1,2-DIMETHYLHYDRAZINE (BioDeep_00001868144)
Main id: BioDeep_00000012667
代谢物信息卡片
1,2-DIMETHYLHYDRAZINE
化学式: C2H8N2 (60.068744800000005)
中文名称: 1,2-二甲基肼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNNC
InChI: InChI=1S/C2H8N2/c1-3-4-2/h3-4H,1-2H3
描述信息
D009676 - Noxae > D002273 - Carcinogens > D004127 - Dimethylhydrazines
D009676 - Noxae > D000477 - Alkylating Agents
D009676 - Noxae > D009153 - Mutagens
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:73755
- KEGG: C19176
- PubChem: 1322
- ChEMBL: CHEMBL162921
- MeSH: 1,2-Dimethylhydrazine
- CAS: 540-73-8
- PubChem: 124489848
- RefMet: 1,2-Dimethylhydrazine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Tao, Zhou Qian, Shen Jichen, Zhang Zhizhong, Lian Xiaoyuan. Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through inhibition of multiple cancer-promoting signal pathways in 1,2-Dimethylhydrazine/dextran sodium sulphate mouse model.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):70-77. doi:
10.19852/j.cnki.jtcm.20231204.001. [PMID: 38213241] - Katharina Ardanareswari, Webiana Lowisia, Bernadeta Soedarini, Jiunn-Wang Liao, Yun-Chin Chung. Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Jun; 78(2):286-291. doi:
10.1007/s11130-023-01051-z. [PMID: 36820999] - Tharani Subarmaniam, Rusydatul Nabila Mahmad Rusli, Kokila Vani Perumal, Yoke Keong Yong, Siti Hadizah, Fezah Othman, Khaled Salem, Nurul Husna Shafie, Rosnani Hasham, Khoo Boon Yin, Khairul Kamilah Abdul Kadir, Hasnah Bahari, Zainul Amiruddin Zakaria. The Potential Chemopreventive Effect of Andrographis paniculata on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065224. [PMID: 36982300] - Rani Mata, Jayachandra Reddy Nakkala, Sudha Rani Sadras. Therapeutic role of biogenic silver and gold nanoparticles against a DMH-induced colon cancer model.
Biomaterials advances.
2023 Mar; 146(?):213279. doi:
10.1016/j.bioadv.2023.213279. [PMID: 36708685] - Bader-Edine Allal, Abdelkader Bounaama, Dany Silva, Clara Quintas, Salim Ismail Dahlouk, Jorge Gonçalves, Bahia Djerdjouri. Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Feb; ?(?):. doi:
10.1007/s00210-023-02403-x. [PMID: 36723607] - Iryna Herasymets, Liudmyla Fira, Ihor Medvid, Dmytro Fira, Oleh Yasinovskyi, Liliia Grytsyshyn. EFFECT OF DRY EXTRACT FROM REISHI MUSHROOMS ON THE STATE OF ANTIOXIDANT SYSTEM IN RATS WITH DMH-INDUCED COLON CARCINOGENESIS.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2023; 76(12):2632-2640. doi:
10.36740/wlek202312112. [PMID: 38290027] - Rentong Hu, Weerachai Chantana, Pornsiri Pitchakarn, Subhawat Subhawa, Bhanumas Chantarasuwan, Piya Temviriyanukul, Teera Chewonarin. Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis.
Scientific reports.
2022 09; 12(1):15472. doi:
10.1038/s41598-022-19843-9. [PMID: 36104433] - Alpa Shree, Johirul Islam, Vikas Yadav, Sarwat Sultana, Haider Ali Khan. Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats.
Environmental toxicology.
2022 Sep; 37(9):2153-2166. doi:
10.1002/tox.23558. [PMID: 35567572] - Vijay L Kumar, Sneh Verma, Prasenjit Das. Protective effect of methanol extract of latex of Calotropis procera in an experimental model of colorectal cancer.
Journal of ethnopharmacology.
2022 Jan; 283(?):114668. doi:
10.1016/j.jep.2021.114668. [PMID: 34587514] - Sahar E M El-Deek, Sary K H Abd-Elghaffar, Randa S Hna, Heba G Mohamed, Heba E M El-Deek. Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway.
Nutrition and cancer.
2022; 74(2):697-714. doi:
10.1080/01635581.2021.1907424. [PMID: 33818196] - Oksana Kachur, Liudmyla Fira, Petro Lykhatskyі, Dmytro Fira, Nataliya Garlitska. Evaluation of membrane-destructive processes in rats with induced carcinogenesis of the colon using the cytostatic vincristine.
Roczniki Panstwowego Zakladu Higieny.
