1,2-Dimethylhydrazine (BioDeep_00000012667)
Secondary id: BioDeep_00001868144
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
Symmetrical-dimethylhydrazine
化学式: C2H8N2 (60.068744800000005)
中文名称: 1,2-二甲基肼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNNC
InChI: InChI=1S/C2H8N2/c1-3-4-2/h3-4H,1-2H3
描述信息
D009676 - Noxae > D002273 - Carcinogens > D004127 - Dimethylhydrazines
D009676 - Noxae > D000477 - Alkylating Agents
D009676 - Noxae > D009153 - Mutagens
同义名列表
19 个代谢物同义名
Symmetrical-dimethylhydrazine; 1,2 Dimethyl hydrazine; 1,2-Dimethyl-hydrazine; 1,2 Dimethylhydrazine; N,N-dimethylhydrazine; 1,2-DIMETHYLHYDRAZINE; Sym dimethylhydrazine; Sym-dimethylhydrazine; N,N dimethylhydrazine; 1,2-Dimethylhydrazin; Hydrazomethane; MeNHNHMe; (CH3NH)2; (MeNH)2; 1,2-DMH; SDMH; DMH; 1,2-Dimethylhydrazine; 1,2-Dimethylhydrazine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:73755
- KEGG: C19176
- PubChem: 1322
- HMDB: HMDB0244081
- Metlin: METLIN44060
- ChEMBL: CHEMBL162921
- Wikipedia: 1,2-dimethylhydrazine
- MeSH: 1,2-Dimethylhydrazine
- chemspider: 1282
- CAS: 540-73-8
- PMhub: MS000026992
- PubChem: 124489848
- RefMet: 1,2-Dimethylhydrazine
- KNApSAcK: 73755
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Tao, Zhou Qian, Shen Jichen, Zhang Zhizhong, Lian Xiaoyuan. Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through inhibition of multiple cancer-promoting signal pathways in 1,2-Dimethylhydrazine/dextran sodium sulphate mouse model.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):70-77. doi:
10.19852/j.cnki.jtcm.20231204.001. [PMID: 38213241] - Katharina Ardanareswari, Webiana Lowisia, Bernadeta Soedarini, Jiunn-Wang Liao, Yun-Chin Chung. Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Jun; 78(2):286-291. doi:
10.1007/s11130-023-01051-z. [PMID: 36820999] - Tharani Subarmaniam, Rusydatul Nabila Mahmad Rusli, Kokila Vani Perumal, Yoke Keong Yong, Siti Hadizah, Fezah Othman, Khaled Salem, Nurul Husna Shafie, Rosnani Hasham, Khoo Boon Yin, Khairul Kamilah Abdul Kadir, Hasnah Bahari, Zainul Amiruddin Zakaria. The Potential Chemopreventive Effect of Andrographis paniculata on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065224. [PMID: 36982300] - Rani Mata, Jayachandra Reddy Nakkala, Sudha Rani Sadras. Therapeutic role of biogenic silver and gold nanoparticles against a DMH-induced colon cancer model.
Biomaterials advances.
2023 Mar; 146(?):213279. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
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Wiadomosci lekarskie (Warsaw, Poland : 1960).
2023; 76(12):2632-2640. doi:
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Scientific reports.
2022 09; 12(1):15472. doi:
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Nutrition and cancer.
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Toxicology letters.
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Experimental physiology.
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Life sciences.
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Canadian journal of physiology and pharmacology.
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Nutricion hospitalaria.
2020 Feb; 37(1):147-154. doi:
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Nutrition and cancer.
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Mutation research. Genetic toxicology and environmental mutagenesis.
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Journal of cancer research and clinical oncology.
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Environmental toxicology.
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Molecules (Basel, Switzerland).
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Investigational new drugs.
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Drug delivery and translational research.
2019 02; 9(1):53-65. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):237-245. doi:
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Drug development and industrial pharmacy.
2018 Oct; 44(10):1572-1582. doi:
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Journal of cancer research and therapeutics.
2018 Oct; 14(6):1379-1388. doi:
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Journal of biochemical and molecular toxicology.
