MolMap_000067; Latrunculin B



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Shi Xu, Qianqian Wang, Yue Liu, Zonghao Liu, Ruoxin Zhao, Xianyong Sheng. Latrunculin B facilitates gravitropic curvature of Arabidopsis root by inhibiting cell elongation, especially the cells in the lower flanks of the transition and elongation zones. Plant signaling & behavior. 2021 04; 16(4):1876348. doi: 10.1080/15592324.2021.1876348. [PMID: 33576719]
  • Conrad V Simoben, Ammar Qaseem, Aurélien F A Moumbock, Kiran K Telukunta, Stefan Günther, Wolfgang Sippl, Fidele Ntie-Kang. Pharmacoinformatic Investigation of Medicinal Plants from East Africa. Molecular informatics. 2020 11; 39(11):e2000163. doi: 10.1002/minf.202000163. [PMID: 32964659]
  • Keisho Maeda, Michiko Sasabe, Shigeru Hanamata, Yasunori Machida, Seiichiro Hasezawa, Takumi Higaki. Actin Filament Disruption Alters Phragmoplast Microtubule Dynamics during the Initial Phase of Plant Cytokinesis. Plant & cell physiology. 2020 Mar; 61(3):445-456. doi: 10.1093/pcp/pcaa003. [PMID: 32030404]
  • Alecia Biel, Morgan Moser, Iris Meier. A Role for Plant KASH Proteins in Regulating Stomatal Dynamics. Plant physiology. 2020 02; 182(2):1100-1113. doi: 10.1104/pp.19.01010. [PMID: 31767690]
  • Rinku Kumar, Sajjita Saha, Bidisha Sinha. Cell spread area and traction forces determine myosin-II-based cortex thickness regulation. Biochimica et biophysica acta. Molecular cell research. 2019 12; 1866(12):118516. doi: 10.1016/j.bbamcr.2019.07.011. [PMID: 31348954]
  • Elisabeth C Kugler, Max van Lessen, Stephan Daetwyler, Karishma Chhabria, Aaron M Savage, Vishmi Silva, Karen Plant, Ryan B MacDonald, Jan Huisken, Robert N Wilkinson, Stefan Schulte-Merker, Paul Armitage, Timothy Ja Chico. Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 2019 08; 20(8):e47047. doi: 10.15252/embr.201847047. [PMID: 31379129]
  • Valentina G Tabbasum, Dermot M F Cooper. Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains. The Journal of membrane biology. 2019 06; 252(2-3):159-172. doi: 10.1007/s00232-019-00060-x. [PMID: 30746562]
  • E P Filipin, D T Pereira, L C Ouriques, Z L Bouzon, C Simioni. Participation of actin filaments, myosin and phosphatidylinositol 3-kinase in the formation and polarisation of tetraspore germ tube of Gelidium floridanum (Rhodophyta, Florideophyceae). Plant biology (Stuttgart, Germany). 2019 Mar; 21(2):352-360. doi: 10.1111/plb.12946. [PMID: 30472775]
  • Gang Li, Xiujuan Yang, Xiaoqing Zhang, Yu Song, Wanqi Liang, Dabing Zhang. Rice Morphology Determinant-Mediated Actin Filament Organization Contributes to Pollen Tube Growth. Plant physiology. 2018 05; 177(1):255-270. doi: 10.1104/pp.17.01759. [PMID: 29581178]
  • Congping Lin, Laurent Lemarchand, Reinhardt Euler, Imogen Sparkes. Modeling the Geometry and Dynamics of the Endoplasmic Reticulum Network. IEEE/ACM transactions on computational biology and bioinformatics. 2018 Mar; 15(2):377-386. doi: 10.1109/tcbb.2015.2389226. [PMID: 29610097]
  • Jessica L Erickson, Norman Adlung, Christina Lampe, Ulla Bonas, Martin H Schattat. The Xanthomonas effector XopL uncovers the role of microtubules in stromule extension and dynamics in Nicotiana benthamiana. The Plant journal : for cell and molecular biology. 2018 03; 93(5):856-870. doi: 10.1111/tpj.13813. [PMID: 29285819]
  • Kazuki Motomura, Tomokazu Kawashima, Frédéric Berger, Tetsu Kinoshita, Tetsuya Higashiyama, Daisuke Maruyama. A pharmacological study of Arabidopsis cell fusion between the persistent synergid and endosperm. Journal of cell science. 2018 01; 131(2):. doi: 10.1242/jcs.204123. [PMID: 28808086]
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  • Jean-Charles Isner, Zaoxu Xu, Joaquim Miguel Costa, Fabien Monnet, Thomas Batstone, Xiaobin Ou, Michael J Deeks, Bernard Genty, Kun Jiang, Alistair M Hetherington. Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. The New phytologist. 2017 Aug; 215(3):1059-1067. doi: 10.1111/nph.14655. [PMID: 28636198]