2022; 73(2):215-220. doi:
10.32394/rpzh.2022.0212. [PMID: 35748566] - Alejandro López-Mejía, Luis Gerardo Ortega-Pérez, Oliver Rafid Magaña-Rodríguez, Luis Alberto Ayala-Ruiz, Jonathan Saúl Piñón-Simental, Daniel Godínez Hernández, Patricia Rios-Chavez. Protective effect of Callistemon citrinus on oxidative stress in rats with 1,2-dimethylhydrazine-induced colon cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):112070. doi:
10.1016/j.biopha.2021.112070. [PMID: 34435594] - Mariana Araújo Vieira do Carmo, Marina Fidelis, Pollyanna Francielli de Oliveira, Lais Quellen Feitoza, Marcos José Marques, Eric Batista Ferreira, Won Young Oh, Fereidoon Shahidi, Jarkko Hellström, Leonardo Augusto Almeida, Rômulo Dias Novaes, Daniel Granato, Luciana Azevedo. Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Aug; 154(?):112287. doi:
10.1016/j.fct.2021.112287. [PMID: 34058233] - Hesham Fathy Hassan Hassan, Ahmed Mohamed Mansour, Salama Abdou Salama, El-Sayed Mohamed El-Sayed. The chemopreventive effect of thymol against dimethylhydrazine and/or high fat diet-induced colon cancer in rats: Relevance to NF-κB.
Life sciences.
2021 Jun; 274(?):119335. doi:
10.1016/j.lfs.2021.119335. [PMID: 33713663] - Isha Rani, Sandeep Kumar, Bhoomika Sharma, Rajendra Prasad, Satinder Kaur, Prerna Sharma, Navneet Agnihotri. Elucidation of underlying molecular mechanism of 5-Fluorouracil chemoresistance and its restoration using fish oil in experimental colon carcinoma.
Molecular and cellular biochemistry.
2021 Mar; 476(3):1517-1527. doi:
10.1007/s11010-020-03999-x. [PMID: 33392922] - Marina Fidelis, Jânio Sousa Santos, Graziela Bragueto Escher, Ramon Silva Rocha, Adriano Gomes Cruz, Thiago Mendanha Cruz, Mariza Boscacci Marques, Juliana Barbosa Nunes, Mariana Araújo Vieira do Carmo, Leonardo Augusto de Almeida, Tai Kaneshima, Luciana Azevedo, Daniel Granato. Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats.
Food chemistry.
2021 Jan; 334(?):127565. doi:
10.1016/j.foodchem.2020.127565. [PMID: 32717686] - Ninan Jisha, A Vysakh, V Vijeesh, P S Anand, M S Latha. Methanolic Extract of Muntingia Calabura L. Mitigates 1,2-Dimethyl Hydrazine Induced Colon Carcinogenesis in Wistar Rats.
Nutrition and cancer.
2021; 73(11-12):2363-2375. doi:
10.1080/01635581.2020.1823438. [PMID: 32972250] - Oksana Kachur, Liudmyla Fira, Petro Lykhatskyi, Dmitro Fira, Solomiia Kramar. State of humoral immunity and cytokine profile in rats under experimental carcinogenesis with applying enterosorporation chemotherapeutic factors.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2020 Dec; 48(288):431-436. doi:
. [PMID: 33387432] - Edgar Oswaldo Zamora-González, Patricia Castro-Félix, María Del Rosario Huizar-López, Josefina Casas-Solís, María de la Luz Blanca Isabel Marques-González, Martha Fabiola Martin Del Campo-Solís, Anne Santerre. Chronic stress decreases ornithine decarboxylase expression and protects against 1,2-dimethylhydrazine-induced colon carcinogenesis.
Molecular biology reports.
2020 Dec; 47(12):9429-9439. doi:
10.1007/s11033-020-06022-0. [PMID: 33259012] - Y Soroka, I Andriichuk, P Lykhatskyi, L Fira, N Lisnychuk. [VIOLATION OF THE PROOXIDANT-ANTIOXIDANT BALANCE IN THE SPLEEN TISSUE UNDER EXPERIMENTAL CARCINOGENESIS].
Georgian medical news.
2020 Nov; ?(308):123-128. doi:
. [PMID: 33395653] - Ninan Jisha, A Vysakh, V Vijeesh, M S Latha. Ethyl acetate fraction of Muntingia calabura L. exerts anti-colorectal cancer potential via regulating apoptotic and inflammatory pathways.
Journal of ethnopharmacology.
2020 Oct; 261(?):113064. doi:
10.1016/j.jep.2020.113064. [PMID: 32505842] - Manal M El Joumaa, Robin I Taleb, Sandra Rizk, Jamilah M Borjac. Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice.
