1-(1-Naphthyl)-2-thiourea (BioDeep_00000012636)

 

Secondary id: BioDeep_00001868139

human metabolite blood metabolite


代谢物信息卡片


N-(naphthalen-1-yl)carbamimidothioic acid

  化学式: C11H10N2S (202.0565)
中文名称: 安妥
  谱图信息: 最多检出来源 Homo sapiens(blood) 82.67%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC=C2NC(=S)N
InChI: InChI=1S/C11H10N2S/c12-11(14)13-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H3,12,13,14)


描述信息

D010575 - Pesticides > D012378 - Rodenticides
D016573 - Agrochemicals

同义名列表

12 个代谢物同义名

N-(naphthalen-1-yl)carbamimidothioic acid; N-(Naphthalen-1-yl)carbamimidothioate; 1-(1-Naphthyl)-2-thiourea; alpha-Naphthyl thiourea; alpha-Naphthylthiourea; a-Naphthylthiourea; Α-naphthylthiourea; 1-Naphthylthiourea; Naphtox; Dirax; ANTU; ANTU



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mohammed Raed Abdullah Al Gburi, Eyup Altinoz, Hulya Elbe, Melike Ozgul Onal, Umit Yilmaz, Nesibe Yilmaz, Melike Karayakali, Mehmet Demir. Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea. Drug and chemical toxicology. 2023 Nov; 46(5):1024-1034. doi: 10.1080/01480545.2022.2119994. [PMID: 36069203]
  • Linlin Wang, Ye Wang, Zhang Lei. Chrysin ameliorates ANTU-induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs. Journal of biochemical and molecular toxicology. 2019 Jul; 33(7):e22332. doi: 10.1002/jbt.22332. [PMID: 30974023]
  • Yu-Wei Wu, Yu-Hui Tsai. Characterization of and mechanism for copper-induced thioureation of serum albumin. Bioconjugate chemistry. 2008 Sep; 19(9):1822-30. doi: 10.1021/bc7004158. [PMID: 18712897]
  • Philippe Hantson, Alfred Bernard, Cedric Hermans. Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clinical toxicology (Philadelphia, Pa.). 2008 Mar; 46(3):230-8. doi: 10.1080/15563650701449448. [PMID: 18344105]
  • Nilgun Solak Tekin, Ishak Ozel Tekin, Figen Barut, Emine Yilmaz Sipahi. Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients. Mediators of inflammation. 2007; 2007(?):78454. doi: 10.1155/2007/78454. [PMID: 17497039]
  • Christine A Winschel, Amar Kalidindi, Ibrahim Zgani, John L Magruder, Vladimir Sidorov. Receptor for anionic pyrene derivatives provides the basis for new biomembrane assays. Journal of the American Chemical Society. 2005 Oct; 127(42):14704-13. doi: 10.1021/ja052397i. [PMID: 16231924]
  • Takeshi Ohya, Masaru Niitsu. Identification of 4-methylspinaceamine--a Pictet-Spengler condensation reaction product of histamine with acetaldehyde--in human urine. Life sciences. 2005 Jan; 76(11):1199-209. doi: 10.1016/j.lfs.2004.06.030. [PMID: 15642591]
  • Elie Azoulay, Habiba Attalah, Kun Yang, Hélène Jouault, Benoît Schlemmer, Christian Brun-Buisson, Laurent Brochard, Alain Harf, Christophe Delclaux. Exacerbation by granulocyte colony-stimulating factor of prior acute lung injury: implication of neutrophils. Critical care medicine. 2002 Sep; 30(9):2115-22. doi: 10.1097/00003246-200209000-00027. [PMID: 12352050]
  • B P Guery, S Nelson, N Viget, P Fialdes, W R Summer, E Dobard, G Beaucaire, C M Mason. Fluorescein-labeled dextran concentration is increased in BAL fluid after ANTU-induced edema in rats. Journal of applied physiology (Bethesda, Md. : 1985). 1998 Sep; 85(3):842-8. doi: 10.1152/jappl.1998.85.3.842. [PMID: 9729556]
  • C Hermans, O Lesur, B Weynand, T Pieters, M Lambert, A Bernard. Clara cell protein (CC16) in pleural fluids: a marker of leakage through the visceral pleura. American journal of respiratory and critical care medicine. 1998 Mar; 157(3 Pt 1):962-9. doi: 10.1164/ajrccm.157.3.9707138. [PMID: 9517618]
  • K Itoh, K Nakamura, T Kimura, S Itoh, T Kamataki. Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). The Journal of toxicological sciences. 1997 Feb; 22(1):45-56. doi: 10.2131/jts.22.45. [PMID: 9076656]
  • K Itoh, T Kimura, T Yokoi, S Itoh, T Kamataki. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Biochimica et biophysica acta. 1993 May; 1173(2):165-71. doi: 10.1016/0167-4781(93)90177-f. [PMID: 8504165]