  • Juan Moral, Gracia Montilla-Bascón, Francisco J Canales, Diego Rubiales, Elena Prats. Cytoskeleton reorganization/disorganization is a key feature of induced inaccessibility for defence to successive pathogen attacks. Molecular plant pathology. 2017 Jun; 18(5):662-671. doi: 10.1111/mpp.12424. [PMID: 27147535]
  • Tomáš Takáč, Slávka Bekešová, Jozef Šamaj. Actin depolymerization-induced changes in proteome of Arabidopsis roots. Journal of proteomics. 2017 02; 153(?):89-99. doi: 10.1016/j.jprot.2016.06.010. [PMID: 27321584]
  • Yuxiang Jiang, Meng Zhang, Shanjin Huang. Analysis of Actin-Based Intracellular Trafficking in Pollen Tubes. Methods in molecular biology (Clifton, N.J.). 2017; 1662(?):125-136. doi: 10.1007/978-1-4939-7262-3_11. [PMID: 28861823]
  • Susanne Muehlich, Margot Rehm, Astrid Ebenau, Margarete Goppelt-Struebe. Synergistic induction of CTGF by cytochalasin D and TGFβ-1 in primary human renal epithelial cells: Role of transcriptional regulators MKL1, YAP/TAZ and Smad2/3. Cellular signalling. 2017 01; 29(?):31-40. doi: 10.1016/j.cellsig.2016.10.002. [PMID: 27721022]
  • Matthew R Fleming, Maile R Brown, Jack Kronengold, Yalan Zhang, David P Jenkins, Gulia Barcia, Rima Nabbout, Anne E Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S Navaratnam, Leonard K Kaczmarek. Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell reports. 2016 08; 16(9):2281-8. doi: 10.1016/j.celrep.2016.07.024. [PMID: 27545877]
  • Hiroyuki Yamaba, Manami Haba, Mayumi Kunita, Tsutomu Sakaida, Hiroshi Tanaka, Youichi Yashiro, Satoru Nakata. Morphological change of skin fibroblasts induced by UV Irradiation is involved in photoaging. Experimental dermatology. 2016 08; 25 Suppl 3(?):45-51. doi: 10.1111/exd.13084. [PMID: 27539902]
  • Katarzyna Śniegowska-Świerk, Ewa Dubas, Marcin Rapacz. Actin microfilaments are involved in the regulation of HVA1 transcript accumulation in drought-treated barley leaves. Journal of plant physiology. 2016 Apr; 193(?):22-5. doi: 10.1016/j.jplph.2016.02.006. [PMID: 26930570]
  • Matthias Spiess, Meriem Echbarthi, Andreas Svanström, Roger Karlsson, Julie Grantham. Over-Expression Analysis of All Eight Subunits of the Molecular Chaperone CCT in Mammalian Cells Reveals a Novel Function for CCTdelta. Journal of molecular biology. 2015 Aug; 427(17):2757-64. doi: 10.1016/j.jmb.2015.06.007. [PMID: 26101841]
  • Chenlei Hua, Kiki Kots, Tijs Ketelaar, Francine Govers, Harold J G Meijer. Effect of Flumorph on F-Actin Dynamics in the Potato Late Blight Pathogen Phytophthora infestans. Phytopathology. 2015 Apr; 105(4):419-23. doi: 10.1094/phyto-04-14-0119-r. [PMID: 25496300]
  • Chao Geng, Qian-Qian Cong, Xiang-Dong Li, An-Li Mou, Rui Gao, Jin-Liang Liu, Yan-Ping Tian. DEVELOPMENTALLY REGULATED PLASMA MEMBRANE PROTEIN of Nicotiana benthamiana contributes to potyvirus movement and transports to plasmodesmata via the early secretory pathway and the actomyosin system. Plant physiology. 2015 Feb; 167(2):394-410. doi: 10.1104/pp.114.252734. [PMID: 25540331]
  • Jiahe Huang, Masaru Fujimoto, Masayuki Fujiwara, Yoichiro Fukao, Shin-Ichi Arimura, Nobuhiro Tsutsumi. Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking. Biochemical and biophysical research communications. 2015 Jan; 456(1):238-44. doi: 10.1016/j.bbrc.2014.11.065. [PMID: 25462567]
  • Kathryn M Wright, Katrin M MacKenzie. Probing protein targeting to plasmodesmata using fluorescence recovery after photo-bleaching. Methods in molecular biology (Clifton, N.J.). 2015; 1217(?):259-74. doi: 10.1007/978-1-4939-1523-1_17. [PMID: 25287209]
  • Rosemary G White. Probing plasmodesmata function with biochemical inhibitors. Methods in molecular biology (Clifton, N.J.). 2015; 1217(?):199-227. doi: 10.1007/978-1-4939-1523-1_14. [PMID: 25287206]
