7-Epiclusianone (BioDeep_00001029292)

   

natural product


代谢物信息卡片


7-Epiclusianone

化学式: C33H42O4 (502.3083)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC1CC2(C(=O)C(=C(C3=CC=CC=C3)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC=C(C)C)C
InChI: InChI=1S/C33H42O4/c1-21(2)14-15-25-20-32(18-16-22(3)4)28(35)26(27(34)24-12-10-9-11-13-24)29(36)33(30(32)37,31(25,7)8)19-17-23(5)6/h9-14,16-17,25,36H,15,18-20H2,1-8H3/t25-,32-,33+/m0/s1

描述信息

An enone that is a tetraprenyl benzophenone derivative isolated from Rheedia gardneriana and Garcinia brasiliensis. It exhibits anti-allergic, antibacterial, trypanocidal and vasodilating activities.

同义名列表

1 个代谢物同义名

7-Epiclusianone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • M S Silva, A P Castro, A T de Castro, I M M Souza, R L Martins-Souza, F A Colombo, T C Elias, M H Santos, M J Marques. The natural compound 7-epiclusianone inhibits superoxide dismutase activity in Schistosoma mansoni. Journal of helminthology. 2018 Sep; 92(5):535-543. doi: 10.1017/s0022149x17000700. [PMID: 28974276]
  • Aline Pereira Castro, Taila Kawano, Lidia Emmanuela Wiazowski Spelta, Andreísa Teixeira de Castro, Neusa Araújo Pereira, Flavia Fernanda Bubula Couto, Marcelo Henrique Dos Santos, Vanessa Bergamin Boralli, Marcos José Marques. In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jan; 38(?):66-73. doi: 10.1016/j.phymed.2017.11.001. [PMID: 29425656]
  • Leilane Sales, Julia Alejandra Pezuk, Kleiton Silva Borges, María Sol Brassesco, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Marcelo Henrique dos Santos, Marisa Ionta, Jaqueline Carvalho de Oliveira. Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma. BMC complementary and alternative medicine. 2015 Oct; 15(?):393. doi: 10.1186/s12906-015-0911-1. [PMID: 26518729]
  • Marisa Ionta, Guilherme A Ferreira-Silva, Evandro L Niero, Éderson D'Martin Costa, Adam A Martens, Welton Rosa, Marisi G Soares, Gláucia M Machado-Santelli, João Henrique G Lago, Marcelo H Santos. 7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells. Molecules (Basel, Switzerland). 2015 Jul; 20(7):12804-16. doi: 10.3390/molecules200712804. [PMID: 26184153]
  • Aline Pereira Castro, Ana Carolina Alves de Mattos, Neusa Araújo Pereira, Naira Ferreira Anchieta, Matheus Siqueira Silva, Danielle Ferreira Dias, Claudinei Alves Silva, Giulliano Vilela Barros, Raquel Lopes Martins Souza, Marcelo Henrique Dos Santos, Marcos José Marques. Potent Schistosomicidal Constituents from Garcinia brasiliensis. Planta medica. 2015 Jun; 81(9):733-41. doi: 10.1055/s-0035-1545927. [PMID: 25905590]
  • Flávia V Santa-Cecília, Lissara A S Freitas, Fabiana C Vilela, Clarice de C Veloso, Cláudia Q da Rocha, Maria E C Moreira, Danielle F Dias, Alexandre Giusti-Paiva, Marcelo H dos Santos. Antinociceptive and anti-inflammatory properties of 7-epiclusianone, a prenylated benzophenone from Garcinia brasiliensis. European journal of pharmacology. 2011 Nov; 670(1):280-5. doi: 10.1016/j.ejphar.2011.08.032. [PMID: 21924261]
  • Paraskev T Nedialkov, Dimitrina Zheleva-Dimitrova, Georgi Momekov, Kaloyan Karlov, Ulrich Girreser, Gerassim M Kitanov. Elegaphenone and 7-epi-clusianone, the major cytotoxic constituents of Hypericum elegans. Natural product research. 2011 Oct; 25(18):1743-50. doi: 10.1080/14786419.2010.524647. [PMID: 21707255]
  • Felipe T Martins, Marcelo H dos Santos, Carla P Coelho, Luiz C A Barbosa, Gizelly C Dias, Mônica P Fracca, Person P Neves, Paulo C Stringheta, Antônio C Doriguetto. A powder X-ray diffraction method for detection of polyprenylated benzophenones in plant extracts associated with HPLC for quantitative analysis. Journal of pharmaceutical and biomedical analysis. 2011 Feb; 54(3):451-7. doi: 10.1016/j.jpba.2010.09.010. [PMID: 20943341]
  • Ramiro Mendonça Murata, Regiane Yatsuda, Marcelo Henrique dos Santos, Luciana K Kohn, Felipe Terra Martins, Tanus Jorge Nagem, Severino Matias Alencar, João Ernesto de Carvalho, Pedro Luiz Rosalen. Antiproliferative effect of benzophenones and their influence on cathepsin activity. Phytotherapy research : PTR. 2010 Mar; 24(3):379-83. doi: 10.1002/ptr.2954. [PMID: 19653314]
  • F J Naldoni, A L R Claudino, J W Cruz, J K Chavasco, P M Faria e Silva, M P Veloso, M H Dos Santos. Antimicrobial activity of benzophenones and extracts from the fruits of Garcinia brasiliensis. Journal of medicinal food. 2009 Apr; 12(2):403-7. doi: 10.1089/jmf.2007.0622. [PMID: 19459744]
  • Luciana Pontes Coelho, Magda Fráguas Serra, Ana Lúcia de Aguiar Pires, Renato Sérgio Balão Cordeiro, Patrícia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, Marco Aurélio Martins. 7-Epiclusianone, a tetraprenylated benzophenone, relaxes airway smooth muscle through activation of the nitric oxide-cGMP pathway. The Journal of pharmacology and experimental therapeutics. 2008 Oct; 327(1):206-14. doi: 10.1124/jpet.108.138032. [PMID: 18591220]
  • L S B Almeida, R M Murata, R Yatsuda, M H Dos Santos, T J Nagem, S M Alencar, H Koo, P L Rosalen. Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Oct; 15(10):886-91. doi: 10.1016/j.phymed.2007.12.003. [PMID: 18276126]
  • Ramiro Mendonca Murata, Luciana Salles Branco de Almeida, Regiane Yatsuda, Marcelo Henrique Dos Santos, Tanus Jorge Nagem, Pedro Luiz Rosalen, Hyun Koo. Inhibitory effects of 7-epiclusianone on glucan synthesis, acidogenicity and biofilm formation by Streptococcus mutans. FEMS microbiology letters. 2008 May; 282(2):174-81. doi: 10.1111/j.1574-6968.2008.01117.x. [PMID: 18371068]
  • Ji Qi, John A Porco. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). Journal of the American Chemical Society. 2007 Oct; 129(42):12682-3. doi: 10.1021/ja0762339. [PMID: 17902679]
  • Josiane Sabbadini Neves, Luciana Pontes Coelho, Renato Sérgio Balão Cordeiro, Marcia Paranho Veloso, Patricia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, Marco Aurélio Martins. Antianaphylactic properties of 7-epiclusianone, a tetraprenylated benzophenone isolated from Garcinia brasiliensis. Planta medica. 2007 Jun; 73(7):644-9. doi: 10.1055/s-2007-981534. [PMID: 17562491]