Aflatoxin Q1 (BioDeep_00000012937)

 

Secondary id: BioDeep_00001868939

human metabolite Endogenous natural product


代谢物信息卡片


14-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1(12),2(9),4,10,13(17)-pentaene-16,18-dione

化学式: C17H12O7 (328.05830019999996)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 5.56%

分子结构信息

SMILES: COC1=C2C3=C(C(=O)CC3O)C(=O)OC2=C4C5C=COC5OC4=C1
InChI: InChI=1S/C17H12O7/c1-21-9-5-10-11(6-2-3-22-17(6)23-10)15-14(9)12-7(18)4-8(19)13(12)16(20)24-15/h2-3,5-7,17-18H,4H2,1H3

描述信息

Aflatoxin Q1 is a mycotoxin. It is a metabolite of Aflatoxin B. It can be found in Aspergillus flavus and Aspergillus parasiticus (Hugo Vanden Bossche, D.W.R. Mackenzie and G. Cauwenbergh. Aspergillus and Aspergillosis, 1987).
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D000348 - Aflatoxins

同义名列表

3 个代谢物同义名

14-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1(12),2(9),4,10,13(17)-pentaene-16,18-dione; SCHEMBL13811699; Aflatoxin Q1



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

37 个相关的代谢反应过程信息。

Reactome(36)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiangwei Du, Dwayne E Schrunk, Dahai Shao, Paula M Imerman, Chong Wang, Steve M Ensley, Wilson K Rumbeiha. Intra-laboratory Development and Evaluation of a Quantitative Method for Measurement of Aflatoxins B1, M1 and Q1 in Animal Urine by High Performance Liquid Chromatography with Fluorescence Detection. Journal of analytical toxicology. 2017 Oct; 41(8):698-707. doi: 10.1093/jat/bkx059. [PMID: 28985321]
  • Hannu Mykkänen, Huilian Zhu, Eeva Salminen, Risto Olavi Juvonen, Wenhua Ling, Jing Ma, Nektaria Polychronaki, Heidi Kemiläinen, Otto Mykkänen, Seppo Salminen, Hani El-Nezami. Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males. International journal of cancer. 2005 Jul; 115(6):879-84. doi: 10.1002/ijc.20951. [PMID: 15723309]
  • A Kussak, B Andersson, K Andersson. Immunoaffinity column clean-up for the high-performance liquid chromatographic determination of aflatoxins B1, B2, G1, G2, M1 and Q1 in urine. Journal of chromatography. B, Biomedical applications. 1995 Oct; 672(2):253-9. doi: 10.1016/0378-4347(95)00227-a. [PMID: 8581131]
  • A Kussak, B Andersson, K Andersson. Determination of aflatoxin Q1 in urine by automated immunoaffinity column clean-up and liquid chromatography. Journal of chromatography. B, Biomedical applications. 1994 Jun; 656(2):329-34. doi: 10.1016/0378-4347(94)00123-5. [PMID: 7987484]
  • B Y Wong, B H Lau, T Yamasaki, R W Teel. Inhibition of dexamethasone-induced cytochrome P450-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 1993 Jul; 2(4):351-6. doi: 10.1097/00008469-199307000-00010. [PMID: 8358288]
  • D W Denning, R Allen, A P Wilkinson, M R Morgan. Transplacental transfer of aflatoxin in humans. Carcinogenesis. 1990 Jun; 11(6):1033-5. doi: 10.1093/carcin/11.6.1033. [PMID: 2112058]
  • T S Fan, G S Zhang, F S Chu. Production and characterization of antibody against aflatoxin Q1. Applied and environmental microbiology. 1984 Mar; 47(3):526-32. doi: 10.1128/aem.47.3.526-532.1984. [PMID: 6712219]