Alphachloralose (BioDeep_00000012385)

 

Secondary id: BioDeep_00000412995

human metabolite Endogenous


代谢物信息卡片


1-[6-hydroxy-2-(trichloromethyl)-tetrahydro-2H-furo[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol

化学式: C8H11Cl3O6 (307.96211960000005)
中文名称: α-氯醛糖
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C1C(C2C(O1)OC(O2)C(Cl)(Cl)Cl)O)O)O
InChI: InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
Bird repellant in grain seed

同义名列表

16 个代谢物同义名

1-[6-hydroxy-2-(trichloromethyl)-tetrahydro-2H-furo[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol; 5-(beta-Formylethyl)-4,6-dihydroxypicolinate; 5-(2-Formylethyl)-4,6-dihydroxypicolinate; Chloralose, 8ci, bsi, inn, iso; Anhydroglucochloral; alpha Chloralose; Chloralose-alpha; alpha-Chloralose; beta Chloralose; beta-Chloralose; Glucochloralose; Chlorlose-alpha; Alphachloralose; Glucochloral; Chloralose; a-Form



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sebastian Bergrath, Jessika Stefanie Castillo-Vargas, Nurcihan Joy Koc, Hendrik Haake, Ullrich Graeven. Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose. Der Anaesthesist. 2019 12; 68(12):843-847. doi: 10.1007/s00101-019-00692-7. [PMID: 31701172]
  • Christian A Reynolds, Donal S O'Leary, Cheng Ly, Scott A Smith, Zeljka Minic. Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat. American journal of physiology. Heart and circulatory physiology. 2019 06; 316(6):H1332-H1340. doi: 10.1152/ajpheart.00724.2018. [PMID: 30875256]
  • Toshimasa Osaka. 2-Deoxy-D-glucose-induced hypothermia in anesthetized rats: Lack of forebrain contribution and critical involvement of the rostral raphe/parapyramidal regions of the medulla oblongata. Brain research bulletin. 2015 Jul; 116(?):73-80. doi: 10.1016/j.brainresbull.2015.06.008. [PMID: 26146232]
  • E Gerace, V Ciccotelli, P Rapetti, A Salomone, M Vincenti. Distribution of chloralose in a fatal intoxication. Journal of analytical toxicology. 2012 Jul; 36(6):452-6. doi: 10.1093/jat/bks040. [PMID: 22572811]
  • Barbora Piknova, Ara Kocharyan, Alan N Schechter, Afonso C Silva. The role of nitrite in neurovascular coupling. Brain research. 2011 Aug; 1407(?):62-8. doi: 10.1016/j.brainres.2011.06.045. [PMID: 21764040]
  • Hongxia Lei, Joao M N Duarte, Vladimir Mlynarik, Agathe Python, Rolf Gruetter. Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex. Journal of neuroscience research. 2010 Feb; 88(2):413-9. doi: 10.1002/jnr.22212. [PMID: 19746430]
  • Kazuto Masamoto, Takayuki Obata, Iwao Kanno. Intracortical microcirculatory change induced by anesthesia in rat somatosensory cortex. Advances in experimental medicine and biology. 2010; 662(?):57-61. doi: 10.1007/978-1-4419-1241-1_7. [PMID: 20204771]
  • Facundo Martín Bertera, Carla Andrea Di Verniero, Marcos Alejandro Mayer, Guillermo Federico Bramuglia, Carlos Alberto Taira, Christian Höcht. Is urethane-chloralose anaesthesia appropriate for pharmacokinetic-pharmacodynamic assessment? Studies with carvedilol. Journal of pharmacological and toxicological methods. 2009 Jan; 59(1):13-20. doi: 10.1016/j.vascn.2008.10.001. [PMID: 18973819]
  • Yatang Li, Jiaheng Qiu, Rui Yan, Zhuo Yang, Tao Zhang. Weakened long-range correlation of renal sympathetic nerve activity in Wistar rats after anaesthesia. Neuroscience letters. 2008 Mar; 433(1):28-32. doi: 10.1016/j.neulet.2007.12.038. [PMID: 18206307]
  • Nancy K Businga, Julie Langenberg, LaVinda Carlson. Successful treatment of capture myopathy in three wild greater sandhill cranes (Grus canadensis tabida). Journal of avian medicine and surgery. 2007 Dec; 21(4):294-8. doi: 10.1647/2005-013r1.1. [PMID: 18351009]
  • Jong Kyung Kim, Shawn G Hayes, Angela E Kindig, Marc P Kaufman. Thin-fiber mechanoreceptors reflexly increase renal sympathetic nerve activity during static contraction. American journal of physiology. Heart and circulatory physiology. 2007 Feb; 292(2):H866-73. doi: 10.1152/ajpheart.00771.2006. [PMID: 17012352]
  • Hamid R Kazerani, Brian L Furman. Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice. Fundamental & clinical pharmacology. 2006 Aug; 20(4):379-84. doi: 10.1111/j.1472-8206.2006.00413.x. [PMID: 16867022]
  • S Federici, I Claudet, E Laporte-Turpin, M O Marcoux, E Cheuret, K Maréchal. [Severe chloralose intoxication in a toddler]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 2006 Apr; 13(4):364-6. doi: 10.1016/j.arcped.2006.01.014. [PMID: 16531025]