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The British journal of nutrition.
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European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
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Chemico-biological interactions.
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Genetics and molecular research : GMR.
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Revista peruana de medicina experimental y salud publica.
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Georgian medical news.
2017 Jan; ?(262):20-24. doi:
NULL. [PMID: 28252422] - Martha Cecilia Téllez-Bañuelos, Jesse Haramati, Karina Franco-Topete, Jorge Peregrina-Sandoval, Ramon Franco-Topete, Galina P Zaitseva. Chronic exposure to endosulfan induces inflammation in murine colon via β-catenin expression and IL-6 production.
Journal of immunotoxicology.
2016 11; 13(6):842-849. doi:
10.1080/1547691x.2016.1206998. [PMID: 27494533] - Tahir Rasool Qamar, Fatima Syed, Muhammad Nasir, Habib Rehman, Muhammad Nauman Zahid, Rui Hai Liu, Sanaullah Iqbal. Novel Combination of Prebiotics Galacto-Oligosaccharides and Inulin-Inhibited Aberrant Crypt Foci Formation and Biomarkers of Colon Cancer in Wistar Rats.
Nutrients.
2016 Aug; 8(8):. doi:
10.3390/nu8080465. [PMID: 27490566] - Arivalagan Sivaranjani, Gunasekaran Sivagami, Namasivayam Nalini. Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis.
Journal of cancer research and therapeutics.
2016 Apr; 12(2):755-62. doi:
10.4103/0973-1482.154925. [PMID: 27461646] - Qing-Chun Li, Yun Liang, Guang-Rui Hu, Yuan Tian. Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats.
Indian journal of pharmacology.
2016 Mar; 48(2):168-71. doi:
10.4103/0253-7613.178834. [PMID: 27127319] - H M Nabil, B N Hassan, A A Tohamy, H F Waaer, A E Abdel Moneim. Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression.
Human & experimental toxicology.
2016 Mar; 35(3):282-92. doi:
10.1177/0960327115584687. [PMID: 25926526] - Bhanu Priya Kilari, Venkata Subbaiah Kotakadi, Josthna Penchalaneni. Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats.
Asian Pacific journal of cancer prevention : APJCP.
2016; 17(1):73-80. doi:
10.7314/apjcp.2016.17.1.73. [PMID: 26838257] - Abdelkader Bounaama, Shabnam Enayat, Muserref Seyma Ceyhan, Hichem Moulahoum, Bahia Djerdjouri, Sreeparna Banerjee. Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.
Nutrition and cancer.
2016; 68(3):495-506. doi:
10.1080/01635581.2016.1152379. [PMID: 27093594] - Mohammad R Mohammadi Malayeri, Abolfazl Dadkhah, Faezeh Fatemi, Salome Dini, Fatemeh Torabi, Mohammad M Tavajjoh, Javad Rabiei. Chemotherapeutic effect of Berberis integerrima hydroalcoholic extract on colon cancer development in the 1,2-dimethyl hydrazine rat model.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2016 ; 71(7-8):225-32. doi:
10.1515/znc-2015-0117. [PMID: 27232632] - Krishnan Manigandan, Dharmar Manimaran, Richard L Jayaraj, Namasivayam Elangovan, Velumani Dhivya, Anubhav Kaphle. Taxifolin curbs NF-κB-mediated Wnt/β-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis.
Biochimie.
2015 Dec; 119(?):103-12. doi:
10.1016/j.biochi.2015.10.014. [PMID: 26482805] - Biniyam Girma, Getnet Yimer, Eyasu Makonnen. Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats.
BMC complementary and alternative medicine.
2015 Oct; 15(?):365. doi:
10.1186/s12906-015-0883-1. [PMID: 26470793] - Ning Liu, Bo Sun, Peiwei Wu, Xi Wei. Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats.
Cell biochemistry and biophysics.
2015 Sep; 73(1):101-6. doi:
10.1007/s12013-015-0621-9. [PMID: 25697750] - Y Dong, G Wu. Azadircta indica as a modulator of membrane stability parameters and surface changes during 1,2 dimethylhydrazine-induced colorectal carcinogenesis.
