Chloralose (BioDeep_00000412995)

Main id: BioDeep_00000012385

 


代谢物信息卡片


Alphachloralose

化学式: C8H11Cl3O6 (307.96211960000005)
中文名称: α-氯醛糖
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C1C(C2C(O1)OC(O2)C(Cl)(Cl)Cl)O)O)O
InChI: InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

描述信息

CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3386; ORIGINAL_PRECURSOR_SCAN_NO 3383
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3405; ORIGINAL_PRECURSOR_SCAN_NO 3400
CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3382; ORIGINAL_PRECURSOR_SCAN_NO 3379
CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3401; ORIGINAL_PRECURSOR_SCAN_NO 3398
CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3393; ORIGINAL_PRECURSOR_SCAN_NO 3392
CONFIDENCE standard compound; INTERNAL_ID 571; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3387; ORIGINAL_PRECURSOR_SCAN_NO 3385

同义名列表

2 个代谢物同义名

Alphachloralose; Chloralose



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sebastian Bergrath, Jessika Stefanie Castillo-Vargas, Nurcihan Joy Koc, Hendrik Haake, Ullrich Graeven. Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose. Der Anaesthesist. 2019 12; 68(12):843-847. doi: 10.1007/s00101-019-00692-7. [PMID: 31701172]
  • Christian A Reynolds, Donal S O'Leary, Cheng Ly, Scott A Smith, Zeljka Minic. Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat. American journal of physiology. Heart and circulatory physiology. 2019 06; 316(6):H1332-H1340. doi: 10.1152/ajpheart.00724.2018. [PMID: 30875256]
  • Toshimasa Osaka. 2-Deoxy-D-glucose-induced hypothermia in anesthetized rats: Lack of forebrain contribution and critical involvement of the rostral raphe/parapyramidal regions of the medulla oblongata. Brain research bulletin. 2015 Jul; 116(?):73-80. doi: 10.1016/j.brainresbull.2015.06.008. [PMID: 26146232]
  • E Gerace, V Ciccotelli, P Rapetti, A Salomone, M Vincenti. Distribution of chloralose in a fatal intoxication. Journal of analytical toxicology. 2012 Jul; 36(6):452-6. doi: 10.1093/jat/bks040. [PMID: 22572811]
  • Barbora Piknova, Ara Kocharyan, Alan N Schechter, Afonso C Silva. The role of nitrite in neurovascular coupling. Brain research. 2011 Aug; 1407(?):62-8. doi: 10.1016/j.brainres.2011.06.045. [PMID: 21764040]
  • Hongxia Lei, Joao M N Duarte, Vladimir Mlynarik, Agathe Python, Rolf Gruetter. Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex. Journal of neuroscience research. 2010 Feb; 88(2):413-9. doi: 10.1002/jnr.22212. [PMID: 19746430]
  • Kazuto Masamoto, Takayuki Obata, Iwao Kanno. Intracortical microcirculatory change induced by anesthesia in rat somatosensory cortex. Advances in experimental medicine and biology. 2010; 662(?):57-61. doi: 10.1007/978-1-4419-1241-1_7. [PMID: 20204771]
  • Facundo Martín Bertera, Carla Andrea Di Verniero, Marcos Alejandro Mayer, Guillermo Federico Bramuglia, Carlos Alberto Taira, Christian Höcht. Is urethane-chloralose anaesthesia appropriate for pharmacokinetic-pharmacodynamic assessment? Studies with carvedilol. Journal of pharmacological and toxicological methods. 2009 Jan; 59(1):13-20. doi: 10.1016/j.vascn.2008.10.001. [PMID: 18973819]
  • Yatang Li, Jiaheng Qiu, Rui Yan, Zhuo Yang, Tao Zhang. Weakened long-range correlation of renal sympathetic nerve activity in Wistar rats after anaesthesia. Neuroscience letters. 2008 Mar; 433(1):28-32. doi: 10.1016/j.neulet.2007.12.038. [PMID: 18206307]