Journal of complementary & integrative medicine.
2020 Sep; 17(3):. doi:
10.1515/jcim-2019-0143. [PMID: 32229665] - Brunno Felipe Ramos Caetano, Mariana Baptista Tablas, Guilherme Ribeiro Romualdo, Maria Aparecida Marchesan Rodrigues, Luís Fernando Barbisan. Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development.
Toxicology letters.
2020 Sep; 329(?):67-79. doi:
10.1016/j.toxlet.2020.04.009. [PMID: 32387197] - Shirin Sadighparvar, Saber Ghazizadeh Darband, Bahman Yousefi, Mojtaba Kaviani, Firouz Ghaderi-Pakdel, Ainaz Mihanfar, Ghader Babaei, Kazhal Mobaraki, Maryam Majidinia. Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: Possible involvement of inflammation and BDNF signalling.
Experimental physiology.
2020 09; 105(9):1598-1609. doi:
10.1113/ep088605. [PMID: 32681548] - Saber Ghazizadeh Darband, Shirin Sadighparvar, Bahman Yousefi, Mojtaba Kaviani, Firouz Ghaderi-Pakdel, Ainaz Mihanfar, Yaghoub Rahimi, Kazhal Mobaraki, Maryam Majidinia. Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis.
Life sciences.
2020 Jul; 253(?):117584. doi:
10.1016/j.lfs.2020.117584. [PMID: 32220623] - Saber Ghazizadeh Darband, Ehsan Saboory, Shirin Sadighparvar, Mojtaba Kaviani, Kazhal Mobaraki, Nasrollah Jabbari, Maryam Majidinia. The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer.
Canadian journal of physiology and pharmacology.
2020 Mar; 98(3):147-155. doi:
10.1139/cjpp-2019-0329. [PMID: 31614098] - David Betancur Ancona, Luis Chel-Guerrero, Arturo Francisco Castellanos Ruelas, Valentino Mukthar Sandoval-Peraza, Rafael Francisco Colin-Flores, Jorge Luis Ble-Castillo, Isela Esther Juárez-Rojop, Juan José Acevedo-Fernández, Patricia Quintana-Owen, Viridiana Olvera Hernández. [Anticancer effect of modified banana (Musa cavendish AAA) starch in rats with 1.2-dimethylhydrazine].
Nutricion hospitalaria.
2020 Feb; 37(1):147-154. doi:
10.20960/nh.02706. [PMID: 31793323] - Canan Gulmez, Onur Atakisi. Kumiss Supplementation Reduces Oxidative Stress and Activates Sirtuin Deacetylases by Regulating Antioxidant System.
Nutrition and cancer.
2020; 72(3):495-503. doi:
10.1080/01635581.2019.1635628. [PMID: 31282756] - Lance K Blevins, Robert B Crawford, Anthony Bach, Michael D Rizzo, Jiajun Zhou, Joseph E Henriquez, D M Isha Olive Khan, Sera Sermet, Lora L Arnold, Karen L Pennington, Nathalia P Souza, Samuel M Cohen, Norbert E Kaminski. Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Nov; 133(?):110793. doi:
10.1016/j.fct.2019.110793. [PMID: 31473338] - Nelci A de Moura, Brunno F R Caetano, Lucas T Bidinotto, Maria A M Rodrigues, Luis F Barbisan. Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats.
Mutation research. Genetic toxicology and environmental mutagenesis.
2019 Oct; 846(?):403076. doi:
10.1016/j.mrgentox.2019.07.006. [PMID: 31585636] - Alejandro López-Mejia, Luis Gerardo Ortega-Pérez, Daniel Godinez-Hernández, Blanca Nateras-Marin, Esperanza Meléndez-Herrera, Patricia Rios-Chavez. Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.
Journal of cancer research and clinical oncology.
2019 Jun; 145(6):1417-1426. doi:
10.1007/s00432-019-02905-3. [PMID: 30923945] - Majid Ahmad Ganaie, Abdulaziz Al Saeedan, Hassan Madhkali, Basit Lateef Jan, Tanvir Khatlani, Ishfaq Ahmad Sheikh, Muneeb U Rehman, Khalida Wani. Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats.
Environmental toxicology.
2019 May; 34(5):610-625. doi:
10.1002/tox.22727. [PMID: 30720227] - M Emília Juan, Glòria Lozano-Mena, Marta Sánchez-González, Joana M Planas. Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071266. [PMID: 30939812] - Maha M Eissa, Cherine A Ismail, Mervat Z El-Azzouni, Amany A Ghazy, Mona A Hadi. Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer.