  • Peter Hermán, Hubert K F Trübel, Fahmeed Hyder. A multiparametric assessment of oxygen efflux from the brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Jan; 26(1):79-91. doi: 10.1038/sj.jcbfm.9600165. [PMID: 15973353]
  • T Rieg, K Richter, H Osswald, V Vallon. Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia. Naunyn-Schmiedeberg's archives of pharmacology. 2004 Oct; 370(4):320-3. doi: 10.1007/s00210-004-0982-x. [PMID: 15549274]
  • Ning Lu, Yan Wang, Frank Blecha, Richard J Fels, Heather P Hoch, Michael J Kenney. Central interleukin-1beta antibody increases renal and splenic sympathetic nerve discharge. American journal of physiology. Heart and circulatory physiology. 2003 May; 284(5):H1536-41. doi: 10.1152/ajpheart.00891.2002. [PMID: 12531724]
  • Sandrine Savin, Bernard Cartigny, Nathalie Azaroual, Luc Humbert, Michel Imbenotte, Djamel Tsouria, Gaston Vermeersch, Michel Lhermitte. 1H NMR spectroscopy and GC-MS analysis of alpha-chloralose. Application to two poisoning cases. Journal of analytical toxicology. 2003 Apr; 27(3):156-61. doi: 10.1093/jat/27.3.156. [PMID: 12731657]
  • Shoshiro Okada, Yoshinori Murakami, Kunihiko Yokotani. Centrally applied nitric oxide donor elevates plasma corticosterone by activation of the hypothalamic noradrenergic neurons in rats. Brain research. 2002 Jun; 939(1-2):26-33. doi: 10.1016/s0006-8993(02)02540-4. [PMID: 12020848]
  • M J Kenney, F Blecha, D A Morgan, R J Fels. Interleukin-1 beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia. American journal of physiology. Heart and circulatory physiology. 2001 Dec; 281(6):H2441-5. doi: 10.1152/ajpheart.2001.281.6.h2441. [PMID: 11709410]
  • G B Proctor, G H Carpenter, L C Anderson, J R Garrett. Nerve-evoked secretion of immunoglobulin A in relation to other proteins by parotid glands in anaesthetized rat. Experimental physiology. 2000 Sep; 85(5):511-8. doi: NULL. [PMID: 11038402]
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  • M D Krasowski, N L Harrison. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. British journal of pharmacology. 2000 Feb; 129(4):731-43. doi: 10.1038/sj.bjp.0703087. [PMID: 10683198]
  • P Kintz, S Doray, V Cirimele, B Ludes. Testing for alpha-chloralose by headspace-GC/MS. A case report. Forensic science international. 1999 Sep; 104(1):59-63. doi: 10.1016/s0379-0738(99)00089-4. [PMID: 10533278]
  • A Shimokawa, T Kunitake, M Takasaki, H Kannan. Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats. Journal of the autonomic nervous system. 1998 Aug; 72(1):46-54. doi: 10.1016/s0165-1838(98)00084-8. [PMID: 9760079]
  • T Mori, K Nishikawa, T Terai, H Yukioka, A Asada. The effects of epidural morphine on cardiac and renal sympathetic nerve activity in alpha-chloralose-anesthetized cats. Anesthesiology. 1998 Jun; 88(6):1558-65. doi: 10.1097/00000542-199806000-00020. [PMID: 9637650]
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  • P Kintz, C Jamey, P Mangin. Trichloroethanol is not a metabolite of alpha chloralose. International journal of legal medicine. 1996; 108(4):191-3. doi: 10.1007/bf01369790. [PMID: 8652423]
  • J Sadowski, E Kompanowska-Jezierska, A Walkowska. Access to rat kidney with minimal anesthesia and surgery: a new experimental model. The American journal of physiology. 1996 Jan; 270(1 Pt 2):R298-303. doi: 10.1152/ajpregu.1996.270.1.r298. [PMID: 8769814]
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  • I Yoneda, M Nishizawa, K T Benson, T L Chaffee, H Goto. Attenuation of arterial baroreflex control of renal sympathetic nerve activity during lidocaine infusion in alpha-chloralose-anesthetized dogs. Acta anaesthesiologica Scandinavica. 1994 Jan; 38(1):70-4. doi: 10.1111/j.1399-6576.1994.tb03840.x. [PMID: 8140878]
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  • M Heimburger, N Pages, M Davy, C el Rawadi, Y Cohen, C Bohuon. Effects of chloral, chloralose and pentobarbitone on monoamine and (neuropeptide Y) NPY levels in various tissues in the rat. Research communications in chemical pathology and pharmacology. 1992 May; 76(2):183-91. doi: . [PMID: 1604044]
  • L Bertrix, Q Timour, R I Mazze, M Freysz, K Samii, G Faucon. Adverse interaction between bupivacaine and halothane on ventricular contractile force and intraventricular conduction in the dog. Anesthesia and analgesia. 1991 Oct; 73(4):434-40. doi: 10.1213/00000539-199110000-00012. [PMID: 1897769]
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