  • Nancy K Businga, Julie Langenberg, LaVinda Carlson. Successful treatment of capture myopathy in three wild greater sandhill cranes (Grus canadensis tabida). Journal of avian medicine and surgery. 2007 Dec; 21(4):294-8. doi: 10.1647/2005-013r1.1. [PMID: 18351009]
  • Jong Kyung Kim, Shawn G Hayes, Angela E Kindig, Marc P Kaufman. Thin-fiber mechanoreceptors reflexly increase renal sympathetic nerve activity during static contraction. American journal of physiology. Heart and circulatory physiology. 2007 Feb; 292(2):H866-73. doi: 10.1152/ajpheart.00771.2006. [PMID: 17012352]
  • Hamid R Kazerani, Brian L Furman. Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice. Fundamental & clinical pharmacology. 2006 Aug; 20(4):379-84. doi: 10.1111/j.1472-8206.2006.00413.x. [PMID: 16867022]
  • S Federici, I Claudet, E Laporte-Turpin, M O Marcoux, E Cheuret, K Maréchal. [Severe chloralose intoxication in a toddler]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 2006 Apr; 13(4):364-6. doi: 10.1016/j.arcped.2006.01.014. [PMID: 16531025]
  • Peter Hermán, Hubert K F Trübel, Fahmeed Hyder. A multiparametric assessment of oxygen efflux from the brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Jan; 26(1):79-91. doi: 10.1038/sj.jcbfm.9600165. [PMID: 15973353]
  • T Rieg, K Richter, H Osswald, V Vallon. Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia. Naunyn-Schmiedeberg's archives of pharmacology. 2004 Oct; 370(4):320-3. doi: 10.1007/s00210-004-0982-x. [PMID: 15549274]
  • Ning Lu, Yan Wang, Frank Blecha, Richard J Fels, Heather P Hoch, Michael J Kenney. Central interleukin-1beta antibody increases renal and splenic sympathetic nerve discharge. American journal of physiology. Heart and circulatory physiology. 2003 May; 284(5):H1536-41. doi: 10.1152/ajpheart.00891.2002. [PMID: 12531724]
  • Sandrine Savin, Bernard Cartigny, Nathalie Azaroual, Luc Humbert, Michel Imbenotte, Djamel Tsouria, Gaston Vermeersch, Michel Lhermitte. 1H NMR spectroscopy and GC-MS analysis of alpha-chloralose. Application to two poisoning cases. Journal of analytical toxicology. 2003 Apr; 27(3):156-61. doi: 10.1093/jat/27.3.156. [PMID: 12731657]
  • Shoshiro Okada, Yoshinori Murakami, Kunihiko Yokotani. Centrally applied nitric oxide donor elevates plasma corticosterone by activation of the hypothalamic noradrenergic neurons in rats. Brain research. 2002 Jun; 939(1-2):26-33. doi: 10.1016/s0006-8993(02)02540-4. [PMID: 12020848]
  • M J Kenney, F Blecha, D A Morgan, R J Fels. Interleukin-1 beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia. American journal of physiology. Heart and circulatory physiology. 2001 Dec; 281(6):H2441-5. doi: 10.1152/ajpheart.2001.281.6.h2441. [PMID: 11709410]
  • G B Proctor, G H Carpenter, L C Anderson, J R Garrett. Nerve-evoked secretion of immunoglobulin A in relation to other proteins by parotid glands in anaesthetized rat. Experimental physiology. 2000 Sep; 85(5):511-8. doi: NULL. [PMID: 11038402]
  • C Molinari, E Grossini, D A Mary, G Vacca. Effect of distension of the gallbladder on plasma renin activity in anesthetized pigs. Circulation. 2000 May; 101(21):2539-45. doi: 10.1161/01.cir.101.21.2539. [PMID: 10831530]
