2-O-(6-Phospho-alpha-mannosyl)-D-glycerate (BioDeep_00000011356)

 

Secondary id: BioDeep_00001872818

human metabolite Endogenous Chemicals and Drugs


代谢物信息卡片


(2R)-3-hydroxy-2-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-[(phosphonooxy)methyl]oxan-2-yl]oxy}propanoic acid

化学式: C9H17O12P (348.0457612)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 1.9%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OC(CO)C(=O)O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C9H17O12P/c10-1-3(8(14)15)20-9-7(13)6(12)5(11)4(21-9)2-19-22(16,17)18/h3-7,9-13H,1-2H2,(H,14,15)(H2,16,17,18)/t3-,4-,5-,6+,7+,9+/m1/s1

描述信息

2-O-(6-Phospho-alpha-mannosyl)-D-glycerate is an alpha-D-mannosylglycerate (MG) that is an intermediate in 2-O-alpha-mannosyl-D-glycerate degradation. It can be generated from 2-O-alpha-mannosyl-D-glycerate via the enzyme 2-O-alpha-mannosyl-D-glycerate transporting phosphotransferase system (mngA). 2-O-Alpha-mannosyl-D-glycerate is a natural extremolyte identified in microorganisms growing under extremely high temperatures up to 100 oC, and had been shown to protect proteins against various stress conditions such as heat, freezing, thawing, and drying. MG that is naturally occurring hyperthermophilic osmolytes, could be potential drug candidates or lead compounds against alpha,beta aggregation associated with Alzheimers disease(PMID: 18304694). In most organisms MG is produced from guanosine pyrophosphate mannose (GDP-alpha-D-mannose) via mannosyl-3-phosphoglycerate in two steps, catalyzed by the enzymes mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase. [HMDB]
2-O-(6-Phospho-alpha-mannosyl)-D-glycerate is an alpha-D-mannosylglycerate (MG) that is an intermediate in 2-O-alpha-mannosyl-D-glycerate degradation. It can be generated from 2-O-alpha-mannosyl-D-glycerate via the enzyme 2-O-alpha-mannosyl-D-glycerate transporting phosphotransferase system (mngA). 2-O-Alpha-mannosyl-D-glycerate is a natural extremolyte identified in microorganisms growing under extremely high temperatures up to 100 oC, and had been shown to protect proteins against various stress conditions such as heat, freezing, thawing, and drying. MG that is naturally occurring hyperthermophilic osmolytes, could be potential drug candidates or lead compounds against alpha,beta aggregation associated with Alzheimers disease(PMID: 18304694). In most organisms MG is produced from guanosine pyrophosphate mannose (GDP-alpha-D-mannose) via mannosyl-3-phosphoglycerate in two steps, catalyzed by the enzymes mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase.

同义名列表

15 个代谢物同义名

(2R)-3-hydroxy-2-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-[(phosphonooxy)methyl]oxan-2-yl]oxy}propanoic acid; 2-O-(6-phospho-alpha-Mannosyl)-delta-glyceric acid; 2-O-(6-Phospho-alpha-D-mannosyl)-D-glyceric acid; 2-O-(6-Phospho-alpha-mannosyl)-D-glyceric acid; 2-O-(6-phospho-alpha-Mannosyl)-delta-glycerate; 2-O-(6-Phospho-alpha-D-mannosyl)-D-glycerate; 2-O-(6-Phospho-a-D-mannosyl)-D-glyceric acid; 2-O-(6-Phospho-α-D-mannosyl)-D-glyceric acid; 2-O-(6-Phospho-alpha-mannosyl)-D-glycerate; 2-O-(6-Phospho-a-mannosyl)-D-glyceric acid; 2-O-(6-Phospho-α-mannosyl)-D-glyceric acid; 2-O-(6-Phospho-a-D-mannosyl)-D-glycerate; 2-O-(6-Phospho-α-D-mannosyl)-D-glycerate; 2-O-(6-Phospho-α-mannosyl)-D-glycerate; 2-O-(6-Phospho-a-mannosyl)-D-glycerate



数据库引用编号

14 个数据库交叉引用编号

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相关代谢途径

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代谢反应

1 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PathBank(1)

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1 个相关的物种来源信息

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