Pathologie-biologie.
2015 Sep; 63(4-5):204-9. doi:
10.1016/j.patbio.2015.06.003. [PMID: 26271242] - C Fernandes, T Marini, F T T Frajacomo, A A Jordao, S B Garcia, V Kannen. Frequency and Duration Modulate Anticarcinogenic Effects of a Physical Training in the Colon.
International journal of sports medicine.
2015 Aug; 36(9):710-5. doi:
10.1055/s-0034-1398624. [PMID: 25806589] - Yuhua Li, Changxu Liu, Dan Xiao, Jing Han, Zhenggang Yue, Yang Sun, Lei Fan, Feng Zhang, Jin Meng, Rong Zhang, Zhipeng Wang, Qibing Mei, Aidong Wen. Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.
Journal of ethnopharmacology.
2015 Jun; 168(?):136-45. doi:
10.1016/j.jep.2015.03.063. [PMID: 25849732] - Rosalía Reynoso-Camacho, Guadalupe Guerrero-Villanueva, Juan de Dios Figueroa, Marco A Gallegos-Corona, Sandra Mendoza, Guadalupe Loarca-Piña, Minerva Ramos-Gomez. Anticarcinogenic Effect of Corn Tortilla Against 1,2-Dimethylhydrazine (DMH)-Induced Colon Carcinogenesis in Sprague-Dawley Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2015 Jun; 70(2):146-52. doi:
10.1007/s11130-015-0471-z. [PMID: 25680741] - Martha Rocío Moreno-Jimenez, Fátima Trujillo-Esquivel, Marco A Gallegos-Corona, Rosalia Reynoso-Camacho, Rubén Francisco González-Laredo, José Alberto Gallegos-Infante, Nuria Elizabeth Rocha-Guzmán, Minerva Ramos-Gomez. Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Jun; 80(?):144-153. doi:
10.1016/j.fct.2015.03.011. [PMID: 25795146] - Sumeet Pandey, Ashish Singh, Nirja Chaudhari, Laxmipriya P Nampoothiri, G Naresh Kumar. Protection against 1,2-di-methylhydrazine-induced systemic oxidative stress and altered brain neurotransmitter status by probiotic Escherichia coli CFR 16 secreting pyrroloquinoline quinone.
Current microbiology.
2015 May; 70(5):690-7. doi:
10.1007/s00284-014-0763-9. [PMID: 25586077] - Antônio Frederico de Freitas Gomides, Reggiani Vilela Gonçalves, Sérgio Oliveira de Paula, Célia Lúcia de Luces Fortes Ferreira, Débora Silva Comastri, Maria do Carmo Gouveia Peluzio. Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon of mice increasing the gene expression of p53.
Nutricion hospitalaria.
2015 Apr; 31(4):1675-81. doi:
10.3305/nh.2015.31.4.8279. [PMID: 25795957] - Venkatachalam Karthikkumar, Gunasekaran Sivagami, Periyasamy Viswanathan, Namasivayam Nalini. Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats.
Journal of basic and clinical physiology and pharmacology.
2015 Mar; 26(2):185-200. doi:
10.1515/jbcpp-2014-0044. [PMID: 25210763] - Hiroshi Jikihara, Guangying Qi, Koichiro Nozoe, Mayumi Hirokawa, Hiromi Sato, Yuka Sugihara, Fumio Shimamoto. Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Oncology reports.
2015 Mar; 33(3):1131-40. doi:
10.3892/or.2014.3705. [PMID: 25573280] - T H Saleem, A M Attya, E A Ahmed, S M M Ragab, M A Ali Abdallah, H M Omar. Possible Protective Effects of Quercetin and Sodium Gluconate Against Colon Cancer Induction by Dimethylhydrazine in Mice.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(14):5823-8. doi:
10.7314/apjcp.2015.16.14.5823. [PMID: 26320457] - Guangying Qi, Sien Zeng, Tiri Takashima, Koichiro Nozoe, Megumi Shobayashi, Koji Kakugawa, Kaori Murakami, Hiroshi Jikihara, Lihua Zhou, Fumio Shimamoto. Inhibitory effect of various breads on DMH-induced aberrant crypt foci and colorectal tumours in rats.