Investigational new drugs.
2019 02; 37(1):47-56. doi:
10.1007/s10637-018-0609-6. [PMID: 29808307] - Malti Arya, Pooja Singh, Chandra B Tripathi, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Anupam Guleria, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf. Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.
Drug delivery and translational research.
2019 02; 9(1):53-65. doi:
10.1007/s13346-018-00605-y. [PMID: 30484258] - Mariana F Fragoso, Guilherme R Romualdo, Lisa A Vanderveer, Janusz Franco-Barraza, Edna Cukierman, Margie L Clapper, Robson F Carvalho, Luis F Barbisan. Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):237-245. doi:
10.1016/j.fct.2018.08.078. [PMID: 30194994] - Narendar Dudhipala, Goverdhan Puchchakayala. Capecitabine lipid nanoparticles for anti-colon cancer activity in 1,2-dimethylhydrazine-induced colon cancer: preparation, cytotoxic, pharmacokinetic, and pathological evaluation.
Drug development and industrial pharmacy.
2018 Oct; 44(10):1572-1582. doi:
10.1080/03639045.2018.1445264. [PMID: 29493289] - Kalaiyarasu Thangaraj, Karthi Natesan, Kandakumar Settu, Mariyappan Palani, Mydhili Govindarasu, Vanitha Subborayan, Manju Vaiyapuri. Orientin mitigates 1, 2-dimethylhydrazine induced lipid peroxidation, antioxidant and biotransforming bacterial enzyme alterations in experimental rats.
Journal of cancer research and therapeutics.
2018 Oct; 14(6):1379-1388. doi:
10.4103/jcrt.jcrt_1363_16. [PMID: 30488860] - Nahed M A Hassanein, Eman S G Hassan, Amany M Hegab, Helmy M Sayd Elahl. Chemopreventive effect of sulindac in combination with epigallocatechin gallate or kaempferol against 1,2-dimethyl hydrazine-induced preneoplastic lesions in rats: A Comparative Study.
Journal of biochemical and molecular toxicology.
2018 Oct; 32(10):e22198. doi:
10.1002/jbt.22198. [PMID: 29999212] - Cuiping Liu, Chen Chen, Fuguo Yang, Xin Li, Lixue Cheng, Yang Song. Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
The British journal of nutrition.
2018 07; 120(2):121-130. doi:
10.1017/s0007114518001290. [PMID: 29947321] - Sirinya Taya, Tarika Thumvijit, Teera Chewonarin, Charatda Punvittayagul, Rawiwan Wongpoomchai. Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2018 03; 27(2):110-117. doi:
10.1097/cej.0000000000000320. [PMID: 27926538] - Nelci A de Moura, Brunno F R Caetano, Leonardo N de Moraes, Robson F Carvalho, Maria A M Rodrigues, Luis F Barbisan. Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Feb; 112(?):11-18. doi:
10.1016/j.fct.2017.12.029. [PMID: 29269057] - Alpa Shree, Syed Kazim Hasan, Johirul Islam, Abul Vafa, Shekh Mohammad Afzal, Preeti Barnwal, Aisha Siddiqi, Rahat Ali, Sarwat Sultana. Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine-Induced Toxicity in Wistar Rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2018; 37(4):273-289. doi:
10.1615/jenvironpatholtoxicoloncol.2018026923. [PMID: 30806235] - Manal F El-Khadragy, Heba M Nabil, Basmaa N Hassan, Amany A Tohamy, Hanaa F Waaer, Hany M Yehia, Afra M Alharbi, Ahmed Esmat Abdel Moneim. Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(3):1072-1083. doi:
10.1159/000487349. [PMID: 29439258] - Hamid E Daaboul, Costantine F Daher, Kikki Bodman-Smith, Robin I Taleb, Wassim N Shebaby, Joelle Boulos, Carole Dagher, Mohamad A Mroueh, Mirvat El-Sibai. Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways.
Chemico-biological interactions.
2017 Sep; 275(?):162-170. doi:
10.1016/j.cbi.2017.08.003. [PMID: 28782499] - R Kamal, D K Dhawan, V D Chadha. Evaluation of 99m Tc-resveratrol as a colon cancer targeting probe.
European journal of cancer care.
2017 Sep; 26(5):. doi:
10.1111/ecc.12504. [PMID: 27194670] - Flavia Martinello, Vinicius Kannen, João José Franco, Bianca Gasparotto, Juliana Yumi Sakita, Atushi Sugohara, Sergio Britto Garcia, Sergio Akira Uyemura. Chemopreventive effects of a Tamarindus indica fruit extract against colon carcinogenesis depends on the dietary cholesterol levels in hamsters.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Sep; 107(Pt A):261-269. doi:
10.1016/j.fct.2017.07.005. [PMID: 28687269] - Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Min Gi, Hideki Wanibuchi. Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis.