  • E Maignan, W X Dong, M Legrand, M Safar, J L Cuche. Sympathetic activity in the rat: effects of anaesthesia on noradrenaline kinetics. Journal of the autonomic nervous system. 2000 Apr; 80(1-2):46-51. doi: 10.1016/s0165-1838(00)00075-8. [PMID: 10742539]
  • M D Krasowski, N L Harrison. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. British journal of pharmacology. 2000 Feb; 129(4):731-43. doi: 10.1038/sj.bjp.0703087. [PMID: 10683198]
  • P Kintz, S Doray, V Cirimele, B Ludes. Testing for alpha-chloralose by headspace-GC/MS. A case report. Forensic science international. 1999 Sep; 104(1):59-63. doi: 10.1016/s0379-0738(99)00089-4. [PMID: 10533278]
  • A Shimokawa, T Kunitake, M Takasaki, H Kannan. Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats. Journal of the autonomic nervous system. 1998 Aug; 72(1):46-54. doi: 10.1016/s0165-1838(98)00084-8. [PMID: 9760079]
  • T Mori, K Nishikawa, T Terai, H Yukioka, A Asada. The effects of epidural morphine on cardiac and renal sympathetic nerve activity in alpha-chloralose-anesthetized cats. Anesthesiology. 1998 Jun; 88(6):1558-65. doi: 10.1097/00000542-199806000-00020. [PMID: 9637650]
  • A Shimokawa, Q H Jin, Y Ishizuka, T Kunitake, M Takasaki, H Kannan. Effects of anesthetics on norepinephrine release in the hypothalamic paraventricular nucleus region of awake rats. Neuroscience letters. 1998 Mar; 244(1):21-4. doi: 10.1016/s0304-3940(98)00119-0. [PMID: 9578135]
  • C J Lawrence, F W Prinzen, S de Lange. The effect of dexmedetomidine on nutrient organ blood flow. Anesthesia and analgesia. 1996 Dec; 83(6):1160-5. doi: 10.1097/00000539-199612000-00005. [PMID: 8942579]
  • P Verwaerde, J M Senard, M Mazerolles, M A Tran, C Damase-Michel, J L Montastruc, P Montastruc. Spectral analysis of blood pressure and heart rate, catecholamine and neuropeptide Y plasma levels in a new model of neurogenic orthostatic hypotension in dog. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 1996 Apr; 6(2):75-82. doi: 10.1007/bf02291227. [PMID: 8726091]
  • P Kintz, C Jamey, P Mangin. Trichloroethanol is not a metabolite of alpha chloralose. International journal of legal medicine. 1996; 108(4):191-3. doi: 10.1007/bf01369790. [PMID: 8652423]
  • J Sadowski, E Kompanowska-Jezierska, A Walkowska. Access to rat kidney with minimal anesthesia and surgery: a new experimental model. The American journal of physiology. 1996 Jan; 270(1 Pt 2):R298-303. doi: 10.1152/ajpregu.1996.270.1.r298. [PMID: 8769814]
  • G Akerström, B Lisander. Antihistaminergic pretreatment prevents tissue extravasation of albumin from intra-abdominal trauma in rats. Acta anaesthesiologica Scandinavica. 1994 Aug; 38(6):569-74. doi: 10.1111/j.1399-6576.1994.tb03953.x. [PMID: 7526587]
  • K Derakhchan, P Pagé, C Lambert, T Kus. Effects of procainamide and propafenone on the composition of the excitable gap in canine atrial reentry tachycardia. The Journal of pharmacology and experimental therapeutics. 1994 Jul; 270(1):47-54. doi: . [PMID: 8035342]
  • I Yoneda, M Nishizawa, K T Benson, T L Chaffee, H Goto. Attenuation of arterial baroreflex control of renal sympathetic nerve activity during lidocaine infusion in alpha-chloralose-anesthetized dogs. Acta anaesthesiologica Scandinavica. 1994 Jan; 38(1):70-4. doi: 10.1111/j.1399-6576.1994.tb03840.x. [PMID: 8140878]