  • H R Amouzadeh, S Sangiah, C W Qualls, R L Cowell, A Mauromoustakos. Xylazine-induced pulmonary edema in rats. Toxicology and applied pharmacology. 1991 May; 108(3):417-27. doi: 10.1016/0041-008x(91)90088-v. [PMID: 1902333]
  • V R Muzykantov, S M Danilov. A new approach to the investigation of oxidative injury to the pulmonary endothelium: use of angiotensin-converting enzyme as a marker. Biomedical science. 1991; 2(1):11-21. doi: NULL. [PMID: 1655078]
  • J P Gardaz, P Py, P M Suter, A F Junod. Effects of oleic acid-, alpha-naphthylthiourea-, and phorbol myristate acetate-induced microvascular damage on indexes of pulmonary endothelial function in anesthetized dogs. The American review of respiratory disease. 1988 Jun; 137(6):1350-5. doi: 10.1164/ajrccm/137.6.1350. [PMID: 2849332]
  • R Corral, J E Hinshaw, S B Clark, S Rounds. Chylomicron metabolism by normal and injured isolated rat lungs. Experimental lung research. 1987; 13(1):45-58. doi: 10.3109/01902148709064308. [PMID: 3115768]
  • J C Parker. Transvascular clearance and distribution of charged macromolecules in ANTU lung injury. Journal of applied physiology (Bethesda, Md. : 1985). 1986 Apr; 60(4):1221-9. doi: 10.1152/jappl.1986.60.4.1221. [PMID: 3084445]
  • C O Feddersen, I F McMurtry, P Henson, N F Voelkel. Acetylcholine-induced pulmonary vasodilation in lung vascular injury. The American review of respiratory disease. 1986 Feb; 133(2):197-204. doi: 10.1164/arrd.1986.133.2.197. [PMID: 3004269]
  • J R McCormick, M Moore, R Chrzanowski, W Cieplinski. The effect of alphanapthylthiourea (ANTU)-induced acute injury on lung binding of antibody to angiotensin converting enzyme (ACE). Advances in experimental medicine and biology. 1986; 198 Pt A(?):503-12. doi: 10.1007/978-1-4684-5143-6_67. [PMID: 3028070]
  • L L Smith. The response of the lung to foreign compounds that produce free radicals. Annual review of physiology. 1986; 48(?):681-92. doi: 10.1146/annurev.ph.48.030186.003341. [PMID: 2423026]
  • R F O'Brien, J S Makarski, S Rounds. Studies on the mechanism of decreased angiotensin I conversion in rat lungs injured with alpha-naphthylthiourea. Experimental lung research. 1985; 8(4):243-59. doi: 10.3109/01902148509087807. [PMID: 2995022]
  • D E Mais, P D Lahr, T R Bosin. Hyperoxia and paraquat alter the kinetics of platelet serotonin uptake. Toxicology and applied pharmacology. 1984 Oct; 76(1):1-8. doi: 10.1016/0041-008x(84)90023-1. [PMID: 6435284]
  • G Rutili, J C Parker, A E Taylor. Fluid balance in ANTU-injured lungs during crystalloid and colloid infusions. Journal of applied physiology: respiratory, environmental and exercise physiology. 1984 Apr; 56(4):993-8. doi: 10.1152/jappl.1984.56.4.993. [PMID: 6202666]
  • A M Havill, M H Gee, J D Washburne, A Premkumar, R Ottaviano, J T Flynn, J A Spath. alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. The American journal of physiology. 1982 Oct; 243(4):H505-11. doi: 10.1152/ajpheart.1982.243.4.h505. [PMID: 6812437]
  • G Rutili, P Kvietys, D Martin, J C Parker, A E Taylor. Increased pulmonary microvasuclar permeability induced by alpha-naphthylthiourea. Journal of applied physiology: respiratory, environmental and exercise physiology. 1982 May; 52(5):1316-23. doi: 10.1152/jappl.1982.52.5.1316. [PMID: 6807946]
  • T N Patil, R Radhakrishnamurty. Effect of alpha-naphthylthiourea on (Na+ + K+)-ATPases in albino rats. Indian journal of biochemistry & biophysics. 1978 Aug; 15(4):294-8. doi: NULL. [PMID: 216629]
  • T N Patil, R Radhakrishnamurty. Influence of alpha-naphthylthiourea on blood glucose & some enzymes in albino rats. Indian journal of biochemistry & biophysics. 1978 Apr; 15(2):108-10. doi: NULL. [PMID: 214397]
  • A CHANUTIN, E C GJESSING, S LUDEWIG. Alpha naphthylthiourea (ANTU) in dogs; electrophoretic and cholesterol studies on blood plasma and pleural effusion. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1947 Feb; 64(2):174-9. doi: 10.3181/00379727-64-15738. [PMID: 20287370]