International journal of molecular sciences.
2017 Aug; 18(8):. doi:
10.3390/ijms18081801. [PMID: 28820464] - César Abel Centurión-Rodríguez, Juan Jorge Huamán-Saavedra, Víctor Raúl Requena-Fuentes. [Effect of Sacha Inchi oil (Plukenetiavolubilis L.) on 1,2-dimethylhydrazine-induced colon carcinogenesis in Holtzman rats].
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru.
2017 Apr; 37(2):129-136. doi:
". [PMID: 28731992] - S M A Limeiras, B C Oliveira, L R Pessatto, J R Pesarini, C A L Kassuya, A C D Monreal, W B Cantero, R Antoniolli-Silva, A C M B Antoniolli-Silva, M E A Stefanello, R J Oliveira. Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.
Genetics and molecular research : GMR.
2017 Mar; 16(1):. doi:
10.4238/gmr16019518. [PMID: 28362989] - Aktarul Islam Siddique, Vijay Mani, Sivaranjani Arivalagan, Nisha Susan Thomas, Nalini Namasivayam. Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis.
Toxicology mechanisms and methods.
2017 Feb; 27(2):136-150. doi:
10.1080/15376516.2016.1273422. [PMID: 28004603] - Karla Ríos-León, Cesar Fuertes-Ruiton, Jorge Arroyo, Julio Ruiz. [Chemoprotective effect of the alkaloid extract of Melocactus bellavistensis against colon cancer induced in rats using 1,2-dimethylhydrazine].
Revista peruana de medicina experimental y salud publica.
2017 Jan; 34(1):70-75. doi:
10.17843/rpmesp.2017.341.2768. [PMID: 28538848] - Yu Soroka, N Lisnychuk, I Demkiv, O Oleshchuk. SORPTION CORRECTION OF NEPHRON SUB-MICROSCOPIC CHANGES CAUSED BY NEOPLASTIC CHRONIC INTOXICATION WITH THE APPLICATION OF CYTOSTATIC THERAPY.
Georgian medical news.
2017 Jan; ?(262):20-24. doi:
NULL. [PMID: 28252422] - Martha Cecilia Téllez-Bañuelos, Jesse Haramati, Karina Franco-Topete, Jorge Peregrina-Sandoval, Ramon Franco-Topete, Galina P Zaitseva. Chronic exposure to endosulfan induces inflammation in murine colon via β-catenin expression and IL-6 production.
Journal of immunotoxicology.
2016 11; 13(6):842-849. doi:
10.1080/1547691x.2016.1206998. [PMID: 27494533] - Tahir Rasool Qamar, Fatima Syed, Muhammad Nasir, Habib Rehman, Muhammad Nauman Zahid, Rui Hai Liu, Sanaullah Iqbal. Novel Combination of Prebiotics Galacto-Oligosaccharides and Inulin-Inhibited Aberrant Crypt Foci Formation and Biomarkers of Colon Cancer in Wistar Rats.
Nutrients.
2016 Aug; 8(8):. doi:
10.3390/nu8080465. [PMID: 27490566] - Arivalagan Sivaranjani, Gunasekaran Sivagami, Namasivayam Nalini. Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis.
Journal of cancer research and therapeutics.
2016 Apr; 12(2):755-62. doi:
10.4103/0973-1482.154925. [PMID: 27461646] - Qing-Chun Li, Yun Liang, Guang-Rui Hu, Yuan Tian. Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats.
Indian journal of pharmacology.
2016 Mar; 48(2):168-71. doi:
10.4103/0253-7613.178834. [PMID: 27127319] - H M Nabil, B N Hassan, A A Tohamy, H F Waaer, A E Abdel Moneim. Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression.
Human & experimental toxicology.
2016 Mar; 35(3):282-92. doi:
10.1177/0960327115584687. [PMID: 25926526] - Bhanu Priya Kilari, Venkata Subbaiah Kotakadi, Josthna Penchalaneni. Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats.
Asian Pacific journal of cancer prevention : APJCP.
2016; 17(1):73-80. doi:
10.7314/apjcp.2016.17.1.73. [PMID: 26838257] - Abdelkader Bounaama, Shabnam Enayat, Muserref Seyma Ceyhan, Hichem Moulahoum, Bahia Djerdjouri, Sreeparna Banerjee. Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.
Nutrition and cancer.
