Farnesylcysteine (BioDeep_00000013007)
Secondary id: BioDeep_00001869897
human metabolite Endogenous
代谢物信息卡片
化学式: C18H31NO2S (325.2075)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(viridiplantae) 19.17%
分子结构信息
SMILES: CC(=CCC/C(=C/CC/C(=C/CSC[C@@H](C(=O)O)N)/C)/C)C
InChI: InChI=1S/C18H31NO2S/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-22-13-17(19)18(20)21/h7,9,11,17H,5-6,8,10,12-13,19H2,1-4H3,(H,20,21)/b15-9+,16-11+/t17-/m0/s1
描述信息
In patients with chronic fatigue syndrome (CFS) we found increased IgM levels to S-farnesyl-L-cysteine. S-farnesyl-L-cysteine plays a key role in regulating cell growth, differentiation and apoptosis through RAS protein activity. The latter depends on their anchorage to the inner surface of the plasma membrane, which is promoted by their common carboxy-terminal S-farnesyl-cysteine. The presence of antibodies to S-farnesyl-L-cysteine suggest that RAS functions may have undergone damage by oxidative/nitrosative stress, causing disturbed functional activity in the regulation of cell growth. (PMID 17159817).
同义名列表
12 个代谢物同义名
(2R)-2-amino-3-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl}propanoic acid; S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]-L-cysteine,(9ci); S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]-L-cysteine; (e,e)-L-S-(3,7,11-Trimethyl-2,6,10-dodecatrienyl)-cysteine; S-all-trans-Farnesyl-L-cysteine; S-trans-trans-Farnesylcysteine; S-(2E,6E)-Farnesyl-L-cysteine; S-Farnesyl cysteine; S-Farnesylcysteine; farnesyl cysteine; Farnesylcysteine; Farnesylcysteine
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:62197
- KEGG: C19691
- PubChem: 54331582
- PubChem: 6438372
- HMDB: HMDB0011627
- Metlin: METLIN62388
- MetaCyc: CPD-12581
- foodb: FDB028328
- chemspider: 4942854
- CAS: 68000-92-0
- PMhub: MS000027360
- PubChem: 135626159
- RefMet: Farnesylcysteine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Michael Maes, Ivana Mihaylova, Marta Kubera, Jean-Claude Leunis, Frank N M Twisk, Michel Geffard. IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.
Metabolic brain disease.
2012 Dec; 27(4):415-23. doi:
10.1007/s11011-012-9316-8
. [PMID: 22614823] - Michael Maes, Ivana Mihaylova, Marta Kubera, Jean-Claude Leunis, Michel Geffard. IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology.
Journal of affective disorders.
2011 Dec; 135(1-3):414-8. doi:
10.1016/j.jad.2011.08.023
. [PMID: 21930301] - David H Huizinga, Ryan Denton, Kelly G Koehler, Ashley Tomasello, Lyndsay Wood, Stephanie E Sen, Dring N Crowell. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.
Molecular plant.
2010 Jan; 3(1):143-55. doi:
10.1093/mp/ssp091
. [PMID: 19969520] - Dring N Crowell, David H Huizinga, Angela K Deem, Corey Trobaugh, Ryan Denton, Stephanie E Sen. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.
The Plant journal : for cell and molecular biology.
2007 Jun; 50(5):839-47. doi:
10.1111/j.1365-313x.2007.03091.x
. [PMID: 17425716] - Z Aharonson, M Gana-Weisz, T Varsano, R Haklai, D Marciano, Y Kloog. Stringent structural requirements for anti-Ras activity of S-prenyl analogues.
Biochimica et biophysica acta.
1998 Feb; 1406(1):40-50. doi:
10.1016/s0925-4439(97)00077-x
. [PMID: 9545527] - H C Rilling, E Bruenger, L M Leining, J E Buss, W W Epstein. Differential prenylation of proteins as a function of mevalonate concentration in CHO cells.
Archives of biochemistry and biophysics.
1993 Mar; 301(2):210-5. doi:
10.1006/abbi.1993.1135
. [PMID: 8460935] - W W Epstein, D Lever, L M Leining, E Bruenger, H C Rilling. Quantitation of prenylcysteines by a selective cleavage reaction.
Proceedings of the National Academy of Sciences of the United States of America.
1991 Nov; 88(21):9668-70. doi:
10.1073/pnas.88.21.9668
. [PMID: 1946384] - J B Stimmel, R J Deschenes, C Volker, J Stock, S Clarke. Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein.
Biochemistry.
1990 Oct; 29(41):9651-9. doi:
10.1021/bi00493a021
. [PMID: 2271607]