  • Takatoshi Yabuuchi, Tomonori Nakai, Seiji Sonobe, Daisuke Yamauchi, Yoshinobu Mineyuki. Preprophase band formation and cortical division zone establishment: RanGAP behaves differently from microtubules during their band formation. Plant signaling & behavior. 2015; 10(9):e1060385. doi: 10.1080/15592324.2015.1060385. [PMID: 26237087]
  • Chopinet Louise, Dague Etienne, Rols Marie-Pierre. AFM sensing cortical actin cytoskeleton destabilization during plasma membrane electropermeabilization. Cytoskeleton (Hoboken, N.J.). 2014 Oct; 71(10):587-94. doi: 10.1002/cm.21194. [PMID: 25308626]
  • Caleb M Rounds, Peter K Hepler, Lawrence J Winship. The apical actin fringe contributes to localized cell wall deposition and polarized growth in the lily pollen tube. Plant physiology. 2014 Sep; 166(1):139-51. doi: 10.1104/pp.114.242974. [PMID: 25037212]
  • Xin Li, Jian-Hua Li, Wei Wang, Nai-Zhi Chen, Tong-Suo Ma, Ya-Nan Xi, Xiao-Lu Zhang, Hai-Fei Lin, Yang Bai, Shan-Jin Huang, Yu-Ling Chen. ARP2/3 complex-mediated actin dynamics is required for hydrogen peroxide-induced stomatal closure in Arabidopsis. Plant, cell & environment. 2014 Jul; 37(7):1548-60. doi: 10.1111/pce.12259. [PMID: 24372484]
  • Hiroki Yasuhara, Kazuki Kitamoto. Aphidicolin-induced nuclear elongation in tobacco BY-2 cells. Plant & cell physiology. 2014 May; 55(5):913-27. doi: 10.1093/pcp/pcu026. [PMID: 24492257]
  • Zuzana Vondráková, Kateřina Eliášová, Martin Vágner. The anti-actin drugs latrunculin and cytochalasin affect the maturation of spruce somatic embryos in different ways. Plant science : an international journal of experimental plant biology. 2014 May; 221-222(?):90-9. doi: 10.1016/j.plantsci.2014.02.006. [PMID: 24656339]
  • Mie Ichikawa, Tomoko Hirano, Kazuhiko Enami, Taylor Fuselier, Naohiro Kato, Chian Kwon, Boris Voigt, Paul Schulze-Lefert, František Baluška, Masa H Sato. Syntaxin of plant proteins SYP123 and SYP132 mediate root hair tip growth in Arabidopsis thaliana. Plant & cell physiology. 2014 Apr; 55(4):790-800. doi: 10.1093/pcp/pcu048. [PMID: 24642714]
  • Koh Meng Aw Yong, Yu Zeng, Donald Vindivich, Jude M Phillip, Pei-Hsun Wu, Denis Wirtz, Robert H Getzenberg. Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis. Journal of cellular physiology. 2014 Mar; 229(3):362-73. doi: 10.1002/jcp.24458. [PMID: 23996089]
  • Zhike Feng, Xiaojiao Chen, Yiqun Bao, Jiahong Dong, Zhongkai Zhang, Xiaorong Tao. Nucleocapsid of Tomato spotted wilt tospovirus forms mobile particles that traffic on an actin/endoplasmic reticulum network driven by myosin XI-K. The New phytologist. 2013 Dec; 200(4):1212-24. doi: 10.1111/nph.12447. [PMID: 24032608]
  • Christelle Rosazza, Annette Buntz, Thorsten Rieß, Dominik Wöll, Andreas Zumbusch, Marie-Pierre Rols. Intracellular tracking of single-plasmid DNA particles after delivery by electroporation. Molecular therapy : the journal of the American Society of Gene Therapy. 2013 Dec; 21(12):2217-26. doi: 10.1038/mt.2013.182. [PMID: 23941812]
  • Yiyan Zheng, Yurong Xie, Yuxiang Jiang, Xiaolu Qu, Shanjin Huang. Arabidopsis actin-depolymerizing factor7 severs actin filaments and regulates actin cable turnover to promote normal pollen tube growth. The Plant cell. 2013 Sep; 25(9):3405-23. doi: 10.1105/tpc.113.117820. [PMID: 24058157]
  • Qiong Liu, Fei Qiao, Ahmed Ismail, Xiaoli Chang, Peter Nick. The plant cytoskeleton controls regulatory volume increase. Biochimica et biophysica acta. 2013 Sep; 1828(9):2111-20. doi: 10.1016/j.bbamem.2013.04.027. [PMID: 23660128]
  • Szilvia Szabo, Yi Xu, Roberto Romero, Tibor Fule, Katalin Karaszi, Gaurav Bhatti, Tibor Varkonyi, Ildiko Varkonyi, Tibor Krenacs, Zhong Dong, Adi L Tarca, Tinnakorn Chaiworapongsa, Sonia S Hassan, Zoltan Papp, Ilona Kovalszky, Nandor Gabor Than. Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. Virchows Archiv : an international journal of pathology. 2013 Sep; 463(3):445-58. doi: 10.1007/s00428-013-1426-0. [PMID: 23807541]