2016; 68(3):495-506. doi:
10.1080/01635581.2016.1152379. [PMID: 27093594] - Mohammad R Mohammadi Malayeri, Abolfazl Dadkhah, Faezeh Fatemi, Salome Dini, Fatemeh Torabi, Mohammad M Tavajjoh, Javad Rabiei. Chemotherapeutic effect of Berberis integerrima hydroalcoholic extract on colon cancer development in the 1,2-dimethyl hydrazine rat model.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2016 ; 71(7-8):225-32. doi:
10.1515/znc-2015-0117. [PMID: 27232632] - Krishnan Manigandan, Dharmar Manimaran, Richard L Jayaraj, Namasivayam Elangovan, Velumani Dhivya, Anubhav Kaphle. Taxifolin curbs NF-κB-mediated Wnt/β-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis.
Biochimie.
2015 Dec; 119(?):103-12. doi:
10.1016/j.biochi.2015.10.014. [PMID: 26482805] - Biniyam Girma, Getnet Yimer, Eyasu Makonnen. Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats.
BMC complementary and alternative medicine.
2015 Oct; 15(?):365. doi:
10.1186/s12906-015-0883-1. [PMID: 26470793] - Ning Liu, Bo Sun, Peiwei Wu, Xi Wei. Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats.
Cell biochemistry and biophysics.
2015 Sep; 73(1):101-6. doi:
10.1007/s12013-015-0621-9. [PMID: 25697750] - Y Dong, G Wu. Azadircta indica as a modulator of membrane stability parameters and surface changes during 1,2 dimethylhydrazine-induced colorectal carcinogenesis.
Pathologie-biologie.
2015 Sep; 63(4-5):204-9. doi:
10.1016/j.patbio.2015.06.003. [PMID: 26271242] - C Fernandes, T Marini, F T T Frajacomo, A A Jordao, S B Garcia, V Kannen. Frequency and Duration Modulate Anticarcinogenic Effects of a Physical Training in the Colon.
International journal of sports medicine.
2015 Aug; 36(9):710-5. doi:
10.1055/s-0034-1398624. [PMID: 25806589] - Yuhua Li, Changxu Liu, Dan Xiao, Jing Han, Zhenggang Yue, Yang Sun, Lei Fan, Feng Zhang, Jin Meng, Rong Zhang, Zhipeng Wang, Qibing Mei, Aidong Wen. Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.
Journal of ethnopharmacology.
2015 Jun; 168(?):136-45. doi:
10.1016/j.jep.2015.03.063. [PMID: 25849732] - Rosalía Reynoso-Camacho, Guadalupe Guerrero-Villanueva, Juan de Dios Figueroa, Marco A Gallegos-Corona, Sandra Mendoza, Guadalupe Loarca-Piña, Minerva Ramos-Gomez. Anticarcinogenic Effect of Corn Tortilla Against 1,2-Dimethylhydrazine (DMH)-Induced Colon Carcinogenesis in Sprague-Dawley Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2015 Jun; 70(2):146-52. doi:
10.1007/s11130-015-0471-z. [PMID: 25680741] - Martha Rocío Moreno-Jimenez, Fátima Trujillo-Esquivel, Marco A Gallegos-Corona, Rosalia Reynoso-Camacho, Rubén Francisco González-Laredo, José Alberto Gallegos-Infante, Nuria Elizabeth Rocha-Guzmán, Minerva Ramos-Gomez. Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Jun; 80(?):144-153. doi:
10.1016/j.fct.2015.03.011. [PMID: 25795146] - Sumeet Pandey, Ashish Singh, Nirja Chaudhari, Laxmipriya P Nampoothiri, G Naresh Kumar. Protection against 1,2-di-methylhydrazine-induced systemic oxidative stress and altered brain neurotransmitter status by probiotic Escherichia coli CFR 16 secreting pyrroloquinoline quinone.
Current microbiology.
2015 May; 70(5):690-7. doi:
10.1007/s00284-014-0763-9. [PMID: 25586077] - Antônio Frederico de Freitas Gomides, Reggiani Vilela Gonçalves, Sérgio Oliveira de Paula, Célia Lúcia de Luces Fortes Ferreira, Débora Silva Comastri, Maria do Carmo Gouveia Peluzio. Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon of mice increasing the gene expression of p53.
Nutricion hospitalaria.
2015 Apr; 31(4):1675-81. doi:
10.3305/nh.2015.31.4.8279. [PMID: 25795957] - Venkatachalam Karthikkumar, Gunasekaran Sivagami, Periyasamy Viswanathan, Namasivayam Nalini. Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats.
Journal of basic and clinical physiology and pharmacology.