  • K Matsukawa, I Ninomiya, N Nishiura. Effects of anesthesia on cardiac and renal sympathetic nerve activities and plasma catecholamines. The American journal of physiology. 1993 Oct; 265(4 Pt 2):R792-7. doi: 10.1152/ajpregu.1993.265.4.r792. [PMID: 8238449]
  • S Suzuki, S Ando, T Imaizumi, A Takeshita. Effects of anesthesia on sympathetic nerve rhythm: power spectral analysis. Journal of the autonomic nervous system. 1993 Apr; 43(1):51-8. doi: 10.1016/0165-1838(93)90321-k. [PMID: 8315209]
  • K Wada, K Sasaki, K Miura, M Yagi, Y Kubota, T Matsumoto, M Haga. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biological & pharmaceutical bulletin. 1993 Feb; 16(2):210-2. doi: 10.1248/bpb.16.210. [PMID: 8364459]
  • K Wada, M Yagi, T Kurihara, M Haga. Studies on the constituents of edible and medicinal plants. III. Effects of seven limonoids on the sleeping time induced in mice by anesthetics. Chemical & pharmaceutical bulletin. 1992 Nov; 40(11):3079-80. doi: 10.1248/cpb.40.3079. [PMID: 1477924]
  • K Pettersson, H Björk. Inhibition of platelet accumulation by beta 1-adrenoceptor blockade in the thoracic aorta of rabbits subjected to experimental sympathetic activation. Cardiovascular drugs and therapy. 1992 Oct; 6(5):505-11. doi: 10.1007/bf00055609. [PMID: 1450095]
  • S Ruch, R H Kennedy, E Seifen. Digoxin cardiotoxicity in aging anesthetized F344 rats. Mechanisms of ageing and development. 1992 Sep; 65(2-3):199-216. doi: 10.1016/0047-6374(92)90036-d. [PMID: 1434949]
  • M Heimburger, N Pages, M Davy, C el Rawadi, Y Cohen, C Bohuon. Effects of chloral, chloralose and pentobarbitone on monoamine and (neuropeptide Y) NPY levels in various tissues in the rat. Research communications in chemical pathology and pharmacology. 1992 May; 76(2):183-91. doi: . [PMID: 1604044]
  • L Bertrix, Q Timour, R I Mazze, M Freysz, K Samii, G Faucon. Adverse interaction between bupivacaine and halothane on ventricular contractile force and intraventricular conduction in the dog. Anesthesia and analgesia. 1991 Oct; 73(4):434-40. doi: 10.1213/00000539-199110000-00012. [PMID: 1897769]
  • I Kaneko, Y Takeuchi, Y Fukumori, T Fukuda. Effect of alpha-chloralose on disposition and pharmacological action of orally administered chlorzoxazone in rats. Journal of pharmacobio-dynamics. 1991 Aug; 14(8):429-34. doi: 10.1248/bpb1978.14.429. [PMID: 1774620]
  • M Boucher, C Dubray, J H Li, M Paire, P Duchêne-Marullaz. Influence of pentobarbital and chloralose anesthesia on quinidine-induced effects on atrial refractoriness and heart rate in the dog. Journal of cardiovascular pharmacology. 1991 Feb; 17(2):199-206. doi: 10.1097/00005344-199102000-00004. [PMID: 1709223]
  • D M Gaumann, T L Yaksh. Alpha-chloralose anesthesia inhibits the somato-sympathetic reflex response in cats more effectively than halothane. Zentralblatt fur Veterinarmedizin. Reihe A. 1990 Oct; 37(9):669-75. doi: 10.1111/j.1439-0442.1990.tb00960.x. [PMID: 2127972]
  • K Pettersson, B Bejne, H Björk, W B Strawn, G Bondjers. Experimental sympathetic activation causes endothelial injury in the rabbit thoracic aorta via beta 1-adrenoceptor activation. Circulation research. 1990 Oct; 67(4):1027-34. doi: 10.1161/01.res.67.4.1027. [PMID: 2170050]