BioMed research international.
2015; 2015(?):829096. doi:
10.1155/2015/829096. [PMID: 26075268] - C Balaji, J Muthukumaran, N Nalini. Chemopreventive effect of sinapic acid on 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis.
Human & experimental toxicology.
2014 Dec; 33(12):1253-68. doi:
10.1177/0960327114522501. [PMID: 24532707] - Angela Verma, Geeta Shukla. Synbiotic (Lactobacillus rhamnosus+Lactobacillus acidophilus+inulin) attenuates oxidative stress and colonic damage in 1,2 dimethylhydrazine dihydrochloride-induced colon carcinogenesis in Sprague-Dawley rats: a long-term study.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Nov; 23(6):550-9. doi:
10.1097/cej.0000000000000054. [PMID: 25025584] - A E Fayed, Azza M Farahat, A E Metwally, M S Massoud And A O Emam. Health stimulating properties of the most popular soft cheese in Egypt Kariesh made using skimmed milk UF-retentate and probiotics.
Acta scientiarum polonorum. Technologia alimentaria.
2014 Oct; 13(4):359-373. doi:
10.17306/j.afs.2014.4.3. [PMID: 28067478] - Rajenderan Vinothkumar, Rajamanickam Vinothkumar, Mani Sudha, Namasivayam Nalini. Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Sep; 23(5):361-71. doi:
10.1097/cej.0b013e32836473ac. [PMID: 23903760] - Sivagami Gunasekaran, Karthikkumar Venkatachalam, Kabalimoorthy Jeyavel, Nalini Namasivayam. Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.
Molecular and cellular biochemistry.
2014 Sep; 394(1-2):187-98. doi:
10.1007/s11010-014-2094-3. [PMID: 24908112] - Celia Cohen, João Felipe Rito Cardoso, Sergio Britto Garcia, Helio Vannucchi. Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Nutrients.
2014 Aug; 6(8):3214-29. doi:
10.3390/nu6083214. [PMID: 25123248] - Isha Rani, Kim Vaiphei, Navneet Agnihotri. Supplementation of fish oil augments efficacy and attenuates toxicity of 5-fluorouracil in 1,2-dimethylhydrazine dihydrochloride/dextran sulfate sodium-induced colon carcinogenesis.
Cancer chemotherapy and pharmacology.
2014 Aug; 74(2):309-22. doi:
10.1007/s00280-014-2497-6. [PMID: 24916547] - Qing-Chao Zhu, Ren-Yuan Gao, Wen Wu, Bo-Min Guo, Jia-Yuan Peng, Huan-Long Qin. Effect of a high-fat diet in development of colonic adenoma in an animal model.
World journal of gastroenterology.
2014 Jul; 20(25):8119-29. doi:
10.3748/wjg.v20.i25.8119. [PMID: 25009384] - Carla C Munari, Ricardo A Furtado, Mirian L Santiago, Simony S Manhas, Jairo K Bastos, Denise C Tavares. Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Jul; 23(4):240-5. doi:
10.1097/cej.0000000000000039. [PMID: 24871557] - Sumeet Pandey, Ashish Singh, Prasant Kumar, Archana Chaudhari, G Nareshkumar. Probiotic Escherichia coli CFR 16 producing pyrroloquinoline quinone (PQQ) ameliorates 1,2-dimethylhydrazine-induced oxidative damage in colon and liver of rats.
Applied biochemistry and biotechnology.
2014 Jun; 173(3):775-86. doi:
10.1007/s12010-014-0897-z. [PMID: 24718737] - O O Hamiza, M U Rehman, R Khan, M Tahir, A Q Khan, A Lateef, S Sultana. Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats.
Human & experimental toxicology.
2014 Feb; 33(2):148-63. doi:
10.1177/0960327113493307. [PMID: 23928829] - R Vinothkumar, R Vinoth Kumar, V Karthikkumar, P Viswanathan, J Kabalimoorthy, N Nalini. Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Environmental toxicology and pharmacology.
