2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (BioDeep_00000012709)

 

Secondary id: BioDeep_00001868508

human metabolite Endogenous


代谢物信息卡片


10-methyl-1,3,8-triazatricyclo[7.4.0.0²,⁷]trideca-2(7),5,8,10,12-pentaen-4-imine

化学式: C11H10N4 (198.0905)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 24.06%

分子结构信息

SMILES: CC1=CC=CN2C1=NC3=C2N=C(C=C3)N
InChI: InChI=1S/C11H10N4/c1-7-3-2-6-15-10(7)13-8-4-5-9(12)14-11(8)15/h2-6H,1H3,(H2,12,14)

描述信息

2-Amino-6-methyldipyrido[1,2-a:3,2-d]imidazole is a powerful mutagen presumed present in cooked food
D009676 - Noxae > D009153 - Mutagens

同义名列表

16 个代谢物同义名

10-methyl-1,3,8-triazatricyclo[7.4.0.0²,⁷]trideca-2(7),5,8,10,12-pentaen-4-imine; 6-Methylpyrido[3,2:4,5]imidazo[1,2-a]pyridin-2-amine; 6-Methyldipyrido[1,2-a:3,2-D]imidazol-2-amine, 9ci; 2-Amino-6-methyldipyridol(1,2-a:3,2-D)imidazole; 2-Amino-6-methyl-dipyrido(1,2-a:3,2-D)imidazole; 2-Amino-6-methyldipyrido(1,2-a:3,2-D)imidazole; 2-Amino-6-methyldipyrido(1,2-a-3,2-D)imidazole; 2-Amino-6-methyldipyrido[1,2-a:3,2-d]imidazole; 6-Methyl-dipyrido(1,2-a:3,2-D)imidazol-2-amine; 6-Methylimidazo[1,2-a:5,4-b]dipyridin-2-amine; 2-Amino-6-methyldipyrid[1,2-a:3,2-D]imidazole; 6-Methyldipyrido(1,2-a:3,2-D)imidazol-2-amine; 6-Me-glu-p-2; Glu-P-1; Glu p-1; Glu-P-1



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Vinod Vijayan, Avik Mazumder. In vitro inhibition of food borne mutagens induced mutagenicity by cinnamon (Cinnamomum cassia) bark extract. Drug and chemical toxicology. 2018 Oct; 41(4):385-393. doi: 10.1080/01480545.2018.1439056. [PMID: 29482462]
  • Chi-Hao Wu, Gow-Chin Yen. Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process. Life sciences. 2004 Nov; 76(1):85-101. doi: 10.1016/j.lfs.2004.07.011. [PMID: 15501482]
  • Sakae Arimoto-Kobayashi, Naomi Inada, Yasuko Sato, Chitose Sugiyama, Keinosuke Okamoto, Hikoya Hayatsu, Tomoe Negishi. Inhibitory effects of (-)-epigallocatechin gallate on the mutation, DNA strand cleavage, and DNA adduct formation by heterocyclic amines. Journal of agricultural and food chemistry. 2003 Aug; 51(17):5150-3. doi: 10.1021/jf0302761. [PMID: 12903983]
  • Yaowarate Intiyot, Takemi Kinouchi, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Usanee Vinitketkumnuen, Yoshinari Ohnishi. Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. The journal of medical investigation : JMI. 2002 Feb; 49(1-2):25-34. doi: ". [PMID: 11901756]
  • M Hirose, S Takahashi, K Ogawa, M Futakuchi, T Shirai. Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1999 Sep; 37(9-10):985-92. doi: 10.1016/s0278-6915(99)00092-7. [PMID: 10541455]
  • H Yoshino, K Urano. Mutagenic activities of exhaust gas and ash from sludge incineration plants. The Science of the total environment. 1998 Apr; 215(1-2):41-9. doi: 10.1016/s0048-9697(98)00120-x. [PMID: 9599455]
  • A Bu-Abbas, X Nunez, M N Clifford, R Walker, C Ioannides. A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect. Mutagenesis. 1996 Nov; 11(6):597-603. doi: 10.1093/mutage/11.6.597. [PMID: 8962430]
  • G C Yen, P D Duh. Antimutagenic effect of methanolic extracts from peanut hulls. Bioscience, biotechnology, and biochemistry. 1996 Oct; 60(10):1698-700. doi: 10.1271/bbb.60.1698. [PMID: 8987671]
  • Y Kanai, O Wada, S Manabe. Urinary excretion levels of carcinogenic glutamic acid pyrolysis products and their N-acetyl derivatives in humans. Nihon eiseigaku zasshi. Japanese journal of hygiene. 1991 Oct; 46(4):922-9. doi: 10.1265/jjh.46.922. [PMID: 1684216]
  • M Peluso, M Castegnaro, C Malaveille, M Friesen, L Garren, A Hautefeuille, P Vineis, F Kadlubar, H Bartsch. 32P Postlabelling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as a major DNA-damaging agent. Carcinogenesis. 1991 Apr; 12(4):713-7. doi: 10.1093/carcin/12.4.713. [PMID: 2013135]
  • Y Yin, O Wada, S Manabe. Exposure level monitor of a carcinogenic glutamic acid pyrolysis product in rabbits. Mutation research. 1989 Nov; 215(1):107-13. doi: 10.1016/0027-5107(89)90223-6. [PMID: 2811912]
  • I Brandt, B Kowalski, J A Gustafsson, J Rafter. Tissue localization of the carcinogenic glutamic acid pyrolysis product Glu-P-1 in control and beta-naphthoflavone-treated mice and rats. Carcinogenesis. 1989 Aug; 10(8):1529-33. doi: 10.1093/carcin/10.8.1529. [PMID: 2752527]
  • Y Kanai, S Manabe, O Wada. In vitro and in vivo N-acetylation of carcinogenic glutamic acid pyrolysis products in humans. Carcinogenesis. 1988 Dec; 9(12):2179-84. doi: 10.1093/carcin/9.12.2179. [PMID: 3191562]
  • Y Kanai, S Manabe, O Wada. Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) in Glu-P-1-injected rats. Mutation research. 1988 Feb; 207(2):63-7. doi: 10.1016/0165-7992(88)90043-7. [PMID: 3340095]
  • S Manabe, H Yanagisawa, S Ishikawa, Y Kitagawa, Y Kanai, O Wada. Accumulation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-aminodipyrido[1,2-a:3',2'-d]imidazole, carcinogenic glutamic acid pyrolysis products, in plasma of patients with uremia. Cancer research. 1987 Nov; 47(22):6150-5. doi: NULL. [PMID: 3664516]
  • S Sato, C Negishi, A Umemoto, T Sugimura. Metabolic aspects of pyrolysis mutagens in food. Environmental health perspectives. 1986 Aug; 67(?):105-9. doi: 10.1289/ehp.8667105. [PMID: 3757943]
  • G Caderni, M Lodovici, M Salvadori, F Bianchini, P Dolara. Inhibition of the mutagenic activity of some heterocyclic dietary carcinogens and other mutagenic/carcinogenic compounds by rat organ preparations. Mutation research. 1986 Jan; 169(1-2):35-40. doi: 10.1016/0165-1218(86)90015-7. [PMID: 3945235]
  • F Kurosaki, K Shudo, T Okamoto, Y Isogai. Induction of cytokinin-autonomous tobacco callus. Transformation of cultured tobacco callus by mutagenic heteroaromatic amines. Biochemical and biophysical research communications. 1981 Oct; 102(4):1130-5. doi: 10.1016/s0006-291x(81)80129-5. [PMID: 7317043]