  • Karin Klappe, Ina Hummel, Jan Willem Kok. Separation of actin-dependent and actin-independent lipid rafts. Analytical biochemistry. 2013 Jul; 438(2):133-5. doi: 10.1016/j.ab.2013.03.018. [PMID: 23541521]
  • Jelena Dinic, Parham Ashrafzadeh, Ingela Parmryd. Actin filaments attachment at the plasma membrane in live cells cause the formation of ordered lipid domains. Biochimica et biophysica acta. 2013 Mar; 1828(3):1102-11. doi: 10.1016/j.bbamem.2012.12.004. [PMID: 23246974]
  • Peter Meszaros, Ina Hummel, Karin Klappe, Oana Draghiciu, Dick Hoekstra, Jan W Kok. The function of the ATP-binding cassette (ABC) transporter ABCB1 is not susceptible to actin disruption. Biochimica et biophysica acta. 2013 Feb; 1828(2):340-51. doi: 10.1016/j.bbamem.2012.10.007. [PMID: 23085402]
  • Stefano Coppola, Francesco Cardarelli, Daniela Pozzi, Laura C Estrada, Michelle A Digman, Enrico Gratton, Angelo Bifone, Carlotta Marianecci, Giulio Caracciolo. The role of cytoskeleton networks on lipid-mediated delivery of DNA. Therapeutic delivery. 2013 Feb; 4(2):191-202. doi: 10.4155/tde.12.151. [PMID: 23343159]
  • Eunsook Park, Andreas Nebenführ. Myosin XIK of Arabidopsis thaliana accumulates at the root hair tip and is required for fast root hair growth. PloS one. 2013; 8(10):e76745. doi: 10.1371/journal.pone.0076745. [PMID: 24116145]
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  • Christina E N Lord, Adrian N Dauphinee, Rebecca L Watts, Arunika H L A N Gunawardena. Unveiling interactions among mitochondria, caspase-like proteases, and the actin cytoskeleton during plant programmed cell death (PCD). PloS one. 2013; 8(3):e57110. doi: 10.1371/journal.pone.0057110. [PMID: 23483897]
  • Tijs Ketelaar, Harold J G Meijer, Marjolein Spiekerman, Rob Weide, Francine Govers. Effects of latrunculin B on the actin cytoskeleton and hyphal growth in Phytophthora infestans. Fungal genetics and biology : FG & B. 2012 Dec; 49(12):1014-22. doi: 10.1016/j.fgb.2012.09.008. [PMID: 23036581]
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  • Pika Miklavc, Elena Hecht, Nina Hobi, Oliver H Wittekindt, Paul Dietl, Christine Kranz, Manfred Frick. Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II. Journal of cell science. 2012 Jun; 125(Pt 11):2765-74. doi: 10.1242/jcs.105262. [PMID: 22427691]
  • Silvan Türkcan, Jean-Baptiste Masson, Didier Casanova, Geneviève Mialon, Thierry Gacoin, Jean-Pierre Boilot, Michel R Popoff, Antigoni Alexandrou. Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu(3+)-doped oxide nanoparticles. Biophysical journal. 2012 May; 102(10):2299-308. doi: 10.1016/j.bpj.2012.03.072. [PMID: 22677383]
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  • Christelle Rosazza, Jean-Michel Escoffre, Andreas Zumbusch, Marie-Pierre Rols. The actin cytoskeleton has an active role in the electrotransfer of plasmid DNA in mammalian cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2011 May; 19(5):913-21. doi: 10.1038/mt.2010.303. [PMID: 21343915]
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  • Yih-Shan Lo, Lin-June Hsiao, Ning Cheng, Alexandra Litvinchuk, Hwa Dai. Characterization of the structure and DNA complexity of mung bean mitochondrial nucleoids. Molecules and cells. 2011 Mar; 31(3):217-24. doi: 10.1007/s10059-011-0036-4. [PMID: 21347700]
  • Xiu-Hua Xue, Chun-Qing Guo, Fei Du, Quan-Long Lu, Chuan-Mao Zhang, Hai-Yun Ren. AtFH8 is involved in root development under effect of low-dose latrunculin B in dividing cells. Molecular plant. 2011 Mar; 4(2):264-78. doi: 10.1093/mp/ssq085. [PMID: 21307369]
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