2015 Mar; 26(2):185-200. doi:
10.1515/jbcpp-2014-0044. [PMID: 25210763] - Hiroshi Jikihara, Guangying Qi, Koichiro Nozoe, Mayumi Hirokawa, Hiromi Sato, Yuka Sugihara, Fumio Shimamoto. Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Oncology reports.
2015 Mar; 33(3):1131-40. doi:
10.3892/or.2014.3705. [PMID: 25573280] - T H Saleem, A M Attya, E A Ahmed, S M M Ragab, M A Ali Abdallah, H M Omar. Possible Protective Effects of Quercetin and Sodium Gluconate Against Colon Cancer Induction by Dimethylhydrazine in Mice.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(14):5823-8. doi:
10.7314/apjcp.2015.16.14.5823. [PMID: 26320457] - Guangying Qi, Sien Zeng, Tiri Takashima, Koichiro Nozoe, Megumi Shobayashi, Koji Kakugawa, Kaori Murakami, Hiroshi Jikihara, Lihua Zhou, Fumio Shimamoto. Inhibitory effect of various breads on DMH-induced aberrant crypt foci and colorectal tumours in rats.
BioMed research international.
2015; 2015(?):829096. doi:
10.1155/2015/829096. [PMID: 26075268] - C Balaji, J Muthukumaran, N Nalini. Chemopreventive effect of sinapic acid on 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis.
Human & experimental toxicology.
2014 Dec; 33(12):1253-68. doi:
10.1177/0960327114522501. [PMID: 24532707] - Angela Verma, Geeta Shukla. Synbiotic (Lactobacillus rhamnosus+Lactobacillus acidophilus+inulin) attenuates oxidative stress and colonic damage in 1,2 dimethylhydrazine dihydrochloride-induced colon carcinogenesis in Sprague-Dawley rats: a long-term study.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Nov; 23(6):550-9. doi:
10.1097/cej.0000000000000054. [PMID: 25025584] - A E Fayed, Azza M Farahat, A E Metwally, M S Massoud And A O Emam. Health stimulating properties of the most popular soft cheese in Egypt Kariesh made using skimmed milk UF-retentate and probiotics.
Acta scientiarum polonorum. Technologia alimentaria.
2014 Oct; 13(4):359-373. doi:
10.17306/j.afs.2014.4.3. [PMID: 28067478] - Rajenderan Vinothkumar, Rajamanickam Vinothkumar, Mani Sudha, Namasivayam Nalini. Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Sep; 23(5):361-71. doi:
10.1097/cej.0b013e32836473ac. [PMID: 23903760] - Sivagami Gunasekaran, Karthikkumar Venkatachalam, Kabalimoorthy Jeyavel, Nalini Namasivayam. Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.
Molecular and cellular biochemistry.
2014 Sep; 394(1-2):187-98. doi:
10.1007/s11010-014-2094-3. [PMID: 24908112] - Celia Cohen, João Felipe Rito Cardoso, Sergio Britto Garcia, Helio Vannucchi. Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Nutrients.
2014 Aug; 6(8):3214-29. doi:
10.3390/nu6083214. [PMID: 25123248] - Isha Rani, Kim Vaiphei, Navneet Agnihotri. Supplementation of fish oil augments efficacy and attenuates toxicity of 5-fluorouracil in 1,2-dimethylhydrazine dihydrochloride/dextran sulfate sodium-induced colon carcinogenesis.
Cancer chemotherapy and pharmacology.
2014 Aug; 74(2):309-22. doi:
10.1007/s00280-014-2497-6. [PMID: 24916547] - Qing-Chao Zhu, Ren-Yuan Gao, Wen Wu, Bo-Min Guo, Jia-Yuan Peng, Huan-Long Qin. Effect of a high-fat diet in development of colonic adenoma in an animal model.
World journal of gastroenterology.
2014 Jul; 20(25):8119-29. doi:
10.3748/wjg.v20.i25.8119. [PMID: 25009384] - Carla C Munari, Ricardo A Furtado, Mirian L Santiago, Simony S Manhas, Jairo K Bastos, Denise C Tavares. Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2014 Jul; 23(4):240-5. doi:
10.1097/cej.0000000000000039. [PMID: 24871557] - Sumeet Pandey, Ashish Singh, Prasant Kumar, Archana Chaudhari, G Nareshkumar. Probiotic Escherichia coli CFR 16 producing pyrroloquinoline quinone (PQQ) ameliorates 1,2-dimethylhydrazine-induced oxidative damage in colon and liver of rats.
Applied biochemistry and biotechnology.