2014 Jan; 37(1):174-84. doi:
10.1016/j.etap.2013.11.022. [PMID: 24355798] - V Ganga Prasad, Shishir Kawade, B S Jayashree, Neetinkumar D Reddy, Albi Francis, Pawan G Nayak, Anoop Kishore, K Nandakumar, C Mallikarjuna Rao, Rekha R Shenoy. Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.
BioMed research international.
2014; 2014(?):569130. doi:
10.1155/2014/569130. [PMID: 24995310] - Pollyanna Francielli de Oliveira, Kelly Jacqueline Barbosa de Andrade, Marcela Cristina Ferreira Paula, Nathália Oliveira Acésio, Thais da Silva Moraes, Priscilla Scalon Freitas Borges, Gustavo Rafael Mazzaron Barcelos, Denise Crispim Tavares. Bixin protects hepatocytes against 1,2-dimethylhydrazine-induced genotoxicity but does not suppress DNA damage and pre-neoplastic lesions in the colon of Wistar rats.
Mutation research. Genetic toxicology and environmental mutagenesis.
2014 Jan; 759(?):37-42. doi:
10.1016/j.mrgentox.2013.07.017. [PMID: 24246722] - Ratasark Summart, Teera Chewonarin. Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial β-glucuronidase.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(2):749-55. doi:
10.7314/apjcp.2014.15.2.749. [PMID: 24568490] - R Vinothkumar, M Sudha, P Viswanathan, J Kabalimoorthy, T Balasubramanian, N Nalini. Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis.
Cell proliferation.
2013 Dec; 46(6):705-20. doi:
10.1111/cpr.12062. [PMID: 24118219] - Angelo Pietro Femia, Laura Raimondi, Giulia Maglieri, Maura Lodovici, Edoardo Mannucci, Giovanna Caderni. Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.
International journal of cancer.
2013 Nov; 133(10):2498-503. doi:
10.1002/ijc.28260. [PMID: 23649733] - Abdolamir Allameh, Abolfazl Dadkhah, Fatemeh Rahbarizadeh, Javad Ashrafi-Helan, Faezeh Fatemi. Effect of dietary caraway essential oils on expression of β-catenin during 1,2-dimethylhydrazine-induced colonic carcinogenesis.
Journal of natural medicines.
2013 Oct; 67(4):690-7. doi:
10.1007/s11418-012-0650-2. [PMID: 22418855] - Shinji Kobuchi, Yukako Ito, Kae Okada, Kazuki Imoto, Kanji Takada. Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats.
European journal of drug metabolism and pharmacokinetics.
2013 Sep; 38(3):171-81. doi:
10.1007/s13318-012-0114-9. [PMID: 23197286] - Nermin Abdel Hamid Sadik, Olfat Gamil Shaker. Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Digestive diseases and sciences.
2013 Sep; 58(9):2507-17. doi:
10.1007/s10620-013-2704-z. [PMID: 23722564] - Antônio Frederico de Freitas Gomides, Sérgio Oliveira de Paula, Damiana Diniz Rosa, Leandro Licusi de Oliveira, Débora Silva Comastri, Maria do Carmo Gouveia Peluzio. Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice.
Acta cirurgica brasileira.
2013 Aug; 28(8):607-13. doi:
10.1590/s0102-86502013000800009. [PMID: 23896841] - Selvaraj Aranganathan, Namasivayam Nalini. Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
Phytotherapy research : PTR.
2013 Jul; 27(7):999-1005. doi:
10.1002/ptr.4826. [PMID: 22899565] - Karthikkumar Venkatachalam, Sivagami Gunasekaran, Victor Antony Santiago Jesudoss, Nalini Namasivayam. The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2013 May; 65(4):409-18. doi:
10.1016/j.etp.2011.12.005. [PMID: 22236574] - Priscila L Sequetto, Tânia T Oliveira, Italo A C Soares, Izabel R S C Maldonado, Vanessa J Mello, Virginia R Pizziolo, Márcia R Almeida, Rômulo D Novaes. The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.
Cell and tissue research.
2013 May; 352(2):327-39. doi:
10.1007/s00441-013-1562-5. [PMID: 23468207]