  • T Kasten, J A Colliver, R D Montrey, G A Dunaway. The effects of various anesthetics on tissue levels of fructose-2,6-bisphosphate in rats. Laboratory animal science. 1990 Jul; 40(4):399-401. doi: NULL. [PMID: 2166868]
  • I Kaneko, Y Fukumori, T Fukuda, Y Takeuchi. Relation of disposition kinetics to pharmacological effect of intravenous administration of chlorzoxazone in rats. Journal of pharmacobio-dynamics. 1990 Jun; 13(6):367-73. doi: 10.1248/bpb1978.13.367. [PMID: 2231268]
  • S D Kivlighn, B S Jandhyala. Antidiuretic effects of neurotensin in chloralose anaesthetized dogs. Clinical and experimental pharmacology & physiology. 1990 Jun; 17(6):401-12. doi: 10.1111/j.1440-1681.1990.tb01339.x. [PMID: 2390805]
  • K L Bennett, R J Linden. Effect of the cessation of an infusion of vasopressin in acutely hypophysectomized anaesthetized dogs. Quarterly journal of experimental physiology (Cambridge, England). 1989 Nov; 74(6):841-9. doi: 10.1113/expphysiol.1989.sp003354. [PMID: 2594936]
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  • J E Faber. Effects of althesin and urethan-chloralose on neurohumoral cardiovascular regulation. The American journal of physiology. 1989 Mar; 256(3 Pt 2):R757-65. doi: 10.1152/ajpregu.1989.256.3.r757. [PMID: 2564259]
  • A J Gorman, T E Bales, W H Waugh. Vagal afferents inhibit the antidiuresis and antinatriuresis secondary to bilateral carotid occlusion in the chloralose-anesthetized dog. Basic research in cardiology. 1989 Mar; 84(2):125-35. doi: 10.1007/bf01907922. [PMID: 2730519]
  • K Matsukawa, I Ninomiya. Anesthetic effects on tonic and reflex renal sympathetic nerve activity in awake cats. The American journal of physiology. 1989 Feb; 256(2 Pt 2):R371-8. doi: 10.1152/ajpregu.1989.256.2.r371. [PMID: 2916695]
  • L O Larson, C B Hantler, J J Lynch, S N Landau, J A Buben, B R Lucchesi, P R Knight. Cardiac electrophysiologic interactions of bepridil, a new calcium antagonist, with enflurane, halothane, and isoflurane. Journal of cardiothoracic anesthesia. 1988 Jun; 2(3):346-55. doi: 10.1016/0888-6296(88)90316-x. [PMID: 17171871]
  • D J Edwards, D Lalka, R L Slaughter, J M Hassett. Differential effect of pentobarbital and chloralose in anesthetic doses on the serum protein binding of lidocaine in the dog. Journal of pharmaceutical sciences. 1988 May; 77(5):466-7. doi: 10.1002/jps.2600770524. [PMID: 3411474]
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  • M Vogt, A D Smith, L D Fuenmayor. Factors influencing the cholinesterases of cerebrospinal fluid in the anaesthetized cat. Neuroscience. 1984 Jul; 12(3):979-95. doi: 10.1016/0306-4522(84)90185-4. [PMID: 6472626]
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  • B J Tucker, O W Peterson, M G Ziegler, R C Blantz. Analysis of adrenergic effects of the anesthetics Inactin and alpha-chloralose. The American journal of physiology. 1982 Sep; 243(3):F253-9. doi: 10.1152/ajprenal.1982.243.3.f253. [PMID: 7114255]
  • J F Mann, W Rascher, A Schömig, T Buu, O Kuchel, R Boucher, J Genest. Contribution of the sympathetic nervous system to the centrally-induced pressor action of angiotensin II in rats. Clinical and experimental pharmacology & physiology. 1982 Mar; 9(2):193-201. doi: 10.1111/j.1440-1681.1982.tb00797.x. [PMID: 7127917]
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