2014 Jun; 173(3):775-86. doi:
10.1007/s12010-014-0897-z. [PMID: 24718737] - O O Hamiza, M U Rehman, R Khan, M Tahir, A Q Khan, A Lateef, S Sultana. Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats.
Human & experimental toxicology.
2014 Feb; 33(2):148-63. doi:
10.1177/0960327113493307. [PMID: 23928829] - R Vinothkumar, R Vinoth Kumar, V Karthikkumar, P Viswanathan, J Kabalimoorthy, N Nalini. Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Environmental toxicology and pharmacology.
2014 Jan; 37(1):174-84. doi:
10.1016/j.etap.2013.11.022. [PMID: 24355798] - V Ganga Prasad, Shishir Kawade, B S Jayashree, Neetinkumar D Reddy, Albi Francis, Pawan G Nayak, Anoop Kishore, K Nandakumar, C Mallikarjuna Rao, Rekha R Shenoy. Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.
BioMed research international.
2014; 2014(?):569130. doi:
10.1155/2014/569130. [PMID: 24995310] - Pollyanna Francielli de Oliveira, Kelly Jacqueline Barbosa de Andrade, Marcela Cristina Ferreira Paula, Nathália Oliveira Acésio, Thais da Silva Moraes, Priscilla Scalon Freitas Borges, Gustavo Rafael Mazzaron Barcelos, Denise Crispim Tavares. Bixin protects hepatocytes against 1,2-dimethylhydrazine-induced genotoxicity but does not suppress DNA damage and pre-neoplastic lesions in the colon of Wistar rats.
Mutation research. Genetic toxicology and environmental mutagenesis.
2014 Jan; 759(?):37-42. doi:
10.1016/j.mrgentox.2013.07.017. [PMID: 24246722] - Ratasark Summart, Teera Chewonarin. Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial β-glucuronidase.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(2):749-55. doi:
10.7314/apjcp.2014.15.2.749. [PMID: 24568490] - R Vinothkumar, M Sudha, P Viswanathan, J Kabalimoorthy, T Balasubramanian, N Nalini. Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis.
Cell proliferation.
2013 Dec; 46(6):705-20. doi:
10.1111/cpr.12062. [PMID: 24118219] - Angelo Pietro Femia, Laura Raimondi, Giulia Maglieri, Maura Lodovici, Edoardo Mannucci, Giovanna Caderni. Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.
International journal of cancer.
2013 Nov; 133(10):2498-503. doi:
10.1002/ijc.28260. [PMID: 23649733] - Abdolamir Allameh, Abolfazl Dadkhah, Fatemeh Rahbarizadeh, Javad Ashrafi-Helan, Faezeh Fatemi. Effect of dietary caraway essential oils on expression of β-catenin during 1,2-dimethylhydrazine-induced colonic carcinogenesis.
Journal of natural medicines.
2013 Oct; 67(4):690-7. doi:
10.1007/s11418-012-0650-2. [PMID: 22418855] - Shinji Kobuchi, Yukako Ito, Kae Okada, Kazuki Imoto, Kanji Takada. Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats.
European journal of drug metabolism and pharmacokinetics.
2013 Sep; 38(3):171-81. doi:
10.1007/s13318-012-0114-9. [PMID: 23197286] - Nermin Abdel Hamid Sadik, Olfat Gamil Shaker. Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Digestive diseases and sciences.
2013 Sep; 58(9):2507-17. doi:
10.1007/s10620-013-2704-z. [PMID: 23722564] - Antônio Frederico de Freitas Gomides, Sérgio Oliveira de Paula, Damiana Diniz Rosa, Leandro Licusi de Oliveira, Débora Silva Comastri, Maria do Carmo Gouveia Peluzio. Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice.
Acta cirurgica brasileira.
2013 Aug; 28(8):607-13. doi:
10.1590/s0102-86502013000800009. [PMID: 23896841] - Selvaraj Aranganathan, Namasivayam Nalini. Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
Phytotherapy research : PTR.
2013 Jul; 27(7):999-1005. doi:
10.1002/ptr.4826. [PMID: 22899565] - Karthikkumar Venkatachalam, Sivagami Gunasekaran, Victor Antony Santiago Jesudoss, Nalini Namasivayam. The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2013 May; 65(4):409-18. doi:
10.1016/j.etp.2011.12.005. [PMID: 22236574] - Priscila L Sequetto, Tânia T Oliveira, Italo A C Soares, Izabel R S C Maldonado, Vanessa J Mello, Virginia R Pizziolo, Márcia R Almeida, Rômulo D Novaes. The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.
Cell and tissue research.
2013 May; 352(2):327-39. doi:
10.1007/s00441-013-1562-5. [PMID: 23468207]